| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R H Reeves, N K Robakis, M L Oster-Granite, H M Wisniewski, J T Coyle, J D Gearhar. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain research. vol 388. issue 3. 1988-01-20. PMID:2960420. |
changes in the brains of individuals with trisomy 21 (down syndrome, ds) over 35 years of age closely resemble ad neuropathology. |
1988-01-20 |
2023-08-11 |
mouse |
| G Lockitch, V K Singh, M L Puterman, W J Godolphin, S Sheps, A J Tingle, F Wong, G Quigle. Age-related changes in humoral and cell-mediated immunity in Down syndrome children living at home. Pediatric research. vol 22. issue 5. 1988-01-06. PMID:2960948. |
to clarify this problem, we studied 64 children with down syndrome (ds) compared with an age-matched control group. |
1988-01-06 |
2023-08-11 |
Not clear |
| G Annerén, M Gebre-Medhi. Trace elements and transport proteins in serum of children with Down syndrome and of healthy siblings living in the same environment. Human nutrition. Clinical nutrition. vol 41. issue 4. 1987-10-22. PMID:2442124. |
twenty-two children with down syndrome (ds), 8 boys and 14 girls, in the age range 5 to 15 years were investigated and compared with a control group of 22 healthy children, 9 boys and 13 girls of the same age group, 9 of them being siblings of patients with ds. |
1987-10-22 |
2023-08-11 |
human |
| P A Martin-DeLeon, M B William. Sexual behavior and Down syndrome: the biological mechanism. American journal of medical genetics. vol 27. issue 3. 1987-10-01. PMID:2957914. |
sufficient evidence of a correlation between infrequent coitus and down syndrome (ds) has now accumulated to warrant reevaluation of the suggested biological mechanisms. |
1987-10-01 |
2023-08-11 |
Not clear |
| K A Lovelan. Behavior of young children with Down syndrome before the mirror: finding things reflected. Child development. vol 58. issue 4. 1987-09-24. PMID:2956073. |
children with down syndrome (ds) and normally developing (nd) children of comparable mental age (16-32 months) were compared in their ability to find things seen in the mirror. |
1987-09-24 |
2023-08-11 |
Not clear |
| K A Lovelan. Behavior of young children with Down syndrome before the mirror: exploration. Child development. vol 58. issue 3. 1987-08-28. PMID:2956072. |
exploratory behaviors of down syndrome (ds) and nondelayed (nd) young children between the mental ages of 16 and 32 months were examined in 4 situations involving finding things seen in a large standing mirror: free play, marked face, finding the reflected mother, and finding a reflected toy. |
1987-08-28 |
2023-08-11 |
Not clear |
| Y H Hsiang, G D Berkovitz, G L Bland, C J Migeon, A C Warre. Gonadal function in patients with Down syndrome. American journal of medical genetics. vol 27. issue 2. 1987-07-28. PMID:2955699. |
gonadal function was evaluated in 100 home-reared persons with down syndrome (ds) including 53 boys and men and 47 girls and women. |
1987-07-28 |
2023-08-11 |
human |
| B A Goodwin, C A Huethe. Revised estimates and projections of Down syndrome births in the United States, and the effects of prenatal diagnosis utilization, 1970-2002. Prenatal diagnosis. vol 7. issue 4. 1987-07-15. PMID:2954038. |
the objectives of this study were to: calculate revised estimates and projections of united states annual down syndrome (ds) births for 1970-2002, and estimate the effects of amniocentesis on these baseline ds birth projections. |
1987-07-15 |
2023-08-11 |
Not clear |
| E R Ashwood, E Cheng, D A Luth. Maternal serum alpha-fetoprotein and fetal trisomy-21 in women 35 years and older: implications for alpha-fetoprotein screening programs. American journal of medical genetics. vol 26. issue 3. 1987-05-14. PMID:2436476. |
a retrospective study of 3,411 women who underwent midtrimester amniocentesis for fetal chromosome analysis between june 1979 and august 1984 was performed to evaluate an association between low maternal serum alpha-fetoprotein (afp) concentrations and down syndrome (ds) pregnancies. |
1987-05-14 |
2023-08-11 |
Not clear |
| T W Hustinx, J M Scheres, J P Geraedts, P van Eltere. [Down's syndrome in the Netherlands]. Tijdschrift voor kindergeneeskunde. vol 54. issue 4. 1986-11-19. PMID:2945285. |
