| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhang, Ying Jin, Fu-Ming Zho. Chronic fluoxetine treatment desensitizes serotoninergic inhibition of GABA inputs and the intrinsic excitability of dorsal raphe serotonin neurons. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766100. |
serotonin reuptake inhibitors (ssris) increase the synaptic and extracellular 5-ht level and are effective in treating depression. |
2024-05-20 |
2024-05-27 |
Not clear |
| Mariana I Arce, Katherine A Breetz, Catherine A Marti. Treatment of Depression in Adolescents With Myasthenia Gravis. Cureus. vol 16. issue 4. 2024-05-18. PMID:38756305. |
this case highlights the value of further investigation into the safety and efficacy of selective serotonin reuptake inhibitors (ssris) in the management of depression among pediatric patients with mg. |
2024-05-18 |
2024-05-27 |
Not clear |
| Si-Ting Chen, Feng Ran, Wen-Wen Shi, Cheng-Kan Liu, Peng-Chao Wang, Hui-Na Luo, Zeng-Ming Yan. Tryptophan in the mouse diet is essential for embryo implantation and decidualization. Frontiers in endocrinology. vol 15. 2024-05-16. PMID:38752181. |
the imbalance between serotonin and kynurenine pathways in trp metabolism is closely related to inflammation and depression. |
2024-05-16 |
2024-05-27 |
mouse |
| Wenbo Wang, Changbo Zhu, Ting Jia, Meidan Zu, Yandong Tang, Liqin Zhou, Yanghua Tian, Bailu Si, Ke Zho. Reviving Bistable Perception in Patients With Depression by Decreasing the Overestimation of Prior Precision. Cognitive science. vol 48. issue 5. 2024-05-14. PMID:38742272. |
these findings indicated that the substantially slower perception switch rate in patients with depression was caused by the greater reliance on top-down priors and that serotonin treatment's efficacy was in its recalibration of these priors and enhancement of pe. |
2024-05-14 |
2024-05-27 |
Not clear |
| Hsin-Chieh Kung, Ngoc-Han Bui, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chie. Biosynthetic Pathways of Tryptophan Metabolites in International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731967. |
biosynthetic pathways of tryptophan metabolites in tryptophan metabolites, such as 5-hydroxytryptophan (5-htp), serotonin, and melatonin, hold significant promise as supplements for managing various mood-related disorders, including depression and insomnia. |
2024-05-11 |
2024-05-27 |
Not clear |
| Shashi B Singh, Atit Tiwari, Maanya R Katta, Riju Kafle, Cyrus Ayubcha, Krishna H Patel, Yash Bhattarai, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revhei. The utility of PET imaging in depression. Frontiers in psychiatry. vol 15. 2024-05-08. PMID:38711875. |
studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, gaba, and glutamate, which are linked to the pathophysiology of depression. |
2024-05-08 |
2024-05-27 |
Not clear |
| Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozz. ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling. iScience. vol 27. issue 5. 2024-05-08. PMID:38711453. |
collectively, these data identify er stress in 5-ht neurons as a cellular pathway involved in the pathophysiology of depression and show that eif2α is critical in eliciting ketamine's fast antidepressant effects. |
2024-05-08 |
2024-05-27 |
mouse |
| Hu-Jiang Shi, Yi-Ren Xue, Hua Shao, Cheng Wei, Ting Liu, Jie He, Yu-Hao Yang, Hong-Mei Wang, Na Li, Si-Qiang Ren, Lei Chang, Zhen Wang, Li-Juan Zh. Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours. Brain : a journal of neurology. 2024-05-03. PMID:38701344. |
the implication of 5-hydroxytryptamine 2c receptor (5-ht2cr) in depression is a topic of debate, and the underlying mechanisms remain largely unclear. |
2024-05-03 |
2024-05-06 |
Not clear |
| M Gärde, G J Matheson, K Varnäs, P Svenningsson, E Hedman-Lagerlöf, J Lundberg, L Farde, M Tige. Altered serotonin 1B receptor binding after escitalopram for depression is correlated with treatment effect. The international journal of neuropsychopharmacology. 2024-05-02. PMID:38695786. |
altered serotonin 1b receptor binding after escitalopram for depression is correlated with treatment effect. |
2024-05-02 |
2024-05-04 |
human |
| Bartosz Bobula, Magdalena Kusek, Grzegorz Hes. The 5-HT Pharmacology, biochemistry, and behavior. 2024-04-30. PMID:38688436. |
