| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debora Garozz. Peripheral nerve tumors in neurofibromatosis 1: An overview on management and indications for surgical treatment in our experience. Neurology India. vol 67. issue Supplement. 2019-12-16. PMID:30688231. |
in comparison with sporadic forms, nf1 pnts present some peculiarities: (1) a large prevalence of neurofibromas; (2) the presence of pathognomonic tumoral forms (plexiform neurofibromas); and, (3) a higher incidence (lifetime risk is equal to 8-13%) and an earlier age of onset (2-3 versus 3-6 decades) of malignant peripheral nerve sheath tumors (mpnsts). |
2019-12-16 |
2023-08-13 |
Not clear |
| Floriane D A Degbelo, Giovanni Cito, Boumédiène Guendil, Michel Christodoulou, Ziad Abbass. Spontaneous Hemothorax in a Patient with von Recklinghausen's Disease: A Case Report and Review of the Literature. The American journal of case reports. vol 20. 2019-12-11. PMID:31076564. |
background von recklinghausen's disease, also known as type 1 neurofibromatosis (nf1), is a genetic disorder characterized by skin tumors, neurofibromas of multiple organs and vascular abnormalities. |
2019-12-11 |
2023-08-13 |
Not clear |
| Daiki Kobayashi, Takaho Tokuda, Kyosuke Sato, Hiroki Okanishi, Megumi Nagayama, Mio Hirayama-Kurogi, Sumio Ohtsuki, Norie Arak. Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA). Molecular & cellular proteomics : MCP. vol 18. issue 2. 2019-11-25. PMID:30381327. |
neurofibromatosis type 1 (nf1) is an autosomal dominant disease that predisposes individuals to developing benign neurofibromas and malignant peripheral nerve sheath tumors (mpnst). |
2019-11-25 |
2023-08-13 |
Not clear |
| Mueez Waqar, Susan Huson, D Gareth Evans, John Ealing, Konstantina Karabatsou, K Joshi George, Calvin So. C2 neurofibromas in neurofibromatosis type 1: genetic and imaging characteristics. Journal of neurosurgery. Spine. vol 30. issue 1. 2019-10-17. PMID:30485203. |
objectivec2 nerve root neurofibromas have been reported frequently in patients with neurofibromatosis type 1 (nf1), although their genetic and imaging characteristics are unexplored. |
2019-10-17 |
2023-08-13 |
Not clear |
| Ritsuko Harigai, Shigeki Sakai, Hiroyuki Nobusue, Chikako Hirose, Oltea Sampetrean, Noriaki Minami, Yukie Hata, Takashi Kasama, Takanori Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Kazuo Kishi, Hideyuki Saya, Yoshimi Arim. Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29666462. |
neurofibromatosis type 1 (nf1) is caused by germline mutations in the nf1 gene and is characterized by café au lait spots and benign tumours known as neurofibromas. |
2019-10-07 |
2023-08-13 |
Not clear |
| Ritsuko Harigai, Shigeki Sakai, Hiroyuki Nobusue, Chikako Hirose, Oltea Sampetrean, Noriaki Minami, Yukie Hata, Takashi Kasama, Takanori Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Kazuo Kishi, Hideyuki Saya, Yoshimi Arim. Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29666462. |
nf1 encodes the tumour suppressor protein neurofibromin, which negatively regulates the small gtpase ras, with the constitutive activation of ras signalling resulting from nf1 mutations being thought to underlie neurofibroma development. |
2019-10-07 |
2023-08-13 |
Not clear |
| Ritsuko Harigai, Shigeki Sakai, Hiroyuki Nobusue, Chikako Hirose, Oltea Sampetrean, Noriaki Minami, Yukie Hata, Takashi Kasama, Takanori Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Kazuo Kishi, Hideyuki Saya, Yoshimi Arim. Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29666462. |
with the use of a cell-based drug screening assay, we have now identified the antiallergy drug tranilast (n-(3,4-dimethoxycinnamoyl) anthranilic acid) as an inhibitor of emt and found that it attenuated the expression of mesenchymal markers and angiogenesis-related genes in nf1-mutated snf96.2 cells and in neurofibroma cells from nf1 patients. |
