| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guihong Li, Fengbo Yu, Ting Lei, Haijun Gao, Peiwen Li, Yuxue Sun, Haiyan Huang, Qingchun M. Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies. Neural regeneration research. vol 11. issue 6. 2016-08-02. PMID:27482235. |
here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction, angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action, and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke. |
2016-08-02 |
2023-08-13 |
Not clear |
| Jinmann Chon, Hee-Sang Kim, Dong Hwan Yun, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Su Kang Kim, Hae Jeong Park, Joo-Ho Chung, Sungjoon Chung, Jinah Ye. Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population. Annals of rehabilitation medicine. vol 40. issue 3. 2016-07-22. PMID:27446775. |
to investigate whether baculoviral inhibitor of apoptosis (iap) repeat containing 5 gene (birc5) polymorphisms are associated with the development and clinical phenotypes of ischemic stroke in korea population. |
2016-07-22 |
2023-08-13 |
Not clear |
| Huinan Zhang, Jingru Meng, Xubo Li, Shimeng Zhou, Di Qu, Ning Wang, Min Jia, Xue Ma, Xiaoxing Lu. Pro-GLP-1, a Pro-drug of GLP-1, is neuroprotective in cerebral ischemia. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 70. 2016-06-24. PMID:25640912. |
our research provides evidence that pre-treatment of mcao mice with pro-glp-1 exerts a neuroprotective effect mediated by a blockade of apoptosis and that pro-glp-1 might be a potential neuroprotective agent candidate against ischemic stroke. |
2016-06-24 |
2023-08-13 |
mouse |
| Mikhail Yu Martynov, Eugeny I Guse. Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. Journal of experimental pharmacology. vol 7. 2016-05-17. PMID:27186142. |
in acute ischemic stroke, citicoline provides neuroprotection by attenuating glutamate exitotoxicity, oxidative stress, apoptosis, and blood-brain barrier dysfunction. |
2016-05-17 |
2023-08-13 |
Not clear |
| Jingjing Su, Houguang Zhou, Yinghong Tao, Jingchun Guo, Zhuangli Guo, Shuo Zhang, Yu Zhang, Yanyan Huang, Yuping Tang, Qiang Dong, Renming H. G-CSF protects human brain vascular endothelial cells injury induced by high glucose, free fatty acids and hypoxia through MAPK and Akt signaling. PloS one. vol 10. issue 4. 2016-04-12. PMID:25849550. |
granulocyte-colony stimulating factor (g-csf) has been shown to play a neuroprotective role in ischemic stroke by mobilizing bone marrow (bm)-derived endothelial progenitor cells (epcs), promoting angiogenesis, and inhibiting apoptosis. |
2016-04-12 |
2023-08-13 |
human |
| P Gharibani, J Modi, J Menzie, A Alexandrescu, Z Ma, R Tao, H Prentice, J-Y W. Comparison between single and combined post-treatment with S-Methyl-N,N-diethylthiolcarbamate sulfoxide and taurine following transient focal cerebral ischemia in rat brain. Neuroscience. vol 300. 2016-03-29. PMID:26022360. |
therefore, we conclude that combined treatment with both detc-meso and taurine synergistically inhibits all three er stress pathways and apoptosis and therefore can be a novel and effective treatment after ischemic stroke. |
2016-03-29 |
2023-08-13 |
rat |
| Zhao Jiang, Lora Talley Watts, Shiliang Huang, Qiang Shen, Pavel Rodriguez, Chunhua Chen, Changman Zhou, Timothy Q Duon. The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core. PloS one. vol 10. issue 6. 2016-03-28. PMID:26121129. |
mb induced neuroprotection, at least in part, by enhancing autophagy and reducing apoptosis in the perfusion-diffusion mismatch tissue following ischemic stroke. |
2016-03-28 |
2023-08-13 |
rat |
| Feng-Tao Ji, Jian-Jun Liang, Li-Ping Miao, Qiang Wu, Ming-Hui Ca. Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury. Molecular medicine reports. vol 12. issue 2. 2016-03-17. PMID:25849432. |
propofol, an intravenous anesthetic, inhibits neuronal apoptosis induced by ischemic stroke, protects the brain from ischemia/reperfusion injury and improves neuronal function. |
2016-03-17 |
2023-08-13 |
rat |
| Jiann-Hwa Chen, Hsing-Chun Kuo, Kam-Fai Lee, Tung-Hu Tsa. Global proteomic analysis of brain tissues in transient ischemia brain damage in rats. International journal of molecular sciences. vol 16. issue 6. 2016-02-29. PMID:26016499. |
proteomic analysis suggested that the differential expression of calb2 during a global ischemic stroke could be involved in the mechanisms of er stress-induced neuronal cell apoptosis, which occurred via ire1-alpha/traf2 complex formation, with activation of jnk1/2 and p38 mapk. |
2016-02-29 |
2023-08-13 |
rat |
| Bin Liu, Yan-hong Zhang, Ying Jiang, Long-ling Li, Qian Chen, Guo-qian He, Xiao-dan Tan, Chang-qing L. Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke. International journal of biological sciences. vol 11. issue 3. 2015-11-20. PMID:25678854. |
gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke. |
2015-11-20 |
2023-08-13 |
rat |