the 5-ht the use of a selective serotonin reuptake inhibitor fluoxetine in depression during pregnancy and the postpartum period might increase the risk of affective disorders and cognitive symptoms in progeny. |
2024-04-30 |
2024-05-03 |
mouse |
| Ying Yang, Ying Lai, Xueli Tong, Zipei Li, Yuanyuan Cheng, Li-Wen Tia. Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway. Journal of ethnopharmacology. 2024-04-26. PMID:38670408. |
neuroinflammation is involved in the pathogenesis of depression disorder by activating microglia cells, increasing proinflammatory cytokines, effecting serotonin synthesis and metabolism, and neuronal apoptosis and neurogenesis. |
2024-04-26 |
2024-04-29 |
Not clear |
| Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huy. The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. Psychological medicine. 2024-04-17. PMID:38629200. |
the selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. |
2024-04-17 |
2024-04-19 |
Not clear |
| Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huy. The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. Psychological medicine. 2024-04-17. PMID:38629200. |
selective serotonin reuptake inhibitors (ssris) are first-line pharmacological treatments for depression and anxiety. |
2024-04-17 |
2024-04-19 |
Not clear |
| Rajagopal Kalirajan, Khare Rishabh, Jupudi Srikanth, Modi Niharika, Negi Preeya, Islam Rezau. Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. Archives of Razi Institute. vol 78. issue 5. 2024-04-09. PMID:38590677. |
according to the monoamine-deficiency hypothesis, the underlying pathophysiology of depression is a deficiency of some neurotransmitters (serotonin, norepinephrine, or dopamine) in the central nervous system. |
2024-04-09 |
2024-04-11 |
Not clear |
| Rajagopal Kalirajan, Khare Rishabh, Jupudi Srikanth, Modi Niharika, Negi Preeya, Islam Rezau. Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. Archives of Razi Institute. vol 78. issue 5. 2024-04-09. PMID:38590677. |
the neurotransmitter serotonin has drawn the most attention concerning depression. |
2024-04-09 |
2024-04-11 |
Not clear |
| Mai M Anwar, Ibrahim M Ibrahim Lail. The ameliorating effect of Rutin on hepatotoxicity and inflammation induced by the daily administration of vortioxetine in rats. BMC complementary medicine and therapies. vol 24. issue 1. 2024-04-08. PMID:38581023. |
vortioxetine (vortx) is a potent and selective type of selective serotonin reuptake inhibitor (ssri) that is mainly prescribed for treating major depression along with mood disorders as the first drug of choice. |
2024-04-08 |
2024-04-10 |
rat |
| Samineh Nasseri, Shadi Hajrasouliha, Salar Vaseghi, Batool Ghorbani Yekt. Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. 2024-04-03. PMID:38568290. |
selective serotonin reuptake inhibitors (ssris) are widely used drugs for the treatment of depression. |
2024-04-03 |
2024-04-05 |
rat |
| Nastaran Talaee, Shataw Azadvar, Sanaz Khodadadi, Nahal Abbasi, Zahra Najafi Asli-Pashaki, Yasaman Mirabzadeh, Gita Kholghi, Shahin Akhondzadeh, Salar Vasegh. Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review. European journal of clinical pharmacology. 2024-04-01. PMID:38558317. |
it seems that selective serotonin reuptake inhibitors (ssris) improve depression via affecting bdnf level. |
2024-04-01 |
2024-04-04 |
human |
| Zainab Zakaraya, Mohammad Abu Assab, Lina N Tamimi, Nida Karameh, Mohammad Hailat, Laila Al-Omari, Wael Abu Dayyih, Omar Alasasfeh, Mohammad Awad, Riad Awa. Pharmacokinetics and Pharmacodynamics: A Comprehensive Analysis of the Absorption, Distribution, Metabolism, and Excretion of Psychiatric Drugs. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543065. |
it is noteworthy that the inclusion of selective serotonin reuptake inhibitors (ssris) and serotonin-norepinephrine reuptake inhibitors (snris) in a comprehensive depression management protocol may demonstrate enhanced effectiveness in clinical environments as opposed to controlled trials. |
2024-03-28 |
2024-03-30 |
human |
| Iseline Cardon, Sonja Grobecker, Frederike Jenne, Tatjana Jahner, Rainer Rupprecht, Vladimir M Milenkovic, Christian H Wetze. Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression. Molecular psychiatry. 2024-03-27. PMID:38532010. |
serotonin effects on human ipsc-derived neural cell functions: from mitochondria to depression. |
2024-03-27 |
2024-03-29 |
human |