| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Ning Yang, Jun-Cai Pu, Lan-Xiang Liu, Guo-Wei Wang, Xin-Yu Zhou, Yu-Qing Zhang, Yi-Yun Liu, Peng Xi. Integrated Metabolomics and Proteomics Analysis Revealed Second Messenger System Disturbance in Hippocampus of Chronic Social Defeat Stress Rat. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:30983951. |
in this study, we combined a non-targeted gas chromatography-mass spectrometry (gc-ms)-based metabolomic approach and isobaric tags for relative and absolute quantitation (itraq)-based proteomic analysis to elucidate metabolite and protein alterations in the hippocampus of rat after chronic social defeat stress (csds), an extensively used animal model of depression. |
2020-09-29 |
2023-08-13 |
rat |
| Paolo Tornese, Nathalie Sala, Daniela Bonini, Tiziana Bonifacino, Luca La Via, Marco Milanese, Giulia Treccani, Mara Seguini, Alessandro Ieraci, Jessica Mingardi, Jens R Nyengaard, Stefano Calza, Giambattista Bonanno, Gregers Wegener, Alessandro Barbon, Maurizio Popoli, Laura Musazz. Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of stress. vol 10. 2020-09-29. PMID:31193464. |
we show here that the chronic mild stress model of depression induces, only in stress-vulnerable rats, depressed-like anhedonic behavior, together with impairment of glutamate/gaba presynaptic release, bdnf mrna trafficking in dendrites and dendritic morphology in hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Nitin Khandelwal, Sandeep Kumar Dey, Sumana Chakravarty, Arvind Kuma. miR-30 Family miRNAs Mediate the Effect of Chronic Social Defeat Stress on Hippocampal Neurogenesis in Mouse Depression Model. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31440139. |
mir-30 family mirnas mediate the effect of chronic social defeat stress on hippocampal neurogenesis in mouse depression model. |
2020-09-29 |
2023-08-13 |
mouse |
| Gianfilippo Coppola, Gareth M Rurak, Stephanie Simard, Natalina Salmas. A Further Analysis and Commentary on: Profiling Changes in Cortical Astroglial Cells Following Chronic Stress. Journal of experimental neuroscience. vol 13. 2020-09-29. PMID:31452604. |
the neuroplasticity hypothesis of depression proposes that major depressive disorders are related to decreased hippocampal and cortical neural plasticity, which is reversed by antidepressant treatment. |
2020-09-29 |
2023-08-13 |
Not clear |
| Dawei Xu, Chengniu Wang, Xinhui Zhu, Wei Zhao, Bo Jiang, Shengyu Cui, Yuyu Sun, Zhiming Cu. The antidepressant-like effects of fluvoxamine in mice involve the mTOR signaling in the hippocampus and prefrontal cortex. Psychiatry research. vol 285. 2020-09-29. PMID:31810748. |
it was found that fluvoxamine treatment fully reversed the effects of cums on the mtor signaling in the hippocampus and pfc, and the usage of rapamycin significantly prevented the antidepressant-like effects of fluvoxamine in the cums model of depression. |
2020-09-29 |
2023-08-13 |
mouse |
| Brendan D Hare, Sriparna Ghosal, Ronald S Duma. Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms. Chronic stress (Thousand Oaks, Calif.). vol 1. 2020-09-28. PMID:28649673. |
stress models also produce molecular and cellular morphological changes in stress sensitive brain regions, including the prefrontal cortex and hippocampus that resemble alterations observed in depression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yun-Ling Huang, Ning-Xi Zeng, Jie Chen, Jie Niu, Wu-Long Luo, Ping Liu, Can Yan, Li-Li W. Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress. Neural regeneration research. vol 15. issue 6. 2020-09-28. PMID:31823896. |
dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal mir-124 expression in rats with depression induced by chronic unpredictable mild stress. |
2020-09-28 |
2023-08-13 |
rat |
| Yun-Ling Huang, Ning-Xi Zeng, Jie Chen, Jie Niu, Wu-Long Luo, Ping Liu, Can Yan, Li-Li W. Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress. Neural regeneration research. vol 15. issue 6. 2020-09-28. PMID:31823896. |
the depression-like behavior phenotype, neurogenesis in the dentate gyrus and mir-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy. |
2020-09-28 |
2023-08-13 |
rat |
| Yun-Ling Huang, Ning-Xi Zeng, Jie Chen, Jie Niu, Wu-Long Luo, Ping Liu, Can Yan, Li-Li W. Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress. Neural regeneration research. vol 15. issue 6. 2020-09-28. PMID:31823896. |
the present study aimed to clarify the dynamic changes of depression-like behavior, dentate gyrus neurogenesis and hippocampal mir-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression treatment. |
2020-09-28 |
2023-08-13 |
rat |
| Yun-Ling Huang, Ning-Xi Zeng, Jie Chen, Jie Niu, Wu-Long Luo, Ping Liu, Can Yan, Li-Li W. Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress. Neural regeneration research. vol 15. issue 6. 2020-09-28. PMID:31823896. |
real-time quantitative reverse transcription polymerase chain reaction assays and fluorescence in situ hybridization were used to measure the expression of hippocampal mir-124 during chronic unpredictable mild stress-induced depression. |
2020-09-28 |
2023-08-13 |
rat |
