| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Klaus Zerres, Sabine Rudnik-Schöneborn, Wolfgang Holzgrev. Do non-invasive prenatal tests promote discrimination against people with Down syndrome? What should be done? Journal of perinatal medicine. vol 49. issue 8. 2021-10-15. PMID:34049429. |
by implementation of non-invasive prenatal testing (nipt) for the diagnosis of down syndrome (ds) in maternity care, an ethical debate is newly inflamed how to deal with this information. |
2021-10-15 |
2023-08-13 |
Not clear |
| Soula Danopoulos, Soumyaroop Bhattacharya, Gail Deutsch, Lina R Nih, Chris Slaunwhite, Thomas J Mariani, Denise Al Ala. Prenatal histological, cellular, and molecular anomalies in trisomy 21 lung. The Journal of pathology. vol 255. issue 1. 2021-10-15. PMID:34050678. |
down syndrome (ds), also known as trisomy 21 (t21), is the most common human chromosomal anomaly. |
2021-10-15 |
2023-08-13 |
human |
| Feng J Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G Pomper, Roger H Reeve. Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates. Acta neuropathologica communications. vol 9. issue 1. 2021-10-15. PMID:34399854. |
down syndrome (ds) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. |
2021-10-15 |
2023-08-13 |
mouse |
| Miri Choi, Ae-Kyeong Kim, Youngwook Ham, Joo-Youn Lee, Daeyong Kim, Ansook Yang, Min Ju Jo, Eunyoung Yoon, Jung-Nyoung Heo, Sang-Bae Han, Min-Hyo Ki, Kyu-Sun Lee, Sungchan Ch. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 92. 2021-10-15. PMID:34500300. |
dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a) is a significant pathogenic factor in down syndrome (ds), wherein dyrk1a is overexpressed by 1.5-fold because of trisomy of human chromosome 21. |
2021-10-15 |
2023-08-13 |
human |
| V K Abdyyev, N O Dashenkova, E B Dashinimaev, E A Vorotelyak, A V Vasilie. NANOS3 downregulation in Down syndrome hiPSCs during primordial germ cell-like cell differentiation. Histochemistry and cell biology. 2021-10-15. PMID:34652540. |
in vitro-derived germ cells from hipscs with down syndrome (ds) express hpgclc core circuitry, eomes, sox17, and prdm14 at relatively low levels. |
2021-10-15 |
2023-08-13 |
human |
| Seon Sook Kim, Eun Hye Lee, Jin Hak Shin, Su Ryeon Se. MAP kinase/ERK kinase 1 (MEK1) phosphorylates regulator of calcineurin 1 (RCAN1) to regulate neuronal differentiation. Journal of cellular physiology. 2021-10-14. PMID:34647615. |
regulator of calcineurin 1 (rcan1) is located close to the down syndrome critical region (dscr) on human chromosome 21 and is related to the down syndrome (ds) phenotype. |
2021-10-14 |
2023-08-13 |
human |
| S Thalman, K L Van Pelt, A-L Lin, N F Johnson, G Jicha, A Caban-Holt, W Robertson, D Lightner, D Powell, E Head, F Schmit. A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. Journal of intellectual disability research : JIDR. vol 64. issue 12. 2021-10-13. PMID:32996650. |
people with down syndrome (ds) develop alzheimer's disease (ad) at an earlier age of onset than those with sporadic ad. |
2021-10-13 |
2023-08-13 |
Not clear |
| Francesco Sella, Sara Onnivello, Maristella Lunardon, Silvia Lanfranchi, Marco Zorz. Training basic numerical skills in children with Down syndrome using the computerized game "The Number Race". Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33483541. |
individuals with down syndrome (ds) present reduced basic numerical skills, which have a negative impact on everyday numeracy and mathematical learning. |
2021-10-13 |
2023-08-13 |
Not clear |
| Stephen Trudeau, Samantha Anne, Todd Otteson, Brandon Hopkins, Rachael Georgopoulos, Carissa Wentlan. Diagnosis and patterns of hearing loss in children with severe developmental delay. American journal of otolaryngology. vol 42. issue 3. 2021-10-12. PMID:33486206. |
this study aimed to evaluate diagnostic and hearing patterns in children with down syndrome (ds), autism spectrum disorder (asd), global developmental delay (gdd), and cerebral palsy (cp) who were unable to complete reliable ba testing due to severe cognitive delay. |
2021-10-12 |
2023-08-13 |
Not clear |
| Francesca Antonaros, Rossella Zenatelli, Giulia Guerri, Matteo Bertelli, Chiara Locatelli, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri, Giuseppe Ramacieri, Guido Cocchi, Pierluigi Strippoli, Maria Caracausi, Allison Piovesa. The transcriptome profile of human trisomy 21 blood cells. Human genomics. vol 15. issue 1. 2021-10-11. PMID:33933170. |