2019-10-07 |
2023-08-13 |
Not clear |
| Beren Karaosmanoglu, Çetin Y Kocaefe, Figen Söylemezoğlu, Banu Anlar, Ali Varan, İbrahim Vargel, Sükriye Ayte. Heightened CXCR4 and CXCL12 expression in NF1-associated neurofibromas. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 34. issue 5. 2019-09-02. PMID:29455242. |
neurofibromas are the most common schwann cell-based tumors in nf1 patients, which are mainly categorized into dermal and plexiform neurofibromas. |
2019-09-02 |
2023-08-13 |
Not clear |
| Daipayan Guha, Benjamin Davidson, Mustafa Nadi, Naif M Alotaibi, Michael G Fehlings, Fred Gentili, Taufik A Valiante, Charles H Tator, Michael Tymianski, Abhijit Guha, Gelareh Zade. Management of peripheral nerve sheath tumors: 17 years of experience at Toronto Western Hospital. Journal of neurosurgery. vol 128. issue 4. 2019-08-30. PMID:28686119. |
recurrence of schwannomas and neurofibromas were seen more frequently in patients diagnosed with nf3 and nf1, respectively. |
2019-08-30 |
2023-08-13 |
Not clear |
| Jaishri O Blakeley, Pierre Wolkenstein, Brigitte C Widemann, James Lee, Lu Q Le, Rhonda Jackson, Marigo Stathis, Sharad K Verm. Creating a comprehensive research strategy for cutaneous neurofibromas. Neurology. vol 91. issue 2 Suppl 1. 2019-08-28. PMID:29987129. |
outside of procedural-based methods, there are currently no established medical treatments for cutaneous neurofibroma (cnf), which afflict up to 99% of patients with nf1. |
2019-08-28 |
2023-08-13 |
Not clear |
| Nicolas Ortonne, Pierre Wolkenstein, Jaishri O Blakeley, Bruce Korf, Scott R Plotkin, Vincent M Riccardi, Douglas C Miller, Susan Huson, Juha Peltonen, Andrew Rosenberg, Steven L Carroll, Sharad K Verma, Victor Mautner, Meena Upadhyaya, Anat Stemmer-Rachamimo. Cutaneous neurofibromas: Current clinical and pathologic issues. Neurology. vol 91. issue 2 Suppl 1. 2019-08-28. PMID:29987130. |
to present the current terminology and natural history of neurofibromatosis 1 (nf1) cutaneous neurofibromas (cnf). |
2019-08-28 |
2023-08-13 |
Not clear |
| Joo Young Kim, Mee Yon Lee, Young Chun Lee, Hye-Young Shi. Neurofibromatosis type 1 with tarsal conjunctiva thickening: A case report. Medicine. vol 98. issue 31. 2019-08-12. PMID:31374061. |
we report a rare case of neurofibroma in the form of tarsal conjunctival thickening of the eyelid in patients with neurofibromatosis type 1 (nf1), common ocular complications of which are lisch nodules, choroidal nodules, and optic nerve glioma. |
2019-08-12 |
2023-08-13 |
Not clear |
| Lan Kluwe, Christian Hagel, Reinhard E Friedrich, Claudia Schnabel, Gerhard Schön, Victor Mautne. Vitamin D receptor expression and serum 25(OH)D concentration inversely associates with burden of neurofibromas. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 28. issue 3. 2019-08-01. PMID:30299316. |
we previously found an inverse correlation of serum 25(oh)d concentration with number of neurofibromas in nf1. |
2019-08-01 |
2023-08-13 |
Not clear |
| Lan Kluwe, Christian Hagel, Reinhard E Friedrich, Claudia Schnabel, Gerhard Schön, Victor Mautne. Vitamin D receptor expression and serum 25(OH)D concentration inversely associates with burden of neurofibromas. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 28. issue 3. 2019-08-01. PMID:30299316. |
the number of dermal neurofibromas was significantly inversely correlated with vdr mrna level and with serum 25(oh)d concentration in nf1 patients. |
2019-08-01 |
2023-08-13 |
Not clear |
| Robert J Allaway, Sara J C Gosline, Salvatore La Rosa, Pamela Knight, Annette Bakker, Justin Guinney, Lu Q L. Cutaneous neurofibromas in the genomics era: current understanding and open questions. British journal of cancer. vol 118. issue 12. 2019-07-16. PMID:29695767. |
