| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margarita R Tumanyan, Olga V Filaretova, Vera V Chechneva, Ruben S Gulasaryan, Iuliia V Butrim, Leo A Bockeri. Repair of complete atrioventricular septal defect in infants with down syndrome: outcomes and long-term results. Pediatric cardiology. vol 36. issue 1. 2015-07-16. PMID:25099029. |
in ds infants, abnormalities of the left av valve (doubling of the mitral valve, single papillary muscle, closely spaced groups of papillary muscles, leaflet or chordal dysplasia, hypoplastic valve ring) occur as statistically significant (8% ds vs 12% nk; p < 0.05) which is rarer than in children having the same defect, but without down syndrome. |
2015-07-16 |
2023-08-13 |
Not clear |
| Maria Giulia Bacalini, Davide Gentilini, Alessio Boattini, Enrico Giampieri, Chiara Pirazzini, Cristina Giuliani, Elisa Fontanesi, Maria Scurti, Daniel Remondini, Miriam Capri, Guido Cocchi, Alessandro Ghezzo, Alberto Del Rio, Donata Luiselli, Giovanni Vitale, Daniela Mari, Gastone Castellani, Mario Fraga, Anna Maria Di Blasio, Stefano Salvioli, Claudio Franceschi, Paolo Garagnan. Identification of a DNA methylation signature in blood cells from persons with Down Syndrome. Aging. vol 7. issue 2. 2015-07-14. PMID:25701644. |
down syndrome (ds) is characterized by a wide spectrum of clinical signs, which include segmental premature aging of central nervous and immune systems. |
2015-07-14 |
2023-08-13 |
Not clear |
| Pratiksha Tilak Rao, John M Solomo. Can response time be trained with bilateral limb training in children with Down syndrome? Journal of neurosciences in rural practice. vol 6. issue 3. 2015-07-13. PMID:26167016. |
response time (rt), that is, the time taken to respond is known to be delayed in children with down syndrome (ds). |
2015-07-13 |
2023-08-13 |
Not clear |
| Julian Kamhieh-Milz, Reham Fadl Hassan Moftah, Gürkan Bal, Matthias Futschik, Viktor Sterzer, Omid Khorramshahi, Martin Burow, Gundula Thiel, Annegret Stuke-Sontheimer, Rabih Chaoui, Sundrela Kamhieh-Milz, Abdulgabar Salam. Differentially expressed microRNAs in maternal plasma for the noninvasive prenatal diagnosis of Down syndrome (trisomy 21). BioMed research international. vol 2014. 2015-07-10. PMID:25478570. |
in this proof-of-concept study, we report on the identification of extracellular mirnas in maternal plasma of down syndrome (ds) pregnancies. |
2015-07-10 |
2023-08-13 |
Not clear |
| b' Fabio Copped\\xc3\\xa. The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects. Frontiers in genetics. vol 6. 2015-07-10. PMID:26161087.' |
subsequently, more than 50 small case-control studies investigated whether or not maternal polymorphisms of folate pathway genes could be risk factors for the birth of a child with down syndrome (ds), yielding conflicting and inconclusive results. |
2015-07-10 |
2023-08-13 |
human |
| Sadeq-Ali Al-Maweri, Bassel Tarakji, Ghadah A Al-Sufyani, Hashem M Al-Shamiri, Giath Gaza. Lip and oral lesions in children with Down syndrome. A controlled study. Journal of clinical and experimental dentistry. vol 7. issue 2. 2015-07-09. PMID:26155347. |
down syndrome (ds) is the most common chromosomal abnormality affecting numerous organs, including the orofacial region. |
2015-07-09 |
2023-08-13 |
Not clear |
| A S Karlsen, S Korbo, H B M Uylings, B Pakkenber. A stereological study of the mediodorsal thalamic nucleus in Down syndrome. Neuroscience. vol 279. 2015-07-08. PMID:25220902. |
the total number of neurons and glial cells in the mediodorsal thalamic (mdt) nucleus of four aged females with down syndrome (ds; mean age 69years) was estimated and compared to six age- and sex-matched controls. |
2015-07-08 |
2023-08-13 |
Not clear |
| Scott V Bratman, Kathleen C Horst, Robert W Carlson, Daniel S Kap. Solid malignancies in individuals with Down syndrome: a case presentation and literature review. Journal of the National Comprehensive Cancer Network : JNCCN. vol 12. issue 11. 2015-07-07. PMID:25361800. |
individuals with down syndrome (ds) are at elevated risk for acute leukemia, whereas solid tumors are uncommon, and most types, including breast cancers, have significantly lower-than-expected age-adjusted incidence rates. |
2015-07-07 |
2023-08-13 |
mouse |
| Caroline Roncadin, Johann Hitzler, Andrea Downie, Isabelle Montour-Proulx, Cheryl Alyman, Elizabeth Cairney, Brenda J Spiegle. Neuropsychological late effects of treatment for acute leukemia in children with Down syndrome. Pediatric blood & cancer. vol 62. issue 5. 2015-07-07. PMID:25545182. |
children with down syndrome (ds) have an elevated risk of developing acute leukemia, but little is known about treatment-related neuropsychological morbidity because they are systematically excluded from research in this area. |
2015-07-07 |
2023-08-13 |
Not clear |
