| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Hun Kim, Daeho Kim, Stephen R Marde. Time to rehospitalization of clozapine versus risperidone in the naturalistic treatment of comorbid alcohol use disorder and schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18262321. |
in this prospective, naturalistic, observational, community-survival-analysis study, we compared the effect of clozapine and risperidone on two-year psychiatric hospitalization rate and time to hospitalization in the treatment of patients with schizophrenia and comorbid aud. |
2008-07-22 |
2023-08-12 |
Not clear |
| Jin Hun Kim, Daeho Kim, Stephen R Marde. Time to rehospitalization of clozapine versus risperidone in the naturalistic treatment of comorbid alcohol use disorder and schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18262321. |
these findings suggest that clozapine should be considered for the treatment of schizophrenia patients with comorbid aud. |
2008-07-22 |
2023-08-12 |
Not clear |
| V Molina, P Tamayo, C Montes, A De Luxán, C Martin, N Rivas, C Sancho, A Domínguez-Gi. Clozapine may partially compensate for task-related brain perfusion abnormalities in risperidone-resistant schizophrenia patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18262704. |
clozapine may partially compensate for task-related brain perfusion abnormalities in risperidone-resistant schizophrenia patients. |
2008-07-22 |
2023-08-12 |
human |
| Amir H Rezvani, Yousef Tizabi, Bruk Getachew, Sheketha R Hauser, D Patrick Caldwell, Christopher Hunter, Edward D Levi. Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18343006. |
clozapine, a widely used antipsychotic drug, has been shown in some studies to be effective in ameliorating the cognitive deficits associated with schizophrenia. |
2008-07-22 |
2023-08-12 |
rat |
| Gil Golden, Gilbert Honigfel. Bioequivalence of clozapine orally disintegrating 100-mg tablets compared with clozapine solid oral 100-mg tablets after multiple doses in patients with schizophrenia. Clinical drug investigation. vol 28. issue 4. 2008-07-09. PMID:18345713. |
bioequivalence of clozapine orally disintegrating 100-mg tablets compared with clozapine solid oral 100-mg tablets after multiple doses in patients with schizophrenia. |
2008-07-09 |
2023-08-12 |
Not clear |
| Gil Golden, Gilbert Honigfel. Bioequivalence of clozapine orally disintegrating 100-mg tablets compared with clozapine solid oral 100-mg tablets after multiple doses in patients with schizophrenia. Clinical drug investigation. vol 28. issue 4. 2008-07-09. PMID:18345713. |
this study compared the bioequivalence of fazaclo (clozapine orally disintegrating tablets) 100 mg to clozaril (clozapine standard oral tablets) 100 mg after multiple doses in patients with schizophrenia. |
2008-07-09 |
2023-08-12 |
Not clear |
| Takashi Kubota, Itsuki Jibiki, Akira Ishikawa, Tomomi Kawamura, Sonoko Kurokawa, Man Wan. Increase in extracellular dopamine levels during clozapine-induced potentiation in the hippocampal dentate gyrus of chronically prepared rabbits. Canadian journal of physiology and pharmacology. vol 86. issue 5. 2008-06-26. PMID:18432285. |
this potentiation is presumably related to clozapine's clinical effect on negative symptoms and cognitive dysfunctions in schizophrenia. |
2008-06-26 |
2023-08-12 |
Not clear |
| Amanda J Wheele. Treatment pathway and patterns of clozapine prescribing for schizophrenia in New Zealand. The Annals of pharmacotherapy. vol 42. issue 6. 2008-06-17. PMID:18477732. |
treatment pathway and patterns of clozapine prescribing for schizophrenia in new zealand. |
2008-06-17 |
2023-08-12 |
Not clear |
| Amanda J Wheele. Treatment pathway and patterns of clozapine prescribing for schizophrenia in New Zealand. The Annals of pharmacotherapy. vol 42. issue 6. 2008-06-17. PMID:18477732. |
to describe the treatment pathway and patterns of clozapine use in patients with schizophrenia, including coprescribed psychotropic medications, and compare the extent of coprescribing of clozapine with that of non-clozapine schizophrenia treatment in community mental health services in the auckland and northland regions of new zealand. |
2008-06-17 |
2023-08-12 |
Not clear |
| Massimo C Mauri, Donatella Moliterno, Matteo Rossattini, Alessandro Colasant. Depression in schizophrenia: comparison of first- and second-generation antipsychotic drugs. Schizophrenia research. vol 99. issue 1-3. 2008-05-27. PMID:18055177. |
