| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soichiro Nakahara, Megumi Adachi, Hiroyuki Ito, Mitsuyuki Matsumoto, Katsunori Tajinda, Theo G M van Er. Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders. Neuroscience journal. vol 2018. 2021-02-18. PMID:29610762. |
in the present review, we overview abnormal network connectivity between the dentate gyrus (dg) and the cornus ammonis area 3 (ca3) subregions of the hippocampus relative to the induction of epilepsy and schizophrenia. |
2021-02-18 |
2023-08-13 |
Not clear |
| Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wan. Chronic Intermittent Hypobaric Hypoxia Restores Hippocampus Function and Rescues Cognitive Impairments in Chronic Epileptic Rats Frontiers in molecular neuroscience. vol 13. 2021-02-16. PMID:33584201. |
chronic intermittent hypobaric hypoxia restores hippocampus function and rescues cognitive impairments in chronic epileptic rats epilepsy is a complex neurological disorder with frequent psychiatric, cognitive, and social comorbidities in addition to recurrent seizures. |
2021-02-16 |
2023-08-13 |
rat |
| Bharathi Hattiangady, Ramkumar Kuruba, Bing Shuai, Remedios Grier, Ashok K Shett. Hippocampal Neural Stem Cell Grafting after Status Epilepticus Alleviates Chronic Epilepsy and Abnormal Plasticity, and Maintains Better Memory and Mood Function. Aging and disease. vol 11. issue 6. 2021-02-15. PMID:33269095. |
hippocampal neural stem cell grafting after status epilepticus alleviates chronic epilepsy and abnormal plasticity, and maintains better memory and mood function. |
2021-02-15 |
2023-08-13 |
rat |
| Bharathi Hattiangady, Ramkumar Kuruba, Bing Shuai, Remedios Grier, Ashok K Shett. Hippocampal Neural Stem Cell Grafting after Status Epilepticus Alleviates Chronic Epilepsy and Abnormal Plasticity, and Maintains Better Memory and Mood Function. Aging and disease. vol 11. issue 6. 2021-02-15. PMID:33269095. |
thus, intrahippocampal grafting of hippocampal nscs shortly after se considerably curbed the progression of epileptogenic processes and srs, which eventually resulted in less severe chronic epilepsy devoid of significant cognitive and mood impairments. |
2021-02-15 |
2023-08-13 |
rat |
| Hyeonho Kim, Hyeji Jung, Hyunsu Jung, Seok-Kyu Kwon, Jaewon Ko, Ji Won U. The small GTPase ARF6 regulates GABAergic synapse development. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:31907062. |
viewed together, our results suggest that modulating arf6 and its regulators could be a therapeutic strategy against brain pathologies involving hippocampal network dysfunction, such as epilepsy. |
2021-02-12 |
2023-08-13 |
mouse |
| Lisa Langenbruch, Laurens Bleß, Andreas Schulte-Mecklenbeck, Benedikt Sundermann, Tobias Brix, Christian E Elger, Nico Melzer, Heinz Wiendl, Sven G Meuth, Catharina C Gross, Stjepana Kova. Blood and cerebrospinal fluid immune cell profiles in patients with temporal lobe epilepsy of different etiologies. Epilepsia. vol 61. issue 10. 2021-02-03. PMID:32893887. |
inflammation plays a role in the pathogenesis of immune-mediated epilepsy, but also in epilepsy of other etiology such as hippocampal sclerosis. |
2021-02-03 |
2023-08-13 |
human |
| Tobias Bauer, Bastian David, Leon Ernst, Albert J Becker, Juri-Alexander Witt, Christoph Helmstaedter, Jan Wagner, Bernd Weber, Christian E Elger, Rainer Surges, Theodor Rübe. Structural network topology in limbic encephalitis is associated with amygdala enlargement, memory performance and serostatus. Epilepsia. vol 61. issue 10. 2021-02-03. PMID:32940355. |
