| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia-Wei Zeng, Juan-Li Zhao, Zhen-Jie Han, Yan-Jun Duan, Li Li. Narrative Review: Pathogenesis of the Inflammatory Response and Intestinal Flora in Depression. Neuropsychiatric disease and treatment. vol 19. 2023-12-01. PMID:38029049. |
the pathogenesis of depression is complex, and the current therapeutic drugs such as tricyclic antidepressants (tcas), monoamine oxidase inhibitors, and secondary serotonin reuptake inhibitors have certain shortcomings. |
2023-12-01 |
2023-12-10 |
Not clear |
| Albino J Oliveira-Maia, Benoit Rive, Joachim Morrens, Yordan Godinov, Jedelyn Cabrieto, Nolen Perualila, Siobhán Mulhern-Haughe. Indirect adjusted comparison of 6-month clinical outcomes between esketamine nasal spray and other real-world polypharmacy treatment strategies for treatment resistant depression: results from the ICEBERG study. Frontiers in psychiatry. vol 14. 2023-12-01. PMID:38025416. |
the efficacy of esketamine nasal spray (ns) as a rapid-acting agent for treatment resistant depression (trd) was demonstrated in comparisons with placebo, when both were given in addition to a newly initiated selective serotonin reuptake inhibitor (ssri)/serotonin norepinephrine reuptake inhibitor (snri). |
2023-11-29 |
2023-12-07 |
Not clear |
| Yu Fang, Yanqing Li, Xin Liao, Jie Deng, Qiannan Wang, Jingtao Liang, Bohua Ya. Journal of medicinal food. 2023-11-27. PMID:38010856. |
increasing evidence suggested that the gut microbiota and the 5-hydroxytryptamine (5-ht) pathway both contribute significantly to depression. |
2023-11-27 |
2023-11-29 |
Not clear |
| Wei Li, Zuqi Shen, Xuan Yin, Weiqi Chang, Xiaorong Chen, Jin Yu, Shifen X. Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors. Translational psychiatry. vol 13. issue 1. 2023-11-24. PMID:37993435. |
the dorsal raphe nucleus (drn), the main brain region producing 5-ht, is crucially involved in the pathophysiology of depression. |
2023-11-24 |
2023-11-28 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a common thread linking different classes of antidepressants. Cell chemical biology. 2023-11-22. PMID:37992715. |
our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis, and the monoamine hypothesis). |
2023-11-22 |
2023-11-29 |
mouse |
| Jing Huang, Weijun Huang, Junzhe Yi, Yiwen Deng, Ruijie Li, Jieying Chen, Jiahao Shi, Yuan Qiu, Tao Wang, Xiaoyong Chen, Xiaoran Zhang, Andy Peng Xian. Mesenchymal stromal cells alleviate depressive and anxiety-like behaviors via a lung vagal-to-brain axis in male mice. Nature communications. vol 14. issue 1. 2023-11-17. PMID:37973914. |
here, using murine depression models, we demonstrated that mscs could alleviate depressive and anxiety-like behaviors not due to a reduction in proinflammatory cytokines, but rather activation of dorsal raphe nucleus (drn) 5-hydroxytryptamine (5-ht) neurons. |
2023-11-17 |
2023-11-20 |
mouse |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Rabab S Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of brain renin-angiotensin system in depression: A new perspective. CNS neuroscience & therapeutics. 2023-11-13. PMID:37953501. |
the pathophysiology of depression is related to the deficiency of serotonin (5ht), which is derived from tryptophan (trp). |
2023-11-13 |
2023-11-20 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Rabab S Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of brain renin-angiotensin system in depression: A new perspective. CNS neuroscience & therapeutics. 2023-11-13. PMID:37953501. |
dysregulation of brain ras triggers the development and progression of depression through the reduction of brain 5ht and expression of brain-derived neurotrophic factor (bdnf) and the induction of mitochondrial dysfunction, oxidative stress, and neuroinflammation. |
2023-11-13 |
2023-11-20 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Rabab S Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of brain renin-angiotensin system in depression: A new perspective. CNS neuroscience & therapeutics. 2023-11-13. PMID:37953501. |
therefore, inhibition of central classical ras by arbs and aceis and activation of non-classical ras prevent the development of depression by regulating 5ht, bdnf, mitochondrial dysfunction, oxidative stress, and neuroinflammation. |
2023-11-13 |
2023-11-20 |
Not clear |
| Ahsen Demirhan Kayacik, Kevser İlciogl. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials. Archives of women's mental health. 2023-11-09. PMID:37945913. |
to identify rcts examining the effect of melatonin supplementation on depression and anxiety scores in postmenopausal women, a comprehensive electronic search was conducted via the cochrane central register of controlled trials, science direct, google scholar, pubmed, medline, scopus and web of science databases using the keywords ("melatonin" or "n-acetyl serotonin") and ("menopause" or "climacteric") and ("depression" or "anxiety"). |
