| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergio Mena, Allison Cruikshank, Janet Best, H F Nijhout, Michael C Reed, Parastoo Hashem. Modulation of serotonin transporter expression by escitalopram under inflammation. Communications biology. vol 7. issue 1. 2024-06-08. PMID:38851804. |
selective serotonin reuptake inhibitors (ssris) are widely used for depression based on the monoamine deficiency hypothesis. |
2024-06-08 |
2024-06-11 |
mouse |
| Rucha Deore, Rashid Ansari, Sanjay N Awathale, Madhav Shelke, Hemant R Badwaik, Sameer N Goyal, Kartik T Nakhat. Lycopene alleviates BCG-induced depressive phenotypes in mice by disrupting 5-HT3 receptor - IDO1 interplay in the brain. European journal of pharmacology. 2024-06-03. PMID:38830456. |
the 5-ht3 receptor and indoleamine 2,3-dioxygenase 1 (ido1) enzyme play a crucial role in the pathogenesis of depression as their activation reduce serotonin contents in the brain. |
2024-06-03 |
2024-06-06 |
mouse |
| Nour Fakih, Marc Fakhour. Alzheimer Disease-Link With Major Depressive Disorder and Efficacy of Antidepressants in Modifying its Trajectory. Journal of psychiatric practice. vol 30. issue 3. 2024-05-31. PMID:38819242. |
antidepressants such as selective serotonin reuptake inhibitors, which are the first line of treatment for mdd, have shown great promise in the treatment of depression in ad, although their effectiveness remains controversial. |
2024-05-31 |
2024-06-06 |
Not clear |
| N Simple Santi, Sashi B Biswal, Birendra Narayan Naik, Jyoti Prakash Sahoo, Bhabagrahi Rat. A Randomized Controlled Trial Comparing Efficacy and Safety of Antidepressant Monotherapy. Cureus. vol 16. issue 4. 2024-05-27. PMID:38800340. |
these issues prompted investigations concerning the various roles of serotonin (5-ht) neurotransmissions in the etiology of depression. |
2024-05-27 |
2024-05-31 |
human |
| Rachel N Schade, Connor B Etheridge, Lauren E Kenney, Adrianna M Ratajska, Katie Rodriguez, Francesca V Lopez, Joshua Gertler, Alyssa Ray, Lauren Santos, Christopher Hess, Dawn Bower. Greater Apathy Associated With Selective Serotonin Reuptake Inhibitor Use in Parkinson's Disease. Journal of geriatric psychiatry and neurology. 2024-05-23. PMID:38780969. |
use of selective serotonin reuptake inhibitors (ssris) has been associated with increased apathy in adolescents and adults with depression. |
2024-05-23 |
2024-05-27 |
Not clear |
| Bingcong Zhao, Zhigang Li, Chuan Shi, Yan Liu, Yang Sun, Bin Li, Jie Zhang, Zhizhong Gong, Yuanzheng Wang, Xuehong Ma, Xinjing Yang, Huili Jiang, Yuanbo Fu, Xin Wang, Yang Li, Hengchia Liu, Tuya Bao, Yutong Fe. Acupuncture as Add-on Therapy to SSRIs Can Improve Outcomes of Treatment for Anxious Depression: Subgroup Analysis of the AcuSDep Trial. Neuropsychiatric disease and treatment. vol 20. 2024-05-21. PMID:38770535. |
this exploratory subgroup analysis aimed to explore the effects of acupuncture as an add-on therapy of selective serotonin reuptake inhibitors (ssris) for patients with ad or non-anxious depression (nad). |
2024-05-21 |
2024-05-27 |
Not clear |
| Wei Zhang, Ying Jin, Fu-Ming Zho. Chronic fluoxetine treatment desensitizes serotoninergic inhibition of GABA inputs and the intrinsic excitability of dorsal raphe serotonin neurons. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766100. |
serotonin reuptake inhibitors (ssris) increase the synaptic and extracellular 5-ht level and are effective in treating depression. |
2024-05-20 |
2024-05-27 |
Not clear |
| Mariana I Arce, Katherine A Breetz, Catherine A Marti. Treatment of Depression in Adolescents With Myasthenia Gravis. Cureus. vol 16. issue 4. 2024-05-18. PMID:38756305. |
this case highlights the value of further investigation into the safety and efficacy of selective serotonin reuptake inhibitors (ssris) in the management of depression among pediatric patients with mg. |
2024-05-18 |
2024-05-27 |
Not clear |
| Si-Ting Chen, Feng Ran, Wen-Wen Shi, Cheng-Kan Liu, Peng-Chao Wang, Hui-Na Luo, Zeng-Ming Yan. Tryptophan in the mouse diet is essential for embryo implantation and decidualization. Frontiers in endocrinology. vol 15. 2024-05-16. PMID:38752181. |
the imbalance between serotonin and kynurenine pathways in trp metabolism is closely related to inflammation and depression. |
2024-05-16 |
2024-05-27 |
mouse |
| Wenbo Wang, Changbo Zhu, Ting Jia, Meidan Zu, Yandong Tang, Liqin Zhou, Yanghua Tian, Bailu Si, Ke Zho. Reviving Bistable Perception in Patients With Depression by Decreasing the Overestimation of Prior Precision. Cognitive science. vol 48. issue 5. 2024-05-14. PMID:38742272. |
