| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert A Coover, Tabitha E Healy, Li Guo, Katherine E Chaney, Robert F Hennigan, Craig S Thomson, Lindsey E Aschbacher-Smith, Michael P Jankowski, Nancy Ratne. Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30470263. |
in patients with the disorder neurofibromatosis type 1, nf1 mutant scs proliferate and form sc tumors called neurofibromas. |
2019-06-03 |
2023-08-13 |
Not clear |
| Yuichi Yoshid. [Neurofibromatosis 1]. Brain and nerve = Shinkei kenkyu no shinpo. vol 71. issue 4. 2019-05-24. PMID:30988223. |
among them, neurofibromatosis 1 (nf1, recklinghausen disease) is characterized by pigmented macules, such as café au lait macules, freckling and numerous neurofibromas. |
2019-05-24 |
2023-08-13 |
Not clear |
| Jonathan S Fletcher, Mitchell G Springer, Kwangmin Choi, Edwin Jousma, Tilat A Rizvi, Eva Dombi, Mi-Ok Kim, Jianqiang Wu, Nancy Ratne. STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma. Oncogene. vol 38. issue 15. 2019-04-29. PMID:30542122. |
here, we show that flll32, a small molecule inhibitor of jak2/stat3 signaling, reduces neurofibroma growth in mice with conditional, biallelic deletion of nf1 in the schwann cell lineage. |
2019-04-29 |
2023-08-13 |
mouse |
| Ashley Cannon, Mei-Jan Chen, Peng Li, Kevin P Boyd, Amy Theos, David T Redden, Bruce Kor. Cutaneous neurofibromas in Neurofibromatosis type I: a quantitative natural history study. Orphanet journal of rare diseases. vol 13. issue 1. 2019-03-14. PMID:29415745. |
a major feature of nf1 is the development of localized cutaneous neurofibromas. |
2019-03-14 |
2023-08-13 |
Not clear |
| Ashley Cannon, Mei-Jan Chen, Peng Li, Kevin P Boyd, Amy Theos, David T Redden, Bruce Kor. Cutaneous neurofibromas in Neurofibromatosis type I: a quantitative natural history study. Orphanet journal of rare diseases. vol 13. issue 1. 2019-03-14. PMID:29415745. |
cutaneous neurofibromas manifest in > 99% of adults with nf1 and are responsible for major negative effects on quality of life. |
2019-03-14 |
2023-08-13 |
Not clear |
| Ashley Cannon, Mei-Jan Chen, Peng Li, Kevin P Boyd, Amy Theos, David T Redden, Bruce Kor. Cutaneous neurofibromas in Neurofibromatosis type I: a quantitative natural history study. Orphanet journal of rare diseases. vol 13. issue 1. 2019-03-14. PMID:29415745. |
the purpose of this study is to conduct a prospective natural history study of 22 adults with nf1 over an 8-year period to quantify cutaneous neurofibroma number and size. |
2019-03-14 |
2023-08-13 |
Not clear |
| Martino Ruggieri, Andrea D Praticò, Rosario Caltabiano, Agata Polizz. Early history of the different forms of neurofibromatosis from ancient Egypt to the British Empire and beyond: First descriptions, medical curiosities, misconceptions, landmarks, and the persons behind the syndromes. American journal of medical genetics. Part A. vol 176. issue 3. 2019-02-28. PMID:29388340. |
the first english language report on nf1 was made by akenside in 1768 and the first systematic review by robert william smith in 1849, while virchow's pupil, friedrich daniel von recklinghausen, in 1882, was the first to understand the origin of skin tumors and to name them neurofibromas. |
2019-02-28 |
2023-08-13 |
human |
| Yuichi Yoshida, Yuko Ehara, Kenjiro Kosaki, Osamu Yamamot. Large number of cutaneous neurofibromas beyond age-appropriate incidence in a patient with a large deletion of NF1. The Journal of dermatology. vol 45. issue 3. 2019-01-16. PMID:29498099. |
large number of cutaneous neurofibromas beyond age-appropriate incidence in a patient with a large deletion of nf1. |
2019-01-16 |
