| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Wu, W Liu, J P Williams, N Ratne. EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation. Oncogene. vol 36. issue 12. 2017-09-01. PMID:27748759. |
neurofibromatosis type 1 (nf1) is an inherited disease in which affected patients are predisposed to develop benign schwann cell (sc) tumours called neurofibromas. |
2017-09-01 |
2023-08-13 |
mouse |
| J Wu, W Liu, J P Williams, N Ratne. EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation. Oncogene. vol 36. issue 12. 2017-09-01. PMID:27748759. |
in the mouse, loss of nf1 in the sc lineage causes neurofibroma formation. |
2017-09-01 |
2023-08-13 |
mouse |
| J Wu, W Liu, J P Williams, N Ratne. EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation. Oncogene. vol 36. issue 12. 2017-09-01. PMID:27748759. |
neurofibroma number increased in homozygous cnp-hegfr mice versus heterozygous littermates, and neurofibroma number and size increased when cnp-hegfr was crossed to nf1 |
2017-09-01 |
2023-08-13 |
mouse |
| M Baier, S Pit. [Eye involvement in neurofibromatosis]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. vol 113. issue 5. 2017-08-30. PMID:27142037. |
characteristics which the two main forms nf1 and nf2 have in common are a positive family history, characteristic skin alterations, such as café au lait macules, axillary or inguinal freckling and neural tumors such as neurofibroma and optic glioma (nf1) as well as (bilateral) vestibular schwannomas (nf2). |
2017-08-30 |
2023-08-13 |
Not clear |
| Pierre Sohier, Armelle Luscan, Angharad Lloyd, Kevin Ashelford, Ingrid Laurendeau, Audrey Briand-Suleau, Dominique Vidaud, Nicolas Ortonne, Eric Pasmant, Meena Upadhyay. Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors. Genes, chromosomes & cancer. vol 56. issue 5. 2017-07-21. PMID:28124441. |
the commonest tumors associated with neurofibromatosis type 1 (nf1) are benign peripheral nerve sheath tumors, called neurofibromas. |
2017-07-21 |
2023-08-13 |
Not clear |
| Hildegard Kehrer-Sawatzki, Victor-Felix Mautner, David N Coope. Emerging genotype-phenotype relationships in patients with large NF1 deletions. Human genetics. vol 136. issue 4. 2017-06-20. PMID:28213670. |
such patients also display significantly more cardiovascular anomalies as compared with patients without large deletions and often exhibit increased numbers of subcutaneous, plexiform and spinal neurofibromas as compared with the general nf1 population. |
2017-06-20 |
2023-08-13 |
Not clear |
| Hua Li, Lung-Ji Chang, Debbie R Neubauer, David F Muir, Margaret R Wallac. Immortalization of human normal and NF1 neurofibroma Schwann cells. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 10. 2017-06-12. PMID:27617404. |
immortalization of human normal and nf1 neurofibroma schwann cells. |
2017-06-12 |
2023-08-13 |
human |
| Souvik Karmakar, Karlyne M Reill. The role of the immune system in neurofibromatosis type 1-associated nervous system tumors. CNS oncology. vol 6. issue 1. 2017-04-18. PMID:28001089. |
the role of mast cells in promoting neurofibroma growth in neurofibromatosis type 1 (nf1) patients was hypothesized decades ago. |
2017-04-18 |
2023-08-13 |
mouse |
| Won Jik Lee, Sung Min Park, Byung Wook Kim, Joon Sung Kim, Jeong Seon Ji, Hwang Cho. [Solitary Neurofibroma of the Sigmoid Colon Presenting as a Subepithelial Tumor Successfully Removed by Endoscopic Resection]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. vol 68. issue 1. 2017-04-11. PMID:27443624. |
neurofibromas are benign, slow-growing nerve sheath tumors of the peripheral nervous system, arising from schwann cells, and classically associated with neurofibromatosis type 1 (nf1, von recklinghausen's disease). |
2017-04-11 |
2023-08-13 |
Not clear |
| Santasree Banerjee, Yi Dai, Shengran Liang, Huishuang Chen, Yanyan Wang, Lihui Tang, Jing Wu, Hui Huan. A novel mutation in NF1 is associated with diverse intra-familial phenotypic variation and astrocytoma in a Chinese family. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 31. 2017-03-23. PMID:27234610. |
neurofibromatosis type 1 (nf1) is a dysregulated neurocutaneous disorder, characterized by neurofibromas and café-au-lait spots. |
2017-03-23 |
2023-08-13 |
Not clear |
| Ellie Rad, Andrew R Te. Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer. Seminars in cell & developmental biology. vol 52. 2017-01-17. PMID:26860753. |
malignant peripheral nerve sheath tumours (mpnsts) can develop from benign neurofibromas and are the main cause of death amongst nf1 patients. |
2017-01-17 |
2023-08-13 |
Not clear |