in this study, brain graphs of 17 le patients with autoantibodies against glutamic acid decarboxylase 65 (gad-le), four le patients with autoantibodies against leucine-rich glioma-inactivated 1, five le patients with autoantibodies against contactin-associated protein-like 2, 26 age- and gender-matched healthy control subjects, and 20 epilepsy control patients with hippocampal sclerosis were constructed based on t1-weighted structural magnetic resonance imaging scans and diffusion tensor imaging. |
2021-02-03 |
2023-08-13 |
human |
| Bastien Herlin, Claude Adam, Marie Odile Habert, Bertrand Mathon, Stéphane Clemenceau, Vincent Navarro, Sophie Dupon. Temporal pole epilepsy surgery-Sparing the hippocampus. Epilepsia. vol 61. issue 10. 2021-02-03. PMID:33053207. |
temporal pole epilepsy surgery-sparing the hippocampus. |
2021-02-03 |
2023-08-13 |
Not clear |
| Ping Yuan, Wei Han, Lingling Xie, Li Cheng, Hengsheng Chen, Jin Chen, Li Jian. The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis. Cell and tissue research. vol 380. issue 3. 2021-01-28. PMID:31900663. |
we used the lithium-pilocarpine-induced epilepsy model in adolescent sprague-dawley rats in order to evaluate hippocampal neurogenesis and epileptogenesis following the onset of status epilepticus (se). |
2021-01-28 |
2023-08-13 |
rat |
| Ping Yuan, Wei Han, Lingling Xie, Li Cheng, Hengsheng Chen, Jin Chen, Li Jian. The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis. Cell and tissue research. vol 380. issue 3. 2021-01-28. PMID:31900663. |
our results clarify the basic concept regarding the involvement of notch signaling in the regulation of hippocampal neurogenesis and epileptogenesis, thereby potentially offering a novel and alternative treatment for epilepsy. |
2021-01-28 |
2023-08-13 |
rat |
| Martin Pail, Jan Cimbálník, Robert Roman, Pavel Daniel, Daniel J Shaw, Jan Chrastina, Milan Brázdi. High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:33097749. |
hippocampal high-frequency electrographic activity (hfos) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. |
2021-01-19 |
2023-08-13 |
human |
| Martin Pail, Jan Cimbálník, Robert Roman, Pavel Daniel, Daniel J Shaw, Jan Chrastina, Milan Brázdi. High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:33097749. |
hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. |
2021-01-19 |
2023-08-13 |
human |
| Francesca Prestori, Ileana Montagna, Egidio D'Angelo, Lisa Mapell. The Optogenetic Revolution in Cerebellar Investigations. International journal of molecular sciences. vol 21. issue 7. 2021-01-13. PMID:32260234. |
the main issues addressed by these studies are the cerebellar role in epilepsy (through connections to the hippocampus and the temporal lobe), schizophrenia and cognition, working memory for decision making, and social behavior. |
2021-01-13 |
2023-08-13 |
Not clear |
| Shabnam Ghiasvand, Chris R Dussourd, Jing Liu, Yu Song, Yevgeny Berdichevsk. Variability of seizure-like activity in an Heliyon. vol 6. issue 11. 2021-01-12. PMID:33299935. |
variability of seizure-like activity in an hippocampal and cortical slice-based models are widely used to study seizures and epilepsy. |
2021-01-12 |
2023-08-13 |
Not clear |
| Sonja Bröe. Not Part of the Temporal Lobe, but Still of Importance? Substantia Nigra and Subthalamic Nucleus in Epilepsy. Frontiers in systems neuroscience. vol 14. 2021-01-01. PMID:33381016. |
the most researched brain region in epilepsy research is the temporal lobe, and more specifically, the hippocampus. |
2021-01-01 |
2023-08-13 |
human |
| Mostafa Farzaneh, Mohammad Sayyah, Hadi Mirzapourdelavar, Hamid Gholami Pourbadie, Mohammad I Zibaii, Hamid Latif. Optogenetic control of perforant pathway kindled seizures by photoinhibition of CA3 after insertion of Jaws into CA3 neuronal cells. Experimental neurology. vol 328. 2020-12-30. PMID:32165254. |
