| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L N Gorobet. Contribution of leptin to the formation of neuroleptic obesity in patients with schizophrenia during antipsychotic therapy. Bulletin of experimental biology and medicine. vol 146. issue 3. 2009-03-30. PMID:19240857. |
we studied the dynamics of serum leptin level and some anthropometric values in patients with schizophrenia treated with risperidone, olanzapine, and clozapine showed gender-dependent specific correlations between the studied parameters. |
2009-03-30 |
2023-08-12 |
Not clear |
| Arzu Gunes, Kristina I Melkersson, Maria Gabriella Scordo, Marja-Liisa Dah. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. Journal of clinical psychopharmacology. vol 29. issue 1. 2009-03-23. PMID:19142110. |
the impact of htr2c and htr2a polymorphisms on body mass index (bmi), glucose-insulin homeostasis, and blood lipid levels was evaluated in 46 patients with schizophrenia or schizoaffective disorder and treated with olanzapine (n = 28) or clozapine (n = 18) for at least 6 months. |
2009-03-23 |
2023-08-12 |
Not clear |
| Adib Essali, Nahla Al-Haj Haasan, Chunbo Li, John Rathbon. Clozapine versus typical neuroleptic medication for schizophrenia. The Cochrane database of systematic reviews. issue 1. 2009-03-19. PMID:19160174. |
clozapine versus typical neuroleptic medication for schizophrenia. |
2009-03-19 |
2023-08-12 |
Not clear |
| Laura Gray, Maarten van den Buuse, Elizabeth Scarr, Brian Dean, Anthony J Hanna. Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation. The international journal of neuropsychopharmacology. vol 12. issue 1. 2009-03-13. PMID:18593507. |
these results demonstrate behavioural abnormalities that are relevant to schizophrenia in the mglur5 knockout mouse and a reversal of behaviours with clozapine treatment. |
2009-03-13 |
2023-08-12 |
mouse |
| I Omer Barlas, Mesut Cetin, M Emin Erdal, Umit B Semiz, Cengiz Basoglu, M Ertan Ay, Hasan Herken, Ozcan Uzu. Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 1. 2009-03-10. PMID:18449897. |
in this study, we aimed to investigate the relationship of the serine/glycine polymorphism of the drd3 gene with therapeutic response to clozapine treatment between turkish schizophrenia patients (n = 92) and healthy controls (n = 100). |
2009-03-10 |
2023-08-12 |
Not clear |
| I Omer Barlas, Mesut Cetin, M Emin Erdal, Umit B Semiz, Cengiz Basoglu, M Ertan Ay, Hasan Herken, Ozcan Uzu. Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 1. 2009-03-10. PMID:18449897. |
our results suggest that an association between the ser/gly polymorphism of drd3 gene and response to clozapine in turkish schizophrenia patients is unlikely to exist. |
2009-03-10 |
2023-08-12 |
Not clear |
| Erminio Costa, Ying Chen, Erbo Dong, Dennis R Grayson, Marija Kundakovic, Ekrem Maloku, William Ruzicka, Rosalba Satta, Marin Veldic, Adrian Zhubi, Alessandro Guidott. GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert review of neurotherapeutics. vol 9. issue 1. 2009-03-03. PMID:19102671. |
the results suggest that clozapine, or sulpiride associated with valproate, by increasing dna demethylation with an unknown mechanism, causes a chromatin remodeling that brings about a beneficial change in the epigenetic gabaergic dysfunction typical of schizophrenia and bipolar disorder patients. |
2009-03-03 |
2023-08-12 |
Not clear |
| Yeni Kim, Boong-Nyun Kim, Soo-Churl Cho, Jae-Won Kim, Min-Sup Shi. Long-term sustained benefits of clozapine treatment in refractory early onset schizophrenia: a retrospective study in Korean children and adolescents. Human psychopharmacology. vol 23. issue 8. 2009-02-27. PMID:18814190. |
long-term sustained benefits of clozapine treatment in refractory early onset schizophrenia: a retrospective study in korean children and adolescents. |
2009-02-27 |
2023-08-12 |
Not clear |
| Yeni Kim, Boong-Nyun Kim, Soo-Churl Cho, Jae-Won Kim, Min-Sup Shi. Long-term sustained benefits of clozapine treatment in refractory early onset schizophrenia: a retrospective study in Korean children and adolescents. Human psychopharmacology. vol 23. issue 8. 2009-02-27. PMID:18814190. |
we retrospectively examined the therapeutic dosage, clinical response, and side effect profiles of long-term clozapine treatment in korean children and adolescents with refractory eos or very early onset schizophrenia (veos). |
2009-02-27 |
2023-08-12 |
Not clear |
| Mei Huang, Zhu Li, Jin Dai, Mohammed Shahid, Erik H F Wong, Herbert Y Meltze. Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 12. 2009-02-20. PMID:18418367. |
these findings indicate that ase is similar to clozapine and other atypical antipsychotic drugs in preferentially increasing the efflux of da, ne, and ach in the mpfc and hip compared with the nac, and suggests that, like these agents, it may also improve cognitive function and negative symptoms in patients with schizophrenia. |
