| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huei-Ying Chen, BaDoi N Phan, Gina Shim, Gregory R Hamersky, Norah Sadowski, Thomas S O'Donnell, Srinidhi Rao Sripathy, Joseph F Bohlen, Andreas R Pfenning, Brady J Mahe. Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes. Molecular psychiatry. 2023-09-28. PMID:37770578. |
transcription factor 4 (tcf4) is a basic helix-loop-helix transcription factor that is implicated in a variety of psychiatric disorders including autism spectrum disorder (asd), major depression, and schizophrenia. |
2023-09-28 |
2023-10-07 |
mouse |
| Fatemeh Yazarlou, Mobina Tabibian, Asaad Azarnezhad, Habib Sadeghi Rad, Leonard Lipovich, Golshid Sanati, Hamid Mostafavi Abdolmaleky, Fatemeh Alizade. Evaluating Gene Expression and Methylation Profiles of TCF4, MBP, and EGR1 in Peripheral Blood of Drug-Free Patients with Schizophrenia: Correlations with Psychopathology, Intelligence, and Cognitive Impairment. Journal of molecular neuroscience : MN. 2023-09-05. PMID:37668894. |
evaluating gene expression and methylation profiles of tcf4, mbp, and egr1 in peripheral blood of drug-free patients with schizophrenia: correlations with psychopathology, intelligence, and cognitive impairment. |
2023-09-05 |
2023-09-07 |
human |
| Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp, Tõnis Timmus. Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia. The Journal of biological chemistry. vol 297. issue 6. 2021-12-11. PMID:34748727. |
functional consequences of tcf4 missense substitutions associated with pitt-hopkins syndrome, mild intellectual disability, and schizophrenia. |
2021-12-11 |
2023-08-13 |
Not clear |
| Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp, Tõnis Timmus. Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia. The Journal of biological chemistry. vol 297. issue 6. 2021-12-11. PMID:34748727. |
some of the missense variations found in schizophrenia patients slightly increase tcf4 transcriptional activity, whereas no effects were detected for missense mutations linked to mild intellectual disability. |
2021-12-11 |
2023-08-13 |
Not clear |
| Katharina Braun, Benjamin M Häberle, Marie-Theres Wittmann, D Chichung Li. Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice. BMC neuroscience. vol 21. issue 1. 2021-09-02. PMID:33228529. |
transcription factor 4 (tcf4) has been linked to human neurodevelopmental disorders such as intellectual disability, pitt-hopkins syndrome (pths), autism, and schizophrenia. |
2021-09-02 |
2023-08-13 |
mouse |
| Marie-Theres Wittmann, Sayako Katada, Elisabeth Sock, Philipp Kirchner, Arif B Ekici, Michael Wegner, Kinichi Nakashima, Dieter Chichung Lie, André Rei. scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse. Development (Cambridge, England). vol 148. issue 14. 2021-08-26. PMID:34184026. |
transcription factor 4 (tcf4) is a crucial regulator of neurodevelopment and has been linked to the pathogenesis of autism, intellectual disability and schizophrenia. |
2021-08-26 |
2023-08-13 |
mouse |
| Laura Tamberg, Mariliis Jaago, Kristi Säälik, Alex Sirp, Jürgen Tuvikene, Anastassia Shubina, Carl Sander Kiir, Kaja Nurm, Mari Sepp, Tõnis Timmusk, Mari Palg. Daughterless, the Disease models & mechanisms. vol 13. issue 7. 2021-08-23. PMID:32641419. |
daughterless, the mammalian transcription factor 4 (tcf4) has been linked to schizophrenia and intellectual disabilities, such as pitt-hopkins syndrome (pths). |
2021-08-23 |
2023-08-13 |
drosophila_melanogaster |
| D M Badowska, M M Brzózka, N Kannaiyan, C Thomas, P Dibaj, A Chowdhury, H Steffens, C W Turck, P Falkai, A Schmitt, S Papiol, V Scheuss, K I Willig, D Martins-de-Souza, J S Rhee, D Malzahn, M J Rossne. Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33037178. |
modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene tcf4. |
2021-06-18 |
2023-08-13 |
mouse |
| D M Badowska, M M Brzózka, N Kannaiyan, C Thomas, P Dibaj, A Chowdhury, H Steffens, C W Turck, P Falkai, A Schmitt, S Papiol, V Scheuss, K I Willig, D Martins-de-Souza, J S Rhee, D Malzahn, M J Rossne. Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33037178. |
the transcription factor tcf4 was confirmed in several large genome-wide association studies as one of the most significant schizophrenia (sz) susceptibility genes. |
2021-06-18 |
2023-08-13 |
mouse |
| José R Teixeira, Ryan A Szeto, Vinicius M A Carvalho, Alysson R Muotri, Fabio Pape. Transcription factor 4 and its association with psychiatric disorders. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33414364. |
moreover, polymorphisms in tcf4 have been associated with schizophrenia and other psychiatric and neurological conditions. |
2021-06-18 |
2023-08-13 |
human |