trisomy 21 (t21) is a genetic alteration characterised by the presence of an extra full or partial human chromosome 21 (hsa21) leading to down syndrome (ds), the most common form of intellectual disability (id). |
2021-10-11 |
2023-08-13 |
human |
| Asmaa A H Al-Awadi, Rashad Abdul-Ghani, Abdulsalam M Al-Mekhlaf. Toxoplasma gondii Infection Among Institutionalized Children with Down syndrome in Sana'a city, Yemen: Implications of Low IgG Seroprevalence. Acta parasitologica. 2021-10-11. PMID:34623612. |
to assess the igg seroprevalence of toxoplasma gondii as an indicator of past exposure and immunity against infection among children with down syndrome (ds) in sana'a city, yemen. |
2021-10-11 |
2023-08-13 |
Not clear |
| E Pittaras, D Colas, B Chuluun, G Allocca, C Helle. Enhancing sleep after training improves memory in Down syndrome model mice. Sleep. 2021-10-07. PMID:34618890. |
down syndrome (ds) is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. |
2021-10-07 |
2023-08-13 |
mouse |
| Xiao-Yan Tang, Lei Xu, Jingshen Wang, Yuan Hong, Yuanyuan Wang, Qian Zhu, Da Wang, Xin-Yue Zhang, Chun-Yue Liu, Kai-Heng Fang, Xiao Han, Shihua Wang, Xin Wang, Min Xu, Anita Bhattacharyya, Xing Guo, Mingyan Lin, Yan Li. DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. The Journal of clinical investigation. vol 131. issue 12. 2021-10-05. PMID:33945512. |
down syndrome (ds), caused by trisomy of chromosome 21, occurs in 1 of every 800 live births. |
2021-10-05 |
2023-08-13 |
Not clear |
| Cristiani Cortez Mendes, Bruna Lancia Zampieri, Lidia Maria Rebolho Batista Arantes, Matias Eliseo Melendez, Joice Matos Biselli, André Lopes Carvalho, Marcos Nogueira Eberlin, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Eny Maria Goloni-Bertollo, Érika Cristina Pavarin. One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome. Human cell. vol 34. issue 6. 2021-10-05. PMID:34410622. |
down syndrome (ds) is the most common chromosomal disorder, resulting from the failure of normal chromosome 21 segregation. |
2021-10-05 |
2023-08-13 |
Not clear |
| Yue Hu, Feng Liu, Wenpeng Peng, Shuxin Song, Chun Zhang, Xianfang Men. Overexpression of miR-99a in hippocampus leads to impairment of reversal learning in mice. Behavioural brain research. vol 416. 2021-10-05. PMID:34425183. |
as one of the most common human genetic disorders, down syndrome (ds) is characterized by a mild-to-moderate cognitive disability, which mainly results from genes overexpression on chromosome 21. |
2021-10-05 |
2023-08-13 |
mouse |
| Anne-Sophie Rebillat, Anne Hiance-Delahaye, Ségolène Falquero, Gianluca Radice, Silvia Sacc. The French translation of the dementia screening questionnaire for individuals with intellectual disabilities is a sensitive tool for screening for dementia in people with Down Syndrome. Research in developmental disabilities. vol 118. 2021-10-05. PMID:34467872. |
people with down syndrome (ds) are at an increased risk of developing alzheimer's disease (ad) relatively early in life. |
2021-10-05 |
2023-08-13 |
Not clear |
| Michele Salemi, Rossella Cannarella, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Concetta Barone, Mariangela Lo Giudice, Aldo E Calogero, Corrado Roman. Role of long non-coding RNAs in Down syndrome patients: a transcriptome analysis study. Human cell. vol 34. issue 6. 2021-10-05. PMID:34510387. |
down syndrome (ds) is defined by the presence of a third copy of chromosome 21. |
2021-10-05 |
2023-08-13 |
human |
| Md Mahiuddin Ahmed, Noah R Johnson, Timothy D Boyd, Christina Coughlan, Heidi J Chial, Huntington Potte. Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners? Frontiers in aging neuroscience. vol 13. 2021-10-05. PMID:34603007. |
innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with down syndrome (ds), neurodegenerative diseases such as alzheimer's disease (ad), and normal aging. |
2021-10-05 |
2023-08-13 |
Not clear |
| Patricia R Shaw, Jenny A Klein, Nadine M Aziz, Tarik F Hayda. Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. Disease models & mechanisms. vol 13. issue 9. 2021-10-01. PMID:32817053. |
mouse models of down syndrome (ds) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with ds. |
2021-10-01 |
2023-08-13 |
mouse |
| Jordan P Harp, Lisa M Koehl, Kathryn L Van Pelt, Christy L Hom, Eric Doran, Elizabeth Head, Ira T Lott, Frederick A Schmit. Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Brain sciences. vol 11. issue 9. 2021-10-01. PMID:34573150. |
primary care integration of down syndrome (ds)-specific dementia screening is strongly advised. |
2021-10-01 |
2023-08-13 |
human |