2009-02-20 |
2023-08-12 |
rat |
| Fabiana B Kohlrausch, Angélica Salatino-Oliveira, Clarissa S Gama, Maria Inês Lobato, Paulo Belmonte-de-Abreu, Mara H Hut. G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics. Pharmacogenomics. vol 9. issue 10. 2009-02-13. PMID:18855531. |
clozapine treatment of schizophrenia is effective only in 30-60% of individuals. |
2009-02-13 |
2023-08-12 |
Not clear |
| Fabiana B Kohlrausch, Angélica Salatino-Oliveira, Clarissa S Gama, Maria Inês Lobato, Paulo Belmonte-de-Abreu, Mara H Hut. G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics. Pharmacogenomics. vol 9. issue 10. 2009-02-13. PMID:18855531. |
since genetic factors are believed to play a significant role in the variation of response to antipsychotics, the aim of the present study was to verify the effect of a g-protein gene polymorphism on clozapine response and clozapine-induced generalized seizures in brazilian patients with schizophrenia. |
2009-02-13 |
2023-08-12 |
Not clear |
| J Cordes, A Sinha-Röder, K G Kahl, J Malevani, J Thuenker, C Lange-Asschenfeldt, H Hauner, M W Agelink, A Klimk. [Therapeutic options for weight management in schizophrenic patients treated with atypical antipsychotics]. Fortschritte der Neurologie-Psychiatrie. vol 76. issue 12. 2009-02-09. PMID:18924059. |
extensive, selective literature review of 2500 articles from the last years (up to december 2007) predominantly from medline and cochrane, using as search terms "antipsychotic or schizophrenia or individual drug names (amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone)" and the terms "bmi, weight gain, metabolic syndrome, diabetes, lipid(s), cholesterol, triglycerides" was conducted. |
2009-02-09 |
2023-08-12 |
Not clear |
| David W Ayer, Karu Jayathilake, Herbert Y Meltze. The InterSePT suicide scale for prediction of imminent suicidal behaviors. Psychiatry research. vol 161. issue 1. 2009-02-02. PMID:18786729. |
clozapine treatment for suicidality in schizophrenia. |
2009-02-02 |
2023-08-12 |
Not clear |
| Renan P Souza, Marco A Romano-Silva, Jeffrey A Lieberman, Herbert Y Meltzer, Albert H C Wong, James L Kenned. Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. Psychopharmacology. vol 200. issue 2. 2009-01-29. PMID:18500637. |
association study of gsk3 gene polymorphisms with schizophrenia and clozapine response. |
2009-01-29 |
2023-08-12 |
human |
| Herbert Y Meltzer, Mei Huan. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Progress in brain research. vol 172. 2009-01-15. PMID:18772033. |
atypical antipsychotic drugs related to clozapine, improve psychosis, cognition and negative symptoms, while producing minimal extrapyramidal side effects, in patients with schizophrenia. |
2009-01-15 |
2023-08-12 |
Not clear |
| Barbora Tislerova, Martin Brunovsky, Jiri Horacek, Tomas Novak, Miloslav Kopecek, Pavel Mohr, Vladimír Krajc. LORETA functional imaging in antipsychotic-naive and olanzapine-, clozapine- and risperidone-treated patients with schizophrenia. Neuropsychobiology. vol 58. issue 1. 2009-01-13. PMID:18781085. |
we included 41 subjects with schizophrenia (antipsychotic naive = 11; clozapine = 8; olanzapine = 10; risperidone = 12) and 20 healthy controls. |
2009-01-13 |
2023-08-12 |
human |
| Barbora Tislerova, Martin Brunovsky, Jiri Horacek, Tomas Novak, Miloslav Kopecek, Pavel Mohr, Vladimír Krajc. LORETA functional imaging in antipsychotic-naive and olanzapine-, clozapine- and risperidone-treated patients with schizophrenia. Neuropsychobiology. vol 58. issue 1. 2009-01-13. PMID:18781085. |
changes in those taking clozapine and olanzapine versus those who were antipsychotic naive suggest a compensatory mechanism in the neurobiological substrate for schizophrenia. |
2009-01-13 |
2023-08-12 |
human |
| Herbert Y Meltzer, Tomiki Sumiyosh. Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia? Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18707769. |
aripiprazole, clozapine, olanzapine, perospirone, quetiapine risperidone, and ziprasidone are examples of atypical antipsychotic drugs which are either direct or indirect 5-ht(1a) agonists which have been shown to improve cognitive function in patients with schizophrenia. |
2009-01-12 |
2023-08-12 |
Not clear |
| Zhu Li, Shikha Snigdha, Alex S Roseman, Jin Dai, Herbert Y Meltze. Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine. European journal of pharmacology. vol 596. issue 1-3. 2009-01-12. PMID:18771666. |
we have demonstrated that the main metabolite of clozapine, n-desmethylclozapine, has a significant role in the ability of clozapine to improve some aspects of cognition in schizophrenia. |
2009-01-12 |
2023-08-12 |
rat |