| Martina Rosato, Sven Stringer, Titia Gebuis, Iryna Paliukhovich, Ka Wan Li, Danielle Posthuma, Patrick F Sullivan, August B Smit, Ronald E van Kestere. Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31142819. |
we show that dysregulation of multiple proteins in this pathway may be due to the combined effects of schizophrenia risk genes tcf4, tbr1, and top3b. |
2021-05-14 |
2023-08-13 |
mouse |
| Yandong Zhang, Zheping Cai, Guanglei Hu, Songhui Hu, Yafei Wang, Na Li, Saiyong Chen, Qiong Liu, Lanhui Zeng, Tianxiang Tang, Yilan Zhang, Lei Xiao, Yu Gu, Yunli Xi. Transcription factor 4 controls positioning of cortical projection neurons through regulation of cell adhesion. Molecular psychiatry. 2021-05-08. PMID:33963287. |
tcf4 mutations are strongly associated with schizophrenia and cause pitt-hopkins syndrome, which is characterized by severe intellectual disability. |
2021-05-08 |
2023-08-13 |
Not clear |
| Jingwen Yin, Dongjian Zhu, You Li, Dong Lv, Huajun Yu, Chunmei Liang, Xudong Luo, Xusan Xu, Jiawu Fu, Haifeng Yan, Zhun Dai, Xia Zhou, Xia Wen, Susu Xiong, Zhixiong Lin, Juda Lin, Bin Zhao, Yajun Wang, Keshen Li, Guoda M. Genetic Variability of TCF4 in Schizophrenia of Southern Chinese Han Population: A Case-Control Study. Frontiers in genetics. vol 10. 2020-10-01. PMID:31191620. |
genetic variability of tcf4 in schizophrenia of southern chinese han population: a case-control study. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mohadeseh Agahi, Zahra Noormohammadi, Iman Salahshourifar, Niloufar Mahdavi Hezave. Genotype Variations of rs13381800 in TCF4 Gene and rs17039988 in NRXN1 Gene among a Sample of Iranian Patients with Schizophrenia. Iranian journal of psychiatry. vol 14. issue 4. 2020-09-28. PMID:32071599. |
genotype variations of rs13381800 in tcf4 gene and rs17039988 in nrxn1 gene among a sample of iranian patients with schizophrenia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Miriam Wedel, Franziska Fröb, Olga Elsesser, Marie-Theres Wittmann, D Chichung Lie, André Reis, Michael Wegne. Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic acids research. vol 48. issue 9. 2020-09-08. PMID:32266943. |
considering that alterations in tcf4 are associated with syndromic and non-syndromic forms of intellectual disability, schizophrenia and autism in humans, our findings point to the possibility of an oligodendroglial contribution to these disorders. |
2020-09-08 |
2023-08-13 |
mouse |
| Abolfazl Doostparast Torshizi, Chris Armoskus, Hanwen Zhang, Marc P Forrest, Siwei Zhang, Tade Souaiaia, Oleg V Evgrafov, James A Knowles, Jubao Duan, Kai Wan. Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia. Science advances. vol 5. issue 9. 2020-05-11. PMID:31535015. |
deconvolution of transcriptional networks identifies tcf4 as a master regulator in schizophrenia. |
2020-05-11 |
2023-08-13 |
Not clear |
| Alexandros Rammos, Lara A Neira Gonzalez, Daniel R Weinberger, Kevin J Mitchell, Kristin K Nicodemu. The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 9. 2020-03-17. PMID:31078131. |
using the pgc2 secondary analysis schizophrenia case-control cohort (n = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on tcf4, fmr1, upregulation from mir137 and downregulation from chd8. |
2020-03-17 |
2023-08-13 |
Not clear |
| Jie Yang, John R Horton, Jia Li, Yun Huang, Xing Zhang, Robert M Blumenthal, Xiaodong Chen. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic acids research. vol 47. issue 16. 2019-12-11. PMID:31081034. |
the psychiatric risk-associated transcription factor 4 (tcf4) is linked to schizophrenia. |
2019-12-11 |
2023-08-13 |
human |
| Zahra Isnaini Mohamed, Shiau Foon Tee, Tze Jen Chow, Siew Yim Loh, Hoi Sen Yong, Abdul Kadir Abu Bakar, Pek Yee Tan. Functional characterization of two variants in the 3'-untranslated region (UTR) of transcription factor 4 gene and their association with schizophrenia in sib-pairs from multiplex families. Asian journal of psychiatry. vol 40. 2019-07-29. PMID:30771755. |
transcription factor 4 (tcf4) gene plays an important role in nervous system development and it always associated with the risk of schizophrenia. |
2019-07-29 |
2023-08-13 |
Not clear |
| Zahra Isnaini Mohamed, Shiau Foon Tee, Tze Jen Chow, Siew Yim Loh, Hoi Sen Yong, Abdul Kadir Abu Bakar, Pek Yee Tan. Functional characterization of two variants in the 3'-untranslated region (UTR) of transcription factor 4 gene and their association with schizophrenia in sib-pairs from multiplex families. Asian journal of psychiatry. vol 40. 2019-07-29. PMID:30771755. |
since mirnas regulate targetgenes by binding to 3'utrs of target mrnas, the functional variants located in 3'utr of tcf4 are highly suggested to affect the gene expressions in schizophrenia. |
2019-07-29 |
2023-08-13 |
Not clear |