| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Buket Basmanav, Andreas J Forstner, Heide Fier, Stefan Herms, Sandra Meier, Franziska Degenhardt, Per Hoffmann, Sandra Barth, Nadine Fricker, Jana Strohmaier, Stephanie H Witt, Michael Ludwig, Christine Schmael, Susanne Moebus, Wolfgang Maier, Rainald Mössner, Dan Rujescu, Marcella Rietschel, Christoph Lange, Markus M Nöthen, Sven Cicho. Investigation of the role of TCF4 rare sequence variants in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168B. issue 5. 2016-03-11. PMID:26010163. |
investigation of the role of tcf4 rare sequence variants in schizophrenia. |
2016-03-11 |
2023-08-13 |
human |
| F Buket Basmanav, Andreas J Forstner, Heide Fier, Stefan Herms, Sandra Meier, Franziska Degenhardt, Per Hoffmann, Sandra Barth, Nadine Fricker, Jana Strohmaier, Stephanie H Witt, Michael Ludwig, Christine Schmael, Susanne Moebus, Wolfgang Maier, Rainald Mössner, Dan Rujescu, Marcella Rietschel, Christoph Lange, Markus M Nöthen, Sven Cicho. Investigation of the role of TCF4 rare sequence variants in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168B. issue 5. 2016-03-11. PMID:26010163. |
transcription factor 4 (tcf4) is one of the most robust of all reported schizophrenia risk loci and is supported by several genetic and functional lines of evidence. |
2016-03-11 |
2023-08-13 |
human |
| F Buket Basmanav, Andreas J Forstner, Heide Fier, Stefan Herms, Sandra Meier, Franziska Degenhardt, Per Hoffmann, Sandra Barth, Nadine Fricker, Jana Strohmaier, Stephanie H Witt, Michael Ludwig, Christine Schmael, Susanne Moebus, Wolfgang Maier, Rainald Mössner, Dan Rujescu, Marcella Rietschel, Christoph Lange, Markus M Nöthen, Sven Cicho. Investigation of the role of TCF4 rare sequence variants in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168B. issue 5. 2016-03-11. PMID:26010163. |
while numerous studies have implicated common genetic variation at tcf4 in schizophrenia risk, the role of rare, small-sized variants at this locus-such as single nucleotide variants and short indels which are below the resolution of chip-based arrays requires further exploration. |
2016-03-11 |
2023-08-13 |
human |
| F Buket Basmanav, Andreas J Forstner, Heide Fier, Stefan Herms, Sandra Meier, Franziska Degenhardt, Per Hoffmann, Sandra Barth, Nadine Fricker, Jana Strohmaier, Stephanie H Witt, Michael Ludwig, Christine Schmael, Susanne Moebus, Wolfgang Maier, Rainald Mössner, Dan Rujescu, Marcella Rietschel, Christoph Lange, Markus M Nöthen, Sven Cicho. Investigation of the role of TCF4 rare sequence variants in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168B. issue 5. 2016-03-11. PMID:26010163. |
the aim of the present study was to investigate the association between rare tcf4 sequence variants and schizophrenia. |
2016-03-11 |
2023-08-13 |
human |
| F Buket Basmanav, Andreas J Forstner, Heide Fier, Stefan Herms, Sandra Meier, Franziska Degenhardt, Per Hoffmann, Sandra Barth, Nadine Fricker, Jana Strohmaier, Stephanie H Witt, Michael Ludwig, Christine Schmael, Susanne Moebus, Wolfgang Maier, Rainald Mössner, Dan Rujescu, Marcella Rietschel, Christoph Lange, Markus M Nöthen, Sven Cicho. Investigation of the role of TCF4 rare sequence variants in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168B. issue 5. 2016-03-11. PMID:26010163. |
however, the results from our association and power analyses suggest that further research into the possible involvement of rare tcf4 sequence variants in schizophrenia risk is warranted by the assessment of larger cohorts with higher statistical power to identify rare variant associations. |