cutaneous neurofibromas (cnf) are a nearly ubiquitous symptom of neurofibromatosis type 1 (nf1), a disorder with a broad phenotypic spectrum caused by germline mutation of the neurofibromatosis type 1 tumour suppressor gene (nf1). |
2019-07-16 |
2023-08-13 |
Not clear |
| Yuchen Zhang, Rongsheng Zhou, Yiping Qu, Maoguo Shu, Shuzhong Guo, Zhuanli Ba. Lipoamide Inhibits NF1 Deficiency-induced Epithelial-Mesenchymal Transition in Murine Schwann Cells. Archives of medical research. vol 48. issue 6. 2019-07-03. PMID:29198560. |
neurofibromatosis type i (nf1) is one of the most common neurocutaneous syndromes characterized by development of adult neurofibromas which is mainly made up of schwann cells. |
2019-07-03 |
2023-08-13 |
Not clear |
| Eva Trevisson, Valeria Morbidoni, Monica Forzan, Cecilia Daolio, Valentina Fumini, Raffaele Parrozzani, Matteo Cassina, Edoardo Midena, Leonardo Salviati, Maurizio Clement. The Arg1038Gly missense variant in the NF1 gene causes a mild phenotype without neurofibromas. Molecular genetics & genomic medicine. vol 7. issue 5. 2019-06-25. PMID:30843352. |
the arg1038gly missense variant in the nf1 gene causes a mild phenotype without neurofibromas. |
2019-06-25 |
2023-08-13 |
Not clear |
| Reetu Kundu, Sanjay Gupta, Robin Kaushik, Rajpal Singh Punia, Ravinder Kau. Isolated giant ileal neurofibroma sans neurofibromatosis. Indian journal of cancer. vol 55. issue 3. 2019-06-24. PMID:30693899. |
neurofibromas are benign neoplasms that are usually seen in hereditary disorders such as von recklinghausen's disease [neurofibromatosis type 1 (nf1)]. |
2019-06-24 |
2023-08-13 |
Not clear |
| Reetu Kundu, Sanjay Gupta, Robin Kaushik, Rajpal Singh Punia, Ravinder Kau. Isolated giant ileal neurofibroma sans neurofibromatosis. Indian journal of cancer. vol 55. issue 3. 2019-06-24. PMID:30693899. |
the occurrence of isolated ileal neurofibroma in patients without the classic manifestations of nf1 or multiple endocrine neoplasia (men) syndromes is an extremely rare entity . |
2019-06-24 |
2023-08-13 |
Not clear |
| Magdalena Koczkowska, Tom Callens, Alicia Gomes, Angela Sharp, Yunjia Chen, Alesha D Hicks, Arthur S Aylsworth, Amedeo A Azizi, Donald G Basel, Gary Bellus, Lynne M Bird, Maria A Blazo, Leah W Burke, Ashley Cannon, Felicity Collins, Colette DeFilippo, Ellen Denayer, Maria C Digilio, Shelley K Dills, Laura Dosa, Robert S Greenwood, Cristin Griffis, Punita Gupta, Rachel K Hachen, Concepción Hernández-Chico, Sandra Janssens, Kristi J Jones, Justin T Jordan, Peter Kannu, Bruce R Korf, Andrea M Lewis, Robert H Listernick, Fortunato Lonardo, Maurice J Mahoney, Mayra Martinez Ojeda, Marie T McDonald, Carey McDougall, Nancy Mendelsohn, David T Miller, Mari Mori, Rianne Oostenbrink, Sebastién Perreault, Mary Ella Pierpont, Carmelo Piscopo, Dinel A Pond, Linda M Randolph, Katherine A Rauen, Surya Rednam, S Lane Rutledge, Veronica Saletti, G Bradley Schaefer, Elizabeth K Schorry, Daryl A Scott, Andrea Shugar, Elizabeth Siqveland, Lois J Starr, Ashraf Syed, Pamela L Trapane, Nicole J Ullrich, Emily G Wakefield, Laurence E Walsh, Michael F Wangler, Elaine Zackai, Kathleen B M Claes, Katharina Wimmer, Rick van Minkelen, Alessandro De Luca, Yolanda Martin, Eric Legius, Ludwine M Messiae. Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype-phenotype correlation. Genetics in medicine : official journal of the American College of Medical Genetics. vol 21. issue 4. 2019-06-18. PMID:30190611. |
neurofibromatosis type 1 (nf1) is characterized by a highly variable clinical presentation, but almost all nf1-affected adults present with cutaneous and/or subcutaneous neurofibromas. |
2019-06-18 |
2023-08-13 |
Not clear |