| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J G Nutt, T G Nygaar. Response to levodopa treatment in dopa-responsive dystonia. Archives of neurology. vol 58. issue 6. 2001-07-05. PMID:11405805. |
dopa-responsive dystonia (drd) is similar to parkinson disease in that both disorders have impaired dopamine synthesis and respond to levodopa treatment. |
2001-07-05 |
2023-08-12 |
Not clear |
| J G Nutt, T G Nygaar. Response to levodopa treatment in dopa-responsive dystonia. Archives of neurology. vol 58. issue 6. 2001-07-05. PMID:11405805. |
dopa-responsive dystonia differs in that dopamine storage is intact in contrast to parkinson disease in which it is markedly reduced. |
2001-07-05 |
2023-08-12 |
Not clear |
| J D O'Sullivan, D C Costa, S Gacinovic, A J Lee. SPECT imaging of the dopamine transporter in juvenile-onset dystonia. Neurology. vol 56. issue 2. 2001-04-05. PMID:11160970. |
spect imaging of the dopamine transporter in juvenile-onset dystonia. |
2001-04-05 |
2023-08-12 |
Not clear |
| Y Hayashi, Y Ohyagi, I Inoue, K Arakawa, T Taniwaki, M Nakagawa, Y Kuwabara, T Yamada, J Kir. [A case of amoxapine-induced tardive dystonia successfully treated with a low dose anti-cholinergic agent]. Rinsho shinkeigaku = Clinical neurology. vol 40. issue 4. 2000-11-24. PMID:10967655. |
however, two dopamine agonists, pergolide and bromocriptine, worsened his dystonia. |
2000-11-24 |
2023-08-12 |
Not clear |
| E Muñoz, P Pastor, M J Martí, R Oliva, E Tolos. A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism. Neuroscience letters. vol 289. issue 1. 2000-10-06. PMID:10899410. |
the disease appeared as an apparently sporadic case and was characterized by dystonia of the legs at onset and a rapid progression to severe generalized parkinsonism but with an excellent maintained response to dopamine agonists treatment. |
2000-10-06 |
2023-08-12 |
Not clear |
| J Hewett, C Gonzalez-Agosti, D Slater, P Ziefer, S Li, D Bergeron, D J Jacoby, L J Ozelius, V Ramesh, X O Breakefiel. Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells. Human molecular genetics. vol 9. issue 9. 2000-08-29. PMID:10814722. |
early-onset torsion dystonia is a hereditary movement disorder thought to be caused by decreased release of dopamine into the basal ganglia, without apparent neuronal degeneration. |
2000-08-29 |
2023-08-12 |
mouse |
| J H Rehders, W Löscher, A Richte. Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799758. |
this finding has been interpreted as a down-regulation in response to enhanced dopamine release because systemic treatments with neuroleptics reduced the severity of dystonia while levodopa exerted prodystonic effects. |
2000-07-27 |
2023-08-12 |
Not clear |
| J H Rehders, W Löscher, A Richte. Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799758. |
amphetamine and the dopamine d(2) agonist quinpirole increased the severity of dystonia after systemic and striatal injections, while the dopamine d(1) agonist skf 38393 exerted only moderate prodystonic effects after systemic administration of a high dose but not after striatal injections. |
2000-07-27 |
2023-08-12 |
Not clear |
| J H Rehders, W Löscher, A Richte. Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799758. |
since striatal injections of compounds which enhance dopaminergic activity aggravated dystonia, while coinjections of dopamine d1 and d2 receptor antagonists reduced the severity of dystonia, the present findings clearly support the hypothesis that striatal dopaminergic overactivity plays a crucial role for the manifestation of dystonic attacks in the hamster model of paroxysmal dystonia. |
2000-07-27 |
2023-08-12 |
Not clear |
| Y Furukawa, O Hornykiewicz, S Fahn, S J Kis. Striatal dopamine in early-onset primary torsion dystonia with the DYT1 mutation. Neurology. vol 54. issue 5. 2000-06-28. PMID:10720299. |
striatal dopamine in early-onset primary torsion dystonia with the dyt1 mutation. |
2000-06-28 |
2023-08-12 |
Not clear |
| Y Furukawa, O Hornykiewicz, S Fahn, S J Kis. Striatal dopamine in early-onset primary torsion dystonia with the DYT1 mutation. Neurology. vol 54. issue 5. 2000-06-28. PMID:10720299. |
