| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroshi Kumagai, Ana Raquel Coelho, Junxiang Wan, Hemal H Mehta, Kelvin Yen, Amy Huang, Hirofumi Zempo, Noriyuki Fuku, Seiji Maeda, Paulo J Oliveira, Pinchas Cohen, Su-Jeong Ki. MOTS-c reduces myostatin and muscle atrophy signaling. American journal of physiology. Endocrinology and metabolism. vol 320. issue 4. 2021-05-24. PMID:33554779. |
these results suggest that through inhibition of myostatin, mots-c could be a potential therapy for insulin resistance-induced skeletal muscle atrophy as well as other muscle wasting phenotypes including sarcopenia. |
2021-05-24 |
2023-08-13 |
mouse |
| Manu V Chakravarthy, Mohammad S Siddiqui, Mikael F Forsgren, Arun J Sanya. Harnessing Muscle-Liver Crosstalk to Treat Nonalcoholic Steatohepatitis. Frontiers in endocrinology. vol 11. 2021-05-21. PMID:33424768. |
population-based studies suggest that sarcopenia is an effect-modifier across the nafld spectrum in that it is tightly linked to an increased risk of non-alcoholic fatty liver, non-alcoholic steatohepatitis (nash), and advanced liver fibrosis, all independent of obesity and insulin resistance. |
2021-05-21 |
2023-08-13 |
Not clear |
| Manu V Chakravarthy, Mohammad S Siddiqui, Mikael F Forsgren, Arun J Sanya. Harnessing Muscle-Liver Crosstalk to Treat Nonalcoholic Steatohepatitis. Frontiers in endocrinology. vol 11. 2021-05-21. PMID:33424768. |
in this perspective review, we discuss key pathophysiological processes driving sarcopenia in nafld: anabolic resistance, insulin resistance, metabolic inflexibility and systemic inflammation. |
2021-05-21 |
2023-08-13 |
Not clear |
| Gregory Habig, Christa Smaltz, Dina Halegoua-DeMarzi. Presence and Implications of Sarcopenia in Non-alcoholic Steatohepatitis. Metabolites. vol 11. issue 4. 2021-05-18. PMID:33920751. |
non-alcoholic steatohepatitis (nash) shares many of the same etiologies as sarcopenia, including insulin resistance, chronic inflammation, and ectopic adipocyte deposition, which are hallmarks of metabolic syndrome (ms). |
2021-05-18 |
2023-08-13 |
Not clear |
| Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fuku. Habitual Miso (Fermented Soybean Paste) Consumption Is Associated with a Low Prevalence of Sarcopenia in Patients with Type 2 Diabetes: A Cross-Sectional Study. Nutrients. vol 13. issue 1. 2021-05-03. PMID:33379405. |
insulin resistance is a risk of sarcopenia, and the presence of sarcopenia is high in patients with type 2 diabetes (t2dm). |
2021-05-03 |
2023-08-13 |
Not clear |
| Young Joo Yang, Dong Joon Ki. An Overview of the Molecular Mechanisms Contributing to Musculoskeletal Disorders in Chronic Liver Disease: Osteoporosis, Sarcopenia, and Osteoporotic Sarcopenia. International journal of molecular sciences. vol 22. issue 5. 2021-04-23. PMID:33807573. |
sarcopenia is associated with insulin resistance and obesity in non-alcoholic fatty liver disease, whereas hyperammonemia, low amount of branched chain amino acids, and hypogonadism contributes to sarcopenia in liver cirrhosis. |
2021-04-23 |
2023-08-13 |
Not clear |
| Jiaxi Zhao, Yiqin Huang, Xiaofeng Y. A Narrative Review of Gut-Muscle Axis and Sarcopenia: The Potential Role of Gut Microbiota. International journal of general medicine. vol 14. 2021-04-22. PMID:33880058. |
the present review highlights that the gut microbiota can affect muscle mass and muscle function from inflammation and immunity,substance and energy metabolism, endocrine and insulin sensitivity, etc., directly or indirectly establishing a connection with sarcopenia, thereby realizing the "gut-muscle axis". |
2021-04-22 |
2023-08-13 |
Not clear |
| A Daniele, A Guarini, S De Summa, M Dellino, G Lerario, S Ciavarella, P Ditonno, A V Paradiso, R Divella, P Casamassima, E Savino, M D Carbonara, C Minoi. Body Composition Change, Unhealthy Lifestyles and Steroid Treatment as Predictor of Metabolic Risk in Non-Hodgkin's Lymphoma Survivors. Journal of personalized medicine. vol 11. issue 3. 2021-04-13. PMID:33802940. |
unhealthy lifestyle, as sedentary, unbalanced diet, smoking, and body composition change are often observed in non-hodgkin's lymphoma (nhl) survivors, and could be determinant for the onset of cancer treatment-induced metabolic syndrome (ctimets), including abdominal obesity, sarcopenia, and insulin resistance. |
2021-04-13 |
2023-08-13 |
Not clear |
| Jinkyung Cho, Youngju Choi, Pavol Sajgalik, Mi-Hyun No, Sang-Hyun Lee, Sujin Kim, Jun-Won Heo, Eun-Jeong Cho, Eunwook Chang, Ju-Hee Kang, Hyo-Bum Kwak, Dong-Ho Par. Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms. Cells. vol 9. issue 10. 2021-04-02. PMID:33066240. |
therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in hf as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in hf and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance. |
2021-04-02 |
2023-08-13 |
Not clear |
| Chenyu Li, Hans-Joachim Ander. 2020 Update in basic kidney research: chronic hypoxia, insulin resistance, sarcopenia, phosphate binders, and peritoneal fibrosis in chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2021-03-21. PMID:33744942. |
