| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rinat Gizatullin, Ghazal Zaboli, Erik G Jönsson, Marie Asberg, Rosario Leopard. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biological psychiatry. vol 59. issue 4. 2006-04-04. PMID:16165107. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the biosynthesis of serotonin (5-ht) and might be related to the pathogenesis of major depression (md). |
2006-04-04 |
2023-08-12 |
Not clear |
| Takehiro Takahashi, Toru Kobayashi, Miwako Ozaki, Yukio Takamatsu, Yasukazu Ogai, Mitsuaki Ohta, Hideko Yamamoto, Kazutaka Iked. G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants. Neuroscience research. vol 54. issue 2. 2006-03-29. PMID:16310876. |
antidepressants, including tricyclic antidepressants (tcas) and selective serotonin reuptake inhibitors (ssris), have been widely used for the treatment of not only depression but also other psychiatric disorders, although the molecular mechanisms of the drug effects have not yet been sufficiently revealed. |
2006-03-29 |
2023-08-12 |
mouse |
| Anna Sivojelezova, Samar Shuhaiber, Lorig Sarkissian, Adrienne Einarson, Gideon Kore. Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome. American journal of obstetrics and gynecology. vol 193. issue 6. 2006-03-28. PMID:16325604. |
citalopram is a selective serotonin reuptake inhibitor indicated for depression. |
2006-03-28 |
2023-08-12 |
Not clear |
| Siegfried Kasper, Christian Spadone, Patrice Verpillat, Jules Angs. Onset of action of escitalopram compared with other antidepressants: results of a pooled analysis. International clinical psychopharmacology. vol 21. issue 2. 2006-03-28. PMID:16421462. |
to study the onset of effect of escitalopram, a selective serotonin reuptake inhibitor (ssri), data were pooled from controlled randomized clinical double-blind trials comparing this drug with other antidepressant drugs (ssris and venlafaxine xr) in major depressive disorder (mdd), with assessments of the primary efficacy parameter [mean change in the montgomery-asberg depression rating scale (madrs) total score from baseline, using last observation carried forward]. |
2006-03-28 |
2023-08-12 |
Not clear |
| Eija Koponen, Tomi Rantamäki, Vootele Voikar, Tommi Saarelainen, Ewen MacDonald, Eero Castré. Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cellular and molecular neurobiology. vol 25. issue 6. 2006-03-27. PMID:16392030. |
neurotrophins and serotonin have both been implicated in the pathophysiology of depression and in the mechanisms of antidepressant treatments. |
2006-03-27 |
2023-08-12 |
mouse |
| Lee E Schechter, Robert H Ring, Chad E Beyer, Zoë A Hughes, Xavier Khawaja, Jessica E Malberg, Sharon Rosenzweig-Lipso. Innovative approaches for the development of antidepressant drugs: current and future strategies. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 2. issue 4. 2006-03-23. PMID:16489368. |
despite the advances in the treatment of depression with selective serotonin reuptake inhibitors (ssris) and serotonin and norepinephrine reuptake inhibitors (snris), there continue to be many unmet clinical needs with respect to both efficacy and side effects. |
2006-03-23 |
2023-08-12 |
Not clear |
| Salvador Peiró, Pedro Cervera, Enrique Bernal-Delgad. [Selective serotonin reuptake inhibitors in childhood depression: a soap opera that reflects serious problems of drug safety]. Gaceta sanitaria. vol 19. issue 5. 2006-03-21. PMID:16242100. |
[selective serotonin reuptake inhibitors in childhood depression: a soap opera that reflects serious problems of drug safety]. |
2006-03-21 |
2023-08-12 |
Not clear |
| Viktor Roman, Irene Walstra, Paul G M Luiten, Peter Meerl. Too little sleep gradually desensitizes the serotonin 1A receptor system. Sleep. vol 28. issue 12. 2006-03-21. PMID:16408408. |
one of the proposed neurobiological mechanisms underlying depression is a disturbance in the brain's serotonergic neurotransmission, particularly a desensitization of the serotonin (5-ht)1a receptor system. |
2006-03-21 |
2023-08-12 |
Not clear |
| Kelly Brock, Bich Nguyen, Nianci Liu, Melissa Watkins, Thomas Reutze. The use of antidepressants in school-age children. The Journal of school nursing : the official publication of the National Association of School Nurses. vol 21. issue 6. 2006-03-10. PMID:16285841. |
the only antidepressant approved by the u.s. food and drug administration for the treatment of depression in children is fluoxetine (prozac), a selective serotonin reuptake inhibitor. |
2006-03-10 |
2023-08-12 |
Not clear |
| Eliyahu Dremencov, Yifat Weizmann, Noa Kinor, Iris Gispan-Herman, Gal Yadi. Modulation of dopamine transmission by 5HT2C and 5HT3 receptors: a role in the antidepressant response. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475958. |
