| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pengfei Li, Meihong Shen, Feng Gao, Jinping Wu, Jiahui Zhang, Fengmeng Teng, Chunbing Zhan. An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress. Molecular neurobiology. vol 54. issue 4. 2017-07-07. PMID:27023223. |
in conclusion, our data indicates that the neuroprotective effects of mir-106b-5p antagomir on cerebral i/r injury are associated with its inhibition of apoptosis and oxidative stress, suggesting a potential therapeutic target for ischemic stroke. |
2017-07-07 |
2023-08-13 |
rat |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tmcao) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1β (il-1β), bax and p53 expression and upregulating anti-apoptotic protein bcl-2 level. |
2017-06-21 |
2023-08-13 |
mouse |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
we next mimicked neuroinflammation in ischemic stroke with il-1β in primary cultured cortical neurons and found that pretreatment with fluoxetine (1 μm) prevented il-1β-induced neuronal apoptosis and upregulation of p53 expression. |
2017-06-21 |
2023-08-13 |
mouse |
| Haiping Zhu, Qunfeng Gui, Xiaobo Hui, Xiaodong Wang, Jian Jiang, Lianshu Ding, Xiaoyang Sun, Yanping Wang, Huaqun Che. TGF-β1/Smad3 Signaling Pathway Suppresses Cell Apoptosis in Cerebral Ischemic Stroke Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-05-26. PMID:28110342. |
tgf-β1/smad3 signaling pathway suppresses cell apoptosis in cerebral ischemic stroke rats. |
2017-05-26 |
2023-08-13 |
rat |
| Bin Chen, Guoxiang Wang, Weiwei Li, Weilin Liu, Ruhui Lin, Jing Tao, Min Jiang, Lidian Chen, Yun Wan. Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke. Experimental cell research. vol 351. issue 2. 2017-05-18. PMID:28069373. |
memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke. |
2017-05-18 |
2023-08-13 |
Not clear |
| Guoping Xing, Zengxiang Luo, Chi Zhong, Xudong Pan, Xiaowei X. Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-24. PMID:28025572. |
influence of mir-155 on cell apoptosis in rats with ischemic stroke: role of the ras homolog enriched in brain (rheb)/mtor pathway. |
2017-04-24 |
2023-08-13 |
rat |
| Guoping Xing, Zengxiang Luo, Chi Zhong, Xudong Pan, Xiaowei X. Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-24. PMID:28025572. |
mir-155 inhibitors exhibited protective effects on ischemic stroke, including down-regulation of infarction size in cerebral tissues in vivo and reduced apoptosis of bv2 cells in vitro with increased expression of rheb, mtor and p-s6k (p<0.05). |
2017-04-24 |
2023-08-13 |
rat |
| Youguang Gao, Ting Chen, Xianghui Lei, Yunfeng Li, Xingui Dai, Yuanyuan Cao, Qionglei Ding, Xiabao Lei, Tao Li, Xianzhong Li. Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27840959. |
the neuroprotective effect of polydatin (pd) against hemorrhagic shock-induced mitochondrial injury has been described previously, and mitochondrial dysfunction and apoptosis were reportedly involved in ischemic stroke. |
2017-04-07 |
2023-08-13 |
rat |
| Youguang Gao, Ting Chen, Xianghui Lei, Yunfeng Li, Xingui Dai, Yuanyuan Cao, Qionglei Ding, Xiabao Lei, Tao Li, Xianzhong Li. Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27840959. |
the findings of this study, therefore, suggest that pd has a dual effect, ameliorating both oxidative stress and mitochondria‑dependent apoptosis, making it a promising new therapy for the treatment of ischemic stroke. |
2017-04-07 |
2023-08-13 |
rat |
| Nan Zhang, Jie Zhong, Song Han, Yun Li, Yanling Yin, Junfa L. MicroRNA-378 Alleviates Cerebral Ischemic Injury by Negatively Regulating Apoptosis Executioner Caspase-3. International journal of molecular sciences. vol 17. issue 9. 2017-03-23. PMID:27598143. |
taken together, our data demonstrated that mir-378 attenuated ischemic injury by negatively regulating the apoptosis executioner, caspase-3, providing a potential therapeutic target for ischemic stroke. |
2017-03-23 |
2023-08-13 |
mouse |
| Deyan Kong, Juehua Zhu, Qian Liu, Yongjun Jiang, Lily Xu, Ning Luo, Zhenqiang Zhao, Qijin Zhai, Hao Zhang, Mingyue Zhu, Xinfeng Li. Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy. Cellular and molecular neurobiology. vol 37. issue 2. 2017-02-23. PMID:27044018. |
