| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong Youl Kim, Nuri Kim, Jong Eun Lee, Midori A Yenar. Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke. Therapeutic hypothermia and temperature management. vol 7. issue 3. 2018-05-29. PMID:28665255. |
apoptosis is a cell death pathway that is activated in ischemic stroke. |
2018-05-29 |
2023-08-13 |
mouse |
| Xiao-Fei Jin, Shan Wang, Min Shen, Xin Wen, Xin-Rui Han, Jun-Chang Wu, Gao-Zhuo Tang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zhen. Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain research bulletin. vol 134. 2018-05-07. PMID:28843352. |
effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the pi3k/akt and nrf2/are signaling pathways. |
2018-05-07 |
2023-08-13 |
rat |
| Xiao-Fei Jin, Shan Wang, Min Shen, Xin Wen, Xin-Rui Han, Jun-Chang Wu, Gao-Zhuo Tang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zhen. Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain research bulletin. vol 134. 2018-05-07. PMID:28843352. |
this study was designed in order to investigate the effects between rehabilitation training on the apoptosis of nerve cells and the recovery of neural and motor functions of rats with ischemic stroke by way of the phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) and nuclear factor e2-related factor 2/antioxidant responsive element (nrf2/are) signaling pathways. |
2018-05-07 |
2023-08-13 |
rat |
| Sheng-Hua Li, Lan Chen, Xiao-Min Pang, Sheng-You Su, Xia Zhou, Chun-Yong Chen, Li-Gang Huang, Jing-Pin Li, Jing-Li Li. Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis. Neurochemistry international. vol 107. 2018-04-03. PMID:28202285. |
decreased mir-146a expression in acute ischemic stroke directly targets the fbxl10 mrna and is involved in modulating apoptosis. |
2018-04-03 |
2023-08-13 |
Not clear |
| Connor Stonesifer, Sydney Corey, Shaila Ghanekar, Zachary Diamandis, Sandra A Acosta, Cesar V Borlonga. Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms. Progress in neurobiology. vol 158. 2018-02-23. PMID:28743464. |
a key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke is the upregulation of endogenous neuroinflammatory processes to levels that destroy hypoxic tissue local to the area of insult, induce apoptosis, and initiate a feedback loop of inflammatory cascades that can expand the region of damage. |
2018-02-23 |
2023-08-13 |
Not clear |
| Fenghui Chen, Lixin Zhang, Erwei Wang, Chaofeng Zhang, Xiaoting L. LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway. Biochemical and biophysical research communications. vol 496. issue 1. 2018-02-15. PMID:29307821. |
ischemic stroke is related to a variety of physiological and pathological processes including autophagy and apoptosis. |
2018-02-15 |
2023-08-13 |
mouse |
| Haojie Yang, Xixiang Xi, Bin Zhao, Zhenxi Su, Zhenyi Wan. KLF4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating MALAT1. Biochemical and biophysical research communications. vol 495. issue 3. 2018-02-14. PMID:29203245. |
klf4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating malat1. |
2018-02-14 |
2023-08-13 |
mouse |
| Tao Li, Juan-Juan Qin, Xia Yang, Yan-Xiao Ji, Fangliang Guo, Wen-Lin Cheng, Xiaolin Wu, Fu-Han Gong, Ying Hong, Xue-Yong Zhu, Jun Gong, Zhihua Wang, Zan Huang, Zhi-Gang She, Hongliang L. The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 50. 2018-01-19. PMID:29114077. |
inflammation, oxidative stress, apoptosis, and excitotoxicity contribute to neuronal death during ischemic stroke; however, the mechanisms underlying these complicated pathophysiological processes remain to be fully elucidated. |
2018-01-19 |
2023-08-13 |
mouse |
| Na Wei, Lin Xiao, Rui Xue, Dandan Zhang, Jun Zhou, Huayan Ren, Si Guo, Jingjing X. MicroRNA-9 Mediates the Cell Apoptosis by Targeting Bcl2l11 in Ischemic Stroke. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26660116. |
microrna-9 mediates the cell apoptosis by targeting bcl2l11 in ischemic stroke. |
2017-12-22 |
2023-08-13 |
mouse |
| Djordje Radak, Niki Katsiki, Ivana Resanovic, Aleksandra Jovanovic, Emina Sudar-Milovanovic, Sonja Zafirovic, Shaker A Mousad, Esma R Isenovi. Apoptosis and Acute Brain Ischemia in Ischemic Stroke. Current vascular pharmacology. vol 15. issue 2. 2017-12-12. PMID:27823556. |
apoptosis and acute brain ischemia in ischemic stroke. |
2017-12-12 |
2023-08-13 |
human |
