| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Celine A Beamer, Diane M Brooks, Diana I Luri. Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia. Journal of neuroscience research. vol 83. issue 7. 2006-07-25. PMID:16528752. |
taken together, these results demonstrate that loss of shp-1 results in greater healing of the infarct due to less apoptosis and more neuronal survival in the ischemic core and suggests that pharmacologic inactivation of shp-1 may have potential therapeutic value in limiting cns degeneration after ischemic stroke. |
2006-07-25 |
2023-08-12 |
mouse |
| Ling Wei, Byung H Han, Ying Li, Christine L Keogh, David M Holtzman, Shan Ping Y. Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16357210. |
based on the notion that 1) ischemic stroke is a relatively common disorder in human neonates, and 2) developing cells are more susceptible to apoptosis, the present study examined whether typical apoptosis was induced by cerebral ischemia in a new neonatal rat model. |
2006-05-25 |
2023-08-12 |
human |
| Chun-Fang Xia, Robert S Smith, Bo Shen, Zhi-Rong Yang, Cesar V Borlongan, Lee Chao, Julie Cha. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension (Dallas, Tex. : 1979). vol 47. issue 4. 2006-04-20. PMID:16534002. |
these results indicate that the kinin b2 receptor promotes survival and protects against brain injury by suppression of apoptosis and inflammation induced by ischemic stroke. |
2006-04-20 |
2023-08-12 |
mouse |
| Chun-Fang Xia, Hang Yin, Cesar V Borlongan, Julie Chao, Lee Cha. Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis. Experimental neurology. vol 197. issue 2. 2006-04-03. PMID:16343485. |
postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis. |
2006-04-03 |
2023-08-12 |
Not clear |
| Chun-Fang Xia, Hang Yin, Yu-Yu Yao, Cesar V Borlongan, Lee Chao, Julie Cha. Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis. Human gene therapy. vol 17. issue 2. 2006-03-10. PMID:16454654. |
kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis. |
2006-03-10 |
2023-08-12 |
human |
| V A Aĭvazian, A S Boiadzhian, L A Manukian, G V Avetisian, G S Grigoria. [Complement componenets, C3 and factors B, in the blood of patients with acute ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol Suppl 15. 2006-02-16. PMID:16447555. |
several studies suggest that activation of compliment cascade contributes to the development of the inflammatory immune response in ischemic stroke and results in tissue injury by initiating apoptosis and necrosis. |
2006-02-16 |
2023-08-12 |
Not clear |
| Taizen Nakase, Shinji Fushiki, Goran Söhl, Martin Theis, Klaus Willecke, Christian C G Nau. Neuroprotective role of astrocytic gap junctions in ischemic stroke. Cell communication & adhesion. vol 10. issue 4-6. 2004-11-15. PMID:14681050. |
astrocytic gap junctions may reduce apoptosis and inflammation in the penumbra following ischemic insult, suggesting that coupled astrocytes fulfill a neuroprotective role under ischemic stroke conditions. |
2004-11-15 |
2023-08-12 |
mouse |
| Oleksandr Ekshyyan, Tak Yee A. Apoptosis in acute and chronic neurological disorders. Frontiers in bioscience : a journal and virtual library. vol 9. 2004-06-02. PMID:14977568. |
however, premature apoptosis and/or aberrations in apoptosis control contribute to the pathogenesis of a variety of neurological disorders including acute brain injury such as trauma, spinal cord injury, ischemic stroke and ischemia/reperfusion as well as chronic disease states such as alzheimer's, parkinson's, huntington's, amyotrophic lateral sclerosis, spinal muscular atrophy, and diabetic neuropathy. |
2004-06-02 |
2023-08-12 |
Not clear |
| Chun-Fang Xia, Hang Yin, Cesar V Borlongan, Lee Chao, Julie Cha. Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis. Hypertension (Dallas, Tex. : 1979). vol 43. issue 2. 2004-04-12. PMID:14698996. |
kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis. |
2004-04-12 |
2023-08-12 |
human |
| Filomena de Nigris, Amir Lerman, Louis J Ignarro, Sharon Williams-Ignarro, Vincenzo Sica, Andrew H Baker, Lilach O Lerman, Yong J Geng, Claudio Napol. Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends in molecular medicine. vol 9. issue 8. 2004-03-31. PMID:12928037. |
however, overall, oxidation and apoptosis appear to promote the progression of diseased arteries towards a lesion that is vulnerable to rupture, and to give rise to myocardial infarction and ischemic stroke. |
2004-03-31 |
2023-08-12 |
Not clear |
| I Irminger-Finger, W C Leung, J Li, M Dubois-Dauphin, J Harb, A Feki, C E Jefford, J V Soriano, M Jaconi, R Montesano, K H Kraus. Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis. Molecular cell. vol 8. issue 6. 2002-01-16. PMID:11779501. |
we suggest that bard1 is a mediator of apoptosis since (1) cell death in vivo (ischemic stroke) and in vitro is accompanied by increased levels of bard1 protein and mrna; (2) overexpression of bard1 induces cell death with all features of apoptosis; and (3) bard1-repressed cells are defective for the apoptotic response to genotoxic stress. |
2002-01-16 |
2023-08-12 |
Not clear |
| J Zaremb. Contribution of tumor necrosis factor alpha to the pathogenesis of stroke. Folia morphologica. vol 59. issue 3. 2000-09-26. PMID:10974781. |
being the final morphological effect of ischemic stroke, tnf-alpha appears also to contribute to neuronal necrosis by its involvement in the process of apoptosis as well as in the death of neurons. |
2000-09-26 |
2023-08-12 |
Not clear |
| S I Savitz, J A Erhardt, J V Anthony, G Gupta, X Li, F C Barone, D M Rosenbau. The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 8. 2000-08-30. PMID:10950380. |
increasing evidence supports a role for oxidative stress, proinflammatory cytokines, and apoptosis in the pathophysiology of focal ischemic stroke. |
2000-08-30 |
2023-08-12 |
rat |
| E M Johnson, L J Greenlund, P T Akins, C Y Hs. Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury. Journal of neurotrauma. vol 12. issue 5. 1996-04-09. PMID:8594212. |
further delineation of the mechanisms of cell death, especially those that trigger apoptosis, is likely to redirect our approaches in the development of new therapeutic interventions for ischemic stroke. |
1996-04-09 |
2023-08-12 |
Not clear |