| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raquel Romay-Tallon, Erin Kulhawy, Kyle J Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M Olivares, Lisa E Kalynchuk, Hector J Carunch. Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30374301. |
naïve depression patients show alterations in serotonin transporter (sert) and serotonin 2a (5ht2a) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. |
2020-10-01 |
2023-08-13 |
human |
| Emmi Naskali, Katja Dettmer, Peter J Oefner, Pedro A B Pereira, Kai Krohn, Petri Auvinen, Annamari Ranki, Nicolas Kluge. Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED. Endocrine connections. vol 8. issue 1. 2020-10-01. PMID:30608907. |
conclusions this exploratory study found low serum levels of 5-ht to be associated with constipation and the presence of tph-1 and aadc aabs, but not with symptoms of depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gerdien A H Korte-Bouws, Eline Albers, Marije Voskamp, Hendrikus Hendriksen, Lidewij R de Leeuw, Onur Güntürkün, Sytze de Roock, Sebastiaan J Vastert, S Mechiel Kort. Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression. Pharmaceuticals (Basel, Switzerland). vol 12. issue 1. 2020-10-01. PMID:30625990. |
in the future, animal studies are needed to investigate whether inflammation-induced changes in these enzymatic pathways and co-factor bh4 lower the levels of the brain neurotransmitters glutamate, noradrenaline, dopamine, serotonin, and melatonin, and consequently, whether they may affect fatigue, cognition, anxiety, and depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Young-Woo Cho, Eun-Jin Kim, Marie Merci Nyiramana, Eui-Jung Shin, Hana Jin, Ji Hyeon Ryu, Kee Ryeon Kang, Gyeong-Won Lee, Hye Jung Kim, Jaehee Han, Dawon Kan. Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca Cancers. vol 11. issue 1. 2020-10-01. PMID:30634506. |
selective serotonin reuptake inhibitors (ssris), a group of antidepressants, are widely used for the treatment of patients with depression and a range of anxiety-related disorders. |
2020-10-01 |
2023-08-13 |
human |
| Yuki Higuchi, Tomoko Soga, Ishwar S Parha. Social Defeat Stress Decreases mRNA for Monoamine Oxidase A and Increases 5-HT Turnover in the Brain of Male Nile Tilapia ( Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30687104. |
social defeat stress decreases mrna for monoamine oxidase a and increases 5-ht turnover in the brain of male nile tilapia ( stress induces various neurobiological responses and causes psychiatric disorders, including depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lynn M Budzak, Waqas Yasin, Jennifer Mulhal. Raising More Than Moods: Escitalopram-Associated Priapism. Federal practitioner : for the health care professionals of the VA, DoD, and PHS. vol 36. issue 2. 2020-10-01. PMID:30867630. |
selective serotonin reuptake inhibitors are a common first choice medication for anxiety and depression treatment, but health care providers should be aware of priapism as a possible adverse effect. |
2020-10-01 |
2023-08-13 |
Not clear |
| Melodi A Bowman, Lynette C Daw. Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30872996. |
targeting serotonin transporters in the treatment of juvenile and adolescent depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hector J Caruncho, Tania Rivera-Baltanas, Raquel Romay-Tallon, Lisa E Kalynchuk, Jose M Olivare. Patterns of Membrane Protein Clustering in Peripheral Lymphocytes as Predictors of Therapeutic Outcomes in Major Depressive Disorder. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30930773. |
this review recapitulates how the ideas were originated, and the main findings demonstrated that analysis of serotonin transporter and serotonin 2 a receptor clustering in peripheral lymphocytes of naïve depression patients resulted in a discrimination of two subpopulations of depressed patients that showed a differential response upon 8 weeks of antidepressant treatment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zheng Gu, Liujie Chu, Yaqiong Ha. Therapeutic effect of resveratrol on mice with depression. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30936978. |
resveratrol can significantly increase the levels of neurotransmitters da and 5-ht in the prefrontal cortex and increase the expression of npy in the brain, which can play an antagonistic role in depression. |
2020-10-01 |
2023-08-13 |
mouse |