| Jianqiang Wu, Vincent W Keng, Deanna M Patmore, Jed J Kendall, Ami V Patel, Edwin Jousma, Walter J Jessen, Kwangmin Choi, Barbara R Tschida, Kevin A T Silverstein, Danhua Fan, Eric B Schwartz, James R Fuchs, Yuanshu Zou, Mi-Ok Kim, Eva Dombi, David E Levy, Gang Huang, Jose A Cancelas, Anat O Stemmer-Rachamimov, Robert J Spinner, David A Largaespada, Nancy Ratne. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell reports. vol 14. issue 8. 2016-12-13. PMID:26904939. |
knockdown of arid1b or gsk3β in stat3(fl/fl);nf1(fl/fl);dhhcre scps rescues neurofibroma formation after in vivo transplantation. |
2016-12-13 |
2023-08-13 |
mouse |
| Anja Harder, Mario Tippmar, Sergej Baschinskij, Christoph Rancso, Jan Janda, Thomas Mairinge. Do juxtaposed compound nevus and neurofibroma with melanocytic differentiation share an identical cell of origin in NF1? European journal of dermatology : EJD. vol 25. issue 6. 2016-11-01. PMID:26463573. |
do juxtaposed compound nevus and neurofibroma with melanocytic differentiation share an identical cell of origin in nf1? |
2016-11-01 |
2023-08-13 |
Not clear |
| John Richard McPherson, Choon-Kiat Ong, Cedric Chuan-Young Ng, Vikneswari Rajasegaran, Hong-Lee Heng, Willie Shun-Shing Yu, Benita Kiat-Tee Tan, Preetha Madhukumar, Melissa Ching-Ching Teo, Joanne Ngeow, Aye-Aye Thike, Steven George Rozen, Puay-Hoon Tan, Ann Siew-Gek Lee, Bin-Tean Teh, Yoon-Sim Ya. Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1. Cancer medicine. vol 4. issue 12. 2016-10-13. PMID:26432421. |
here, we describe the exome sequencing of breast cancer, mpnst, and neurofibroma from a patient with nf1. |
2016-10-13 |
2023-08-13 |
Not clear |
| John Richard McPherson, Choon-Kiat Ong, Cedric Chuan-Young Ng, Vikneswari Rajasegaran, Hong-Lee Heng, Willie Shun-Shing Yu, Benita Kiat-Tee Tan, Preetha Madhukumar, Melissa Ching-Ching Teo, Joanne Ngeow, Aye-Aye Thike, Steven George Rozen, Puay-Hoon Tan, Ann Siew-Gek Lee, Bin-Tean Teh, Yoon-Sim Ya. Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1. Cancer medicine. vol 4. issue 12. 2016-10-13. PMID:26432421. |
in addition, we showed independent somatic nf1 mutations in all the three tumors (frameshift insertion in breast cancer (p.a985fs), missense mutation in mpnst (p.g23r), and inframe deletion in dermal neurofibroma (p.l1876del-inf)), indicating that a second hit in nf1 resulting in the loss of function could be important for tumor formation. |
2016-10-13 |
2023-08-13 |
Not clear |
| Ahmed-Abdel-Fattah Nofal, Mohammad-Waheed El-Anwa. Intraparotid Neurofibroma of the Facial Nerve: A Case Report. Iranian journal of otorhinolaryngology. vol 28. issue 87. 2016-09-07. PMID:27602341. |
intraparotid neurofibromas of the facial nerve are extremely rare and mostly associated with neurofibromatosis type 1 (nf1). |
2016-09-07 |
2023-08-13 |
Not clear |
| Baris Gundogdu, Servet Yolbas, Ahmet Yildirim, Murat Gonen, Suleyman Serdar Koc. Coexistence of Ankylosing Spondylitis and Neurofibromatosis Type 1. Case reports in rheumatology. vol 2016. 2016-09-06. PMID:27597922. |
neurofibromatosis type 1 (nf1) is a multisystem genetic disease which is characterized by cutaneous findings, most importantly café-au-lait spots and axillary freckling, by skeletal dysplasia, and by the growth of both benign and malignant nervous system neoplasms, most notably benign neurofibromas. |
2016-09-06 |
2023-08-13 |
Not clear |
| H Li, X Zhao, X Yan, W J Jessen, M-O Kim, E Dombi, P P Liu, G Huang, J W. Runx1 contributes to neurofibromatosis type 1 neurofibroma formation. Oncogene. vol 35. issue 11. 2016-08-15. PMID:26073082. |
neurofibromatosis type 1 (nf1) patients are predisposed to neurofibromas but the driver(s) that contribute to neurofibroma formation are not fully understood. |
2016-08-15 |
2023-08-13 |
mouse |
| H Li, X Zhao, X Yan, W J Jessen, M-O Kim, E Dombi, P P Liu, G Huang, J W. Runx1 contributes to neurofibromatosis type 1 neurofibroma formation. Oncogene. vol 35. issue 11. 2016-08-15. PMID:26073082. |
these results suggest that runx1 has an important role in nf1 neurofibroma initiation, and inhibition of runx1 function might provide a novel potential therapeutic treatment strategy for neurofibroma patients. |
2016-08-15 |
2023-08-13 |
mouse |
| Steven L Carrol. The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics. The American journal of pathology. vol 186. issue 3. 2016-08-09. PMID:26740486. |
studies of human neurofibromatosis type 1-associated tumors suggest that nf1 tumor suppressor loss in schwann cells triggers cell-autonomous and intercellular changes, resulting in development of benign neurofibromas; subsequent neurofibroma-mpnst progression is caused by aberrant growth factor signaling and mutations affecting the p16(ink4a)-cyclin d1-cdk4-rb and p19(arf)-mdm2-p53 cell cycle pathways. |
2016-08-09 |
2023-08-13 |
mouse |