| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Kishore, T G Nygaard, R de la Fuente-Fernandez, A B Naini, M Schulzer, E Mak, T J Ruth, D B Calne, B J Snow, A J Stoess. Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography. Neurology. vol 50. issue 4. 1998-05-07. PMID:9566390. |
we tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (drd) have increased dopamine d2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. |
1998-05-07 |
2023-08-12 |
human |
| R de la Fuente-Fernánde. Tardive dyskinesia in dopa-responsive dystonia: a reappraisal of the dopamine hypothesis of tardive dyskinesia. Neurology. vol 50. issue 4. 1998-05-07. PMID:9566407. |
tardive dyskinesia in dopa-responsive dystonia: a reappraisal of the dopamine hypothesis of tardive dyskinesia. |
1998-05-07 |
2023-08-12 |
Not clear |
| J S Perlmutter, L W Tempel, K J Black, D Parkinson, R D Tod. MPTP induces dystonia and parkinsonism. Clues to the pathophysiology of dystonia. Neurology. vol 49. issue 5. 1997-12-08. PMID:9371934. |
the pathophysiology of dystonia is unclear, but several clues implicate striatal dopamine dysfunction. |
1997-12-08 |
2023-08-12 |
Not clear |
| J S Perlmutter, L W Tempel, K J Black, D Parkinson, R D Tod. MPTP induces dystonia and parkinsonism. Clues to the pathophysiology of dystonia. Neurology. vol 49. issue 5. 1997-12-08. PMID:9371934. |
we now suggest that parkinsonism or dystonia may occur following striatal dopamine deficiency. |
1997-12-08 |
2023-08-12 |
Not clear |
| J S Perlmutter, L W Tempel, K J Black, D Parkinson, R D Tod. MPTP induces dystonia and parkinsonism. Clues to the pathophysiology of dystonia. Neurology. vol 49. issue 5. 1997-12-08. PMID:9371934. |
dystonia corresponded temporally with a decreased striatal dopamine content and a transient decrease in d2-like receptor number. |
1997-12-08 |
2023-08-12 |
Not clear |
| J S Perlmutter, L W Tempel, K J Black, D Parkinson, R D Tod. MPTP induces dystonia and parkinsonism. Clues to the pathophysiology of dystonia. Neurology. vol 49. issue 5. 1997-12-08. PMID:9371934. |
the association of striatal dopamine deficiency with dystonia and parkinsonism implies that other factors influence clinical manifestations. |
1997-12-08 |
2023-08-12 |
Not clear |
| T Nagatsu, H Ichinos. GTP cyclohydrolase I gene, dystonia, juvenile parkinsonism, and Parkinson's disease. Journal of neural transmission. Supplementum. vol 49. 1997-10-03. PMID:9266429. |
we found that dominantly inherited, hereditary progressive dystonia (hpd), first described by segawa and also called dopa responsive dystonia (drd), is caused by the mutations of gtp cyclohydrolase i gene, the partial decrease in the enzyme activity, and probably in striatal dopamine level, to less than 20% of the normal values. |
1997-10-03 |
2023-08-12 |
Not clear |
| H Ichinose, T Nagats. Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205791. |
we found that mutations of gtp cyclohydrolase i, the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, which is the cofactor of dopamine-synthesizing tyrosine hydroxylase, cause dominantly inherited hereditary progressive dystonia with marked diurnal fluctuation (hpd, segawa's disease) probably owing to the decrease of dopamine in the basal ganglia. |
1997-09-04 |
2023-08-12 |
Not clear |
| H Ichinose, T Nagats. Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205791. |
these results indicate that tyrosine hydroxylase in the nigrostriatal dopamine neurons may be most sensitive to tetrahydrobiopterin deficiency causing dystonia. |
1997-09-04 |
2023-08-12 |
Not clear |
| J Fan. Hyperactive behavioural effects induced by intranigral infusion of a pyridinium metabolite of haloperidol in rats. Canadian journal of physiology and pharmacology. vol 74. issue 12. 1997-05-08. PMID:9047047. |
this apparent dopamine agonist effect of hp+ may be relevant to some of the clinical side effects of haloperidol such as acute dystonia and chronic tardive dyskinesia, which have been proposed to be the result of dopaminergic hyperactivity. |
1997-05-08 |
2023-08-12 |
rat |
| N Yanagisaw. [Clinical characteristics and trends in research of Parkinson's disease and parkinsonism in Japan]. Nihon rinsho. Japanese journal of clinical medicine. vol 55. issue 1. 1997-03-26. PMID:9014416. |
reports on this syndrome have been accumulated in japan and gene abnormality in a enzyme relating to dopamine metabolism was discovered in the hereditary progressive dystonia with marked diurnal fluctuation (segawa). |