2023-08-13 |
Not clear |
| Rafaela Elvira Rozza-de-Menezes, Carolina de Almeida Ito Brum, Nicolle Cavalcante Gaglionone, Lilian Machado de Sousa Almeida, Raquel Machado Andrade-Losso, Brenda Vasconcelos Barboza Paiva, Pedro Leonardo Sanches Faveret, André Vallejo da Silva, Orlando Hiroshi Kiono Siqueira, Vincent M Riccardi, Karin Soares Cunh. Prevalence and clinicopathological characteristics of lipomatous neurofibromas in neurofibromatosis 1: An investigation of 229 cutaneous neurofibromas and a systematic review of the literature. Journal of cutaneous pathology. vol 45. issue 10. 2018-12-27. PMID:29959804. |
we aimed to investigate the prevalence and clinicopathological features of lnfs of neurofibromatosis 1 (nf1)-associated cutaneous neurofibromas and to review the literature systematically. |
2018-12-27 |
2023-08-13 |
Not clear |
| Magdalena Koczkowska, Yunjia Chen, Tom Callens, Alicia Gomes, Angela Sharp, Sherrell Johnson, Meng-Chang Hsiao, Zhenbin Chen, Meena Balasubramanian, Christopher P Barnett, Troy A Becker, Shay Ben-Shachar, Debora R Bertola, Jaishri O Blakeley, Emma M M Burkitt-Wright, Alison Callaway, Melissa Crenshaw, Karin S Cunha, Mitch Cunningham, Maria D D'Agostino, Karin Dahan, Alessandro De Luca, Anne Destrée, Radhika Dhamija, Marica Eoli, D Gareth R Evans, Patricia Galvin-Parton, Jaya K George-Abraham, Karen W Gripp, Jose Guevara-Campos, Neil A Hanchard, Concepcion Hernández-Chico, LaDonna Immken, Sandra Janssens, Kristi J Jones, Beth A Keena, Aaina Kochhar, Jan Liebelt, Arelis Martir-Negron, Maurice J Mahoney, Isabelle Maystadt, Carey McDougall, Meriel McEntagart, Nancy Mendelsohn, David T Miller, Geert Mortier, Jenny Morton, John Pappas, Scott R Plotkin, Dinel Pond, Kenneth Rosenbaum, Karol Rubin, Laura Russell, Lane S Rutledge, Veronica Saletti, Rhonda Schonberg, Allison Schreiber, Meredith Seidel, Elizabeth Siqveland, David W Stockton, Eva Trevisson, Nicole J Ullrich, Meena Upadhyaya, Rick van Minkelen, Helene Verhelst, Margaret R Wallace, Yoon-Sim Yap, Elaine Zackai, Jonathan Zonana, Vickie Zurcher, Kathleen Claes, Yolanda Martin, Bruce R Korf, Eric Legius, Ludwine M Messiae. Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848. American journal of human genetics. vol 102. issue 1. 2018-12-11. PMID:29290338. |
both variants predispose to a distinct mild nf1 phenotype with neither externally visible cutaneous/plexiform neurofibromas nor other tumors. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jody F Longo, Shannon M Weber, Brittany P Turner-Ivey, Steven L Carrol. Recent Advances in the Diagnosis and Pathogenesis of Neurofibromatosis Type 1 (NF1)-associated Peripheral Nervous System Neoplasms. Advances in anatomic pathology. vol 25. issue 5. 2018-11-26. PMID:29762158. |
the diagnosis of a neurofibroma or a malignant peripheral nerve sheath tumor (mpnst) often raises the question of whether the patient has the genetic disorder neurofibromatosis type 1 (nf1) as well as how this will impact the patient's outcome, what their risk is for developing additional neoplasms and whether treatment options differ for nf1-associated and sporadic peripheral nerve sheath tumors. |
2018-11-26 |
2023-08-13 |
Not clear |
| Kwangmin Choi, Kakajan Komurov, Jonathan S Fletcher, Edwin Jousma, Jose A Cancelas, Jianqiang Wu, Nancy Ratne. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Scientific reports. vol 7. 2018-11-01. PMID:28256556. |
neurofibromas are benign peripheral nerve tumors driven by nf1 loss in schwann cells (scs). |
2018-11-01 |
2023-08-13 |
mouse |
