| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cletus Cheyuo, Asha Jacob, Rongqian Wu, Mian Zhou, Lei Qi, Weifeng Dong, Youxin Ji, Wayne W Chaung, Haichao Wang, Jeffrey Nicastro, Gene F Coppa, Ping Wan. Recombinant human MFG-E8 attenuates cerebral ischemic injury: its role in anti-inflammation and anti-apoptosis. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21964436. |
excessive inflammation and apoptosis contribute to the pathogenesis of ischemic stroke. |
2012-07-27 |
2023-08-12 |
human |
| Masahiro Ohsawa, Junpei Mutoh, Megumi Asato, Shohei Yamamoto, Hideki Ono, Hiroaki Hisa, Junzo Kame. Carnosine has antinociceptive properties in the inflammation-induced nociceptive response in mice. European journal of pharmacology. vol 682. issue 1-3. 2012-07-17. PMID:22366199. |
recent studies have revealed that carnosine has neuroprotective activity in zinc-induced neural cell apoptosis and ischemic stroke. |
2012-07-17 |
2023-08-12 |
mouse |
| Pei Wang, Yun-Feng Guan, Hui Du, Qi-Wei Zhai, Ding-Feng Su, Chao-Yu Mia. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy. vol 8. issue 1. 2012-06-06. PMID:22113203. |
nicotinamide phosphoribosyltransferase (nampt, also known as visfatin), the rate-limiting enzyme in mammalian nad (+) biosynthesis, protects against ischemic stroke through inhibiting neuronal apoptosis and necrosis. |
2012-06-06 |
2023-08-12 |
rat |
| B I Kuznik, N S Lin'kova, V Kh Khavinso. [Heat shock proteins: aging changes, development thrombotic diseases and peptidergic regulation of genes]. Advances in gerontology = Uspekhi gerontologii. vol 24. issue 4. 2012-05-29. PMID:22550861. |
heat shock proteins, which are regulators of proliferation, apoptosis, differentiation of cells and intracellular homeostasis, play important role in activity of immune, cardiovascular and other systems and take part in development of atherosclerosis, heart attack, ischemic stroke and other thrombotic diseases. |
2012-05-29 |
2023-08-12 |
Not clear |
| Rachna S Pandya, Lijuan Mao, Hua Zhou, Shuanhu Zhou, Jiang Zeng, A John Popp, Xin Wan. Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Central nervous system agents in medicinal chemistry. vol 11. issue 2. 2012-03-29. PMID:21521165. |
this review focuses on central nervous system agents targeting these biochemical pathways and mediators of ischemic stroke, mainly those that counteract apoptosis, inflammation, and oxidation, and well as glutamate inhibitors which have been shown to provide neuroprotection in experimental animals. |
2012-03-29 |
2023-08-12 |
Not clear |
| Noura M Dabbouseh, Agnieszka Ardel. Cocaine mediated apoptosis of vascular cells as a mechanism for carotid artery dissection leading to ischemic stroke. Medical hypotheses. vol 77. issue 2. 2011-11-29. PMID:21546166. |
cocaine mediated apoptosis of vascular cells as a mechanism for carotid artery dissection leading to ischemic stroke. |
2011-11-29 |
2023-08-12 |
human |
| Ning Liu, Jingwei Shang, Fengfeng Tian, Hiroyoshi Nishi, Koji Ab. In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice. Brain research. vol 1397. 2011-10-06. PMID:21571257. |
detection and protection of apoptosis, autophagy and neurovascular unit (nvu) are essentially important in understanding and treatment for ischemic stroke patients. |
2011-10-06 |
2023-08-12 |
mouse |
| Shiu-Hwa Yeh, Li-Chin Ou, Po-Wu Gean, Jan-Jong Hung, Wen-Chang Chan. Selective inhibition of early--but not late--expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage. Brain pathology (Zurich, Switzerland). vol 21. issue 3. 2011-08-18. PMID:21029239. |
taken together, these results demonstrate that hif-1α induced by ischemia in early and late times leads cellular apoptosis and survival, respectively, and provides a new insight into the divergent roles of hif-1α expression in neurons after ischemic stroke. |
2011-08-18 |
2023-08-12 |
rat |
| Naohiko Oku, Toru Kashiwagi, Jun Hatazaw. Nuclear neuroimaging in acute and subacute ischemic stroke. Annals of nuclear medicine. vol 24. issue 9. 2011-03-31. PMID:20953742. |
in the later phase of subacute ischemic stroke, inflammation and apoptosis can be visualized by means of peripheral-type benzodiazepine receptor imaging and annexin v imaging, respectively. |
2011-03-31 |
2023-08-12 |
Not clear |
| Ning Liu, Kentaro Deguchi, Jingwei Shang, Xuemei Zhang, Fengfeng Tian, Toru Yamashita, Yasuyuki Ohta, Yoshio Ikeda, Tohru Matsuura, Koji Ab. In vivo optical imaging of early-stage apoptosis in mouse brain after transient cerebral ischemia. Journal of neuroscience research. vol 88. issue 16. 2011-03-03. PMID:20936709. |
apoptosis is one of the mechanisms contributing to neuronal degeneration in ischemic stroke. |
2011-03-03 |
2023-08-12 |
mouse |
