| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel E Case. Pathophysiology of antipsychotic drug-induced movement disorders. The Journal of clinical psychiatry. vol 65 Suppl 9. 2004-07-13. PMID:15189109. |
the association of atypical antipsychotic agents with fewer drug-induced movement disorders than conventional agents has engendered several pathophysiologic hypotheses: (1) the hypothesis that, unlike conventional antipsychotic agents, atypical antipsychotics have greater activity in blocking serotonin-2a (5-ht(2a)) receptors than dopamine-2 (d(2)) receptors, which mitigates extrapyramidal symptoms; (2) the hypothesis that atypical antipsychotics block d(2) receptors only long enough to cause an antipsychotic action, but not as long as conventional agents; (3) the hypothesis that, in tardive dyskinesia, the nigrostriatal dopamine receptor system might develop increased sensitivity to dopamine as a result of treatment with conventional antipsychotic drugs, but this may not occur with atypical antipsychotics; and (4) the hypothesis that there might be a genetic association in tardive dystonia relating to the dopamine d(3) allele. |
2004-07-13 |
2023-08-12 |
Not clear |
| Wen-Juh Hwang, Wei-Jen Yao, Shiaw-Pyng Wey, Gann Tin. Clinical and [99mTc]TRODAT-1/[123I]IBZM SPECT imaging findings in dopa-responsive dystonia. European neurology. vol 51. issue 1. 2004-02-27. PMID:14631126. |
we report the clinical and dopamine transporter/d2 receptor single-photon emission computed tomographic (spect) imaging findings in a 39-year-old woman with a 24-year history of dopa-responsive dystonia (drd). |
2004-02-27 |
2023-08-12 |
Not clear |
| T D Sange. Childhood onset generalised dystonia can be modelled by increased gain in the indirect basal ganglia pathway. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 11. 2003-12-02. PMID:14617707. |
the model provides a consistent explanation for the association of dystonia with parkinsonism and disorders characterised by dopamine depletion, the ability to treat some dystonias with dopamine, the ability of neuroleptic drug treatment to cause an acute dystonic reaction treatable with anticholinergic drugs, and the ability of pallidotomy or deep brain stimulation of the internal pallidum to alleviate symptoms of generalised dystonia. |
2003-12-02 |
2023-08-12 |
Not clear |
| Sarah J Augood, Z Hollingsworth, David S Albers, Lichuan Yang, Joanne Leung, Xandra O Breakefield, David G Standaer. Dopamine transmission in DYT1 dystonia. Advances in neurology. vol 94. 2003-10-23. PMID:14509654. |
dopamine transmission in dyt1 dystonia. |
2003-10-23 |
2023-08-12 |
Not clear |
| Anjum Misbahuddin, Mark R Placzek, Thomas T Warne. Focal dystonia is associated with a polymorphism of the dopamine D5 receptor gene. Advances in neurology. vol 94. 2003-10-23. PMID:14509667. |
focal dystonia is associated with a polymorphism of the dopamine d5 receptor gene. |
2003-10-23 |
2023-08-12 |
Not clear |
| Raúl De La Fuente-Fernández, Sarah Furtado, Mark Guttman, Yoshiaki Furukawa, Chong S Lee, Donald B Calne, Thomas J Ruth, A Jon Stoess. VMAT2 binding is elevated in dopa-responsive dystonia: visualizing empty vesicles by PET. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710012. |
dopa-responsive dystonia (drd) is a lifelong disorder in which dopamine deficiency is not associated with neuronal loss and therefore it is an ideal human model for investigating the compensatory changes that occur in response to this biochemical abnormality. |
2003-07-17 |
2023-08-12 |
human |
| F Brancati, E M Valente, M Castori, N Vanacore, M Sessa, G Galardi, A Berardelli, A R Bentivoglio, G Defazio, P Girlanda, G Abbruzzese, A Albanese, B Dallapiccol. Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 5. 2003-05-27. PMID:12700316. |
role of the dopamine d5 receptor (drd5) as a susceptibility gene for cervical dystonia. |
2003-05-27 |
2023-08-12 |
Not clear |
| Mélanie Langlois, Francois Richer, Sylvain Chouinar. New perspectives on dystonia. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 30 Suppl 1. 2003-05-08. PMID:12691475. |
in recent years, a great deal has been learned on the more common primary dystonias such as primary torsion dystonia and on dystonia-plus syndromes such as dopamine responsive dystonia. |
2003-05-08 |
2023-08-12 |
Not clear |
| Kazuo Mihara, Tsuyoshi Kondo, Hisashi Higuchi, Hitoshi Takahashi, Keizo Yoshida, Tetsuo Shimizu, Sunao Kanek. Tardive dystonia and genetic polymorphisms of cytochrome P4502D6 and dopamine D2 and D3 receptors: a preliminary finding. American journal of medical genetics. vol 114. issue 6. 2003-02-03. PMID:12210290. |
tardive dystonia and genetic polymorphisms of cytochrome p4502d6 and dopamine d2 and d3 receptors: a preliminary finding. |
2003-02-03 |
2023-08-12 |
Not clear |