| Bin Liu, Yan-hong Zhang, Ying Jiang, Long-ling Li, Qian Chen, Guo-qian He, Xiao-dan Tan, Chang-qing L. Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke. International journal of biological sciences. vol 11. issue 3. 2015-11-20. PMID:25678854. |
apoptosis plays an essential role in ischemic stroke pathogenesis. |
2015-11-20 |
2023-08-13 |
rat |
| Chunyan Wang, Fangqin Li, Yu Guan, Lei Zhu, Yiping Fei, Jiadong Zhang, Yujun Pa. Bone marrow stromal cells combined with oxiracetam influences the expression of B-cell lymphoma 2 in rats with ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 23. issue 10. 2015-11-17. PMID:25267587. |
upregulation of bcl-2 resulting in a decrease of apoptosis may be one of the mechanisms of bmscs treatment for cerebral ischemic stroke. |
2015-11-17 |
2023-08-13 |
rat |
| P Dong, J Zhao, Y Zhang, J Dong, L Zhang, D Li, L Li, X Zhang, B Yang, W Le. Aging causes exacerbated ischemic brain injury and failure of sevoflurane post-conditioning: role of B-cell lymphoma-2. Neuroscience. vol 275. 2015-10-07. PMID:24929064. |
these findings suggest that aging-associated reduction in basal bcl-2 expression in the brain contributes to increased neuronal injury by enhancing cell apoptosis after ischemic stroke. |
2015-10-07 |
2023-08-13 |
rat |
| Rui-ying Liu, Wei-jie Wu, Rui Tan, Bin Xie, Zhen-dong Zhong, Jing-ping He, Yao Chen, Xin-li Kan. [Intervention effect of Tibetan patent medicine Ruyi Zhenbao pills in acute ischemic stroke in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 3. 2015-07-23. PMID:26084187. |
in this study, a right middle cerebral artery occlusion was established in rats to observe the multi-path and multi-aspect intervention effects of tibetan patent medicine ruyi zhenbao pills in reducing injuries to nissl bodies, cerebral edema and inflammatory reactions and preventing cellular apoptosis, in order to lay a foundation for defining its therapeutic mechanism in acute ischemic stroke. |
2015-07-23 |
2023-08-13 |
rat |
| Judith Mallolas, Rocío Rodríguez, Carme Gubern, Susanna Camós, Joaquín Serena, Mar Castellano. A polymorphism in the promoter region of the survivin gene is related to hemorrhagic transformation in patients with acute ischemic stroke. Neuromolecular medicine. vol 16. issue 4. 2015-07-20. PMID:25344020. |
different mechanisms, including bbb protection by the inhibition or activation of different angiogenic growth factors and the inhibition of apoptosis during angiogenesis, may explain the protective effect of this polymorphism on ht development in ischemic stroke. |
2015-07-20 |
2023-08-13 |
Not clear |
| Keisuke Mishiro, Takahiko Imai, Sou Sugitani, Akira Kitashoji, Yukiya Suzuki, Toshinori Takagi, Huayue Chen, Yasunori Oumi, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Har. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PloS one. vol 9. issue 8. 2015-05-12. PMID:25133692. |
diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. |
2015-05-12 |
2023-08-13 |
mouse |
| Xiping Liang, Qin Hu, Bo Li, Devin McBride, Hetao Bian, Pierre Spagnoli, Di Chen, Jiping Tang, John H Zhan. Follistatin-like 1 attenuates apoptosis via disco-interacting protein 2 homolog A/Akt pathway after middle cerebral artery occlusion in rats. Stroke. vol 45. issue 10. 2015-01-26. PMID:25139876. |
follistatin-like 1 (fstl1), an extracellular glycoprotein, has been reported to decrease apoptosis in ischemic cardiac diseases, but its effect in ischemic stroke has not been examined. |
2015-01-26 |
2023-08-13 |
rat |
| Adam Hafeez, Omar Elmadhoun, Changya Peng, Jamie Y Ding, Xiaokun Geng, Murali Guthikonda, Yuchuan Din. Reduced Apoptosis by Ethanol and Its Association with PKC-δ and Akt Signaling in Ischemic Stroke. Aging and disease. vol 5. issue 6. 2014-12-09. PMID:25489491. |
reduced apoptosis by ethanol and its association with pkc-δ and akt signaling in ischemic stroke. |
2014-12-09 |
2023-08-13 |
rat |
| Lin Wang, Feng Jiang, Qifeng Li, Xiaoguang He, Jie M. Mild hypothermia combined with neural stem cell transplantation for hypoxic-ischemic encephalopathy: neuroprotective effects of combined therapy. Neural regeneration research. vol 9. issue 19. 2014-11-25. PMID:25422635. |
neural stem cell transplantation is a useful treatment for ischemic stroke, but apoptosis often occurs in the hypoxic-ischemic environment of the brain after cell transplantation. |
2014-11-25 |
2023-08-13 |
mouse |
| Dong-Mei Liu, Zhen-Hui Wang, Li Liu, Xiu-Mei Zhang, Feng-Lan Lo. Acetylpuerarin increases cell viability and reduces apoptosis in rat hippocampal neurons following oxygen‑glucose deprivation/reperfusion. Molecular medicine reports. vol 8. issue 5. 2014-11-13. PMID:24026460. |
in conclusion, acetylpuerarin protects against ogd/r-induced neuronal apoptosis predominantly in the first 24 h following ischemia, which may be useful in mediating neuronal apoptosis in ischemic stroke patients. |
2014-11-13 |
2023-08-12 |
rat |