these findings indicated that the substantially slower perception switch rate in patients with depression was caused by the greater reliance on top-down priors and that serotonin treatment's efficacy was in its recalibration of these priors and enhancement of pe. |
2024-05-14 |
2024-05-27 |
Not clear |
| Hsin-Chieh Kung, Ngoc-Han Bui, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chie. Biosynthetic Pathways of Tryptophan Metabolites in International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731967. |
biosynthetic pathways of tryptophan metabolites in tryptophan metabolites, such as 5-hydroxytryptophan (5-htp), serotonin, and melatonin, hold significant promise as supplements for managing various mood-related disorders, including depression and insomnia. |
2024-05-11 |
2024-05-27 |
Not clear |
| Shashi B Singh, Atit Tiwari, Maanya R Katta, Riju Kafle, Cyrus Ayubcha, Krishna H Patel, Yash Bhattarai, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revhei. The utility of PET imaging in depression. Frontiers in psychiatry. vol 15. 2024-05-08. PMID:38711875. |
studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, gaba, and glutamate, which are linked to the pathophysiology of depression. |
2024-05-08 |
2024-05-27 |
Not clear |
| Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozz. ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling. iScience. vol 27. issue 5. 2024-05-08. PMID:38711453. |
collectively, these data identify er stress in 5-ht neurons as a cellular pathway involved in the pathophysiology of depression and show that eif2α is critical in eliciting ketamine's fast antidepressant effects. |
2024-05-08 |
2024-05-27 |
mouse |
| Hu-Jiang Shi, Yi-Ren Xue, Hua Shao, Cheng Wei, Ting Liu, Jie He, Yu-Hao Yang, Hong-Mei Wang, Na Li, Si-Qiang Ren, Lei Chang, Zhen Wang, Li-Juan Zh. Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours. Brain : a journal of neurology. 2024-05-03. PMID:38701344. |
the implication of 5-hydroxytryptamine 2c receptor (5-ht2cr) in depression is a topic of debate, and the underlying mechanisms remain largely unclear. |
2024-05-03 |
2024-05-06 |
Not clear |
| M Gärde, G J Matheson, K Varnäs, P Svenningsson, E Hedman-Lagerlöf, J Lundberg, L Farde, M Tige. Altered serotonin 1B receptor binding after escitalopram for depression is correlated with treatment effect. The international journal of neuropsychopharmacology. 2024-05-02. PMID:38695786. |
altered serotonin 1b receptor binding after escitalopram for depression is correlated with treatment effect. |
2024-05-02 |
2024-05-04 |
human |
| Bartosz Bobula, Magdalena Kusek, Grzegorz Hes. The 5-HT Pharmacology, biochemistry, and behavior. 2024-04-30. PMID:38688436. |
the 5-ht the use of a selective serotonin reuptake inhibitor fluoxetine in depression during pregnancy and the postpartum period might increase the risk of affective disorders and cognitive symptoms in progeny. |
2024-04-30 |
2024-05-03 |
mouse |
| Ying Yang, Ying Lai, Xueli Tong, Zipei Li, Yuanyuan Cheng, Li-Wen Tia. Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway. Journal of ethnopharmacology. 2024-04-26. PMID:38670408. |
neuroinflammation is involved in the pathogenesis of depression disorder by activating microglia cells, increasing proinflammatory cytokines, effecting serotonin synthesis and metabolism, and neuronal apoptosis and neurogenesis. |
2024-04-26 |
2024-04-29 |
Not clear |
| Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huy. The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. Psychological medicine. 2024-04-17. PMID:38629200. |
the selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. |
2024-04-17 |
2024-04-19 |
Not clear |
| Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huy. The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. Psychological medicine. 2024-04-17. PMID:38629200. |
selective serotonin reuptake inhibitors (ssris) are first-line pharmacological treatments for depression and anxiety. |
2024-04-17 |
2024-04-19 |
Not clear |
| Rajagopal Kalirajan, Khare Rishabh, Jupudi Srikanth, Modi Niharika, Negi Preeya, Islam Rezau. Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. Archives of Razi Institute. vol 78. issue 5. 2024-04-09. PMID:38590677. |
according to the monoamine-deficiency hypothesis, the underlying pathophysiology of depression is a deficiency of some neurotransmitters (serotonin, norepinephrine, or dopamine) in the central nervous system. |
2024-04-09 |
2024-04-11 |
Not clear |