1997-03-26 |
2023-08-12 |
human |
| H Miwa, Y Mizun. [Dystonia preceding dopa-responsive parkinsonism--heterogeneous clinical features]. No to shinkei = Brain and nerve. vol 48. issue 2. 1996-12-11. PMID:8865694. |
from the clinical and pharmacological points of views, this type of dystonia-parkinsonism, characterized by dystonia with later development of dopa-responsive parkinsonism, is a syndrome showing heterogeneous dopa-response, and it remains uncertain, at the present, that whether or not patients reported here share the same clinicopathological background such as striatal dopamine deficiency. |
1996-12-11 |
2023-08-12 |
Not clear |
| M Segaw. [Pathophysiologies of dystonia and myoclonus--consideration from the standpoint of treatment]. Rinsho shinkeigaku = Clinical neurology. vol 35. issue 12. 1996-12-04. PMID:8752407. |
naturally, the main lesion of the dystonia responding to levodopa is in the nigrostriatal dopamine neuron. |
1996-12-04 |
2023-08-12 |
Not clear |
| A E Lan. Hemiatrophy, juvenile-onset exertional alternating leg paresis, hypotonia, and hemidystonia and adult-onset hemiparkinsonism: the spectrum of hemiparkinsonism-hemiatrophy syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 4. 1995-11-03. PMID:7565831. |
the role of dopamine deficiency in dystonia and the role of levodopa in the development of fluctuations in parkinson's disease are discussed. |
1995-11-03 |
2023-08-12 |
Not clear |
| S A Factor, G D Podskalny, K D Barro. Persistent neuroleptic-induced rigidity and dystonia in AIDS dementia complex: a clinico-pathological case report. Journal of the neurological sciences. vol 127. issue 1. 1995-04-28. PMID:7699386. |
patients with aids dementia complex (adc) appear to have an increased likelihood of developing acute onset parkinsonism and dystonia when treated with dopamine antagonists. |
1995-04-28 |
2023-08-12 |
Not clear |
| G Berding, K F Gratz, H Kolbe, G J Meyer, R Dengler, B O Knoop, H Hundeshage. 123I-IBZM SPECT: reconstruction methodology and results in parkinsonism and dystonia. Nuklearmedizin. Nuclear medicine. vol 33. issue 5. 1995-01-13. PMID:7997377. |
in 58 patients with parkinsonism or dystonia striatal dopamine d2 receptors were investigated using 123i-iodobenzamide (123i-ibzm) single-photon emission computed tomography (spect). |
1995-01-13 |
2023-08-12 |
Not clear |
| A H Rajput, W R Gibb, X H Zhong, K S Shannak, S Kish, L G Chang, O Hornykiewic. Dopa-responsive dystonia: pathological and biochemical observations in a case. Annals of neurology. vol 35. issue 4. 1994-05-10. PMID:7908789. |
we conclude that disturbed dopamine synthetic capacity or a reduced arborization of striatal dopamine terminals may be the major disturbance in dopa-responsive dystonia. |
1994-05-10 |
2023-08-12 |
Not clear |
| T G Nygaard, K C Wilhelmsen, N J Risch, D L Brown, J M Trugman, T C Gilliam, S Fahn, D E Week. Linkage mapping of dopa-responsive dystonia (DRD) to chromosome 14q. Nature genetics. vol 5. issue 4. 1994-03-10. PMID:8298648. |
dopa-responsive dystonia (drd) is an autosomal-dominant neurological disorder which appears to result from a genetically determined deficiency of striatal dopamine. |
1994-03-10 |
2023-08-12 |
Not clear |
| D Bravi, M M Mouradian, J W Roberts, T L Davis, T N Chas. End-of-dose dystonia in Parkinson's disease. Neurology. vol 43. issue 10. 1993-11-12. PMID:8413978. |
dystonia onset thus appears to reflect the degree, rather than the rate, of reduction in dopaminergic stimulation, and may involve the preferential interaction of dopamine with a receptor subpopulation that does not mediate its antiparkinsonian efficacy. |
1993-11-12 |
2023-08-12 |
Not clear |
| K Leenders, P Hartvig, L Forsgren, G Holmgren, B Almay, S A Eckernäs, H Lundqvist, B Långströ. Striatal [11C]-N-methyl-spiperone binding in patients with focal dystonia (torticollis) using positron emission tomography. Journal of neural transmission. Parkinson's disease and dementia section. vol 5. issue 2. 1993-08-20. PMID:8101445. |
specific binding of [11c]-n-methyl-spiperone to striatal dopamine d2 receptors was assessed using positron emission tomography (pet) in 6 patients with adult-onset focal dystonia (predominantly spasmodic torticollis) and in 5 healthy subjects. |
1993-08-20 |
2023-08-12 |
human |