in conclusion, mscs potentially protect the cortical neurons from ogd-injury in vitro, through rescuing neurons from the cell death of parthanatos, necroptosis, and apoptosis, but not autophagy, which could provide some evidence to the mechanism explanation on stem cell treatment for ischemic stroke. |
2017-02-23 |
2023-08-13 |
Not clear |
| Hao Zhou, Wu-Shuang Yang, Ying Li, Tong Ren, Lu Peng, Han Guo, Jin-Feng Liu, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Ji. Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4/NF-κB and ERK1/2 signaling pathways in mice with acute ischemic stroke. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 1. 2017-02-21. PMID:27738712. |
oleoylethanolamide attenuates apoptosis by inhibiting the tlr4/nf-κb and erk1/2 signaling pathways in mice with acute ischemic stroke. |
2017-02-21 |
2023-08-13 |
mouse |
| Hao Zhou, Wu-Shuang Yang, Ying Li, Tong Ren, Lu Peng, Han Guo, Jin-Feng Liu, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Ji. Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4/NF-κB and ERK1/2 signaling pathways in mice with acute ischemic stroke. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 1. 2017-02-21. PMID:27738712. |
our data showed that oea treatment alleviated cell apoptosis in a mouse model of ischemic stroke, accompanied by suppression of bax, as well as upregulation of antiapoptotic protein bcl-2 level. |
2017-02-21 |
2023-08-13 |
mouse |
| P P Tregub, N A Malinovskaya, V P Kulikov, A B Salmina, M E Nagibaeva, A S Zabrodina, G E Gertsog, S K Antonov. Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia. Bulletin of experimental biology and medicine. vol 161. issue 5. 2017-02-14. PMID:27709386. |
we compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. |
2017-02-14 |
2023-08-13 |
Not clear |
| Shihoko Kimura-Ohba, Yi Yan. Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke. Oxidative medicine and cellular longevity. vol 2016. 2016-12-13. PMID:26925194. |
oxidative dna damage mediated by intranuclear mmp activity is associated with neuronal apoptosis in ischemic stroke. |
2016-12-13 |
2023-08-13 |
Not clear |
| S Mustafa, H L Martin, L Burkly, A Costa, M L Martins, M Schwaninger, P Teisman. The role of TWEAK/Fn14 signaling in the MPTP-model of Parkinson's disease. Neuroscience. vol 319. 2016-11-14. PMID:26808775. |
the tumor necrosis factor like weak inducer of apoptosis (tweak) and its receptor, fibroblast growth factor-inducible 14 (fn14), mediate inflammation and neuronal apoptosis in cerebral edema, ischemic stroke and multiple sclerosis. |
2016-11-14 |
2023-08-13 |
mouse |
| Yuan Zhang, Ting Wang, Ke Yang, Ji Xu, Lijie Ren, Weiping Li, Wenlan Li. Cerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci-Reductone Dioxygenase 1 Translocation. Frontiers in molecular neuroscience. vol 9. 2016-09-16. PMID:27630541. |
in conclusion, our data demonstrate that enoph1 activation may contribute to ogd-induced endothelial cell death and bbb disruption through promoting ros generation and the activation of apoptosis associated proteins, thus representing a new therapeutic target for ischemic stroke. |
2016-09-16 |
2023-08-13 |
rat |
| Yi-Hao Deng, Hong-Yun He, Li-Qiang Yang, Peng-Yue Zhan. Dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke. Neural regeneration research. vol 11. issue 7. 2016-09-16. PMID:27630694. |
dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke. |
2016-09-16 |
2023-08-13 |
rat |
| Hung-Jen Shih, Jiin-Cherng Yen, Allen W Chiu, Yung-Chiong Chow, Wynn H T Pan, Chun-Jen Huan. FTY720 inhibits germ cell apoptosis in testicular torsion/detorsion. The Journal of surgical research. vol 202. issue 1. 2016-09-05. PMID:27083962. |
fty720, an agonist of the sphingosine-1-phosphate receptor 1 (s1pr1), inhibits apoptosis in ischemic stroke. |
2016-09-05 |
2023-08-13 |
rat |
| Wansheng Liu, Xiaosheng Chen, Yu Zhan. Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke. American journal of translational research. vol 8. issue 7. 2016-08-10. PMID:27508039. |
effects of microrna-21 and microrna-24 inhibitors on neuronal apoptosis in ischemic stroke. |
2016-08-10 |
2023-08-13 |
Not clear |