| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Blümcke, J C Schewe, S Normann, O Brüstle, J Schramm, C E Elger, O D Wiestle. Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy. Hippocampus. vol 11. issue 3. 2002-05-30. PMID:11769312. |
a striking increase of nestin-immunoreactive cells within the hilus and dentate gyrus could be observed in a group of young patients with temporal lobe epilepsy (tle) and surgical treatment before age 2 years compared to adult tle patients and controls. |
2002-05-30 |
2023-08-12 |
human |
| Paul S Buckmaster, Veronica Otero-Corchón, Marcelo Rubinstein, Malcolm J Lo. Heightened seizure severity in somatostatin knockout mice. Epilepsy research. vol 48. issue 1-2. 2002-04-02. PMID:11823109. |
patients and experimental models of temporal lobe epilepsy display loss of somatostatinergic neurons in the dentate gyrus. |
2002-04-02 |
2023-08-12 |
mouse |
| G T Finnerty, M A Whittington, J G Jeffery. Altered dentate filtering during the transition to seizure in the rat tetanus toxin model of epilepsy. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731534. |
the dentate gyrus is thought to be a key area in containing the spread of seizure discharges in temporal lobe epilepsy. |
2002-01-28 |
2023-08-12 |
rat |
| W J Zhu, S N Rope. Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus. Annals of neurology. vol 50. issue 2. 2001-12-20. PMID:11506401. |
therefore, bdnf enhances fast excitatory transmission in the epileptic human dentate gyrus and may play an important role in epileptogenesis in temporal lobe epilepsy. |
2001-12-20 |
2023-08-12 |
human |
| F R Tang, W L Le. Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy. Journal of neurocytology. vol 30. issue 2. 2001-12-14. PMID:11577252. |
by immunocytochemical study by both light and electron microscopy of the hippocampus of patients with mesial temporal lobe epilepsy, we have shown that mglur2/3 and mglur4alpha immunoreaction product was mainly localised in the molecular layer of the dentate gyrus and ca2 area. |
2001-12-14 |
2023-08-12 |
Not clear |
| J Behr, U Heinemann, I Mod. Kindling induces transient NMDA receptor-mediated facilitation of high-frequency input in the rat dentate gyrus. Journal of neurophysiology. vol 85. issue 5. 2001-08-30. PMID:11353034. |
to elucidate the gating mechanism of the epileptic dentate gyrus on seizure-like input, we investigated dentate gyrus field potentials and granule cell excitatory postsynaptic potentials (epsps) following high-frequency stimulation (10-100 hz) of the lateral perforant path in an experimental model of temporal lobe epilepsy (i.e., kindled rats). |
2001-08-30 |
2023-08-12 |
rat |
| K Wu, L S Leun. Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis. Neuroscience. vol 104. issue 2. 2001-08-16. PMID:11377842. |
enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis. |
2001-08-16 |
2023-08-12 |
rat |
| K Wu, L S Leun. Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis. Neuroscience. vol 104. issue 2. 2001-08-16. PMID:11377842. |
we used kainic acid in rats as an animal model of temporal lobe epilepsy, and studied the neural interactions of the dentate gyrus in urethane-anesthetized rats in vivo. |
2001-08-16 |
2023-08-12 |
rat |
| P R Patrylo, D D Spencer, A Williamso. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. Journal of neurophysiology. vol 85. issue 4. 2001-07-05. PMID:11287477. |
to test whether gaba transport is compromised in both the forward (uptake) and reverse (heterotransport) direction in the sclerotic epileptic dentate gyrus, the physiological effects of microapplied gaba and nipecotic acid (npa; a compound that induces heterotransport) were examined in granule cells in hippocampal slices from kainate (ka)-induced epileptic rats and patients with temporal lobe epilepsy (tle). |
2001-07-05 |
2023-08-12 |
human |
| L E Sundstrom, C Brana, M Gatherer, J Mepham, A Rougie. Somatostatin- and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy. Brain : a journal of neurology. vol 124. issue Pt 4. 2001-05-03. PMID:11287369. |
somatostatin- and neuropeptide y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy. |
2001-05-03 |
2023-08-12 |
Not clear |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
degeneration of ca3-pyramidal neurons in hippocampus after intracerebroventricular kainic acid (ka) administration, a model of temporal lobe epilepsy, results in hyperexcitability within both dentate gyrus and the ca1 subfield. |