2023-11-09 |
2023-11-20 |
Not clear |
| Jiawen Liu, Tianwei Meng, Chaojie Wang, Weiping Cheng, Qi Zhang, Guangyu Chen. Natural products for the treatment of depression: Insights into signal pathways influencing the hypothalamic-pituitary-adrenal axis. Medicine. vol 102. issue 44. 2023-11-07. PMID:37932977. |
contemporary therapeutic approaches for depression encompass the administration of serotonin reuptake inhibitors, monoamine oxidase inhibitors, and tricyclic antidepressants, albeit these pharmaceuticals potentially induce adverse neurological and gastrointestinal effects. |
2023-11-07 |
2023-11-08 |
Not clear |
| Dogukan Koc, Hanan El Marroun, Bruno H Stricker, Ryan L Muetzel, Henning Tiemeie. Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories from Late Childhood to Adolescence. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2023-11-05. PMID:37926188. |
during pregnancy, both selective serotonin reuptake inhibitor (ssri) exposure and maternal depression have been associated with poor offspring neurodevelopmental outcomes. |
2023-11-05 |
2023-11-08 |
Not clear |
| Kristal Potter, Erysa J Gayle, Subrata De. Effect of gut microbiome on serotonin metabolism: a personalized treatment approach. Naunyn-Schmiedeberg's archives of pharmacology. 2023-11-03. PMID:37922012. |
the goal of the current work is to review the effect of the gut microbiome on serotonin metabolism, and how it can potentially contribute to the development of a personalized treatment approach for depression and anxiety. |
2023-11-03 |
2023-11-08 |
Not clear |
| Philip J Cowe. SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC? Current topics in behavioral neurosciences. 2023-11-03. PMID:37922101. |
the widespread adoption of selective serotonin reuptake inhibitors (ssris) as first-line pharmacological treatments in the management of clinical depression transformed the landscape of drug therapy for this condition. |
2023-11-03 |
2023-11-08 |
Not clear |
| b' Edgar Specker, Radoslaw Wesolowski, Anja Sch\\xc3\\xbctz, Susann Matthes, Keven Mallow, Malgorzata Wasinska-Kalwa, Lars Winkler, Andreas Oder, Natalia Alenina, Dirk Pleimes, Jens Peter von Kries, Udo Heinemann, Michael Bader, Marc Nazar\\xc3\\xa. Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. Journal of medicinal chemistry. 2023-10-31. PMID:37905925.' |
a reduction of serotonin levels, especially in the brain, can cause dysregulation leading to depression or insomnia. |
2023-10-31 |
2023-11-08 |
Not clear |
| Gaël Villanueva-Charbonneau, Stéphane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-Édouard Giguère, Marie-Ève Koué, Édouard Kouass. Serotonin Transporter mRNA Expression Is Reduced in the Peripheral Blood Mononuclear Cells of Subjects with Major Depression but Normal in Fibromyalgia. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891852. |
serotonin transporter mrna expression is reduced in the peripheral blood mononuclear cells of subjects with major depression but normal in fibromyalgia. |
2023-10-30 |
2023-11-08 |
human |
| Enav Z Zusman, Cecil M Y Chau, Jeffrey N Bone, Kaia Hookenson, Ursula Brain, Melissa B Glier, Ruth E Grunau, Joanne Weinberg, Angela M Devlin, Tim F Oberlande. Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6-year-old children of depressed mothers: A cohort study. Developmental psychobiology. vol 65. issue 7. 2023-10-20. PMID:37860904. |
prenatal exposure to maternal depression and serotonin reuptake inhibitor (sri) antidepressants both affect the development of the hypothalamic-pituitary-adrenal (hpa) system, possibly via the neurotransmitter serotonin (5ht). |
2023-10-20 |
2023-11-08 |
Not clear |
| Hongyan Pei, Rui Du, Zhongmei He, Jinhao Bi, Liping Zhai, Heping She. Atractylenolide I improves behaviors in mice with depression-like phenotype by modulating neurotransmitter balance via 5-HT2A. Phytotherapy research : PTR. 2023-10-19. PMID:37857401. |
through elevated plus maze, open field, tail suspension, and forced swimming tests, the behavioral changes of mice with depression (chronic unpredictable mild stress [cums]) were examined, and the levels of neurotransmitters including serotonin, dopamine, and norepinephrine (5-ht, da, and ne) were determined. |
2023-10-19 |
2023-11-08 |
mouse |
| Paul R Albert, Pierre Blie. Does serotonin matter in depression? Journal of psychiatry & neuroscience : JPN. vol 48. issue 5. 2023-10-19. PMID:37857415. |
does serotonin matter in depression? |
2023-10-19 |
2023-11-08 |
Not clear |
| Arya Rahbarnia, Zhaoxia Li, Paul J Fletche. Effects of psilocybin, the 5-HT Psychopharmacology. 2023-10-19. PMID:37855864. |
effects of psilocybin, the 5-ht neuropsychiatric disorders such as depression are characterized in part by attention deficits. |
2023-10-19 |
2023-11-08 |
Not clear |