| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Makova, S Kasparova, T Tvrdik, M Vinas Noguera, K Belovicova, K Csatlosova, M Dubovick. Mirtazapine modulates Glutamate and GABA levels in the animal model of maternal depression. MRI and Behavioural brain research. 2023-01-14. PMID:36641082. |
mirtazapine modulates glutamate and gaba levels in the animal model of maternal depression. |
2023-01-14 |
2023-08-14 |
rat |
| Yilu Sun, Jia Zhao, Jianhui Ron. Dissecting the molecular mechanisms underlying the antidepressant activities of herbal medicines through the comprehensive review of the recent literatures. Frontiers in psychiatry. vol 13. 2023-01-09. PMID:36620687. |
the pathophysiology of depression is tightly regulated by the biosynthesis, transport and signaling of neurotransmitters [e.g., serotonin, norepinephrine, dopamine, or γ-aminobutyric acid (gaba)] in the central nervous system. |
2023-01-09 |
2023-08-14 |
Not clear |
| Xiao-Hui Tang, Yu-Gang Diao, Zhuo-Yu Ren, Yan-Yu Zang, Guang-Fen Zhang, Xing-Ming Wang, Gui-Fang Duan, Jin-Chun Shen, Kenji Hashimoto, Zhi-Qiang Zhou, Jian-Jun Yan. A role of GABA Neuropharmacology. 2022-12-24. PMID:36565851. |
a role of gaba ketamine can produce rapid-acting antidepressant effects in treatment-resistant patients with depression. |
2022-12-24 |
2023-08-14 |
mouse |
| Djawad Radjabzadeh, Jos A Bosch, André G Uitterlinden, Aeilko H Zwinderman, M Arfan Ikram, Joyce B J van Meurs, Annemarie I Luik, Max Nieuwdorp, Anja Lok, Cornelia M van Duijn, Robert Kraaij, Najaf Ami. Gut microbiome-wide association study of depressive symptoms. Nature communications. vol 13. issue 1. 2022-12-06. PMID:36473852. |
these bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (gaba), which are key neurotransmitters for depression. |
2022-12-06 |
2023-08-14 |
human |
| b' Lucia \\xc5\\xbdigov\\xc3\\xa1, Petra Massarov\\xc3\\xa1, Katar\\xc3\\xadna Vranecov\\xc3\\xa1, Orsolya Hrub\\xc3\\xa1, Adriana Adami\\xc4\\x8dkov\\xc3\\xa1, Andrea Ga\\xc5\\xbeov\\xc3\\xa. Neuroactive steroids - new possibilities in the treatment of postpartum depression. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. vol 71. issue 4. 2022-10-08. PMID:36208918.' |
the structure represents the neuroactive steroid - allopregnanolone, which acts as an agonist on the δ-subunit of the gaba receptor and improves the symptoms of postpartum depression. |
2022-10-08 |
2023-08-14 |
Not clear |
| Keyrian Louis Le Gratiet, Christopher K Anderson, Nagore Puente, Pedro Grandes, Charlotte Copas, Patrick C Nahirney, Kerry R Delaney, Raad Nashm. Differential Subcellular Distribution and Release Dynamics of Co-transmitted Cholinergic and GABAergic Synaptic Inputs Modifies Dopaminergic Neuronal Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-04. PMID:36195440. |
while soma-localized ach/gaba co-transmission showed depression of the gaba component with repeated stimulation, ach-mediated nicotinic responses were largely maintained. |
2022-10-04 |
2023-08-14 |
mouse |
| Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Tami Shandro, Jean-Michel Le Melled. Decreased GABA+ levels in the medial prefrontal cortex of perimenopausal women: a 3T 1H-MRS study. The international journal of neuropsychopharmacology. 2022-09-23. PMID:36146906. |
previous research has shown that depression is associated with decreased gamma-aminobutyric acid (gaba) levels in the medial prefrontal cortex (mpfc) of md patients. |
2022-09-23 |
2023-08-14 |
Not clear |
| Xi Gu, Junhao Wang, Xiaodan Jian. miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons. ACS chemical neuroscience. 2022-09-08. PMID:36074953. |
dysfunction of γ-aminobutyric acid (gaba)ergic interneurons may cause a variety of neurological and psychiatric disorders such as epilepsy, autism, alzheimer's disease, and depression. |
2022-09-08 |
2023-08-14 |
human |
| Mona Guath, Johan Lundin Kleberg, Jan Weis, Ebba Widegren, Matilda Frick, Stefan Möller, Lisa Klevebrant, Barry Karlsson, David Fällmar, Johanna Mårtensson, Daniel S Pine, Karin Brocki, Malin Gingnell, Andreas Fric. Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents. Behavioural brain research. 2022-08-20. PMID:35987307. |
participants completed the revised child anxiety and depression scale (rcads) and underwent a reward learning task while measuring pupil dilation and a single voxel dorsal anterior cingulate cortex (dacc) mega-press magnetic resonance spectroscopy scan assessing choline, glutamate and gaba concentrations. |
2022-08-20 |
2023-08-14 |
human |
| G Anjali Narayan, Kathryn R Hill, Kenneth Wengler, Xiang He, Junying Wang, Jie Yang, Ramin V Parsey, Christine DeLorenz. Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial. Molecular psychiatry. 2022-08-18. PMID:35982258. |
does the change in glutamate to gaba ratio correlate with change in depression severity? |
2022-08-18 |
2023-08-14 |
Not clear |
| Benjamin Spurny-Dworak, Godber Mathis Godbersen, Murray Bruce Reed, Jakob Unterholzner, Thomas Vanicek, Pia Baldinger-Melich, Andreas Hahn, Georg S Kranz, Wolfgang Bogner, Rupert Lanzenberger, Siegfried Kaspe. The Impact of Theta-Burst Stimulation on Cortical GABA and Glutamate in Treatment-Resistant Depression: A Surface-Based MRSI Analysis Approach. Frontiers in molecular neuroscience. vol 15. 2022-08-01. PMID:35909445. |
