| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Friedl, H Clusmann, T Kral, D Dietrich, J Schram. Analysing metabotropic glutamate group III receptor mediated modulation of synaptic transmission in the amygdala-kindled dentate gyrus of the rat. Brain research. vol 821. issue 1. 1999-04-22. PMID:10064795. |
in the human dentate gyrus of patients suffering from temporal lobe epilepsy (tle), group iii mglur mediated inhibition of synaptic transmission is almost lost in the sub-group with ammon's horn sclerosis. |
1999-04-22 |
2023-08-12 |
human |
| R Gutiérrez, V Armand, S Schuchmann, U Heineman. Epileptiform activity induced by low Mg2+ in cultured rat hippocampal slices. Brain research. vol 815. issue 2. 1999-02-26. PMID:9878794. |
besides the establishment of reciprocal connections between area ca1 and the dentate gyrus (dg), collateral excitatory connections between granule cells are formed which are similar to those appearing in several epilepsy models and in the dg from patients with temporal lobe epilepsy. |
1999-02-26 |
2023-08-12 |
rat |
| G W Mathern, J K Pretorius, H I Kornblum, D Mendoza, A Lozada, J P Leite, L Chimelli, D E Born, I Fried, A C Sakamoto, J A Assirati, W J Peacock, G A Ojemann, P D Adelso. Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Neurobiology of disease. vol 5. issue 3. 1999-01-07. PMID:9848088. |
in temporal lobe epilepsy patients, these results support the hypothesis that pyramidal cell glur5 and glur6 mrna levels are decreased as a consequence of seizures, and in hs patients granule cell ka2 and glur5 mrna levels are increased in association with aberrant fascia dentata mossy fiber sprouting and/or hippocampal neuronal loss. |
1999-01-07 |
2023-08-12 |
Not clear |
| I Spigelman, X X Yan, A Obenaus, E Y Lee, C G Wasterlain, C E Riba. Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy. Neuroscience. vol 86. issue 1. 1998-10-20. PMID:9692747. |
mossy fibre sprouting and re-organization in the inner molecular layer of the dentate gyrus is a characteristic of many models of temporal lobe epilepsy including that induced by perforant-path stimulation. |
1998-10-20 |
2023-08-12 |
human |
| W W Lytton, K M Hellman, T P Sutul. Computer models of hippocampal circuit changes of the kindling model of epilepsy. Artificial intelligence in medicine. vol 13. issue 1-2. 1998-09-24. PMID:9654380. |
this hypothesis can best be evaluated in the case of temporal lobe epilepsy, where evidence of rewiring (synaptic reorganization) can be found in the dentate gyrus. |
1998-09-24 |
2023-08-12 |
Not clear |
| D Lurton, B El Bahh, L Sundstrom, A Rougie. Granule cell dispersion is correlated with early epileptic events in human temporal lobe epilepsy. Journal of the neurological sciences. vol 154. issue 2. 1998-06-18. PMID:9562302. |
granule cell dispersion (gcd) into the dentate gyrus (dg) molecular layer was observed in hippocampal specimens in 10 out of 22 cases of human non-lesional temporal lobe epilepsy (tle) and was associated with hippocampal sclerosis (hs). |
1998-06-18 |
2023-08-12 |
human |
| D King, R A Bronen, D D Spencer, S S Spence. Topographic distribution of seizure onset and hippocampal atrophy: relationship between MRI and depth EEG. Electroencephalography and clinical neurophysiology. vol 103. issue 6. 1998-04-23. PMID:9546496. |
medial temporal lobe epilepsy (mtle) is associated with hippocampal cell loss and organization of the dentate gyrus. |
1998-04-23 |
2023-08-12 |
Not clear |
| M L Simmons, G W Terman, C Chavki. Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. Journal of neurophysiology. vol 78. issue 4. 1997-11-13. PMID:9325355. |
spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. |
1997-11-13 |
2023-08-12 |
rat |
| M L Simmons, G W Terman, C Chavki. Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. Journal of neurophysiology. vol 78. issue 4. 1997-11-13. PMID:9325355. |
temporal lobe epilepsy is associated with a characteristic pattern of synaptic reorganization in the hippocampal formation, consisting of neuronal loss and aberrant growth of mossy fiber collaterals into the dentate gyrus inner molecular layer. |
1997-11-13 |
2023-08-12 |
rat |
| P S Buckmaster, F E Dude. Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats. The Journal of comparative neurology. vol 385. issue 3. 1997-10-28. PMID:9300766. |
we sought to describe quantitatively the morphological and functional changes that occur in the dentate gyrus of kainate-treated rats, an experimental model of temporal lobe epilepsy. |