2001-02-08 |
2023-08-12 |
rat |
| J L Hardison, M M Okazaki, J V Nadle. Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth. Journal of neurophysiology. vol 84. issue 5. 2001-01-04. PMID:11067980. |
the recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. |
2001-01-04 |
2023-08-12 |
rat |
| C E Ribak, P H Tran, I Spigelman, M M Okazaki, J V Nadle. Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry. The Journal of comparative neurology. vol 428. issue 2. 2000-12-21. PMID:11064364. |
mossy fiber sprouting into the inner molecular layer of the dentate gyrus is an important neuroplastic change found in animal models of temporal lobe epilepsy and in humans with this type of epilepsy. |
2000-12-21 |
2023-08-12 |
rat |
| T B Schumacher, H Beck, R Steffens, I Blümcke, J Schramm, C E Elger, C Steinhäuse. Modulation of calcium channels by group I and group II metabotropic glutamate receptors in dentate gyrus neurons from patients with temporal lobe epilepsy. Epilepsia. vol 41. issue 10. 2000-11-02. PMID:11051119. |
modulation of calcium channels by group i and group ii metabotropic glutamate receptors in dentate gyrus neurons from patients with temporal lobe epilepsy. |
2000-11-02 |
2023-08-12 |
Not clear |
| A Pitkänen, J Nissinen, K Lukasiuk, L Jutila, L Paljärvi, T Salmenperä, K Karkola, M Vapalahti, A Yline. Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy. Epilepsia. vol 41 Suppl 6. 2000-10-17. PMID:10999515. |
if the sprouting of granule cell axons or mossy fibers in the dentate gyrus is critical for the generation of spontaneous seizures in temporal lobe epilepsy (tle), one could hypothesize that epileptic animals or humans with increased sprouting would have more frequent seizures. |
2000-10-17 |
2023-08-12 |
human |
| J Behr, U Heinemann, I Mod. Glutamate receptor activation in the kindled dentate gyrus. Epilepsia. vol 41 Suppl 6. 2000-10-17. PMID:10999529. |
the contribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), n-methyl-d-aspartate (nmda), and kainate receptor activation to the enhanced seizure susceptibility of the dentate gyrus was investigated in an experimental model of temporal lobe epilepsy. |
2000-10-17 |
2023-08-12 |
Not clear |
| M Barbarosie, J Louvel, I Kurcewicz, M Avol. CA3-released entorhinal seizures disclose dentate gyrus epileptogenicity and unmask a temporoammonic pathway. Journal of neurophysiology. vol 83. issue 3. 2000-04-11. PMID:10712442. |
thus our data indicate that the increased epileptogenicity of the dentate gyrus (a prominent feature of temporal lobe epilepsy as well), may depend on perforant path propagation of entorhinal ictal discharges, irrespective of mossy fiber reorganization. |
2000-04-11 |
2023-08-12 |
mouse |
| U V Nägerl, I Mody, M Jeub, A A Lie, C E Elger, H Bec. Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684884. |
in mesial temporal lobe epilepsy (mtle), the predominant form of epilepsy in adults, and in animal models of the disease, there is a conspicuous loss of the intracellular ca(2+)-binding protein calbindin-d(28k) (cb) from granule cells (gcs) of the dentate gyrus. |
2000-03-09 |
2023-08-12 |
human |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
our results show the following: (i) in both groups of temporal lobe epilepsy patients, there was a significant loss in cell number in all major hippocampal sub-areas compared with autopsy control tissue; (ii) in hs patients, when compared with non-hs patients, there was a further decline in the number of principal cells in all hippocampal sub-areas analysed, which was associated with an increase in gfap immunoreactivity; (iii) the decline in cell density was accompanied by a reduced number of synaptic terminals; (iv) in the hs group, there were sprouted mossy fibres in the supragranular layer (sgl) of the dentate gyrus; (v) there was an increase in synaptophysin immunostaining in the sgl indicating that functionally active nerve terminals were formed; and (vi) b-50 immunoreactivity was also increased in the sgl in the hs group compared with the non-hs and control groups. |
2000-02-14 |
2023-08-12 |
Not clear |
| P S Buckmaster, A L Jongen-Rêl. Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 21. 1999-11-19. PMID:10531454. |
patients with temporal lobe epilepsy display neuron loss in the hilus of the dentate gyrus. |
1999-11-19 |
2023-08-12 |
rat |