although nigrostriatal dopaminergic dysfunction has been suggested in early onset primary torsion dystonia (ptd) with the dyt1 mutation, the actual status of brain dopamine (da) is unknown. |
2000-06-28 |
2023-08-12 |
Not clear |
| A Ekesbo, P E Andrén, L M Gunne, C Sonesson, J Tedrof. Motor effects of (-)-OSU6162 in primates with unilateral 6-hydroxydopamine lesions. European journal of pharmacology. vol 389. issue 2-3. 2000-04-18. PMID:10688984. |
on the other hand, pretreatment with (-)-osu6162 attenuated rotational behavior induced by apomorphine (apomorphini hydrochloridum), l-dopa (3,4-dihydroxyphenylalanine), and the dopamine d2 receptor agonist, quinpirole (trans-(-)-4ar-4,4a, 5,6,7,8,8a,9-octahydro-5-propyl-1h-pyrazolol[3,4-g]quinoline hydrochloride), without inducing motor impairment such as akinesia or dystonia. |
2000-04-18 |
2023-08-12 |
monkey |
| H Ichinose, T Suzuki, H Inagaki, T Ohye, T Nagats. Molecular genetics of dopa-responsive dystonia. Biological chemistry. vol 380. issue 12. 2000-03-07. PMID:10661862. |
the causative genes of two types of hereditary dopa-responsive dystonia (drd) due to dopamine (da) deficiency in the nigrostriatum da neurons have been elucidated. |
2000-03-07 |
2023-08-12 |
human |
| L Peacock, G Jensen, K Nicholson, J Gerlac. Extrapyramidal side effects during chronic combined dopamine D1 and D2 antagonist treatment in Cebus apella monkeys. European archives of psychiatry and clinical neuroscience. vol 249. issue 5. 1999-12-30. PMID:10591986. |
previous studies in non-human primates have shown that tolerance to dystonia occurs during chronic dopamine d1 (d1) but not d2 antagonism and induction/aggravation of oral dyskinesia (td) during d2 but not d1 antagonism. |
1999-12-30 |
2023-08-12 |
monkey |
| S J Augood, D M Martin, L J Ozelius, X O Breakefield, J B Penney, D G Standaer. Distribution of the mRNAs encoding torsinA and torsinB in the normal adult human brain. Annals of neurology. vol 46. issue 5. 1999-11-24. PMID:10553994. |
that torsina mrna is enriched in several basal ganglia nuclei, including the dopamine neurons in the substantia nigra, is intriguing since it suggests that dyt1 dystonia may be associated with a dysfunction in dopamine transmission. |
1999-11-24 |
2023-08-12 |
human |
| Y Furukawa, T G Nygaard, M Gütlich, A H Rajput, C Pifl, L DiStefano, L J Chang, K Price, M Shimadzu, O Hornykiewicz, J W Haycock, S J Kis. Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia. Neurology. vol 53. issue 5. 1999-11-15. PMID:10496263. |
to determine the mechanism leading to striatal dopamine (da) loss in dopa-responsive dystonia (drd). |
1999-11-15 |
2023-08-12 |
Not clear |
| J N Nobrega, M Gernert, W Löscher, R Raymond, T Belej, A Richte. Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392843. |
tyrosine hydroxylase immunoreactivity and [3h]win 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. |
1999-10-06 |
2023-08-12 |
Not clear |
| J N Nobrega, M Gernert, W Löscher, R Raymond, T Belej, A Richte. Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392843. |
recent pharmacological studies and receptor analyses have suggested that dopamine neurotransmission is enhanced in mutant dystonic hamsters (dt(sz)), a model of idiopathic paroxysmal dystonia which displays attacks of generalized dystonia in response to mild stress. |
1999-10-06 |
2023-08-12 |
Not clear |
| J N Nobrega, M Gernert, W Löscher, R Raymond, T Belej, A Richte. Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392843. |
the selective dopamine uptake inhibitor gbr 12909 (20 mg/kg) aggravated dystonia in mutant hamsters, further suggesting that acute alterations in dopamine transporter function during stimulation may be an important component of dystonia in this model. |
1999-10-06 |
2023-08-12 |
Not clear |
| R de la Fuente-Fernánde. Drug-induced motor complications in dopa-responsive dystonia: implications for the pathogenesis of dyskinesias and motor fluctuations. Clinical neuropharmacology. vol 22. issue 4. 1999-09-28. PMID:10442251. |
dopa-responsive dystonia (drd) is characterized by striatal dopamine depletion with preserved nigrostriatal terminals. |
1999-09-28 |
2023-08-12 |
Not clear |