| Kazuo Mihara, Tsuyoshi Kondo, Hisashi Higuchi, Hitoshi Takahashi, Keizo Yoshida, Tetsuo Shimizu, Sunao Kanek. Tardive dystonia and genetic polymorphisms of cytochrome P4502D6 and dopamine D2 and D3 receptors: a preliminary finding. American journal of medical genetics. vol 114. issue 6. 2003-02-03. PMID:12210290. |
this study aimed to investigate relationship tardive dystonia and several genetic factors such as polymorphism of cytochrome p4502d6, and receptor polymorphisms of dopamine d(2) (taqi a and -141c ins/del polymorphisms) and d(3) (ser(9)gly polymorphism). |
2003-02-03 |
2023-08-12 |
Not clear |
| Chin-Chang Huang, Tzu-Chen Yen, Yi-Hsin Weng, Chin-Song L. Normal dopamine transporter binding in dopa responsive dystonia. Journal of neurology. vol 249. issue 8. 2002-12-23. PMID:12195447. |
normal dopamine transporter binding in dopa responsive dystonia. |
2002-12-23 |
2023-08-12 |
Not clear |
| Birgit Assmann, Martin Köhler, Georg F Hoffmann, Simon Heales, Robert Surtee. Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia. Pediatric research. vol 52. issue 1. 2002-12-10. PMID:12084853. |
to test the hypothesis that there may be abnormalities in serotonin turnover in dnd we measured cerebrospinal fluid (csf) concentrations of homovanillic (hva) and 5-hydroxyindoleacetic (hiaa) acids, metabolites of dopamine and serotonin, respectively, in 18 children with dystonia not responsive to levodopa. |
2002-12-10 |
2023-08-12 |
Not clear |
| Sarah J Augood, Z Hollingsworth, D S Albers, L Yang, J-C Leung, B Muller, C Klein, X O Breakefield, D G Standaer. Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study. Neurology. vol 59. issue 3. 2002-09-03. PMID:12177384. |
dopamine transmission in dyt1 dystonia: a biochemical and autoradiographical study. |
2002-09-03 |
2023-08-12 |
Not clear |
| Sarah J Augood, Z Hollingsworth, D S Albers, L Yang, J-C Leung, B Muller, C Klein, X O Breakefield, D G Standaer. Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study. Neurology. vol 59. issue 3. 2002-09-03. PMID:12177384. |
indices of dopamine transmission were measured in the postmortem striatum of dyt1 dystonia brains. |
2002-09-03 |
2023-08-12 |
Not clear |
| Yoshiaki Furukawa, Gregory Kapatos, John W Haycock, Julian Worsley, Henry Wong, Stephen J Kish, Torbjoern G Nygaar. Brain biopterin and tyrosine hydroxylase in asymptomatic dopa-responsive dystonia. Annals of neurology. vol 51. issue 5. 2002-07-31. PMID:12112113. |
it is assumed that brain biopterin and dopamine loss should not be as severe in asymptomatic dopa-responsive dystonia caused by gch1 mutations as it is in symptomatic dopa-responsive dystonia. |
2002-07-31 |
2023-08-12 |
Not clear |
| Padraic J Grattan-Smith, Ron A Wevers, Gerry C Steenbergen-Spanjers, Victor S C Fung, John Earl, Bridget Wilcke. Tyrosine hydroxylase deficiency: clinical manifestations of catecholamine insufficiency in infancy. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 2. 2002-05-17. PMID:11921123. |
signs of dopamine deficiency include tremor, hypersensitivity to levadopa (l-dopa) therapy, oculogyric crises, akinesia, rigidity, and dystonia. |
2002-05-17 |
2023-08-12 |
Not clear |
| A L DeStefano, L I Golbe, M H Mark, A M Lazzarini, N E Maher, M Saint-Hilaire, R G Feldman, M Guttman, R L Watts, O Suchowersky, A L Lafontaine, N Labelle, M F Lew, C H Waters, J H Growdon, C Singer, L J Currie, G F Wooten, P Vieregge, P P Pramstaller, C Klein, J P Hubble, M Stacy, E Montgomery, M E MacDonald, J F Gusella, R H Myer. Genome-wide scan for Parkinson's disease: the GenePD Study. Neurology. vol 57. issue 6. 2001-10-18. PMID:11571351. |
the chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. |
2001-10-18 |
2023-08-12 |
Not clear |
| M R Placzek, A Misbahuddin, K R Chaudhuri, N W Wood, K P Bhatia, T T Warne. Cervical dystonia is associated with a polymorphism in the dopamine (D5) receptor gene. Journal of neurology, neurosurgery, and psychiatry. vol 71. issue 2. 2001-09-27. PMID:11459908. |
cervical dystonia is associated with a polymorphism in the dopamine (d5) receptor gene. |
2001-09-27 |
2023-08-12 |
Not clear |
| M R Placzek, A Misbahuddin, K R Chaudhuri, N W Wood, K P Bhatia, T T Warne. Cervical dystonia is associated with a polymorphism in the dopamine (D5) receptor gene. Journal of neurology, neurosurgery, and psychiatry. vol 71. issue 2. 2001-09-27. PMID:11459908. |
a case-control allelic association study is described of 100 patients with cervical dystonia and 100 controls using polymorphisms within d1-5 receptor and dopamine transporter genes. |
2001-09-27 |
2023-08-12 |
Not clear |
| T Nagats. [Molecular mechanisms of neurotransmission]. Rinsho shinkeigaku = Clinical neurology. vol 40. issue 12. 2001-09-27. PMID:11464453. |
autosomal dominant dopa-responsive dystonia (drd) (segawa's disease) with mutations of gtp cyclohydrolase i (ichinose et al, nature genet 8, 236-242, 1994) causes a partial decrease in dopamine in the nigrostriatal dopamine neurons and produces a dystonia phenotype (segawa's syndrome). |
2001-09-27 |
2023-08-12 |
mouse |