| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barbara L Shay, Michael Sawchuk, David W Machacek, Shawn Hochma. Serotonin 5-HT2 receptors induce a long-lasting facilitation of spinal reflexes independent of ionotropic receptor activity. Journal of neurophysiology. vol 94. issue 4. 2005-12-30. PMID:16033939. |
serotonin more easily produced llfr in one substrain and a long-lasting depression of reflexes (lldr) in the other. |
2005-12-30 |
2023-08-12 |
rat |
| Herman M van Praa. Can stress cause depression? The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 6 Suppl 2. 2005-12-27. PMID:16166019. |
focussing on 5-ht and the stress hormones, this question was answered in the affirmative, based on the following two considerations: (1) changes in the 5-ht and stress hormone systems produced by sustained stress, mimic to a substantial extent the disturbances in these systems that may be observed in depression; (2) substantial evidence indicates that the 5-ht and stress hormone disturbances in depression are of pathophysiological significance and not merely a consequence of the depressed state or a product of stress generated by the depressed state. |
2005-12-27 |
2023-08-12 |
Not clear |
| S Hayley, M O Poulter, Z Merali, H Anisma. The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16154288. |
corticotropin releasing hormone, and corticoids) and central neurotransmitters (serotonin and gaba), alterations of neuronal plasticity or even neuronal survival may play a role in depression. |
2005-12-22 |
2023-08-12 |
Not clear |
| Yasuyuki Gondo, Nobuyoshi Hirose, Yasumichi Arai, Ken Yamamura, Ken-Ichirou Shimizu, Michiyo Takayama, Yoshinori Ebihara, Susumu Nakazawa, Hiroki Inagaki, Yukie Masui, Koji Kitagaw. Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians. Mechanisms of ageing and development. vol 126. issue 11. 2005-12-15. PMID:16095668. |
negative affect such as depression and anxiety has been reported to be associated with morbidity and mortality, and polymorphisms of the serotonin transporter (5htt) gene may be associated with such affect disorders. |
2005-12-15 |
2023-08-12 |
human |
| Saffron A G Willis-Owen, Maria G Turri, Marcus R Munafò, Paul G Surtees, Nick W J Wainwright, Richard D Brixey, Jonathan Flin. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biological psychiatry. vol 58. issue 6. 2005-12-07. PMID:16023085. |
the serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. |
2005-12-07 |
2023-08-12 |
human |
| Saffron A G Willis-Owen, Maria G Turri, Marcus R Munafò, Paul G Surtees, Nick W J Wainwright, Richard D Brixey, Jonathan Flin. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biological psychiatry. vol 58. issue 6. 2005-12-07. PMID:16023085. |
a promoter-based length polymorphism (5-httlpr) of the human serotonin gene (slc6a4) has exhibited inconsistent association with emotionality phenotypes, such as major depression (md) and the personality trait neuroticism (n). |
2005-12-07 |
2023-08-12 |
human |
| Surachai Likasitwattanaku. Serotonin syndrome: a case report. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 88. issue 7. 2005-12-01. PMID:16241032. |
the author reports a child with suprasellar region tumor who presented with depression and obsessive-compulsive disorder and received a combination of sertaline (selective serotonin reuptake inhibitor) and clomipramine (tricyclic antidepressant). |
2005-12-01 |
2023-08-12 |
Not clear |
| Patricia F Coogan, Julie R Palmer, Brian L Strom, Lynn Rosenber. Use of selective serotonin reuptake inhibitors and the risk of breast cancer. American journal of epidemiology. vol 162. issue 9. 2005-11-29. PMID:16177141. |
selective serotonin reuptake inhibitors (ssris) were introduced in 1987 and, by 1997, were prescribed to 58% of americans receiving outpatient treatment for depression. |
2005-11-29 |
2023-08-12 |
Not clear |
| L Lima, S Mata, M Urbin. Allelic isoforms and decrease in serotonin transporter mRNA in lymphocytes of patients with major depression. Neuroimmunomodulation. vol 12. issue 5. 2005-11-22. PMID:16166809. |
allelic isoforms and decrease in serotonin transporter mrna in lymphocytes of patients with major depression. |
2005-11-22 |
2023-08-12 |
human |
| L Lima, S Mata, M Urbin. Allelic isoforms and decrease in serotonin transporter mRNA in lymphocytes of patients with major depression. Neuroimmunomodulation. vol 12. issue 5. 2005-11-22. PMID:16166809. |
serotonin transporter, measured by the specific binding of [(3)h]paroxetine, has been reported to be reduced in circulating lymphocytes of patients with major depression. |
2005-11-22 |
