| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Magdalena M Brzózka, Moritz J Rossne. Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4. Behavioural brain research. vol 237. 2013-04-26. PMID:23069005. |
the basic helix-loop-helix (bhlh) transcription factor tcf4 was confirmed in the combined analysis of several large genome-wide association studies (gwas) as one of the rare highly replicated significant schizophrenia (sz) susceptibility genes in large case-control cohorts. |
2013-04-26 |
2023-08-12 |
mouse |
| K V Wirgenes, I E Sønderby, U K Haukvik, M Mattingsdal, M Tesli, L Athanasiu, K Sundet, J I Røssberg, A M Dale, A A Brown, I Agartz, I Melle, S Djurovic, O A Andreasse. TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders. Translational psychiatry. vol 2. 2013-03-04. PMID:22832956. |
tcf4 is involved in neurodevelopment, and intergenic and intronic variants in or close to the tcf4 gene have been associated with susceptibility to schizophrenia. |
2013-03-04 |
2023-08-12 |
Not clear |
| Hisatsugu Koshimizu, Yasuyuki Fukui, Keizo Takao, Koji Ohira, Koichi Tanda, Kazuo Nakanishi, Keiko Toyama, Masanobu Oshima, Makoto Mark Taketo, Tsuyoshi Miyakaw. Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Frontiers in behavioral neuroscience. vol 5. 2012-10-02. PMID:22347851. |
a tumor suppressor gene, adenomatous polyposis coli (apc), is expressed in the nervous system from embryonic to adulthood stages, and transmits the wnt signaling pathway in which schizophrenia susceptibility genes, including t-cell factor 4 (tcf4) and calcineurin (cn), are involved. |
2012-10-02 |
2023-08-12 |
mouse |
| Boris B Quednow, Jürgen Brinkmeyer, Arian Mobascher, Michael Nothnagel, Francesco Musso, Gerhard Gründer, Noah Savary, Nadine Petrovsky, Ingo Frommann, Leonhard Lennertz, Katja N Spreckelmeyer, Thomas F Wienker, Norbert Dahmen, Norbert Thuerauf, Marion Clepce, Falk Kiefer, Tomislav Majic, Rainald Mössner, Wolfgang Maier, Jürgen Gallinat, Amalia Diaz-Lacava, Mohammad R Toliat, Holger Thiele, Peter Nürnberg, Michael Wagner, Georg Wintere. Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 16. 2012-07-12. PMID:22451930. |
schizophrenia risk polymorphisms in the tcf4 gene interact with smoking in the modulation of auditory sensory gating. |
2012-07-12 |
2023-08-12 |
human |
| Boris B Quednow, Jürgen Brinkmeyer, Arian Mobascher, Michael Nothnagel, Francesco Musso, Gerhard Gründer, Noah Savary, Nadine Petrovsky, Ingo Frommann, Leonhard Lennertz, Katja N Spreckelmeyer, Thomas F Wienker, Norbert Dahmen, Norbert Thuerauf, Marion Clepce, Falk Kiefer, Tomislav Majic, Rainald Mössner, Wolfgang Maier, Jürgen Gallinat, Amalia Diaz-Lacava, Mohammad R Toliat, Holger Thiele, Peter Nürnberg, Michael Wagner, Georg Wintere. Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 16. 2012-07-12. PMID:22451930. |
p50 suppression was significantly decreased in carriers of schizophrenia risk alleles of the tcf4 polymorphisms rs9960767, rs10401120rs, rs17597926, and 17512836 (p < 0.0002-0.00005). |
2012-07-12 |
2023-08-12 |
human |
| Boris B Quednow, Jürgen Brinkmeyer, Arian Mobascher, Michael Nothnagel, Francesco Musso, Gerhard Gründer, Noah Savary, Nadine Petrovsky, Ingo Frommann, Leonhard Lennertz, Katja N Spreckelmeyer, Thomas F Wienker, Norbert Dahmen, Norbert Thuerauf, Marion Clepce, Falk Kiefer, Tomislav Majic, Rainald Mössner, Wolfgang Maier, Jürgen Gallinat, Amalia Diaz-Lacava, Mohammad R Toliat, Holger Thiele, Peter Nürnberg, Michael Wagner, Georg Wintere. Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 16. 2012-07-12. PMID:22451930. |
our finding suggests that sensory gating is modulated by an interaction of tcf4 genotype with smoking, and both factors may play a role in early information processing deficits also in schizophrenia. |
2012-07-12 |
2023-08-12 |
human |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
impact of tcf4 on the genetics of schizophrenia. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
subsequently, a polymorphism of tcf4 was shown in a genome-wide association study to slightly increase the risk of schizophrenia. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
we have further analysed the impact of this tcf4 variant rs9960767 on early information processing and cognitive functions in schizophrenia patients. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
we have shown in a sample of 401 schizophrenia patients that tcf4 influences verbal memory in the rey auditory verbal learning test. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
