| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula Zaręba, Kinga Sałat, Georg C Höfner, Kamil Łątka, Marek Bajda, Gniewomir Latacz, Krzysztof Kotniewicz, Anna Rapacz, Adrian Podkowa, Maciej Maj, Krzysztof Jóźwiak, Barbara Filipek, Klaus T Wanner, Barbara Malawska, Katarzyna Kuli. Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. European journal of medicinal chemistry. vol 221. 2021-08-06. PMID:34015586. |
numerous studies have indicated that inhibitors of the gaba transporters mgat1-4 offer a promising strategy for the treatment of several neurological disorders, including epilepsy, neuropathic pain, and depression. |
2021-08-06 |
2023-08-13 |
Not clear |
| Ji-Hong Liu, Ze-Lin Li, Yi-Si Liu, Huai-De Chu, Neng-Yuan Hu, Ding-Yu Wu, Lang Huang, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Ga. Astrocytic GABA Neuroscience bulletin. vol 36. issue 7. 2021-07-19. PMID:32166647. |
in addition, much evidence has implicated altered function of the gamma-aminobutyric acid (gabaergic) system in the pathophysiology of depression. |
2021-07-19 |
2023-08-13 |
Not clear |
| Fu-Wen Zhou, Adam C Puch. Short-Term Plasticity in Cortical GABAergic Synapses on Olfactory Bulb Granule Cells Is Modulated by Endocannabinoids. Frontiers in cellular neuroscience. vol 15. 2021-07-15. PMID:33633545. |
selective optical activation of chr2 positive axons/terminals generated strong, frequency-dependent short-term depression of gaba |
2021-07-15 |
2023-08-13 |
Not clear |
| Vera J Erchinger, Jeremy Miller, Thomas Jones, Ute Kessler, Juan Bustillo, Jan Haavik, Jonathan Petrillo, Gregory Ziomek, Åsa Hammar, Ketil J Oedegaard, Vince D Calhoun, Shawn M McClintock, Lars Ersland, Leif Oltedal, Christopher C Abbot. Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and behavior. vol 10. issue 11. 2021-06-24. PMID:32940003. |
results of prior studies investigating the role of the inhibitory neurotransmitter gamma-aminobutyric acid ("gaba+", gaba and coedited macromolecules) in the pathophysiology and treatment of depression remain inconclusive. |
2021-06-24 |
2023-08-13 |
human |
| Pradeep Paudel, Samir Ross, Xing-Cong L. Molecular Targets of Cannabinoids Associated with Depression. Current medicinal chemistry. 2021-06-24. PMID:34165403. |
this review highlights cannabinoid (cb) receptors, monoamine oxidase (mao), n-methyl-d-aspartate (nmda) receptor, gamma-aminobutyric acid (gaba) receptor, and cholecystokinin (cck) receptor as key molecular targets of cannabinoids that are associated with depression. |
2021-06-24 |
2023-08-13 |
Not clear |
| P N Suresh Kumar, Abhay Sharma, Chittaranjan Andrad. A pilot, open-label investigation of the efficacy of glucosamine for the treatment of major depression. Asian journal of psychiatry. vol 52. 2021-06-21. PMID:32388446. |
glucosamine hydrochloride normalizes gaba antagonist- and social defeat-induced behavioral alterations and upregulation of immune response genes in drosophila and mice, respectively, increases hippocampal neurogenesis in mice, and demonstrates efficacy in murine behavioral models of depression. |
2021-06-21 |
2023-08-13 |
mouse |
| Chad Diederichs, Marilena M DeMayo, Jaeden Cole, Lakshmi N Yatham, Ashley D Harris, Alexander McGir. Intermittent Theta-Burst Stimulation Transcranial Magnetic Stimulation Increases GABA in the Medial Prefrontal Cortex: A Preliminary Sham-Controlled Magnetic Resonance Spectroscopy Study in Acute Bipolar Depression. Frontiers in psychiatry. vol 12. 2021-05-30. PMID:34045983. |
intermittent theta-burst stimulation transcranial magnetic stimulation increases gaba in the medial prefrontal cortex: a preliminary sham-controlled magnetic resonance spectroscopy study in acute bipolar depression. |
2021-05-30 |
2023-08-13 |
Not clear |
| Dayong Lee, Peter Stout, Donald Egdor. Houston Cocktail: Driving under influence of hydrocodone, alprazolam, and carisoprodol. Forensic science international. vol 323. 2021-05-24. PMID:33964487. |
concurrent use of opioids, benzodiazepines, and skeletal muscle relaxants potentiates the drug effect and respiratory depression via interactions of μ-opioid and gaba |
2021-05-24 |
2023-08-13 |
Not clear |
| Kinga Gawlińska, Joanna Jastrzębska, Sara Gamberini, Dawid Gawliński, Renata Pieniążek, Agata Suder, Karolina Wydra, Małgorzata Frankowsk. The impact of GABA European journal of pharmacology. vol 883. 2021-05-18. PMID:32621910. |
the impact of gaba depression and cocaine use disorder represent frequent co-current diagnoses and the gaba |
2021-05-18 |
2023-08-13 |
Not clear |
| Maciej Korczak, Przemysław Kurowski, Anna Leśniak, Alfhild Grönbladh, Anna Filipowska, Magdalena Bujalska-Zadrożn. GABA European journal of pharmacology. vol 885. 2021-05-18. PMID:32871173. |
gaba affecting over 320 million people around the world, depression has become a formidable challenge for modern medicine. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tracie A Paine, Sara Chang, Rachel Poyl. Contribution of GABA Behavioural brain research. vol 378. 2021-04-28. PMID:31560920. |