in 348 patients with down syndrome (ds) born in the netherlands in 1981 and 1982 chromosome studies had been performed before december 1st 1984. |
1986-11-19 |
2023-08-11 |
Not clear |
| J T Coyle, M L Oster-Granite, J D Gearhar. The neurobiologic consequences of Down syndrome. Brain research bulletin. vol 16. issue 6. 1986-11-18. PMID:2875770. |
trisomy of the whole or distal part of human chromosome 21 (hsa 21) (ts21) results in down syndrome (ds), which is characterized in part by mental retardation and associated neurological abnormalities. |
1986-11-18 |
2023-08-11 |
human |
| J D Gearhart, H S Singer, T H Moran, M Tiemeyer, M L Oster-Granite, J T Coyl. Mouse chimeras composed of trisomy 16 and normal (2N) cells: preliminary studies. Brain research bulletin. vol 16. issue 6. 1986-11-18. PMID:2875771. |
many humans with trisomy 21 (down syndrome (ds)) have psychomotor and cognitive retardation, congenital heart disease, and hematologic abnormalities. |
1986-11-18 |
2023-08-11 |
mouse |
| R H Reeves, J D Gearhart, J W Littlefiel. Genetic basis for a mouse model of Down syndrome. Brain research bulletin. vol 16. issue 6. 1986-11-18. PMID:2944567. |
the trisomy 16 (ts16) mouse has been proposed as a model for down syndrome (ds) in humans, based on genetic homology between mouse chromosome 16 (mmu 16) and human chromosome 21 (hsa 21). |
1986-11-18 |
2023-08-11 |
mouse |
| B F Crandall, T B Lebherz, K Tabs. Maternal age and amniocentesis: should this be lowered to 30 years? Prenatal diagnosis. vol 6. issue 4. 1986-10-20. PMID:2944088. |
we believe that 27 per cent of down syndrome (ds) pregnancies could be identified if 50 per cent of pregnant women in this age category availed themselves of the test. |
1986-10-20 |
2023-08-11 |
Not clear |
| G Annerén, J S Gronowitz, C F Källander, V A Sundqvis. Mothers of children with Down syndrome have higher herpes simplex virus type 2 (HSV-2) antibody levels. Human genetics. vol 72. issue 1. 1986-03-05. PMID:3002957. |
the antibody response to herpes simplex virus (hsv) was studied in 53 mothers of children with down syndrome (ds) and compared with that in 154 controls, using sera sampled during pregnancy or at delivery. |
1986-03-05 |
2023-08-11 |
Not clear |
| P H Jongbloe. The ageing gamete in relation to birth control failures and Down syndrome. European journal of pediatrics. vol 144. issue 4. 1986-02-18. PMID:2934254. |
this hypothesis is supported by the decreasing incidence of down syndrome (ds) in general in recent years, and the increase among the younger maternal age categories as well as the effect of birth order. |
1986-02-18 |
2023-08-11 |
human |
| P H Jongbloet, O J Vriez. Down syndrome: increased frequency of maternal meiosis I nondisjunction during the transitional stages of the ovulatory seasons. Human genetics. vol 71. issue 3. 1986-01-06. PMID:2933319. |
in a month-of-birth study of down syndrome (ds) individuals, we found--in agreement with a previous collaborative european study (jongbloet et al. |
1986-01-06 |
2023-08-11 |
Not clear |
| K M Johnson, C A Huether, E B Hook, C A Crowe, B A Reeder, A Sommer, M M McCorquodale, P K Cros. False-positive reporting of Down syndrome on Ohio and New York birth certificates. Genetic epidemiology. vol 2. issue 2. 1985-12-13. PMID:2932367. |
two separate investigations were conducted on the inaccuracy of down syndrome (ds) reporting on birth certificates; ie, false-positive cases in which an individual coded as ds did not in fact have ds. |
1985-12-13 |
2023-08-11 |
Not clear |
| C Brahe, A Serra, N E Morto. Erythrocyte catechol-O-methyltransferase activity: genetic analysis in nuclear families with one child affected by Down syndrome. American journal of medical genetics. vol 21. issue 2. 1985-08-06. PMID:3160238. |
erythrocyte catechol-o-methyltransferase (comt) activity was measured in 142 members of 32 nuclear families in which one child had down syndrome (ds). |
1985-08-06 |
2023-08-11 |
human |
| E E Ekwo, B F Seals, J O Kim, R A Williamson, J W Hanso. Factors influencing maternal estimates of genetic risk. American journal of medical genetics. vol 20. issue 3. 1985-05-28. PMID:3158198. |
all women were at risk of having a child with congenital anomalies either because of maternal age at pregnancy or family history of down syndrome (ds) or other congenital anomalies. |
1985-05-28 |
2023-08-11 |
Not clear |