| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boris B Quednow, Ulrich Ettinger, Rainald Mössner, Dan Rujescu, Ina Giegling, David A Collier, Anne Schmechtig, Kai-Uwe Kühn, Hans-Jürgen Möller, Wolfgang Maier, Michael Wagner, Veena Kumar. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543597. |
in a large-scale meta-analysis, it has been recently shown that the transcription factor 4 (tcf4) gene is among the most prominent susceptibility genes for schizophrenia. |
2011-08-05 |
2023-08-12 |
mouse |
| Boris B Quednow, Ulrich Ettinger, Rainald Mössner, Dan Rujescu, Ina Giegling, David A Collier, Anne Schmechtig, Kai-Uwe Kühn, Hans-Jürgen Möller, Wolfgang Maier, Michael Wagner, Veena Kumar. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543597. |
we therefore investigated the impact of the schizophrenia susceptibility gene tcf4 (rs9960767) on sensorimotor gating of the asr in healthy humans and in patients with a schizophrenia spectrum disorder. |
2011-08-05 |
2023-08-12 |
mouse |
| Boris B Quednow, Ulrich Ettinger, Rainald Mössner, Dan Rujescu, Ina Giegling, David A Collier, Anne Schmechtig, Kai-Uwe Kühn, Hans-Jürgen Möller, Wolfgang Maier, Michael Wagner, Veena Kumar. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543597. |
in both samples, ppi was strongly decreased in carriers of the schizophrenia risk allele c of the tcf4 gene (meta-analysis across both samples: p = 0.00002), whereas startle reactivity and habituation were unaffected by tcf4 genotype. |
2011-08-05 |
2023-08-12 |
mouse |
| Boris B Quednow, Ulrich Ettinger, Rainald Mössner, Dan Rujescu, Ina Giegling, David A Collier, Anne Schmechtig, Kai-Uwe Kühn, Hans-Jürgen Möller, Wolfgang Maier, Michael Wagner, Veena Kumar. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543597. |
sensorimotor gating is modulated by tcf4 genotype, indicating an influential role of tcf4 gene variations in the development of early information-processing deficits in schizophrenia. |
2011-08-05 |
2023-08-12 |
mouse |
| Leonhard Lennertz, Dan Rujescu, Michael Wagner, Ingo Frommann, Svenja Schulze-Rauschenbach, Anna Schuhmacher, Martin W Landsberg, Petra Franke, Hans-Jürgen Möller, Wolfgang Wölwer, Wolfgang Gaebel, Heinz Häfner, Wolfgang Maier, Rainald Mössne. Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients. Neuropsychobiology. vol 63. issue 3. 2011-06-21. PMID:21228604. |
novel schizophrenia risk gene tcf4 influences verbal learning and memory functioning in schizophrenia patients. |
2011-06-21 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Dan Rujescu, Michael Wagner, Ingo Frommann, Svenja Schulze-Rauschenbach, Anna Schuhmacher, Martin W Landsberg, Petra Franke, Hans-Jürgen Möller, Wolfgang Wölwer, Wolfgang Gaebel, Heinz Häfner, Wolfgang Maier, Rainald Mössne. Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients. Neuropsychobiology. vol 63. issue 3. 2011-06-21. PMID:21228604. |
recently, a role of the transcription factor 4 (tcf4) gene in schizophrenia has been reported in a large genome-wide association study. |
2011-06-21 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Dan Rujescu, Michael Wagner, Ingo Frommann, Svenja Schulze-Rauschenbach, Anna Schuhmacher, Martin W Landsberg, Petra Franke, Hans-Jürgen Möller, Wolfgang Wölwer, Wolfgang Gaebel, Heinz Häfner, Wolfgang Maier, Rainald Mössne. Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients. Neuropsychobiology. vol 63. issue 3. 2011-06-21. PMID:21228604. |
thus, we hypothesized that the disease-associated c allele of the rs9960767 polymorphism of the tcf4 gene led to impaired vdm functioning in schizophrenia patients. |
2011-06-21 |
2023-08-12 |
Not clear |
| Tao Li, Zhiqiang Li, Peng Chen, Qian Zhao, Ti Wang, Ke Huang, Junyan Li, You Li, Jie Liu, Zhen Zeng, Guoyin Feng, Lin He, Yongyong Sh. Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biological psychiatry. vol 68. issue 7. 2011-01-13. PMID:20673877. |
common variants in major histocompatibility complex region and tcf4 gene are significantly associated with schizophrenia in han chinese. |