| Kwangmin Choi, Kakajan Komurov, Jonathan S Fletcher, Edwin Jousma, Jose A Cancelas, Jianqiang Wu, Nancy Ratne. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Scientific reports. vol 7. 2018-11-01. PMID:28256556. |
while in 1-month-old nf1 mutant nerve neither scs nor macrophages significantly differed from their normal counterparts, both macrophages and scs showed significantly altered cytokine gene expression in neurofibromas. |
2018-11-01 |
2023-08-13 |
mouse |
| Kayla Rosnau, S Shahrukh Hashmi, Hope Northrup, John Slopis, Sarah Noblin, Myla Ashfa. Knowledge and Self-Esteem of Individuals with Neurofibromatosis Type 1 (NF1). Journal of genetic counseling. vol 26. issue 3. 2018-09-10. PMID:27815662. |
neurofibromatosis type 1 (nf1) is a progressive genetic disorder characterized by physical findings such as café-au-lait macules, lisch nodules, and neurofibromas in addition to other medical complications. |
2018-09-10 |
2023-08-13 |
Not clear |
| Rafaela E Rozza-de-Menezes, Nicolle C Gaglionone, Raquel M Andrade-Losso, Orlando H K Siqueira, Lilian M Almeida, Kamila da S Peruzini, Marco A C Guimarães-Filho, Carolina I Brum, Mauro Geller, Karin S Cunh. Receptor of ghrelin is expressed in cutaneous neurofibromas of individuals with neurofibromatosis 1. Orphanet journal of rare diseases. vol 12. issue 1. 2018-09-04. PMID:29262839. |
multiple cutaneous neurofibromas are a hallmark of neurofibromatosis 1 (nf1). |
2018-09-04 |
2023-08-13 |
Not clear |
| Rafaela E Rozza-de-Menezes, Nicolle C Gaglionone, Raquel M Andrade-Losso, Orlando H K Siqueira, Lilian M Almeida, Kamila da S Peruzini, Marco A C Guimarães-Filho, Carolina I Brum, Mauro Geller, Karin S Cunh. Receptor of ghrelin is expressed in cutaneous neurofibromas of individuals with neurofibromatosis 1. Orphanet journal of rare diseases. vol 12. issue 1. 2018-09-04. PMID:29262839. |
we aimed to investigate ghs-r expression in nf1 cutaneous neurofibromas and its relationship with tumors volume, and patient's age and gender. |
2018-09-04 |
2023-08-13 |
Not clear |
| Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshid. Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. The Journal of dermatology. vol 45. issue 1. 2018-08-17. PMID:28891076. |
most nf1 patients develop cutaneous neurofibromas. |
2018-08-17 |
2023-08-13 |
Not clear |
| Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshid. Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. The Journal of dermatology. vol 45. issue 1. 2018-08-17. PMID:28891076. |
our data will enable physicians to estimate the overall state of cutaneous neurofibromas in nf1 and will be useful for handling cutaneous manifestations before they become a serious condition. |
2018-08-17 |
2023-08-13 |
Not clear |
| C Santoro, T Giugliano, M A B Melone, M Cirillo, C Schettino, P Bernardo, G Cirillo, S Perrotta, G Pilus. Multiple spinal nerve enlargement and SOS1 mutation: Further evidence of overlap between neurofibromatosis type 1 and Noonan phenotype. Clinical genetics. vol 93. issue 1. 2018-08-06. PMID:28456002. |
neurofibromatosis type 1 (nf1) has long been considered a well-defined, recognizable monogenic disorder, with neurofibromas constituting a pathognomonic sign. |
2018-08-06 |
2023-08-13 |
Not clear |
| Katarzyna J Radomska, Piotr Topilk. Boundary cap cells in development and disease. Current opinion in neurobiology. vol 47. 2018-07-27. PMID:29174469. |
strikingly, those two locations constitute the privileged sites for development of benign peripheral nerve sheath tumors called neurofibromas in patients with neurofibromatosis type 1 (nf1), making bcs attractive candidates for the 'cell of origin' of this disease. |
2018-07-27 |
2023-08-13 |
Not clear |