| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Zhang, Jing Yang, Wei Jiang, Rong Li, Min Zhu, Feng Xiong, Cui Son. Brain Development Measured With MRI in Children With Down Syndrome Correlates With Blood Biochemical Biomarkers. Pediatric neurology. vol 92. 2020-04-20. PMID:30612744. |
down syndrome (ds) is a neurodegenerative disease with unknown mechanisms. |
2020-04-20 |
2023-08-13 |
Not clear |
| Sylvia E Perez, Jennifer C Miguel, Bin He, Michael Malek-Ahmadi, Eric E Abrahamson, Milos D Ikonomovic, Ira Lott, Eric Doran, Melissa J Alldred, Stephen D Ginsberg, Elliott J Mufso. Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia. Acta neuropathologica. vol 137. issue 3. 2020-04-20. PMID:30734106. |
although, by age 40, individuals with down syndrome (ds) develop amyloid-β (aβ) plaques and tau-containing neurofibrillary tangles (nfts) linked to cognitive impairment in alzheimer's disease (ad), not all people with ds develop dementia. |
2020-04-20 |
2023-08-13 |
Not clear |
| Fabio Di Domenico, Antonella Tramutola, Eugenio Barone, Chiara Lanzillotta, Olivia Defever, Andrea Arena, Ilaria Zuliani, Cesira Foppoli, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, D Allan Butterfield, Marzia Perluig. Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome. Redox biology. vol 23. 2020-04-20. PMID:30876754. |
interestingly, down syndrome (ds) neuropathology shares many features with ad, such as the deposition of both amyloid plaques and neurofibrillary tangles. |
2020-04-20 |
2023-08-13 |
mouse |
| Adam Hsieh, Amir Gilad, Kevin Wong, Michael Cohen, Jessica Lev. Obstructive Sleep Apnea in Children With Down Syndrome: Screening and Effect of Guidelines. Clinical pediatrics. vol 58. issue 9. 2020-04-20. PMID:31030547. |
previous studies have shown low rates of screening for obstructive sleep apnea in children with down syndrome (ds), a high-prevalence population. |
2020-04-20 |
2023-08-13 |
human |
| Maurice Labuhn, Kelly Perkins, Sören Matzk, Leila Varghese, Catherine Garnett, Elli Papaemmanuil, Marlen Metzner, Alison Kennedy, Vyacheslav Amstislavskiy, Thomas Risch, Raj Bhayadia, David Samulowski, David Cruz Hernandez, Bilyana Stoilova, Valentina Iotchkova, Udo Oppermann, Carina Scheer, Kenichi Yoshida, Adrian Schwarzer, Jeffrey W Taub, John D Crispino, Mitchell J Weiss, Yasuhide Hayashi, Takashi Taga, Etsuro Ito, Seishi Ogawa, Dirk Reinhardt, Marie-Laure Yaspo, Peter J Campbell, Irene Roberts, Stefan N Constantinescu, Paresh Vyas, Dirk Heckl, Jan-Henning Klusman. Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer cell. vol 36. issue 2. 2020-04-20. PMID:31303423. |
myeloid leukemia in down syndrome (ml-ds) clonally evolves from transient abnormal myelopoiesis (tam), a preleukemic condition in ds newborns. |
2020-04-20 |
2023-08-13 |
Not clear |
| Ping Jun Zhu, Sanjeev Khatiwada, Ya Cui, Lucas C Reineke, Sean W Dooling, Jean J Kim, Wei Li, Peter Walter, Mauro Costa-Mattiol. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science (New York, N.Y.). vol 366. issue 6467. 2020-04-17. PMID:31727829. |
down syndrome (ds) is the most common genetic cause of intellectual disability. |
2020-04-17 |
2023-08-13 |
mouse |
| Jorge Román Corona-Rivera, Francisco Javier Martínez-Macías, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Christian Peña-Padilla, Izabel Maryalexandra Rios-Flores, Paola Alejandra Flores-Guevara, Mireya Orozco-Vela, Cristian Irela Aranda-Sánchez, Sinhué Alejandro Brukman-Jiméne. Prevalence and risk factors for Down syndrome: A hospital-based single-center study in Western Mexico. American journal of medical genetics. Part A. vol 179. issue 3. 2020-04-16. PMID:30666778. |
although hispanics of mexican origin in the united states have been identified as a population with a particularly higher rate of down syndrome (ds), there is a paucity of studies concerning this topic in mexico. |
2020-04-16 |
2023-08-13 |
Not clear |
| Michael S Rafii, Alexander M Kleschevnikov, Mariko Sawa, William C Moble. Down syndrome. Handbook of clinical neurology. vol 167. 2020-04-16. PMID:31753140. |
down syndrome (ds; trisomy 21) is the most common chromosomal disorder in humans. |
2020-04-16 |
2023-08-13 |
Not clear |
| F Bertapelli, J S Curtis, B Carlson, M Johnson, B Abadie, S Agiovlasiti. Step-counting accuracy of activity monitors in persons with Down syndrome. Journal of intellectual disability research : JIDR. vol 63. issue 1. 2020-04-15. PMID:30239068. |
however, the evidence on the step-counting accuracy of these devices - especially accelerometers - is limited in persons with down syndrome (ds). |
2020-04-15 |
2023-08-13 |
Not clear |
| Nilay Bas Ikizoglu, Esen Kiyan, Beldan Polat, Pinar Ay, Bulent Karadag, Refika Ers. Are home sleep studies useful in diagnosing obstructive sleep apnea in children with down syndrome? Pediatric pulmonology. vol 54. issue 10. 2020-04-15. PMID:31290291. |