the impact of theta-burst stimulation on cortical gaba and glutamate in treatment-resistant depression: a surface-based mrsi analysis approach. |
2022-08-01 |
2023-08-14 |
Not clear |
| Jie Shao, Yang Wei, Xinlin We. A comprehensive review on bioavailability, safety and antidepressant potential of natural bioactive components from tea. Food research international (Ottawa, Ont.). vol 158. 2022-07-15. PMID:35840236. |
tea bioactive compounds (l-theanine, catechin, tea pigment and gaba) can regulate depression by inhibiting hyperactive hpa axis, reducing the inflammatory response, restoring the monoaminergic system, inhibiting monoamine oxidase levels, increasing the enrichment of intestinal flora and promoting microbial-gut-brain axis activity. |
2022-07-15 |
2023-08-14 |
Not clear |
| Fernanda-Marie Tette, Samuel K Kwofie, Michael D Wilso. Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Current issues in molecular biology. vol 44. issue 4. 2022-06-20. PMID:35723354. |
therapeutic anti-depressant potential of microbial gaba produced by the role of the microbiota-gut-brain (mgb) axis in mood regulation and depression treatment has gained attention in recent years, as evidenced by the growing number of animal and human studies that have reported the anti-depressive and associated gamma-aminobutyric acid-ergic (gabaergic) effects of probiotics developed from |
2022-06-20 |
2023-08-14 |
human |
| Riley T Paulsen, Brian D Burrel. Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Frontiers in synaptic neuroscience. vol 14. 2022-04-04. PMID:35368247. |
activity-dependent modulation of tonic gaba currents by endocannabinoids in endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses. |
2022-04-04 |
2023-08-13 |
Not clear |
| Xiaoyan Xue, Jin Pan, Hongxiu Zhang, Yanting Lu, Qiancheng Mao, Ke M. Baihe Dihuang (Lilium Henryi Baker and Rehmannia Glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via miRNA-144-3p mediated GABA synthesis and release. Journal of ethnopharmacology. 2022-03-26. PMID:35337919. |
baihe dihuang (lilium henryi baker and rehmannia glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via mirna-144-3p mediated gaba synthesis and release. |
2022-03-26 |
2023-08-13 |
Not clear |
| Moitreyee Chattopadhyay, Souvik Basak, Atish Barua, Malaya Gupta, Dibyajyoti Das, Tanushree Karmakar, Gautam Kumar Bagch. Neuropharmacological Alterations by a Rice Contaminant Stenotrophomonas maltophilia: a Detailed Bio-molecular and Mechanistic Landscape. Applied biochemistry and biotechnology. 2022-01-10. PMID:35006552. |
throughout the study, both acute and chronic exposure of the cell lysate showed a decrease in the locomotor activity and a time-dependent increase of the depression (p < 0.001-0.0001, two-way anova), supported by bioamine (dopamine, noradrenaline, adrenaline, serotonin, and gaba) depletion in rodents' brain possibly due to ufa-amino acid decarboxylase interaction favoring bioamine depletion as revealed by our study. |
2022-01-10 |
2023-08-13 |
human |
| Balwinder Singh, John D Port, Vanessa Pazdernik, Brandon J Coombes, Jennifer L Vande Voort, Mark A Fry. Racemic ketamine treatment attenuates anterior cingulate cortex GABA deficits among remitters in treatment-resistant depression: A pilot study. Psychiatry research. Neuroimaging. vol 320. 2022-01-01. PMID:34973601. |
racemic ketamine treatment attenuates anterior cingulate cortex gaba deficits among remitters in treatment-resistant depression: a pilot study. |
2022-01-01 |
2023-08-13 |
Not clear |
| b' Ivana Peri\\xc4\\x87, Andrijana Stanisavljevi\\xc4\\x87, Peter Gass, Dragana Filipovi\\xc4\\x8. Fluoxetine exerts subregion/layer specific effects on parvalbumin/GAD67 protein expression in the dorsal hippocampus of male rats showing social isolation-induced depressive-like behaviour. Brain research bulletin. vol 173. 2021-12-09. PMID:34048829.' |
the molecular background of depression is intensively studied in terms of alterations of inhibitory circuits, mediated by gamma aminobutyric acid (gaba) signalization. |
2021-12-09 |
2023-08-13 |
rat |
| Edem Ekpenyong Edem, Blessing Eghosa Ihaza, Adedamola Adediran Fafure, Azeez Olakunle Ishola, Kate Eberechukwu Nebo, Linus Anderson Enye, Elizabeth Toyin Akinluy. Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice. Drug metabolism and personalized therapy. 2021-12-09. PMID:34881837. |
gaba and glutamate neurotransmission play critical roles in both the neurobiology of depression and cognition; and virgin coconut oil (vco) is reported to support brain health. |
2021-12-09 |
2023-08-13 |
mouse |
| Si-Long Deng, Zhuang-Li Hu, Li Mao, Bo Gao, Qiong Yang, Fang Wang, Jian-Guo Che. The effects of Kctd12, an auxiliary subunit of GABA Pharmacological research. vol 163. 2021-11-18. PMID:33285230. |
the effects of kctd12, an auxiliary subunit of gaba adaptive responses to stress are critical to enhance physical and mental well-being, but excessive or prolonged stress may cause inadaptability and increase the risks of psychiatric disorders, such as depression. |
2021-11-18 |
2023-08-13 |
Not clear |