| Fengwu Li, Wei Shi, Ethan Y Zhao, Xiaokun Geng, Xiaorong Li, Changya Peng, Jiamei Shen, Sainan Wang, Yuchuan Din. Enhanced apoptosis from early physical exercise rehabilitation following ischemic stroke. Journal of neuroscience research. vol 95. issue 4. 2017-11-16. PMID:27571707. |
enhanced apoptosis from early physical exercise rehabilitation following ischemic stroke. |
2017-11-16 |
2023-08-13 |
rat |
| Xing Li, Yin Zhao, Qian Xia, Lu Zheng, Lu Liu, Baoming Zhao, Jing Sh. Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding. Cell death & disease. vol 7. issue 9. 2017-10-04. PMID:27584794. |
previous data have suggested that the nuclear translocation of annexin 1 (anxa1) is involved in neuronal apoptosis after ischemic stroke. |
2017-10-04 |
2023-08-13 |
Not clear |
| Yinsheng Guo, Yue Ma, Yanwei Zhang, Li Zhou, Suli Huang, Ying Wen, Fei Zou, Jinquan Chen. Autophagy-related gene microarray and bioinformatics analysis for ischemic stroke detection. Biochemical and biophysical research communications. vol 489. issue 1. 2017-09-25. PMID:28528975. |
these findings clarified the role of mitochondrial autophagy and apoptosis in ischemic stroke and provided more important biomarkers for the prevention diagnosis and therapeutic implications in is. |
2017-09-25 |
2023-08-13 |
Not clear |
| Shou-Cai Zhao, Ling-Song Ma, Zhao-Hu Chu, Heng Xu, Wen-Qian Wu, Fudong Li. Regulation of microglial activation in stroke. Acta pharmacologica Sinica. vol 38. issue 4. 2017-09-22. PMID:28260801. |
when ischemic stroke occurs, oxygen and energy depletion triggers a cascade of events, including inflammatory responses, glutamate excitotoxicity, oxidative stress, and apoptosis that result in a profound brain injury. |
2017-09-22 |
2023-08-13 |
Not clear |
| Xinchun Ye, Tong Shen, Jinxia Hu, Liang Zhang, Yunshan Zhang, Lei Bao, Chengcheng Cui, Guoliang Jin, Kun Zan, Zuohui Zhang, Xinxin Yang, Hongjuan Shi, Jie Zu, Ming Yu, Chengjie Song, Yulan Wang, Suhua Qi, Guiyun Cu. Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse. Experimental neurology. vol 292. 2017-07-28. PMID:28274860. |
purinergic 2x7 receptor/nlrp3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse. |
2017-07-28 |
2023-08-13 |
mouse |
| Xinchun Ye, Tong Shen, Jinxia Hu, Liang Zhang, Yunshan Zhang, Lei Bao, Chengcheng Cui, Guoliang Jin, Kun Zan, Zuohui Zhang, Xinxin Yang, Hongjuan Shi, Jie Zu, Ming Yu, Chengjie Song, Yulan Wang, Suhua Qi, Guiyun Cu. Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse. Experimental neurology. vol 292. 2017-07-28. PMID:28274860. |
in this study, we investigated whether p2x7r/nlrp3 pathway is involved in the caspase-3 dependent neuronal apoptosis after ischemic stroke by using a focal cortex ischemic stroke model. |
2017-07-28 |
2023-08-13 |
mouse |
| Xinchun Ye, Tong Shen, Jinxia Hu, Liang Zhang, Yunshan Zhang, Lei Bao, Chengcheng Cui, Guoliang Jin, Kun Zan, Zuohui Zhang, Xinxin Yang, Hongjuan Shi, Jie Zu, Ming Yu, Chengjie Song, Yulan Wang, Suhua Qi, Guiyun Cu. Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse. Experimental neurology. vol 292. 2017-07-28. PMID:28274860. |
in addition, in vitro data also support the hypothesis that p2x7r/nlrp3 pathway plays a vital role in caspase-3 dependent neuronal apoptosis after ischemic stroke. |
2017-07-28 |
2023-08-13 |
mouse |
| Pengfei Li, Meihong Shen, Feng Gao, Jinping Wu, Jiahui Zhang, Fengmeng Teng, Chunbing Zhan. An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress. Molecular neurobiology. vol 54. issue 4. 2017-07-07. PMID:27023223. |
in conclusion, our data indicates that the neuroprotective effects of mir-106b-5p antagomir on cerebral i/r injury are associated with its inhibition of apoptosis and oxidative stress, suggesting a potential therapeutic target for ischemic stroke. |
2017-07-07 |
2023-08-13 |
rat |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tmcao) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1β (il-1β), bax and p53 expression and upregulating anti-apoptotic protein bcl-2 level. |
2017-06-21 |
2023-08-13 |
mouse |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
we next mimicked neuroinflammation in ischemic stroke with il-1β in primary cultured cortical neurons and found that pretreatment with fluoxetine (1 μm) prevented il-1β-induced neuronal apoptosis and upregulation of p53 expression. |
2017-06-21 |
2023-08-13 |
mouse |