1997-10-28 |
2023-08-12 |
human |
| P S Buckmaster, F E Dude. Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats. The Journal of comparative neurology. vol 385. issue 3. 1997-10-28. PMID:9300766. |
these findings from the dentate gyrus of epileptic kainate-treated rats are strikingly similar to those reported for human temporal lobe epilepsy, and they suggest that neuron loss and axon reorganization in the temporal hippocampus may be important in epileptogenesis. |
1997-10-28 |
2023-08-12 |
human |
| D Lurton, E A Cavalheir. Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy. Experimental brain research. vol 116. issue 1. 1997-10-23. PMID:9305828. |
neuropeptide-y (npy) is expressed by granule cells and mossy fibres of the hippocampal dentate gyrus during experimental temporal lobe epilepsy (tle). |
1997-10-23 |
2023-08-12 |
Not clear |
| P S Buckmaster, F E Dude. Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization. Journal of neurophysiology. vol 77. issue 5. 1997-07-30. PMID:9163384. |
neuron loss in the hilus of the dentate gyrus and granule cell axon reorganization have been proposed as etiologic factors in human temporal lobe epilepsy. |
1997-07-30 |
2023-08-12 |
human |
| G W Mathern, E H Bertram, T L Babb, J K Pretorius, P A Kuhlman, S Spradlin, D Mendoz. In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-D-aspartate, AMPA and GABA(A) receptors. Neuroscience. vol 77. issue 4. 1997-07-01. PMID:9130782. |
the hippocampal pathological findings in the limbic status model are similar to those in humans with hippocampal sclerosis and mesial temporal lobe epilepsy, and support the hypothesis that synaptic reorganization of both excitatory and inhibitory systems in the fascia dentata is an important pathophysiological mechanism that probably contributes to or generates chronic limbic seizures. |
1997-07-01 |
2023-08-12 |
rat |
| J M Parent, T W Yu, R T Leibowitz, D H Geschwind, R S Sloviter, D H Lowenstei. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 10. 1997-06-02. PMID:9133393. |
in both human temporal lobe epilepsy and rodent models of limbic epilepsy, this same neuronal population undergoes extensive remodeling, including reorganization of mossy fibers, dispersion of the granule cell layer, and the appearance of granule cells in ectopic locations within the dentate gyrus. |
1997-06-02 |
2023-08-12 |
human |
| J N Simpson, W Q Zhang, G Bing, J S Hon. Kainic acid-induced sprouting of dynorphin- and enkephalin-containing mossy fibers in the dentate gyrus of the rat hippocampus. Brain research. vol 747. issue 2. 1997-05-27. PMID:9046008. |
the kainic acid-induced sprouting of mossy fibers containing dynorphin and enkephalin strongly resembles the pattern observed in the dentate gyrus of humans with temporal lobe epilepsy. |
1997-05-27 |
2023-08-12 |
rat |
| S B Bausch, C Chavki. Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987772. |
the pilocarpine model of temporal lobe epilepsy was used to study the time-dependent changes in dentate gyrus circuitry after seizures. |
1997-02-04 |
2023-08-12 |
Not clear |
| S B Bausch, C Chavki. Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987772. |
these results illustrate the anatomical reorganization and functional changes in dentate gyrus circuitry evident in an animal model of temporal lobe epilepsy and provide evidence of compensatory changes after trauma to the hippocampal formation. |
1997-02-04 |
2023-08-12 |
Not clear |
| G W Mathern, J P Leite, T L Babb, J K Pretorius, P A Kuhlman, D Mendoza, I Fried, A C Sakamoto, J A Assirati, P D Adelson, W J Peacoc. Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining. Neuroreport. vol 7. issue 5. 1996-12-11. PMID:8804045. |
this study determined in temporal lobe epilepsy patients and rats injected with intrahippocampal kainate (ka) whether fascia dentata molecular layer mossy fiber sprouting was associated with increases in nmdar2 immunoreactivity (ir). |
1996-12-11 |
2023-08-12 |
human |
| E H Buhl, T S Otis, I Mod. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science (New York, N.Y.). vol 271. issue 5247. 1996-02-21. PMID:8553076. |
in the kindling model of temporal lobe epilepsy, several physiological indicators of inhibition by gamma-aminobutyric acid (gaba) in the hippocampal dentate gyrus are consistent with an augmented, rather than a diminished, inhibition. |
1996-02-21 |
2023-08-12 |
human |