contrary to expectations, carriers of the schizophrenia-associated allele showed better recognition, thus indicating that while tcf4 influences verbal memory, the tcf4-mediated schizophrenia risk is not determined by the influence of tcf4 on verbal memory. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
moreover, in a pharmacogenetic approach, tcf4 does not modulate the improvement of positive or negative schizophrenia symptoms during treatment with antipsychotics. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
as measured by prepulse inhibition, the schizophrenia risk allele c of tcf4 rs9960767 reduces sensorimotor gating. |
2012-02-28 |
2023-08-12 |
Not clear |
| Leonhard Lennertz, Boris B Quednow, Jens Benninghoff, Michael Wagner, Wolfgang Maier, Rainald Mössne. Impact of TCF4 on the genetics of schizophrenia. European archives of psychiatry and clinical neuroscience. vol 261 Suppl 2. 2012-02-28. PMID:21932083. |
this indicates that tcf4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia. |
2012-02-28 |
2023-08-12 |
Not clear |
| Stacy Steinberg, Simone de Jong, Ole A Andreassen, Thomas Werge, Anders D Børglum, Ole Mors, Preben B Mortensen, Omar Gustafsson, Javier Costas, Olli P H Pietiläinen, Ditte Demontis, Sergi Papiol, Johanna Huttenlocher, Manuel Mattheisen, René Breuer, Evangelos Vassos, Ina Giegling, Gillian Fraser, Nicholas Walker, Annamari Tuulio-Henriksson, Jaana Suvisaari, Jouko Lönnqvist, Tiina Paunio, Ingrid Agartz, Ingrid Melle, Srdjan Djurovic, Eric Strengman, Gesche Jürgens, Birte Glenthøj, Lars Terenius, David M Hougaard, Torben Ørntoft, Carsten Wiuf, Michael Didriksen, Mads V Hollegaard, Merete Nordentoft, Ruud van Winkel, Gunter Kenis, Lilia Abramova, Vasily Kaleda, Manuel Arrojo, Julio Sanjuán, Celso Arango, Swetlana Sperling, Moritz Rossner, Michele Ribolsi, Valentina Magni, Alberto Siracusano, Claus Christiansen, Lambertus A Kiemeney, Jan Veldink, Leonard van den Berg, Andres Ingason, Pierandrea Muglia, Robin Murray, Markus M Nöthen, Engilbert Sigurdsson, Hannes Petursson, Unnur Thorsteinsdottir, Augustine Kong, I Alex Rubino, Marc De Hert, János M Réthelyi, István Bitter, Erik G Jönsson, Vera Golimbet, Angel Carracedo, Hannelore Ehrenreich, Nick Craddock, Michael J Owen, Michael C O'Donovan, Mirella Ruggeri, Sarah Tosato, Leena Peltonen, Roel A Ophoff, David A Collier, David St Clair, Marcella Rietschel, Sven Cichon, Hreinn Stefansson, Dan Rujescu, Kari Stefansso. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Human molecular genetics. vol 20. issue 20. 2012-01-23. PMID:21791550. |
common variants at vrk2 and tcf4 conferring risk of schizophrenia. |
2012-01-23 |
2023-08-12 |
Not clear |
| Hywel J Williams, Valentina Moskvina, Rhodri L Smith, Sarah Dwyer, Giancarlo Russo, Michael J Owen, Michael C O'Donova. Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 7. 2012-01-17. PMID:21812098. |
association between tcf4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mrna expression in adult human brain. |
2012-01-17 |
2023-08-12 |
human |
| Hywel J Williams, Valentina Moskvina, Rhodri L Smith, Sarah Dwyer, Giancarlo Russo, Michael J Owen, Michael C O'Donova. Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 7. 2012-01-17. PMID:21812098. |
we conclude that association between schizophrenia and tcf4 is not mediated by a relatively common non-synonymous variant, or by a variant that alters mrna expression as measured in adult human brain. |
2012-01-17 |
2023-08-12 |
human |
| Mari Sepp, Kaja Kannike, Ave Eesmaa, Mari Urb, Tõnis Timmus. Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing. PloS one. vol 6. issue 7. 2011-11-22. PMID:21789225. |
specifically, human tcf4 gene is implicated in susceptibility to schizophrenia and tcf4 haploinsufficiency is the cause of the pitt-hopkins mental retardation syndrome. |
2011-11-22 |
2023-08-12 |
human |
| Nicholas J Bray, F Markus Leweke, Shitij Kapur, Andreas Meyer-Lindenber. The neurobiology of schizophrenia: new leads and avenues for treatment. Current opinion in neurobiology. vol 20. issue 6. 2011-11-10. PMID:20934321. |
these include znf804a, tcf4 and nrgn, which contain common variants that weakly increase schizophrenia susceptibility, and nrxn1, in which rare copy number variants have a greater impact on schizophrenia risk. |
2011-11-10 |
2023-08-12 |
Not clear |
| Boris B Quednow, Ulrich Ettinger, Rainald Mössner, Dan Rujescu, Ina Giegling, David A Collier, Anne Schmechtig, Kai-Uwe Kühn, Hans-Jürgen Möller, Wolfgang Maier, Michael Wagner, Veena Kumar. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543597. |
the schizophrenia risk allele c of the tcf4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. |
2011-08-05 |
2023-08-12 |
mouse |