2020 update in basic kidney research: chronic hypoxia, insulin resistance, sarcopenia, phosphate binders, and peritoneal fibrosis in chronic kidney disease. |
2021-03-21 |
2023-08-13 |
Not clear |
| Saad Emhmed Ali, Mindie H Nguye. Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease-The Union of Two Culprits. Life (Basel, Switzerland). vol 11. issue 2. 2021-03-16. PMID:33557355. |
metabolic disorders, such as obesity and insulin resistance, are closely associated with sarcopenia and nafld. |
2021-03-16 |
2023-08-13 |
Not clear |
| Paul C Gues. Multiplex Analysis of Circulating Hormone Levels in Rat Models of Age-Related Diseases. Methods in molecular biology (Clifton, N.J.). vol 2138. 2021-03-08. PMID:32219765. |
as an example, we have analyzed serum from 12-week-old rats using multiplexes for the hormones insulin, leptin, growth hormone, corticosterone, and testosterone, which have been implicated in sarcopenia. |
2021-03-08 |
2023-08-13 |
rat |
| Ines Bilic-Curcic, Maja Cigrovski Berkovic, Lucija Virovic-Jukic, Anna Mrzlja. Shifting perspectives - interplay between non-alcoholic fatty liver disease and insulin resistance in lean individuals. World journal of hepatology. vol 13. issue 1. 2021-02-16. PMID:33584988. |
the development of nafld in lean subjects seems to be interconnected with metabolic phenotype, precisely visceral fat tissue, sarcopenia, and insulin resistance. |
2021-02-16 |
2023-08-13 |
human |
| Kiyotaka Uchiyama, Shu Wakino, Junichiro Irie, Junki Miyamoto, Ayumi Matsui, Takaya Tajima, Tomoaki Itoh, Yoichi Oshima, Ayumi Yoshifuji, Ikuo Kimura, Hiroshi Ito. Contribution of uremic dysbiosis to insulin resistance and sarcopenia. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 35. issue 9. 2021-02-03. PMID:32535631. |
contribution of uremic dysbiosis to insulin resistance and sarcopenia. |
2021-02-03 |
2023-08-13 |
Not clear |
| Kiyotaka Uchiyama, Shu Wakino, Junichiro Irie, Junki Miyamoto, Ayumi Matsui, Takaya Tajima, Tomoaki Itoh, Yoichi Oshima, Ayumi Yoshifuji, Ikuo Kimura, Hiroshi Ito. Contribution of uremic dysbiosis to insulin resistance and sarcopenia. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 35. issue 9. 2021-02-03. PMID:32535631. |
chronic kidney disease (ckd) leads to insulin resistance (ir) and sarcopenia, which are associated with a high mortality risk in ckd patients; however, their pathophysiologies remain unclear. |
2021-02-03 |
2023-08-13 |
Not clear |
| Alajos Pár, Jenő Péter Hegyi, Szilárd Váncsa, Gabriella Pá. Sarcopenia - 2021: Pathophysiology, diagnosis, therapy Orvosi hetilap. vol 162. issue 1. 2021-01-15. PMID:33388736. |
this paper overviews the pathophysiology of sarcopenia and the factors involved in the muscle mass loss, i.e., physical inactivity, insulin resistance, low-grade chronic inflammation, hepatokines and myokines. |
2021-01-15 |
2023-08-13 |
Not clear |
| Junko Yabuuchi, Seiji Ueda, Sho-Ichi Yamagishi, Nao Nohara, Hajime Nagasawa, Keiichi Wakabayashi, Takanori Matsui, Higashimoto Yuichiro, Tomoyasu Kadoguchi, Tomoyuki Otsuka, Tomohito Gohda, Yusuke Suzuk. Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease. Scientific reports. vol 10. issue 1. 2021-01-14. PMID:33077879. |
various pathological conditions related to ckd, such as chronic inflammation, insulin resistance, and endothelial dysfunction, are thought to be associated with the development and progression of sarcopenia. |
2021-01-14 |
2023-08-13 |
mouse |
| David G Le Couteur, Samantha M Solon-Biet, Victoria C Cogger, Rosilene Ribeiro, Rafael de Cabo, David Raubenheimer, Gregory J Cooney, Stephen J Simpso. Branched chain amino acids, aging and age-related health. Ageing research reviews. vol 64. 2020-12-30. PMID:33132154. |
many studies report apparently inconsistent conclusions about the relationships between blood levels of bcaas or dietary manipulation of bcaas with age-related changes in body composition, sarcopenia, obesity, insulin and glucose metabolism, and aging biology itself. |
2020-12-30 |
2023-08-13 |
Not clear |
| Shelley E Harris, Toryn M Poolman, Anastasia Arvaniti, Roger D Cox, Laura L Gathercole, Jeremy W Tomlinso. The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. American journal of physiology. Gastrointestinal and liver physiology. vol 319. issue 3. 2020-12-14. PMID:32755310. |
in parallel the development of a robust hepatic phenotype, alios-fed mice displayed many of the extrahepatic manifestations of nafld, including hyperlipidemia, increased fat mass, sarcopenia, and insulin resistance. |
2020-12-14 |
2023-08-13 |
mouse |
| Kassandra Lanchais, Frederic Capel, Anne Tournadr. Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis? Nutrients. vol 12. issue 1. 2020-11-16. PMID:31952247. |
as observed during the aging process, several comorbidities, such as cardiovascular disorders (cvd), insulin resistance, metabolic syndrome and sarcopenia, are frequently associated to ra. |
2020-11-16 |
2023-08-13 |
human |