| Ignasi Sahún, Damien Marechal, Patricia Lopes Pereira, Valérie Nalesso, Agnes Gruart, José Maria Delgado Garcia, Stylianos E Antonarakis, Mara Dierssen, Yann Heraul. Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome. Genetics. vol 197. issue 3. 2015-07-06. PMID:24752061. |
down syndrome (ds) is due to increased copy number of human chromosome 21. |
2015-07-06 |
2023-08-13 |
mouse |
| Min-A Kim, You Sun Lee, Nan Hee Yee, Jeong Soo Choi, Jung Yun Choi, Kyung Se. Prevalence of congenital heart defects associated with Down syndrome in Korea. Journal of Korean medical science. vol 29. issue 11. 2015-07-06. PMID:25408587. |
congenital heart defect (chd) is common in infants with down syndrome (ds), which is the principle cause of mortality. |
2015-07-06 |
2023-08-13 |
Not clear |
| J Timothy Caldwell, Yubin Ge, Jeffrey W Tau. Prognosis and management of acute myeloid leukemia in patients with Down syndrome. Expert review of hematology. vol 7. issue 6. 2015-07-03. PMID:25231553. |
children with down syndrome (ds) are at a substantially increased risk to develop acute myeloid leukemia (aml). |
2015-07-03 |
2023-08-13 |
Not clear |
| Hazem S Abou-Youssef, Manal M Kamal, Dina A Mehane. Triple test screening for Down syndrome: an Egyptian-tailored study. PloS one. vol 9. issue 10. 2015-07-02. PMID:25330176. |
the incidence of down syndrome (ds) in egypt varies between 1:555 and 1:770 and its screening by triple test is becoming increasingly popular nowadays. |
2015-07-02 |
2023-08-13 |
Not clear |
| Stamatis Agiovlasitis, Jeffrey A McCubbin, Joonkoo Yun, Jeffrey J Widrick, Michael J Pavo. Gait characteristics of adults with Down syndrome explain their greater metabolic rate during walking. Gait & posture. vol 41. issue 1. 2015-06-25. PMID:25457480. |
the altered gait patterns of adults with down syndrome (ds) may contribute to their higher net metabolic rate (net-mr) during walking than adults without ds, leading to mobility limitations. |
2015-06-25 |
2023-08-13 |
human |
| Li-Sha Chen, Dan Xue, Zuo-Ming Xi, Dan-Na Liu, Peng-Shu Zou, Ming Ma, Ying Xia, Xia-Hui Chen, Guang-Bin Qiu, Dong-Hua Ca. A very rare case of trisomy 4q32.3-4q35.2 and trisomy 21q11.2-21q22.11 in a patient with recombinant chromosomes 4 and 21. Gene. vol 563. issue 1. 2015-06-25. PMID:25752286. |
we report the case of a patient with a clinical phenotype consistent with down syndrome (ds) who has a novel karyotypic abnormality. |
2015-06-25 |
2023-08-13 |
Not clear |
| Elizabeth Smith, Christopher Jarrol. Demonstrating the effects of phonological similarity and frequency on item and order memory in Down syndrome using process dissociation. Journal of experimental child psychology. vol 128. 2015-06-22. PMID:25089885. |
individuals with down syndrome (ds) tend to experience a vstm deficit. |
2015-06-22 |
2023-08-13 |
Not clear |
| b' S\\xc3\\xa9verine Coutadeur, H\\xc3\\xa9l\\xc3\\xa8ne Benyamine, Laurence Delalonde, Catherine de Oliveira, Bertrand Leblond, Alicia Foucourt, Thierry Besson, Anne-Sophie Casagrande, Thierry Taverne, Ang\\xc3\\xa9lique Girard, Matthew P Pando, Laurent D\\xc3\\xa9sir\\xc3\\xa. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer\'s disease: effect on Tau and amyloid pathologies in vitro. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25556849.' |
the dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a) gene is located within the down syndrome (ds) critical region on chromosome 21 and is implicated in the generation of tau and amyloid pathologies that are associated with the early onset alzheimer's disease (ad) observed in ds. |
2015-06-22 |
2023-08-13 |
Not clear |
| H T El-Bassyouni, H H Afifi, M M Eid, R M Kamal, H H El-Gebali, Gsm El-Saeed, M M Thomas, S A Abdel-Maksou. Oxidative Stress -a Phenotypic Hallmark of Fanconi Anemia and Down Syndrome: The Effect of Antioxidants. Annals of medical and health sciences research. vol 5. issue 3. 2015-06-22. PMID:26097763. |
oxidative stress plays a major role in the pathogenesis of leukemia-prone diseases such as fanconi anemia (fa) and down syndrome (ds). |
2015-06-22 |
2023-08-13 |
Not clear |
| Els-Marie M Andersson, Stefan Axelsson, Marit E Austeng, Britt Øverland, Ingrid E Valen, Terese A Jensen, Harriet Akr. Bilateral hypodontia is more common than unilateral hypodontia in children with Down syndrome: a prospective population-based study. European journal of orthodontics. vol 36. issue 4. 2015-06-19. PMID:24014738. |
however, patterns of hypodontia have not been fully explored in children with down syndrome (ds). |
2015-06-19 |
2023-08-12 |
Not clear |
| Gabriele Deidda, Martina Parrini, Shovan Naskar, Ignacio F Bozarth, Andrea Contestabile, Laura Cancedd. Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome. Nature medicine. vol 21. issue 4. 2015-06-19. PMID:25774849. |
down syndrome (ds) is the most frequent genetic cause of intellectual disability, and altered gabaergic transmission through cl(-)-permeable gabaa receptors (gabaars) contributes considerably to learning and memory deficits in ds mouse models. |
2015-06-19 |
2023-08-13 |
mouse |