| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Camfield, R Fontana, K A Wesnes, J Mills, R J Crof. Effects of aging and depression on mnemonic discrimination ability. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. vol 25. issue 3. 2019-01-22. PMID:28506139. |
these findings may be viewed as putative behavioral correlates of decreased pattern separation ability, which may be indicative of altered hippocampal neurogenesis in aging and depression. |
2019-01-22 |
2023-08-13 |
human |
| Gouri J Mahajan, Eric J Vallender, Michael R Garrett, Lavanya Challagundla, James C Overholser, George Jurjus, Lesa Dieter, Maryam Syed, Damian G Romero, Hamed Benghuzzi, Craig A Stockmeie. Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 82. 2019-01-22. PMID:29175309. |
decreased hippocampal volume with increasing duration of depression suggests altered gene expression or even a decrease in neurogenesis. |
2019-01-22 |
2023-08-13 |
human |
| Chong Gao, Qiaohui Du, Wenting Li, Ruixia Deng, Qi Wang, Aimin Xu, Jiangang She. Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29675572. |
our previous study indicates that adaptor protein, phosphotyrosine interacting with ph domain and leucine zipper 2 (appl2), could affect the activity and sensitivity of glucocorticoid receptor (gr) and mediate impaired hippocampal neurogenesis, which contribute the development of depression. |
2019-01-18 |
2023-08-13 |
mouse |
| Chong Gao, Qiaohui Du, Wenting Li, Ruixia Deng, Qi Wang, Aimin Xu, Jiangang She. Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29675572. |
baicalin treatment inhibited appl2/gr signaling pathway and improved neurogenesis at svz, ob, and hippocampus in appl2 tg mice and chronic corticosterone-induced depression mouse model. |
2019-01-18 |
2023-08-13 |
mouse |
| Reidun Aesoy, Haruna Muwonge, Kathrine S Asrud, Misbah Sabir, Solveig L Witsoe, Ronja Bjornstad, Reidun K Kopperud, Erling A Hoivik, Stein Ove Doskeland, Marit Bakk. Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PloS one. vol 13. issue 7. 2019-01-14. PMID:30048476. |
in the hippocampus, epac contributes to the control of neuronal growth and differentiation and has been implicated in memory and learning as well as in anxiety and depression. |
2019-01-14 |
2023-08-13 |
mouse |
| Lucas Melo Neves, Carla Silva-Batista, Raquel Marquesini, Telma Fátima da Cunha, Elisa Dimateo, Luciana Nascimento, Acácio Moreira-Neto, Angelo Corrêa de Lima Miliatto, Sheila das Chagas Mendes, Flavia Saad, Jamile Sanches Codogno, Renato Hoffmann Nunes, Raphael Mendes Ritti-Dias, Valeria Juday, Beny Lafer, Carlos Ugrinowitsc. Aerobic exercise program with or without motor complexity as an add-on to the pharmacological treatment of depression - study protocol for a randomized controlled trial. Trials. vol 19. issue 1. 2019-01-07. PMID:30305151. |
patients with major depression disorder presents increased rates of cognitive decline, reduced hippocampal volume, poor sleep quality, hypertension, obesity, suicidal ideation and behavior, and decreased functionality. |
2019-01-07 |
2023-08-13 |
Not clear |
| Lucas Melo Neves, Carla Silva-Batista, Raquel Marquesini, Telma Fátima da Cunha, Elisa Dimateo, Luciana Nascimento, Acácio Moreira-Neto, Angelo Corrêa de Lima Miliatto, Sheila das Chagas Mendes, Flavia Saad, Jamile Sanches Codogno, Renato Hoffmann Nunes, Raphael Mendes Ritti-Dias, Valeria Juday, Beny Lafer, Carlos Ugrinowitsc. Aerobic exercise program with or without motor complexity as an add-on to the pharmacological treatment of depression - study protocol for a randomized controlled trial. Trials. vol 19. issue 1. 2019-01-07. PMID:30305151. |
therefore, this randomized controlled trial will compare the effects of cae and aemc on depression score, cognitive function, hippocampal volume, brain-derived neurotrophic factor expression, sleep parameters, cardiovascular risk parameters, suicidal behavior, functionality, and treatment costs in patients with depression. |
2019-01-07 |
2023-08-13 |
Not clear |
| Yunan Zhao, Zixuan Lin, Lin Chen, Liufeng Ouyang, Ling Gu, Feiyan Chen, Qiang Zhan. Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam. Progress in neuro-psychopharmacology & biological psychiatry. vol 83. 2019-01-03. PMID:29369777. |
hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam. |
2019-01-03 |
2023-08-13 |
mouse |
| Yunan Zhao, Zixuan Lin, Lin Chen, Liufeng Ouyang, Ling Gu, Feiyan Chen, Qiang Zhan. Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam. Progress in neuro-psychopharmacology & biological psychiatry. vol 83. 2019-01-03. PMID:29369777. |