2016-03-11 |
2023-08-13 |
human |
| Helena Cousijn, Marc Eissing, Guillén Fernández, Simon E Fisher, Barbara Franke, Marcel Zwiers, Paul J Harrison, Alejandro Arias-Vásque. No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. Schizophrenia research. vol 159. issue 2-3. 2015-08-19. PMID:25217366. |
no effect of schizophrenia risk genes mir137, tcf4, and znf804a on macroscopic brain structure. |
2015-08-19 |
2023-08-13 |
Not clear |
| Helena Cousijn, Marc Eissing, Guillén Fernández, Simon E Fisher, Barbara Franke, Marcel Zwiers, Paul J Harrison, Alejandro Arias-Vásque. No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. Schizophrenia research. vol 159. issue 2-3. 2015-08-19. PMID:25217366. |
single nucleotide polymorphisms (snps) within the mir137, tcf4, and znf804a genes show genome-wide association to schizophrenia. |
2015-08-19 |
2023-08-13 |
Not clear |
| Dominika Sieradzka, Robert A Power, Daniel Freeman, Alastair G Cardno, Philip McGuire, Robert Plomin, Emma L Meaburn, Frank Dudbridge, Angelica Ronal. Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? PloS one. vol 9. issue 4. 2015-06-29. PMID:24718684. |
the analyses on the 28 individual snps previously associated with schizophrenia found that two snps in tcf4 returned a significant association with the speq paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴). |
2015-06-29 |
2023-08-13 |
Not clear |
| Satomi Umeda-Yano, Ryota Hashimoto, Hidenaga Yamamori, Cynthia Shannon Weickert, Yuka Yasuda, Kazutaka Ohi, Michiko Fujimoto, Akira Ito, Masatoshi Taked. Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia. Neuroscience letters. vol 568. 2014-12-09. PMID:24686180. |
we measured the expression levels of the genes identified in gwas (znf804a, opcml, rpgrip1l, nrgn, and tcf4) of the postmortem brain tissues of patients with schizophrenia and controls from two separate sample sets (i.e., the australian tissue resource center and stanley medical research institute). |
2014-12-09 |
2023-08-12 |
Not clear |
| Satomi Umeda-Yano, Ryota Hashimoto, Hidenaga Yamamori, Cynthia Shannon Weickert, Yuka Yasuda, Kazutaka Ohi, Michiko Fujimoto, Akira Ito, Masatoshi Taked. Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia. Neuroscience letters. vol 568. 2014-12-09. PMID:24686180. |
no difference was observed between the patients with schizophrenia and controls from the australian tissue resource center samples in the mrna levels of znf804a, opcml, rpgrip1l, nrgn, or tcf4. |
2014-12-09 |
2023-08-12 |
Not clear |
| Javier González-Penas, Manuel Arrojo, Mario Páramo, Eduardo Paz, Santiago Agra, Ramón Ramos-Ríos, Julio Brenlla, Javier Costa. Absence of low frequency variants associated with schizophrenia at the ultraconserved non-coding region of TCF4. Psychiatry research. vol 215. issue 1. 2014-10-17. PMID:24210665. |
absence of low frequency variants associated with schizophrenia at the ultraconserved non-coding region of tcf4. |
2014-10-17 |
2023-08-12 |
Not clear |
| Boris B Quednow, Magdalena M Brzózka, Moritz J Rossne. Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective. Cellular and molecular life sciences : CMLS. vol 71. issue 15. 2014-09-02. PMID:24413739. |
transcription factor 4 (tcf4) and schizophrenia: integrating the animal and the human perspective. |
2014-09-02 |
2023-08-12 |
mouse |
| Ammar Albanna, Zia Choudhry, Philippe-Olivier Harvey, Ferid Fathalli, Clifford Cassidy, Sarojini M Sengupta, Srividya N Iyer, Aldanie Rho, Martin Lepage, Ashok Malla, Ridha Joobe. TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. Schizophrenia research. vol 152. issue 1. 2014-08-29. PMID:24275585. |