| Katherine Amodeo, Ruth B Schneider, Irene Hegeman Richar. Call to Caution with the Use of Atypical Antipsychotics for Treatment of Depression in Older Adults. Geriatrics (Basel, Switzerland). vol 1. issue 4. 2020-10-01. PMID:31022826. |
atypical antipsychotics are increasingly being used to manage depression in older adults where these symptoms can often be refractory to first-line treatment with selective serotonin reuptake inhibitors (ssris) or serotonin norepinephrine reuptake inhibitors (snris). |
2020-10-01 |
2023-08-13 |
Not clear |
| Amber E Faquih, Raheel I Memon, Hudaisa Hafeez, Muhammad Zeshan, Sadiq Navee. A Review of Novel Antidepressants: A Guide for Clinicians. Cureus. vol 11. issue 3. 2020-10-01. PMID:31106085. |
depression may not be caused by the simple deficiency of serotonin in the brain, but rather a complex interplay of various neurotransmitters including serotonin, norepinephrine, glutamate, and histamine at certain brain areas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rachel A Saylor, Melinda Hersey, Alyssa West, Anna Marie Buchanan, Shane N Berger, H Frederik Nijhout, Michael C Reed, Janet Best, Parastoo Hashem. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31110471. |
the biology of depression is not well understood, but experts agree that a key neurotransmitter of interest is serotonin. |
2020-10-01 |
2023-08-13 |
Not clear |
| Swati Shah, Sanhita Sinharay, Kenta Matsuda, William Schreiber-Stainthorp, Siva Muthusamy, Dianne Lee, Paul Wakim, Vanessa Hirsch, Avindra Nath, Michele Di Mascio, Dima A Hammou. Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31178771. |
potential mechanism for hiv-associated depression: upregulation of serotonin transporters in siv-infected macaques detected by 11c-dasb pet. |
2020-10-01 |
2023-08-13 |
Not clear |
| Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Gordon A Bar. Differences Between the Prenatal Effects of Fluoxetine or Buspirone Alone or in Combination on Pain and Affective Behaviors in Prenatally Stressed Male and Female Rats. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31244623. |
the selective serotonin reuptake inhibitor fluoxetine and the 5-ht1a receptor agonist buspirone are used to treat depression and anxiety. |
2020-10-01 |
2023-08-13 |
rat |
| Zoltan Ungvari, Stefano Tarantini, Andriy Yabluchanskiy, Anna Csisza. Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation. Frontiers in genetics. vol 10. 2020-10-01. PMID:31616477. |
potential adverse cardiovascular effects of treatment with fluoxetine and other selective serotonin reuptake inhibitors (ssris) in patients with geriatric depression: implications for atherogenesis and cerebromicrovascular dysregulation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zoltan Ungvari, Stefano Tarantini, Andriy Yabluchanskiy, Anna Csisza. Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation. Frontiers in genetics. vol 10. 2020-10-01. PMID:31616477. |
selective serotonin reuptake inhibitors (ssris), including fluoxetine, are often prescribed to treat geriatric depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yong Soo Park, Ki-Wug Sun. Selective serotonin reuptake inhibitor escitalopram inhibits 5-HT The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 23. issue 6. 2020-09-30. PMID:31680773. |
as an s-enantiomer of citalopram, it shows better therapeutic outcome in depression and anxiety disorder treatment because it has higher selectivity for serotonin reuptake transporter than citalopram. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
effect of electroacupuncture on reuptake of serotonin via mirna-16 expression in a rat model of depression. |
2020-09-30 |
2023-08-13 |
rat |
| b' Lidia Bravo, Meritxell Llorca-Torralba, Esther Berrocoso, Juan Antonio Mic\\xc3\\xb. Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31942167.' |
accordingly, drugs that modulate the monaminergic system and that were originally designed to treat depression are now considered to be first line treatments for certain types of neuropathic pain (e.g., serotonin and noradrenaline (and also dopamine) reuptake inhibitors). |
2020-09-30 |
2023-08-13 |
Not clear |
| Jonathan M Gregory, Joshua D Rosenblat, Roger S McIntyr. Deconstructing Diabetes and Depression: Clinical Context, Treatment Strategies, and New Directions. Focus (American Psychiatric Publishing). vol 14. issue 2. 2020-09-30. PMID:31975802. |
selective serotonin reuptake inhibitors effectively treat depression of patients with diabetes and positively influence glycemic control. |
2020-09-30 |
2023-08-13 |
Not clear |