2011-01-13 |
2023-08-12 |
human |
| Magdalena M Brzózka, Konstantin Radyushkin, Sven P Wichert, Hannelore Ehrenreich, Moritz J Rossne. Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain. Biological psychiatry. vol 68. issue 1. 2010-10-11. PMID:20434134. |
cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene tcf4 in the brain. |
2010-10-11 |
2023-08-12 |
mouse |
| Magdalena M Brzózka, Konstantin Radyushkin, Sven P Wichert, Hannelore Ehrenreich, Moritz J Rossne. Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain. Biological psychiatry. vol 68. issue 1. 2010-10-11. PMID:20434134. |
the combined analysis of several large genome-wide association studies identified the basic helix-loop-helix (bhlh) transcription factor tcf4 as one of the most significant schizophrenia susceptibility genes. |
2010-10-11 |
2023-08-12 |
mouse |
| Derek J Blake, Marc Forrest, Ria M Chapman, Caroline L Tinsley, Michael C O'Donovan, Michael J Owe. TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia bulletin. vol 36. issue 3. 2010-09-16. PMID:20421335. |
recently, a meta-analysis of several genome-wide association studies found, in addition to several other markers, a single nucleotide polymorphism in intron 4 of the tcf4 gene that was associated with schizophrenia. |
2010-09-16 |
2023-08-12 |
Not clear |
| Derek J Blake, Marc Forrest, Ria M Chapman, Caroline L Tinsley, Michael C O'Donovan, Michael J Owe. TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia bulletin. vol 36. issue 3. 2010-09-16. PMID:20421335. |
variants in the tcf4 gene may therefore be associated with a range of neuropsychiatric phenotypes, including schizophrenia. |
2010-09-16 |
2023-08-12 |
Not clear |
| Derek J Blake, Marc Forrest, Ria M Chapman, Caroline L Tinsley, Michael C O'Donovan, Michael J Owe. TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia bulletin. vol 36. issue 3. 2010-09-16. PMID:20421335. |
these data suggest that tcf4, nrxn1, and cntnap2 may participate in a biological pathway that is altered in patients with schizophrenia and other neuropsychiatric disorders. |
2010-09-16 |
2023-08-12 |
Not clear |
| Hreinn Stefansson, Roel A Ophoff, Stacy Steinberg, Ole A Andreassen, Sven Cichon, Dan Rujescu, Thomas Werge, Olli P H Pietiläinen, Ole Mors, Preben B Mortensen, Engilbert Sigurdsson, Omar Gustafsson, Mette Nyegaard, Annamari Tuulio-Henriksson, Andres Ingason, Thomas Hansen, Jaana Suvisaari, Jouko Lonnqvist, Tiina Paunio, Anders D Børglum, Annette Hartmann, Anders Fink-Jensen, Merete Nordentoft, David Hougaard, Bent Norgaard-Pedersen, Yvonne Böttcher, Jes Olesen, René Breuer, Hans-Jürgen Möller, Ina Giegling, Henrik B Rasmussen, Sally Timm, Manuel Mattheisen, István Bitter, János M Réthelyi, Brynja B Magnusdottir, Thordur Sigmundsson, Pall Olason, Gisli Masson, Jeffrey R Gulcher, Magnus Haraldsson, Ragnheidur Fossdal, Thorgeir E Thorgeirsson, Unnur Thorsteinsdottir, Mirella Ruggeri, Sarah Tosato, Barbara Franke, Eric Strengman, Lambertus A Kiemeney, Ingrid Melle, Srdjan Djurovic, Lilia Abramova, Vasily Kaleda, Julio Sanjuan, Rosa de Frutos, Elvira Bramon, Evangelos Vassos, Gillian Fraser, Ulrich Ettinger, Marco Picchioni, Nicholas Walker, Timi Toulopoulou, Anna C Need, Dongliang Ge, Joeng Lim Yoon, Kevin V Shianna, Nelson B Freimer, Rita M Cantor, Robin Murray, Augustine Kong, Vera Golimbet, Angel Carracedo, Celso Arango, Javier Costas, Erik G Jönsson, Lars Terenius, Ingrid Agartz, Hannes Petursson, Markus M Nöthen, Marcella Rietschel, Paul M Matthews, Pierandrea Muglia, Leena Peltonen, David St Clair, David B Goldstein, Kari Stefansson, David A Collie. Common variants conferring risk of schizophrenia. Nature. vol 460. issue 7256. 2009-09-18. PMID:19571808. |
our findings implicating the mhc region are consistent with an immune component to schizophrenia risk, whereas the association with nrgn and tcf4 points to perturbation of pathways involved in brain development, memory and cognition. |
2009-09-18 |
2023-08-12 |
Not clear |