| Yun-Ling Huang, Ning-Xi Zeng, Jie Chen, Jie Niu, Wu-Long Luo, Ping Liu, Can Yan, Li-Li W. Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress. Neural regeneration research. vol 15. issue 6. 2020-09-28. PMID:31823896. |
these findings indicate that during chronic unpredictable mild stress-induced depression, the behavioral phenotype, mir-124 expression in the hippocampus, neurogenesis in the dentate gyrus and neuronal numbers showed dynamic changes, which suggested that various pathological changes occur at different stages of depression. |
2020-09-28 |
2023-08-13 |
rat |
| Chunmei Geng, Yi Qiao, Yujin Guo, Wenxiu Han, Bin Wu, Changshui Wang, Jun Zhang, Dan Chen, Mengqi Yang, Pei Jian. Integrated metabolomics and lipidomics profiling of hippocampus reveal metabolite biomarkers in a rat model of chronic unpredictable mild stress-induced depression. Annals of translational medicine. vol 7. issue 23. 2020-09-28. PMID:32042797. |
integrated metabolomics and lipidomics profiling of hippocampus reveal metabolite biomarkers in a rat model of chronic unpredictable mild stress-induced depression. |
2020-09-28 |
2023-08-13 |
human |
| Chunmei Geng, Yi Qiao, Yujin Guo, Wenxiu Han, Bin Wu, Changshui Wang, Jun Zhang, Dan Chen, Mengqi Yang, Pei Jian. Integrated metabolomics and lipidomics profiling of hippocampus reveal metabolite biomarkers in a rat model of chronic unpredictable mild stress-induced depression. Annals of translational medicine. vol 7. issue 23. 2020-09-28. PMID:32042797. |
thus, our study aimed to conduct integrated metabolomics and lipidomics to identify metabolites and lipids biomarkers in the hippocampus in rat models of cums-induced depression. |
2020-09-28 |
2023-08-13 |
human |
| Shaohua Xu, Yiyun Liu, Juncai Pu, Siwen Gui, Xiaogang Zhong, Lu Tian, Xuemian Song, Xunzhong Qi, Haiyang Wang, Peng Xi. Chronic Stress in a Rat Model of Depression Disturbs the Glutamine-Glutamate-GABA Cycle in the Striatum, Hippocampus, and Cerebellum. Neuropsychiatric disease and treatment. vol 16. 2020-09-28. PMID:32158215. |
chronic stress in a rat model of depression disturbs the glutamine-glutamate-gaba cycle in the striatum, hippocampus, and cerebellum. |
2020-09-28 |
2023-08-13 |
rat |
| Dan Xiang, Jiawei Xiao, Siqi Sun, Linyan Fu, Lihua Yao, Gaohua Wang, Zhongchun Li. Differential Regulation of DNA Methylation at the CRMP2 Promoter Region Between the Hippocampus and Prefrontal Cortex in a CUMS Depression Model. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32256396. |
differential regulation of dna methylation at the crmp2 promoter region between the hippocampus and prefrontal cortex in a cums depression model. |
2020-09-28 |
2023-08-13 |
rat |
| Dan Xiang, Jiawei Xiao, Siqi Sun, Linyan Fu, Lihua Yao, Gaohua Wang, Zhongchun Li. Differential Regulation of DNA Methylation at the CRMP2 Promoter Region Between the Hippocampus and Prefrontal Cortex in a CUMS Depression Model. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32256396. |
the aim of this study was to explore the relationship between the expression and dna methylation of crmp2 in the hippocampus and prefrontal cortex of a rat depression model. |
2020-09-28 |
2023-08-13 |
rat |
| Dan Xiang, Jiawei Xiao, Siqi Sun, Linyan Fu, Lihua Yao, Gaohua Wang, Zhongchun Li. Differential Regulation of DNA Methylation at the CRMP2 Promoter Region Between the Hippocampus and Prefrontal Cortex in a CUMS Depression Model. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32256396. |
our data provide evidence that altered expression of crmp2 in the hippocampus and prefrontal cortex is associated with the pathogenesis of depression. |
2020-09-28 |
2023-08-13 |
rat |
| Dan Xiang, Jiawei Xiao, Siqi Sun, Linyan Fu, Lihua Yao, Gaohua Wang, Zhongchun Li. Differential Regulation of DNA Methylation at the CRMP2 Promoter Region Between the Hippocampus and Prefrontal Cortex in a CUMS Depression Model. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32256396. |
moreover, the results also suggest regional differences in the regulation of dna methylation in the crmp2 promoter between the hippocampus and prefrontal cortex during the development of depression. |
2020-09-28 |
2023-08-13 |
rat |
| Carolina Flores-Muñoz, Bárbara Gómez, Elena Mery, Paula Mujica, Ivana Gajardo, Claudio Córdova, Daniela Lopez-Espíndola, Claudia Durán-Aniotz, Claudio Hetz, Pablo Muñoz, Arlek M Gonzalez-Jamett, Álvaro O Ardile. Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32265655. |
the acute inhibition of panx1 activity with the drug probenecid (pbn) did not change neurodegenerative parameters such as amyloid deposition or astrogliosis, but it significantly reduced excitatory synaptic defects in the ad model by normalizing long-term potentiation (ltp) and depression and improving dendritic arborization and spine density in hippocampal neurons of the tg mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Tao Yang, Zheng Nie, Haifeng Shu, Yongqin Kuang, Xin Chen, Jingmin Cheng, Sixun Yu, Huiying Li. The Role of BDNF on Neural Plasticity in Depression. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32351365. |
using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. |
2020-09-28 |
2023-08-13 |
Not clear |