in this study, we utilized a repeated corticosterone (cort) injection paradigm to develop a mouse depression model wherein we examined the occurrence of alterations in hippocampal astrocyte population by using two astrocytic markers, namely, glial fibrillary acidic protein (gfap) and s100β. |
2019-01-03 |
2023-08-13 |
mouse |
| Matthew Timberlake, Kevin Prall, Bhaskar Roy, Yogesh Dwived. Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats. Psychoneuroendocrinology. vol 89. 2018-12-31. PMID:29414031. |
recent evidence suggests that the cellular response to stress often elicits the unfolded protein response (upr), which has an active role in major depression in emotionally relevant regions of the brain, such as the hippocampus. |
2018-12-31 |
2023-08-13 |
rat |
| Matthew Timberlake, Kevin Prall, Bhaskar Roy, Yogesh Dwived. Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats. Psychoneuroendocrinology. vol 89. 2018-12-31. PMID:29414031. |
the present study examined the hippocampus associated expression profile of tlr genes and their interaction with the upr chaperone grp94 in stress-induced rodent model of depression (restraint stress model). |
2018-12-31 |
2023-08-13 |
rat |
| Matthew Timberlake, Kevin Prall, Bhaskar Roy, Yogesh Dwived. Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats. Psychoneuroendocrinology. vol 89. 2018-12-31. PMID:29414031. |
since, increased inflammatory activity in vulnerable areas like hippocampus is coherently associated with depressed brain; our present data suggest that the upr may be an integral part of increased activity of inflammatory regulations in depression. |
2018-12-31 |
2023-08-13 |
rat |
| Wei-Guan Chen, Jia-Xuan Zheng, Xi Xu, Yu-Ming Hu, Yu-Min M. Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation. Psychiatry research. vol 264. 2018-12-31. PMID:29677620. |
hippocampal fxr plays a role in the pathogenesis of depression: a preliminary study based on lentiviral gene modulation. |
2018-12-31 |
2023-08-13 |
rat |
| Guoxiang Fang, Ying Wan. Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats. Neurochemical research. vol 43. issue 9. 2018-12-31. PMID:29987693. |
these results indicate that rtms can be used as an antidepressive therapy for juvenile depression at least partly mediated by increasing hippocampal 2-ag and cb1 receptor expression levels. |
2018-12-31 |
2023-08-13 |
rat |
| Yan Jun Cao, Qiong Wang, Xing Xing Zheng, Ying Cheng, Yan Zhan. Involvement of SNARE complex in the hippocampus and prefrontal cortex of offspring with depression induced by prenatal stress. Journal of affective disorders. vol 235. 2018-12-21. PMID:29674253. |
involvement of snare complex in the hippocampus and prefrontal cortex of offspring with depression induced by prenatal stress. |
2018-12-21 |
2023-08-13 |
Not clear |
| Yukihiko Shirayama, Michio Takahashi, Fumio Osone, Akira Hara, Toshiyuki Okub. Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2018-12-19. PMID:29560915. |
myo-inositol, glutamate, and glutamine in the prefrontal cortex, hippocampus, and amygdala in major depression. |
2018-12-19 |
2023-08-13 |
Not clear |
| Yukihiko Shirayama, Michio Takahashi, Fumio Osone, Akira Hara, Toshiyuki Okub. Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2018-12-19. PMID:29560915. |
our a priori hypothesis was that myo-inositol and glutamate were downregulated in the hippocampus and amygdala in depression. |
2018-12-19 |
2023-08-13 |
Not clear |
| Ping Zhang, Dan Zeng, Yi-Li Yi, Yi-Yun Tang, Wei Zou, Xue-Feng Yang, Chun-Yan Wang, Xiao-Qing Tan. β2-microglobulin induces depressive- and anxiety-like behaviors in rat. PloS one. vol 13. issue 5. 2018-12-19. PMID:29795686. |
based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to investigate whether b2m leads to depressive- and anxiety-like behaviors. |
2018-12-19 |
2023-08-13 |
rat |
| Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Juncai Pu, Lining Yang, Shuai Yuan, Libo Zhao, Chanjun Zhou, Hanping Zhang, Peng Xi. Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression. Translational psychiatry. vol 8. issue 1. 2018-12-18. PMID:29317595. |
hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression. |
2018-12-18 |
2023-08-13 |
rat |
| Merete Osler, Lauge Sørensen, Maarten Rozing, Oriol Puig Calvo, Mads Nielsen, Egill Rostru. Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953. Human brain mapping. vol 39. issue 4. 2018-12-17. PMID:29322596. |
after exclusion of men (n = 3) with scores in the range of clinical depression the inverse correlation between depressive symptoms and hippocampal volume became insignificant (r = -13, p = .08). |
2018-12-17 |
2023-08-13 |
Not clear |