2023-08-12 |
human |
| L Lima, S Mata, M Urbin. Allelic isoforms and decrease in serotonin transporter mRNA in lymphocytes of patients with major depression. Neuroimmunomodulation. vol 12. issue 5. 2005-11-22. PMID:16166809. |
due to this observation, the objective of the present report was to determine the levels of serotonin transporter mrna in lymphocytes obtained from 29 major depression patients (4 men, age 33.10+/-1.63 years) and from 30 subjects included as a control group (4 men, age 37.54+/-2.18 years) using rt-pcr. |
2005-11-22 |
2023-08-12 |
human |
| L Lima, S Mata, M Urbin. Allelic isoforms and decrease in serotonin transporter mRNA in lymphocytes of patients with major depression. Neuroimmunomodulation. vol 12. issue 5. 2005-11-22. PMID:16166809. |
the reduction in lymphocyte serotonin transporter described in major depression might be due to a decrease in the level of its mrna and in the number of cells expressing it. |
2005-11-22 |
2023-08-12 |
human |
| J Wang, F-Q Huo, Y-Q Li, T Chen, F Han, J-S Tan. Thalamic nucleus submedius receives GABAergic projection from thalamic reticular nucleus in the rat. Neuroscience. vol 134. issue 2. 2005-11-15. PMID:15964693. |
the present results provide a morphological evidence for a hypothesis that a disinhibitory effect on output neurons elicited by opioid or 5-hydroxytryptamine inhibiting a gabaergic terminal in the thalamic nucleus submedius may lead to activation of the descending inhibitory system and depression of the nociceptive inputs at the spinal cord level. |
2005-11-15 |
2023-08-12 |
rat |
| Ashwana D Fricker, Carl Rios, Lakshmi A Devi, Ivone Gome. Serotonin receptor activation leads to neurite outgrowth and neuronal survival. Brain research. Molecular brain research. vol 138. issue 2. 2005-11-14. PMID:15925428. |
serotonin 5-ht1 receptors are implicated in anxiety and depression. |
2005-11-14 |
2023-08-12 |
Not clear |
| Alessandro Serretti, Francesco Benedetti, Raffaella Zanardi, Enrico Smerald. The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15939518. |
among these, gene variants in sequences of serotonin pathway proteins were candidate, both for the well known evidence of its involvement in the development of depressive symptomathology and for the wide-world use of selective serotonin reuptake inhibitors as first choice treatment of depression. |
2005-10-27 |
2023-08-12 |
Not clear |
| Jeffrey L Rausc. Initial conditions of psychotropic drug response: studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:16005136. |
initial conditions of psychotropic drug response: studies of serotonin transporter long promoter region (5-httlpr), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome. |
2005-10-27 |
2023-08-12 |
human |
| Kazufumi Hirano, Takahiro Seki, Norio Sakai, Yasuhiro Kato, Hisakuni Hashimoto, Shinya Uchida, Shizuo Yamad. Effects of continuous administration of paroxetine on ligand binding site and expression of serotonin transporter protein in mouse brain. Brain research. vol 1053. issue 1-2. 2005-10-27. PMID:16051196. |
selective serotonin reuptake inhibitors (ssris), such as paroxetine, are utilized in the treatment of depression and anxiety disorders. |
2005-10-27 |
2023-08-12 |
mouse |
| Jun-ichi Iga, Shu-ichi Ueno, Ken Yamauchi, Ikuyo Motoki, Sumiko Tayoshi, Koshi Ohta, Hongwei Song, Kyoko Morita, Kazuhito Rokutan, Tetsuro Ohmor. Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. Neuroscience letters. vol 389. issue 1. 2005-10-27. PMID:16055263. |
serotonin transporter mrna expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. |
2005-10-27 |
2023-08-12 |
human |
| Jun-ichi Iga, Shu-ichi Ueno, Ken Yamauchi, Ikuyo Motoki, Sumiko Tayoshi, Koshi Ohta, Hongwei Song, Kyoko Morita, Kazuhito Rokutan, Tetsuro Ohmor. Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. Neuroscience letters. vol 389. issue 1. 2005-10-27. PMID:16055263. |
serotonin transporter (5htt) is thought to be involved in the pathophysiology of major depression and the target of antidepressants. |
2005-10-27 |
2023-08-12 |
human |
| Jun-ichi Iga, Shu-ichi Ueno, Ken Yamauchi, Ikuyo Motoki, Sumiko Tayoshi, Koshi Ohta, Hongwei Song, Kyoko Morita, Kazuhito Rokutan, Tetsuro Ohmor. Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. Neuroscience letters. vol 389. issue 1. 2005-10-27. PMID:16055263. |
our investigation suggested that the increased expression of 5htt mrna in peripheral leukocytes may be related with the pathophysiology of depression and its reduction after treatment may reflect the adaptive change induced by the antidepressant. |
2005-10-27 |
2023-08-12 |
human |