| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Münch, Yossi Buskila, Erika Gyenges. Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum. Journal of neuroinflammation. vol 20. issue 1. 2023-10-14. PMID:37833764. |
the basal forebrain cholinergic neurons (bfcn) provide the primary source of cholinergic innervation of the human cerebral cortex and may be differentially vulnerable in various neurodegenerative diseases. |
2023-10-14 |
2023-10-15 |
mouse |
| Serenella Anzilotti, Valeria Valente, Paola Brancaccio, Cristina Franco, Antonella Casamassa, Giovanna Lombardi, Alessandra Palazzi, Andrea Conte, Simona Paladino, Lorella Maria Teresa Canzoniero, Lucio Annunziato, Giovanna Maria Pierantoni, Giuseppe Pignatar. Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-20. PMID:37729728. |
amyotrophic lateral sclerosis (als) is a progressive and often fatal neurodegenerative disease characterized by the loss of motor neurons (mns) in spinal cord, motor cortex and brainstem. |
2023-09-20 |
2023-10-07 |
mouse |
| Megan F Duffy, Jinhui Ding, Rebekah G Langston, Syed I Shah, Mike A Nalls, Sonja W Scholz, D Thad Whitaker, Pavan K Auluck, Stefano Marenco, J Raphael Gibbs, Mark R Cookso. Divergent patterns of healthy aging across human brain regions at single-cell resolution reveal links to neurodegenerative disease. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577533. |
we sampled 155,192 nuclei from two cortical regions (entorhinal cortex and middle temporal gyrus) and two subcortical regions (putamen and subventricular zone) relevant to neurodegenerative diseases or the proliferative niche. |
2023-08-14 |
2023-08-16 |
human |
| Laura López-Pingarrón, Henrique Almeida, Marisol Soria-Aznar, Marcos C Reyes-Gonzales, María Pilar Terrón, Joaquín J Garcí. Role of Oxidative Stress on the Etiology and Pathophysiology of Amyotrophic Lateral Sclerosis (ALS) and Its Relation with the Enteric Nervous System. Current issues in molecular biology. vol 45. issue 4. 2023-05-16. PMID:37185741. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease affecting motor neurons in the spinal cord, cerebral cortex, and medulla oblongata. |
2023-05-16 |
2023-08-14 |
Not clear |
| Jibo Wang, Haowen Qiao, Zhenyan Wang, Wen Zhao, Tao Chen, Bin Li, Lili Zhu, Sihan Chen, Longjun Gu, Ying Wu, Zhentao Zhang, Linlin Bi, Pu Che. Rationally Design and Acoustically Assemble Human Cerebral Cortex-like Microtissues from hiPSC-derived Neural Progenitors and Neurons. Advanced materials (Deerfield Beach, Fla.). 2023-05-12. PMID:37170683. |
overall, we provided a high-fidelity human-relevant in vitro histotypic models for cerebral cortex, and these models will facilitate wide applications in probing the mechanisms of neurodegenerative diseases and screening the candidates of neuroprotective agents. |
2023-05-12 |
2023-08-14 |
human |
| Bárbara Teruel-Peña, José Luís Gómez-Urquiza, Nora Suleiman-Martos, Isabel Prieto, Francisco José García-Cózar, Manuel Ramírez-Sánchez, Carmen Fernández-Martos, Germán Domínguez-Vía. Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108335. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord, brain stem, and cerebral cortex. |
2023-04-28 |
2023-08-14 |
human |
| Julia K Kühlwein, Wolfgang P Ruf, Katharina Kandler, Simon Witzel, Christina Lang, Medhanie A Mulaw, Arif B Ekici, Jochen H Weishaupt, Albert C Ludolph, Veselin Grozdanov, Karin M Danze. ALS is imprinted in the chromatin accessibility of blood cells. Cellular and molecular life sciences : CMLS. vol 80. issue 5. 2023-04-24. PMID:37095391. |
by combining simultaneous atac-seq and rna-seq with single-cell sequencing in pbmcs and motor cortex from als patients, we demonstrate that epigenetic changes associated with the neurodegenerative disease can be found in the periphery, thus strongly suggesting a mechanistic link between the epigenetic regulation and disease pathogenesis. |
2023-04-24 |
2023-08-14 |
Not clear |
| Liting Han, Hanni Jiang, Xufeng Yao, Zhe Ren, Zhongsen Qu, Tonggang Yu, Shichang Luo, Tao W. Revealing the correlations between brain cortical characteristics and susceptibility genes for Alzheimer disease: a cross-sectional study. Quantitative imaging in medicine and surgery. vol 13. issue 4. 2023-04-17. PMID:37064375. |
alzheimer disease (ad) is a progressive neurodegenerative disease closely related to genes and characterized by the atrophy of the cerebral cortex. |
2023-04-17 |
2023-08-14 |
human |
| Xiujuan Fu, Yizi He, Yongzhi Xie, Zuneng L. A conjoint analysis of bulk RNA-seq and single-nucleus RNA-seq for revealing the role of ferroptosis and iron metabolism in ALS. Frontiers in neuroscience. vol 17. 2023-03-20. PMID:36937665. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by progressive and selective degeneration of motor neurons in the motor cortex of brain and spinal cord. |
2023-03-20 |
2023-08-14 |
mouse |
| Francesca De Lorenzo, Patrick Lüningschrör, Jinhan Nam, Liam Beckett, Federica Pilotto, Emilia Galli, Päivi Lindholm, Cora Rüdt von Collenberg, Simon Tii Mungwa, Sibylle Jablonka, Julia Kauder, Nadine Thau-Habermann, Susanne Petri, Dan Lindholm, Smita Saxena, Michael Sendtner, Mart Saarma, Merja H Voutilaine. CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. Brain : a journal of neurology. 2023-03-17. PMID:36928391. |
amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects motor neurons (mns) in the spinal cord, brainstem, and motor cortex, leading to paralysis and eventually to death within 3 to 5 years of symptom onset. |
2023-03-17 |
2023-08-14 |
mouse |
| Yusuf Tamam, Beran Yokuş, Cüneyt Tamam, Hande Yüceer, Selim Karahan, Bernan Em, Şerife Banu Tamam, Erdem Tüzü. The Effect of Lidocaine on the Experimental Model of Streptozotocin-Induced Alzheimer's Disease. Noro psikiyatri arsivi. vol 60. issue 1. 2023-03-13. PMID:36911558. |
alzheimer's disease (ad) is a neurodegenerative disease caused by the accumulation of amyloid plaques in the cerebral cortex and hippocampus. |
2023-03-13 |
2023-08-14 |
rat |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711790. |
cryogenic electron microscopy (cryo-em) studies have unveiled the structure of tau and tmem106b, from the cerebral cortex, in several neurodegenerative diseases; however, whether tau and tmem106b filaments from the gray and white matter share a common fold requires additional investigation. |
2023-01-30 |
2023-08-14 |
Not clear |
| Gregory A Shilovsky, Tatyana S Putyatina, Alexander V Marko. Evolution of Longevity as a Species-Specific Trait in Mammals. Biochemistry. Biokhimiia. vol 87. issue 12. 2023-01-30. PMID:36717448. |
this difference between these phenomena reaches its peak in mammals due to the development of endothermy and cephalization associated with the cerebral cortex expansion, which leads to the upregulated production of oxidative radicals by the mitochondria (and, consequently, accelerated aging), increase in the number of non-dividing differentiated cells, accumulation of the age-related damage in these cells, and development of neurodegenerative diseases. |
2023-01-30 |
2023-08-14 |
Not clear |
| Pan Wang, Shuman Zhang, Chunli Hu, Lili Ren, Jing B. Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ Molecular biology reports. 2023-01-05. PMID:36602704. |
regulatory role of melatonin in notch1 signaling pathway in cerebral cortex of aβ soluble amyloid-beta (aβ) oligomers are thought to play a key role in the pathogenesis of alzheimer's disease (ad), which is the most common age-associated neurodegenerative diseases with obvious neuropathological changes and functional decline in both cortical and subcortical regions. |
2023-01-05 |
2023-08-14 |
Not clear |
| Rebecca L Gould, Benjamin J Thompson, Charlotte Rawlinson, Pavithra Kumar, David White, Marc A Serfaty, Christopher D Graham, Lance M McCracken, Matt Bursnall, Mike Bradburn, Tracey Young, Robert J Howard, Ammar Al-Chalabi, Laura H Goldstein, Vanessa Lawrence, Cindy Cooper, Pamela J Shaw, Christopher J McDermot. A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol. BMC neurology. vol 22. issue 1. 2022-11-15. PMID:36380299. |
motor neuron disease (mnd) is a rapidly progressive, fatal neurodegenerative disease that predominantly affects motor neurons from the motor cortex to the spinal cord and causes progressive wasting and weakening of bulbar, limb, abdominal and thoracic muscles. |
2022-11-15 |
2023-08-14 |
Not clear |
| Ming-Li Li, Shi-Hao Wu, Bo Song, Jing Yang, Li-Yuan Fan, Yang Yang, Yun-Chao Wang, Jing-Hua Yang, Yuming X. Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease. Aging cell. 2022-09-27. PMID:36165462. |
by integrating multiple datasets, we found entorhinal cortex aging was closely related to multiple neurodegenerative diseases, particularly for ad. |
2022-09-27 |
2023-08-14 |
Not clear |
| Ming-Li Li, Shi-Hao Wu, Bo Song, Jing Yang, Li-Yuan Fan, Yang Yang, Yun-Chao Wang, Jing-Hua Yang, Yuming X. Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease. Aging cell. 2022-09-27. PMID:36165462. |
altogether, this study provides a comprehensive cellular and molecular atlas of the primate entorhinal cortex at single-cell resolution and provides new insights into potential therapeutic targets against age-related neurodegenerative diseases. |
2022-09-27 |
2023-08-14 |
Not clear |
| Non-Nuoc Tran, Byung-Hoon Le. Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies. Frontiers in cell and developmental biology. vol 10. 2022-09-26. PMID:36158183. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease in which motor neurons in spinal cord and motor cortex are progressively lost. |
2022-09-26 |
2023-08-14 |
Not clear |
| b' Bel\\xc3\\xa9n Proa\\xc3\\xb1o, Julia Casani-Cubel, Mar\\xc3\\xada Benlloch, Ana Rodriguez-Mateos, Esther Navarro-Illana, Jose Mar\\xc3\\xada Lajara-Romance, Jose Enrique de la Rubia Ort\\xc3\\xa. Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis? Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140184.' |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease that is characterized by the loss of upper and lower motor neurons (mns) in the cerebral cortex, brainstem and spinal cord, with consequent weakness, atrophy and the progressive paralysis of all muscles. |
2022-09-23 |
2023-08-14 |
Not clear |
| Banaja P Dash, Axel Freischmidt, Jochen H Weishaupt, Andreas Herman. Downstream Effects of Mutations in International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077049. |
downstream effects of mutations in amyotrophic lateral sclerosis (als) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (mns) present in the spinal cord, brain stem and motor cortex. |
2022-09-09 |
2023-08-14 |
human |