| Guillemette Chapuisat, Marie-Aimée Dronne, Emmanuel Grenier, Marc Hommel, Jean-Pierre Boisse. In silico study of the influence of intensity and duration of blood flow reduction on cell death through necrosis or apoptosis during acute ischemic stroke. Acta biotheoretica. vol 58. issue 2-3. 2010-12-06. PMID:20665072. |
in silico study of the influence of intensity and duration of blood flow reduction on cell death through necrosis or apoptosis during acute ischemic stroke. |
2010-12-06 |
2023-08-12 |
Not clear |
| Guillemette Chapuisat, Marie-Aimée Dronne, Emmanuel Grenier, Marc Hommel, Jean-Pierre Boisse. In silico study of the influence of intensity and duration of blood flow reduction on cell death through necrosis or apoptosis during acute ischemic stroke. Acta biotheoretica. vol 58. issue 2-3. 2010-12-06. PMID:20665072. |
ischemic stroke involves numerous and complex pathophysiological mechanisms including blood flow reduction, ionic exchanges, spreading depressions and cell death through necrosis or apoptosis. |
2010-12-06 |
2023-08-12 |
Not clear |
| Stepani Bendel, Timo Koivisto, Olli-Pekka Ryynänen, Esko Ruokonen, Jarkko Romppanen, Vesa Kiviniemi, Ari Uusar. Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study. Critical care (London, England). vol 14. issue 2. 2010-11-10. PMID:20426845. |
insulin like growth factor-i (igf-i) regulates neuronal growth and apoptosis in ischemic stroke. |
2010-11-10 |
2023-08-12 |
Not clear |
| Rong Jin, Shiyong Yu, Zifang Song, Joseph W Quillin, Daniel P Deasis, Josef M Penninger, Anil Nanda, D Neil Granger, Guohong L. Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochemical and biophysical research communications. vol 399. issue 3. 2010-09-14. PMID:20678469. |
inhibition of microglial activation may protect the brain by attenuating blood-brain barrier damage and neuronal apoptosis after ischemic stroke. |
2010-09-14 |
2023-08-12 |
mouse |
| Chorng-Horng Lin, Michael Chen, Mu-Chien Su. Circulating apoptotic factors in patients with acute cerebral infarction. Clinical biochemistry. vol 43. issue 9. 2010-08-18. PMID:20347759. |
studies on animal models have shown that apoptosis plays a role in acute ischemic stroke, but the clinical significance of apoptosis in human stroke has not been well established. |
2010-08-18 |
2023-08-12 |
human |
| Ye-Cheng Liu, Zhi-Wei Qi, Sui Ma, Xiao-Yu Cui, Hou-Li Wang, Shu-Bin Guo, Zhong Wang, Xue-Zhong Y. [Apoptosis of gastric mucosa and gastric barrier dysfunction in acute ischemic stroke]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 30. issue 2. 2010-05-28. PMID:18505114. |
[apoptosis of gastric mucosa and gastric barrier dysfunction in acute ischemic stroke]. |
2010-05-28 |
2023-08-12 |
Not clear |
| Ye-Cheng Liu, Zhi-Wei Qi, Sui Ma, Xiao-Yu Cui, Hou-Li Wang, Shu-Bin Guo, Zhong Wang, Xue-Zhong Y. [Apoptosis of gastric mucosa and gastric barrier dysfunction in acute ischemic stroke]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 30. issue 2. 2010-05-28. PMID:18505114. |
to evaluate the role of gastric mucosa apoptosis in the stress of ischemic stroke, and to discuss the relationship between gastric mucosa apoptosis and gastric barrier. |
2010-05-28 |
2023-08-12 |
Not clear |
| Toru Yamashita, Kentaro Deguchi, Shoko Nagotani, Tatsushi Kamiya, Koji Ab. Gene and stem cell therapy in ischemic stroke. Cell transplantation. vol 18. issue 9. 2010-03-26. PMID:19523331. |
possible strategies for treating ischemic stroke include neuroprotection (preventing injured neurons from undergoing apoptosis in the acute phase of cerebral ischemia) and stem cell therapy (the repair of disrupted neuronal networks with newly born neurons in the chronic phase of cerebral ischemia). |
2010-03-26 |
2023-08-12 |
Not clear |
| K K Wan. Caspases: a drug discovery perspective. Current opinion in drug discovery & development. vol 2. issue 5. 2009-12-11. PMID:19649979. |
recent advances in the elucidation of the biochemical machinery of apoptosis have allowed us to appreciate the significance of unscheduled apoptosis in a wide range of human diseases and disorders, such as ischemic stroke, traumatic brain injury, alzheimer's disease, drug-induced liver injury and cardiac ischemia. |
2009-12-11 |
2023-08-12 |
human |
| Toru Yamashita, Kentaro Deguchi, Yoshihide Sehara, Violeta Lukic-Panin, Hanzhe Zhang, Tatsushi Kamiya, Koji Ab. Therapeutic strategy for ischemic stroke. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:18770029. |
possible strategies for treating ischemic stroke include: (1) neuroprotection: preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia; (2) stem cell therapy: the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischemia. |
2009-06-03 |
2023-08-12 |
rat |