this action of serotonin appears to be linked to depressive-like behavior and to onset of behavioral effects of antidepressants in an animal model of depression. |
2006-03-10 |
2023-08-12 |
Not clear |
| Ramin V Parsey, Maria A Oquendo, R Todd Ogden, Doreen M Olvet, Norman Simpson, Yung-Yu Huang, Ronald L Van Heertum, Victoria Arango, J John Man. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biological psychiatry. vol 59. issue 2. 2006-03-09. PMID:16154547. |
altered serotonin 1a binding in major depression: a [carbonyl-c-11]way100635 positron emission tomography study. |
2006-03-09 |
2023-08-12 |
human |
| Akira Kugaya, Gerard Sanacor. Beyond monoamines: glutamatergic function in mood disorders. CNS spectrums. vol 10. issue 10. 2006-03-08. PMID:16400244. |
the monoamine theory has implicated abnormalities in serotonin and norepinephrine in the pathophysiology of major depression and bipolar illness and contributed greatly to our understanding of mood disorders and their treatment. |
2006-03-08 |
2023-08-12 |
human |
| C Looney, K B Thor, D Ricca, L Marso. Differential effects of simultaneous or sequential administration of paroxetine and WAY-100,635 on ejaculatory behavior. Pharmacology, biochemistry, and behavior. vol 82. issue 3. 2006-03-02. PMID:16253317. |
clinical treatment of depression or anxiety with selective serotonin reuptake inhibitors (ssris) often results in delayed ejaculation or anorgasmia. |
2006-03-02 |
2023-08-12 |
rat |
| Janna L Morrison, Dan W Rurak, Caly Chien, David J Kennaway, Nancy Gruber, I Caroline McMillen, K Wayne Rigg. Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep. Journal of the Society for Gynecologic Investigation. vol 12. issue 5. 2006-02-28. PMID:15979548. |
depression during pregnancy is frequently treated with the selective serotonin reuptake inhibitor (ssri), fluoxetine (fx), commonly known as prozac (eli lilly & co, indianapolis, in). |
2006-02-28 |
2023-08-12 |
Not clear |
| Madelaine M Wohlreich, James M Martinez, Craig H Mallinckrodt, Apurva Prakash, John G Watkin, Maurizio Fav. An open-label study of duloxetine for the treatment of major depressive disorder: comparison of switching versus initiating treatment approaches. Journal of clinical psychopharmacology. vol 25. issue 6. 2006-02-28. PMID:16282837. |
the efficacy of duloxetine in patients switching from selective serotonin reuptake inhibitor/venlafaxine did not differ significantly from that observed in untreated patients initiating duloxetine therapy (baseline-to-end point mean changes: 17-item hamilton rating scale for depression total score, -13.1 vs. -13.5; hamilton rating scale for anxiety, -10.6 vs. -10.3; and clinical global impression of severity, -2.22 vs. -2.38, respectively). |
2006-02-28 |
2023-08-12 |
Not clear |
| Victor L Serebruan. Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? The American journal of medicine. vol 119. issue 2. 2006-02-27. PMID:16443409. |
selective serotonin reuptake inhibitors (ssris) are first line agents to treat clinical depression. |
2006-02-27 |
2023-08-12 |
Not clear |
| Leith C R Meyer, Andrea Fuller, Duncan Mitchel. Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 290. issue 2. 2006-02-23. PMID:16166206. |
neurophysiological studies have shown that serotonergic ligands that bind to 5-ht1a, 5-ht7, and 5-ht4 serotonin receptors in brain stem have beneficial effects on respiratory neurons during opioid-induced respiratory depression. |
2006-02-23 |
2023-08-12 |
Not clear |
| Julie K Staley, Gerard Sanacora, Gilles Tamagnan, Paul K Maciejewski, Robert T Malison, Robert M Berman, Meena Vythilingam, Akira Kugaya, Ronald M Baldwin, John P Seibyl, Dennis Charney, Robert B Inni. Sex differences in diencephalon serotonin transporter availability in major depression. Biological psychiatry. vol 59. issue 1. 2006-02-21. PMID:16139815. |
sex differences in diencephalon serotonin transporter availability in major depression. |
2006-02-21 |
2023-08-12 |
Not clear |
| Maida J Sewitch, Régis Blais, Elham Rahme, Brian Bexton, Sophie Galarnea. Pharmacologic response to depressive disorders among adolescents. Psychiatric services (Washington, D.C.). vol 56. issue 9. 2006-02-15. PMID:16148322. |
the purpose of this study was to identify determinants of use of psychoactive medication and receipt of selective serotonin reuptake inhibitors (ssris) among adolescents with a diagnosis of new-onset depression. |
2006-02-15 |
2023-08-12 |
Not clear |
| S Mata, M Urbina, E Manzano, T Ortiz, L Lim. Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression. Journal of neuroimmunology. vol 170. issue 1-2. 2006-02-14. PMID:16242784. |
the objective of this work was to determine the presence of noradrenaline transporters, the turnover rate of noradrenaline and serotonin in lymphocytes of major depression patients, and to correlate the biochemical parameters with the severity of the disorder. |
2006-02-14 |
2023-08-12 |
Not clear |