the data were drawn from a retrospective, naturalistic, observational study in which 222 subjects diagnosed as being affected by schizophrenia during a re-exacerbation phase received 6 weeks of monotherapy with fluphenazine decanoate, haloperidol decanoate, haloperidol, clozapine, olanzapine, quetiapine, risperidone or l-sulpiride. |
2008-05-27 |
2023-08-12 |
human |
| Istvan Bitter, Tamas Treuer, Yulia Dyachkova, Ferenc Martenyi, Margaret McBride, Gabor S Ungvar. Antipsychotic prescription patterns in outpatient settings: 24-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 3. 2008-05-22. PMID:17884390. |
this report describes antipsychotic prescription patterns for outpatients with schizophrenia prescribed olanzapine (n=3,222), clozapine (n=236), risperidone (n=1,117), quetiapine (n=189) or haloperidol (n=256) monotherapy at study entry and treated in a naturalistic, clinical practice setting over 24 months. |
2008-05-22 |
2023-08-12 |
Not clear |
| Alaattin Duran, M Mufit Ugur, Senol Turan, Murat Emu. Clozapine use in two women with schizophrenia during pregnancy. Journal of psychopharmacology (Oxford, England). vol 22. issue 1. 2008-05-22. PMID:18187538. |
clozapine use in two women with schizophrenia during pregnancy. |
2008-05-22 |
2023-08-12 |
Not clear |
| Alaattin Duran, M Mufit Ugur, Senol Turan, Murat Emu. Clozapine use in two women with schizophrenia during pregnancy. Journal of psychopharmacology (Oxford, England). vol 22. issue 1. 2008-05-22. PMID:18187538. |
the first woman (case 1) had two deliveries while she was receiving clozapine treatment for schizophrenia. |
2008-05-22 |
2023-08-12 |
Not clear |
| Ana Paula Werneck de Castro, Helio Elki. Rehospitalization rates of patients with schizophrenia discharged on haloperidol, risperidone or clozapine. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 29. issue 3. 2008-04-24. PMID:17891257. |
rehospitalization rates of patients with schizophrenia discharged on haloperidol, risperidone or clozapine. |
2008-04-24 |
2023-08-12 |
Not clear |
| Donald C Goff, J Steven Lamberti, Andrew C Leon, Michael F Green, Alexander L Miller, Jayendra Patel, Theo Manschreck, Oliver Freudenreich, Steven A Johnso. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17487227. |
stable schizophrenia patients treated with clozapine (n=52), olanzapine (n=40), or risperidone (n=13) were randomly assigned to add-on treatment with cx516 900 mg three times daily or placebo for 4 weeks. |
2008-04-23 |
2023-08-12 |
human |
| Donald C Goff, J Steven Lamberti, Andrew C Leon, Michael F Green, Alexander L Miller, Jayendra Patel, Theo Manschreck, Oliver Freudenreich, Steven A Johnso. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17487227. |
cx516 was not effective for cognition or for symptoms of schizophrenia when added to clozapine, olanzapine, or risperidone. |
2008-04-23 |
2023-08-12 |
human |
| John D Elsworth, J David Jentsch, Bret A Morrow, D Eugene Redmond, Robert H Rot. Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17507917. |
the mechanism responsible for the therapeutic effects of the prototypical atypical antipsychotic drug, clozapine, is still not understood; however, there is persuasive evidence from in vivo studies in normal rodents and primates that the ability to elevate dopamine neurotransmission preferentially in the prefrontal cortex is a key component to the beneficial effects of clozapine in schizophrenia. |
2008-04-23 |
2023-08-12 |
monkey |
| John D Elsworth, J David Jentsch, Bret A Morrow, D Eugene Redmond, Robert H Rot. Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17507917. |
theoretically, such an effect of clozapine would counteract the deficient dopaminergic innervation of the prefrontal cortex that appears to be part of the pathophysiology of schizophrenia. |
2008-04-23 |
2023-08-12 |
monkey |
| John D Elsworth, J David Jentsch, Bret A Morrow, D Eugene Redmond, Robert H Rot. Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17507917. |
thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of da tone in the prefrontal cortex. |
2008-04-23 |
2023-08-12 |
monkey |
| Amir H Rezvani, Ehsan Kholdebarin, Elizabeth Dawson, Edward D Levi. Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17295931. |
for the current study, in a model of cognitive impairment of schizophrenia with the nmda antagonist dizocilpine (0.05 mg/kg), we examined the effects of clozapine and nicotine on significantly impaired attentional hit accuracy. |
2008-04-15 |
2023-08-12 |
rat |