medial temporal lobe epilepsy (mtle) is among the most common and most drug-resistant types of epilepsies associated with remodeling of the trisynaptic circuit of the hippocampus. |
2020-12-30 |
2023-08-13 |
rat |
| Gülçin Vardar, Fabian Gerth, Xiao Jakob Schmitt, Pia Rautenstrauch, Thorsten Trimbuch, Julian Schubert, Holger Lerche, Christian Rosenmund, Christian Freun. Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32572454. |
even though the synaptic output remained unchanged in excitatory hippocampal stx1b+/- neurons exogenously expressing stx1b mutants, the manifestation of clear and distinct molecular disease mechanisms by these mutants suggest that certain forms of epilepsies can be conceptualized by assigning mutations to structurally sensitive regions of the stx1b-munc18-1 interface, translating into distinct neurophysiological phenotypes. |
2020-12-30 |
2023-08-13 |
mouse |
| Alberto Parras, Laura de Diego-Garcia, Mariana Alves, Edward Beamer, Giorgia Conte, Eva M Jimenez-Mateos, James Morgan, Ivana Ollà, Yasmina Hernandez-Santana, Norman Delanty, Michael A Farrell, Donncha F O'Brien, Alejandro Ocampo, David C Henshall, Raúl Méndez, José J Lucas, Tobias Enge. Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32594159. |
in the hippocampus of mice subjected to status epilepticus and epilepsy, we report >25% of the transcriptome displays changes in their poly(a) tail length, with deadenylation disproportionately affecting genes previously associated with epilepsy. |
2020-12-30 |
2023-08-13 |
mouse |
| Sean N Hatton, Khoa H Huynh, Leonardo Bonilha, Eugenio Abela, Saud Alhusaini, Andre Altmann, Marina K M Alvim, Akshara R Balachandra, Emanuele Bartolini, Benjamin Bender, Neda Bernasconi, Andrea Bernasconi, Boris Bernhardt, Núria Bargallo, Benoit Caldairou, Maria E Caligiuri, Sarah J A Carr, Gianpiero L Cavalleri, Fernando Cendes, Luis Concha, Esmaeil Davoodi-Bojd, Patricia M Desmond, Orrin Devinsky, Colin P Doherty, Martin Domin, John S Duncan, Niels K Focke, Sonya F Foley, Antonio Gambardella, Ezequiel Gleichgerrcht, Renzo Guerrini, Khalid Hamandi, Akari Ishikawa, Simon S Keller, Peter V Kochunov, Raviteja Kotikalapudi, Barbara A K Kreilkamp, Patrick Kwan, Angelo Labate, Soenke Langner, Matteo Lenge, Min Liu, Elaine Lui, Pascal Martin, Mario Mascalchi, José C V Moreira, Marcia E Morita-Sherman, Terence J O'Brien, Heath R Pardoe, José C Pariente, Letícia F Ribeiro, Mark P Richardson, Cristiane S Rocha, Raúl Rodríguez-Cruces, Felix Rosenow, Mariasavina Severino, Benjamin Sinclair, Hamid Soltanian-Zadeh, Pasquale Striano, Peter N Taylor, Rhys H Thomas, Domenico Tortora, Dennis Velakoulis, Annamaria Vezzani, Lucy Vivash, Felix von Podewils, Sjoerd B Vos, Bernd Weber, Gavin P Winston, Clarissa L Yasuda, Alyssa H Zhu, Paul M Thompson, Christopher D Whelan, Neda Jahanshad, Sanjay M Sisodiya, Carrie R McDonal. White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study. Brain : a journal of neurology. vol 143. issue 8. 2020-12-30. PMID:32814957. |
diffusion-weighted mri data were analysed from 1069 healthy controls and 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n = 599), temporal lobe epilepsy with normal mri (n = 275), genetic generalized epilepsy (n = 182) and non-lesional extratemporal epilepsy (n = 193). |
2020-12-30 |
2023-08-13 |
human |
| Emmanuel Cheng Seng Leong, Udaya Seneviratn. "Benign" temporal lobe epilepsy with hippocampal sclerosis: A forgotten entity? Epilepsy & behavior reports. vol 14. 2020-12-16. PMID:33313502. |
mesial temporal lobe epilepsy, a well-characterized epilepsy syndrome, is most commonly accompanied by the pathological feature of hippocampal sclerosis. |
2020-12-16 |
2023-08-13 |
Not clear |