| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Chen, Wanming Chen, Li Xu, Lingshu Luan, Ruijie Peng, Xiaobin Zhang, Haidong Yan. Decreased serum VEGF and NRG1β1 levels in male patients with chronic schizophrenia: VEGF correlation with clinical symptoms and cognitive deficits. Journal of psychiatric research. vol 176. 2024-06-08. PMID:38850582. |
vascular endothelial growth factor (vegf) and neuregulin1 (nrg1) are multifunctional trophic factors reported to be dysregulated in schizophrenia. |
2024-06-08 |
2024-06-11 |
Not clear |
| Peng Chen, Wanming Chen, Li Xu, Lingshu Luan, Ruijie Peng, Xiaobin Zhang, Haidong Yan. Decreased serum VEGF and NRG1β1 levels in male patients with chronic schizophrenia: VEGF correlation with clinical symptoms and cognitive deficits. Journal of psychiatric research. vol 176. 2024-06-08. PMID:38850582. |
the aim of this study was to investigate the associations of serum vegf and nrg1 with clinical symptoms and cognitive deficits specifically in male patients with chronic schizophrenia. |
2024-06-08 |
2024-06-11 |
Not clear |
| Ye Lv, Lin Wen, Wen-Juan Hu, Chong Deng, Hui-Wen Ren, Ya-Nan Bao, Bo-Wei Su, Ping Gao, Zi-Yue Man, Yi-Yang Luo, Cheng-Jie Li, Zhi-Xin Xiang, Bing Wang, Zhi-Lin Lua. Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes. Metabolic brain disease. 2023-08-05. PMID:37542622. |
this review may serve as a summary of past research on schizophrenia genomics and susceptibility genes (nrg1, disc1, reln, bdnf, msi2), which may point the way to future schizophrenia genetics research. |
2023-08-05 |
2023-08-14 |
Not clear |
| Rose Chesworth, Gabriela Visini, Tim Kar. Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk. Psychopharmacology. 2023-05-26. PMID:37233814. |
here we investigated if genetic risk for schizophrenia could affect drug reward and reinforcement for cocaine in an established mouse model of genetic risk for schizophrenia, the neuregulin 1 transmembrane domain heterozygous (nrg1 tm het) mouse. |
2023-05-26 |
2023-08-14 |
mouse |
| Jonaid Ahmad Malik, Zahid Yaseen, Lahari Thotapalli, Sakeel Ahmed, Mohd Farooq Shaikh, Sirajudheen Anwa. Understanding translational research in schizophrenia: A novel insight into animal models. Molecular biology reports. 2023-01-24. PMID:36692676. |
polymorphism of genes such as dysbindin, dics1, and nrg1 has also been reported in schizophrenia. |
2023-01-24 |
2023-08-14 |
Not clear |
| Jianfeng Dong, Wen Chen, Nana Liu, Shujuan Chang, Wei Zhu, Jiuhong Kan. NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice. Cell death discovery. vol 8. issue 1. 2022-12-02. PMID:36460658. |
nrg1 knockdown rescues pv interneuron gabaergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice. |
2022-12-02 |
2023-08-14 |
mouse |
| Jianfeng Dong, Wen Chen, Nana Liu, Shujuan Chang, Wei Zhu, Jiuhong Kan. NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice. Cell death discovery. vol 8. issue 1. 2022-12-02. PMID:36460658. |
and the mrna and protein level of neuregulin 1(nrg1), which is a critical schizophrenia gene, increased significantly in fgr mouse mpfc. |
2022-12-02 |
2023-08-14 |
mouse |
| Jianfeng Dong, Wen Chen, Nana Liu, Shujuan Chang, Wei Zhu, Jiuhong Kan. NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice. Cell death discovery. vol 8. issue 1. 2022-12-02. PMID:36460658. |
furthermore, nrg1 knockdown in fgr mouse mpfc improved pv interneuron gabaergic maturation and rescued schizophrenia behaviors including hyperactivity, social novelty defects, cognition decline, and sensorimotor gating deficits in fgr mice. |
2022-12-02 |
2023-08-14 |
mouse |
| Jianfeng Dong, Wen Chen, Nana Liu, Shujuan Chang, Wei Zhu, Jiuhong Kan. NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice. Cell death discovery. vol 8. issue 1. 2022-12-02. PMID:36460658. |
nrg1 knockdown in mpfc significantly rescues schizophrenia behaviors in fgr mouse. |
2022-12-02 |
2023-08-14 |
mouse |
| Nan Su, Weiqi Zhang, Nicole Eter, Peter Heiduschka, Mingyue Zhan. Overexpression of Neuregulin-1 Type III Has Impact on Visual Function in Mice. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562880. |
abnormal nrg1 expression has been observed in schizophrenia in clinical studies. |
2022-05-14 |
2023-08-13 |
mouse |
| Haidong Yang, Wen Pan, Wenhuan Xiao, Man Yang, Jianchun Xu, Jin Li, Xiaobin Zhan. Antipsychotic drugs increase Neuregulin1β1 serum levels in first-episode drug-naïve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms. BMC psychiatry. vol 22. issue 1. 2022-03-26. PMID:35337293. |
neuregulin1 (nrg1) plays a role in neuronal migration, regulation of synaptic plasticity, and neural survival, and has been considered to be among the candidate genes for schizophrenia. |
2022-03-26 |
2023-08-13 |
Not clear |