obstructive sleep apnea syndrome (osas) is frequent in children with down syndrome (ds) and polysomnography (psg) is recommended for all children with ds. |
2020-04-15 |
2023-08-13 |
Not clear |
| Bruno Facon, David Magi. Does the Development of Syntax Comprehension Show a Premature Asymptote Among Persons With Down Syndrome? A Cross-Sectional Analysis. American journal on intellectual and developmental disabilities. vol 124. issue 2. 2020-04-13. PMID:30835529. |
uncertainty persists regarding the post-childhood trajectory of syntactic acquisition of persons with down syndrome (ds). |
2020-04-13 |
2023-08-13 |
human |
| Stina Lou, Kathrine Carstensen, Ida Vogel, Lone Hvidman, Camilla Palmhøj Nielsen, Maja Lanther, Olav Bjørn Peterse. Receiving a prenatal diagnosis of Down syndrome by phone: a qualitative study of the experiences of pregnant couples. BMJ open. vol 9. issue 3. 2020-04-13. PMID:30867204. |
to examine how pregnant couples experience receiving a prenatal diagnosis of down syndrome (ds) by phone-a practice that has been routine care in the central denmark region for years. |
2020-04-13 |
2023-08-13 |
Not clear |
| Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, Tamara Al-Janabi, Kin Y Mok, John Hardy, Andre Strydo. Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 2. 2020-04-10. PMID:30503169. |
down syndrome (ds) is associated with an almost universal development of alzheimer's disease. |
2020-04-10 |
2023-08-13 |
Not clear |
| Colleen Keen, Jessica Ezzell Hunter, Emily Graves Allen, Carissa Rocheleau, Martha Waters, Stephanie L Sherma. The association between maternal occupation and down syndrome: A report from the national Down syndrome project. International journal of hygiene and environmental health. vol 223. issue 1. 2020-04-07. PMID:31519426. |
among live births, down syndrome (ds) due to trisomy 21 is the most commonly occurring autosomal trisomy, typically resulting from meiotic nondisjunction. |
2020-04-07 |
2023-08-13 |
Not clear |
| Dean Huggard, W J Koay, Lynne Kelly, Fiona McGrane, Emer Ryan, Niamh Lagan, Edna Roche, Joanne Balfe, T Ronan Leahy, Orla Franklin, Ana Moreno-Oliveira, Ashanty M Melo, Derek G Doherty, Eleanor J Mollo. Altered Toll-Like Receptor Signalling in Children with Down Syndrome. Mediators of inflammation. vol 2019. 2020-04-06. PMID:31611734. |
children with down syndrome (ds) are prone to infections from these pathogens and have an increased risk of autoimmunity. |
2020-04-06 |
2023-08-13 |
Not clear |
| Jenna Reardanz, Frances A Conners, Kristina L McDonald, Nisha Sing. Peer Victimization and Communication Skills in Adolescents with Down Syndrome: Preliminary Findings. Journal of autism and developmental disorders. vol 50. issue 1. 2020-04-03. PMID:31571067. |
in this preliminary study, we examined peer victimization in adolescents with down syndrome (ds) and how it relates to language and communication skills. |
2020-04-03 |
2023-08-13 |
Not clear |
| Theodora Panagaki, Elisa B Randi, Fiona Augsburger, Csaba Szab. Overproduction of H Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 38. 2020-03-31. PMID:31481613. |
overproduction of h down syndrome (ds) is associated with significant perturbances in mitochondrial function. |
2020-03-31 |
2023-08-13 |
Not clear |
| Wei Zhang, Tima Mohammadi, Julie Sou, Aslam H Ani. Cost-effectiveness of prenatal screening and diagnostic strategies for Down syndrome: A microsimulation modeling analysis. PloS one. vol 14. issue 12. 2020-03-31. PMID:31800591. |
down syndrome (ds) is the most frequently occurring fetal chromosomal abnormality and different prenatal screening strategies are used for determining risk of ds worldwide. |
2020-03-31 |
2023-08-13 |
Not clear |
| Taralee Hamner, Manisha D Udhnani, Karol Z Osipowicz, Nancy Raitano Le. Pediatric Brain Development in Down Syndrome: A Field in Its Infancy. Journal of the International Neuropsychological Society : JINS. vol 24. issue 9. 2020-03-30. PMID:29789029. |
as surprisingly little is known about the developing brain studied in vivo in youth with down syndrome (ds), the current review summarizes the small ds pediatric structural neuroimaging literature and begins to contextualize existing research within a developmental framework. |
2020-03-30 |
2023-08-13 |
Not clear |
| Stella Sakhon, Kelly Edwards, Alison Luongo, Melanie Murphy, Jamie Edgi. Small Sets of Novel Words Are Fully Retained After 1-Week in Typically Developing Children and Down Syndrome: A Fast Mapping Study. Journal of the International Neuropsychological Society : JINS. vol 24. issue 9. 2020-03-30. PMID:30375315. |
down syndrome (ds) is a population with known hippocampal impairment, with studies showing that individuals with ds display difficulties in spatial navigation and remembering arbitrary bindings. |
2020-03-30 |
2023-08-13 |
Not clear |