contribution of gaba gaba dysfunction is associated with a number of psychiatric conditions including schizophrenia, autism and depression. |
2021-04-28 |
2023-08-13 |
Not clear |
| Matea Nikolac Perkovic, Marina Sagud, Lucija Tudor, Marcela Konjevod, Dubravka Svob Strac, Nela Piva. A Load to Find Clinically Useful Biomarkers for Depression. Advances in experimental medicine and biology. vol 1305. 2021-04-12. PMID:33834401. |
future multimodal preclinical and clinical research that involves (epi)genetic, molecular, cellular, imaging, and other studies is necessary to advance our understanding of the role of monoamines, gaba, hpa axis, neurotrophins, metabolome, and glycome in the pathogenesis of depression and their potential as diagnostic, prognostic, and treatment response biomarkers. |
2021-04-12 |
2023-08-13 |
Not clear |
| Ipsit Srivastava, Erika Vazquez-Juarez, Lukas Henning, Marta Gómez-Galán, Maria Lindsko. Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression. Cells. vol 9. issue 7. 2021-03-05. PMID:32708718. |
blocking astrocytic gaba restores synaptic plasticity in prefrontal cortex of rat model of depression. |
2021-03-05 |
2023-08-13 |
rat |
| Ipsit Srivastava, Erika Vazquez-Juarez, Lukas Henning, Marta Gómez-Galán, Maria Lindsko. Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression. Cells. vol 9. issue 7. 2021-03-05. PMID:32708718. |
in this study we found decreased plasticity and increased tonic gaba inhibition in the prelimbic area in acute slices from the medial prefrontal cortex in the flinders sensitive line (fsl) rat model of depression. |
2021-03-05 |
2023-08-13 |
rat |
| Sharmineh Sharafi, Leila Nategh. Optimization of gamma-aminobutyric acid production by probiotic bacteria through response surface methodology. Iranian journal of microbiology. vol 12. issue 6. 2021-02-23. PMID:33613913. |
gamma-aminobutyric acid (gaba) is a non-protein four-carbon amino acid that has many physiological properties, including reducing blood pressure, accelerating protein synthesis in the brain, and treatment of insomnia and depression. |
2021-02-23 |
2023-08-13 |
Not clear |
| Zhen Wu, Pengyu Wang, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zha. Effect of adzuki bean sprout fermented milk enriched in γ-aminobutyric acid on mild depression in a mouse model. Journal of dairy science. vol 104. issue 1. 2021-02-22. PMID:33162095. |
this study focused on the ability of adzuki bean (vigna angularis) sprout fermented milk, which is rich in γ-aminobutyric acid (gaba), to relieve anxiety and mild depression. |
2021-02-22 |
2023-08-13 |
mouse |
| Sophie Schweizer-Schubert, Jennifer L Gordon, Tory A Eisenlohr-Moul, Samantha Meltzer-Brody, Katja M Schmalenberger, Radoslaw Slopien, Anna-Lena Zietlow, Ulrike Ehlert, Beate Ditze. Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABA Frontiers in medicine. vol 7. 2021-02-16. PMID:33585496. |
steroid hormone sensitivity in reproductive mood disorders: on the role of the gaba women worldwide are two to three times more likely to suffer from depression in their lifetime than are men. |
2021-02-16 |
2023-08-13 |
Not clear |
| Paola Ortelli, Davide Ferrazzoli, Luca Sebastianelli, Michael Engl, Roberto Romanello, Raffaele Nardone, Ilenia Bonini, Giacomo Koch, Leopold Saltuari, Angelo Quartarone, Antonio Oliviero, Markus Kofler, Viviana Versac. Neuropsychological and neurophysiological correlates of fatigue in post-acute patients with neurological manifestations of COVID-19: Insights into a challenging symptom. Journal of the neurological sciences. vol 420. 2021-02-09. PMID:33359928. |
abnormal sp shortening and lack of mep depression concur with a reduction in post-exhaustion corticomotor inhibition, suggesting a possible gaba |
2021-02-09 |
2023-08-13 |
human |
| Thu Ha Pham, Céline Defaix, Thi Mai Loan Nguyen, Indira Mendez-David, Laurent Tritschler, Denis J David, Alain M Gardie. Cortical and raphe GABA Pharmacology, biochemistry, and behavior. vol 192. 2021-01-22. PMID:32201299. |
cortical and raphe gaba at sub-anaesthetic doses, ketamine, a non competitive n-methyl-d-aspartate (nmda) receptor antagonist, has demonstrated remarkable and rapid antidepressant (ad) efficacy in patients with treatment-resistant depression (trd). |
2021-01-22 |
2023-08-13 |
Not clear |
| Sabrina Duranti, Lorena Ruiz, Gabriele Andrea Lugli, Héctor Tames, Christian Milani, Leonardo Mancabelli, Walter Mancino, Giulia Longhi, Luca Carnevali, Andrea Sgoifo, Abelardo Margolles, Marco Ventura, Patricia Ruas-Madiedo, Francesca Turron. Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA. Scientific reports. vol 10. issue 1. 2021-01-07. PMID:32839473. |
gamma aminobutyric acid (gaba) is the principal inhibitory neurotransmitter playing a key role in anxiety and depression disorders in mammals. |
2021-01-07 |
2023-08-13 |
human |