| Sowmya Gunasekaran, Reena Sarah Jacob, Ramakrishnapillai Vyomakesannair Omkuma. Differential expression of miR-148b, miR-129-2 and miR-296 in animal models of schizophrenia-Relevance to NMDA receptor hypofunction. Neuropharmacology. 2022-03-11. PMID:35276119. |
expression of some genes implicated in schizophrenia such as neuregulin 1 (nrg1), bdnf and camkiiα, were also altered in these models. |
2022-03-11 |
2023-08-13 |
Not clear |
| Yan Zhang, Chu-Yi Zhang, Jing Yuan, Xiao-Zhou Zeng, Shan-Shan Zhai, Xiao Xiao, Ming Li, Jian-Zhong Yan. Epistatic interactions of NRG1 and ERBB4 on antipsychotic treatment response in first-episode schizophrenia patients. Schizophrenia research. vol 241. 2022-02-10. PMID:35144058. |
epistatic interactions of nrg1 and erbb4 on antipsychotic treatment response in first-episode schizophrenia patients. |
2022-02-10 |
2023-08-13 |
Not clear |
| Tilmann Götze, Maria Clara Soto-Bernardini, Mingyue Zhang, Hendrik Mießner, Lisa Linhoff, Magdalena M Brzózka, Viktorija Velanac, Christian Dullin, Fernanda Ramos-Gomes, Maja Peng, Hümeyra Husseini, Eva Schifferdecker, Robert Fledrich, Michael W Sereda, Katrin Willig, Frauke Alves, Moritz J Rossner, Klaus-Armin Nave, Weiqi Zhang, Markus H Schwa. Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks. Schizophrenia bulletin. vol 47. issue 5. 2021-11-30. PMID:33871014. |
the neuregulin 1 (nrg1) erbb4 module is at the core of an "at risk" signaling pathway in schizophrenia. |
2021-11-30 |
2023-08-13 |
mouse |
| Carmen Navarro-Gonzalez, Héctor Carceller, Marina Benito Vicente, Irene Serra, Marta Navarrete, Yaiza Domínguez-Canterla, Ángela Rodríguez-Prieto, Ana González-Manteiga, Pietro Fazzar. Nrg1 haploinsufficiency alters inhibitory cortical circuits. Neurobiology of disease. vol 157. 2021-10-01. PMID:34246770. |
neuregulin 1 (nrg1) and its receptor erbb4 are schizophrenia (sz) risk genes that control the development of both excitatory and inhibitory cortical circuits. |
2021-10-01 |
2023-08-13 |
mouse |
| Peng Chen, Hongyang Jing, Mingtao Xiong, Qian Zhang, Dong Lin, Dongyan Ren, Shunqi Wang, Dongmin Yin, Yongjun Chen, Tian Zhou, Baoming Li, Erkang Fei, Bing-Xing Pa. Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation. Cell death & disease. vol 12. issue 4. 2021-09-17. PMID:33854034. |
the genes encoding for neuregulin1 (nrg1), a growth factor, and its receptor erbb4 are both risk factors of major depression disorder and schizophrenia (sz). |
2021-09-17 |
2023-08-13 |
mouse |
| JianZhong Yang, ChuanYuan Kang, Changjiang Wu, Yuanyuan Lin, Lei Zeng, Jing Yuan, Yan Zhang, YuJun Wei, Li Xu, Fang Zho. Pharmacogenetic associations of NRG1 polymorphisms with neurocognitive performance and clinical symptom response to risperidone in the untreated schizophrenia. Schizophrenia research. vol 231. 2021-07-05. PMID:33770628. |
pharmacogenetic associations of nrg1 polymorphisms with neurocognitive performance and clinical symptom response to risperidone in the untreated schizophrenia. |
2021-07-05 |
2023-08-13 |
Not clear |
| JianZhong Yang, ChuanYuan Kang, Changjiang Wu, Yuanyuan Lin, Lei Zeng, Jing Yuan, Yan Zhang, YuJun Wei, Li Xu, Fang Zho. Pharmacogenetic associations of NRG1 polymorphisms with neurocognitive performance and clinical symptom response to risperidone in the untreated schizophrenia. Schizophrenia research. vol 231. 2021-07-05. PMID:33770628. |
to explore pharmacogenetic relationships of nrg1 genotypes with neurocognitive performance and clinical symptoms after 12 week treatment of risperidone in chinese han first-episode schizophrenia. |
2021-07-05 |
2023-08-13 |
Not clear |
| Jill R Crittenden, Theresa A Gipson, Anne C Smith, Hilary A Bowden, Ferah Yildirim, Kyle B Fischer, Michael Yim, David E Housman, Ann M Graybie. Striatal transcriptome changes linked to drug-induced repetitive behaviors. The European journal of neuroscience. vol 53. issue 8. 2021-06-29. PMID:33759265. |
nrg1 is known to be a schizophrenia and autism susceptibility gene that encodes a ligand for erb-b receptors, which are involved in neuronal migration, myelination, and cell survival, including that of dopamine-containing neurons. |
2021-06-29 |
2023-08-13 |
mouse |
| François Mouton-Liger, Julien Dumurgier, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Hugo Vanderstichele, Eugeen Vanmechelen, Elodie Bouaziz-Amar, Kaj Blennow, Jacques Hugon, Claire Paque. CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32690068. |
the presynaptic protein neuregulin1 (nrg1) is cleaved by beta-site app cleaving enzyme 1 (bace1) in a similar way as amyloid precursor protein (app) nrg1 can activate post-synaptic receptor tyrosine-protein kinase erbb4 (erbb4) and was linked to schizophrenia. |
2021-06-24 |
2023-08-13 |
Not clear |