single nucleotide polymorphisms in tcf4 gene have been consistently associated with schizophrenia in genome wide association studies, including the c allele of rs9960767. |
2014-08-29 |
2023-08-12 |
Not clear |
| Marc P Forrest, Adrian J Waite, Enca Martin-Rendon, Derek J Blak. Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation. PloS one. vol 8. issue 8. 2014-06-26. PMID:24058414. |
genome-wide association studies have also found that common variants in tcf4 are associated with an increased risk of schizophrenia. |
2014-06-26 |
2023-08-12 |
human |
| Ilaria Guella, Adolfo Sequeira, Brandi Rollins, Linda Morgan, Federica Torri, Theo G M van Erp, Richard M Myers, Jack David Barchas, Alan F Schatzberg, Stanley J Watson, Huda Akil, William E Bunney, Steven G Potkin, Fabio Macciardi, Marquis P Vawte. Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex. Journal of psychiatric research. vol 47. issue 9. 2014-02-14. PMID:23786914. |
we investigated the expression levels of mir-137 and three candidate target genes (znf804a, cacna1c, tcf4) in the dlpfc of postmortem brain tissue from 2 independent cohorts: (1) 26 subjects (10 control (ctr), 7 schizophrenia (sz), 9 bipolar disorder (bd)) collected at the uci brain bank; and (2) 99 subjects (33 ctr, 35 sz, 31 bd) obtained from the stanley medical research institute (smri). |
2014-02-14 |
2023-08-12 |
human |
| Xianghua Zhu, Huang Gu, Zhen Liu, Zhansheng Xu, Xiongying Chen, Xiaochen Sun, Jinguo Zhai, Qiumei Zhang, Min Chen, Keqin Wang, Xiaoxiang Deng, Feng Ji, Chuanxin Liu, Jun Li, Qi Dong, Chuansheng Che. Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 4. 2013-10-29. PMID:23249814. |
associations between tcf4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls. |
2013-10-29 |
2023-08-12 |
Not clear |
| Katherinne Navarrete, Inti Pedroso, Simone De Jong, Hreinn Stefansson, Stacy Steinberg, Kari Stefansson, Roel A Ophoff, Leonard C Schalkwyk, David A Collie. TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 1. 2013-09-16. PMID:23129290. |
in this review, we present a systematic bioinformatics and literature review of the genomics, biological function and interactome of tcf4 in the context of schizophrenia. |
2013-09-16 |
2023-08-12 |
human |
| Katherinne Navarrete, Inti Pedroso, Simone De Jong, Hreinn Stefansson, Stacy Steinberg, Kari Stefansson, Roel A Ophoff, Leonard C Schalkwyk, David A Collie. TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 1. 2013-09-16. PMID:23129290. |
combined gene co-expression analyses and curated protein-protein interaction data provide a network involving tcf4 and other putative schizophrenia susceptibility genes. |
2013-09-16 |
2023-08-12 |
human |
| Carrie Wright, Jessica A Turner, Vince D Calhoun, Nora Perrone-Bizzozer. Potential Impact of miR-137 and Its Targets in Schizophrenia. Frontiers in genetics. vol 4. 2013-05-03. PMID:23637704. |
using targetscan and the schizophrenia gene resource (szgr) database, we found that in addition to csmd1, c10orf26, cacna1c, tcf4, and znf804a, five schizophrenia risk genes whose transcripts are also validated mir-137 targets, there are other schizophrenia-associated genes that may be targets of mir-137, including erbb4, gabra1, grin2a, grm5, gsk3b, nrg2, and htr2c. |
2013-05-03 |
2023-08-12 |
Not clear |
| Magdalena M Brzózka, Moritz J Rossne. Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4. Behavioural brain research. vol 237. 2013-04-26. PMID:23069005. |
deficits in trace fear memory in a mouse model of the schizophrenia risk gene tcf4. |
2013-04-26 |
2023-08-12 |
mouse |