| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yatao Liu, Wei Liu, Xiaoqing Wang, Zhanhai Wan, Fengxian Gu, Li Ma, Yufang Len. Hippocampal astrocyte dysfunction contributes to etomidate-induced long-lasting synaptic inhibition. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31558319. |
interestingly, hippocampal astrocyte inhibition (designer receptors exclusively activated by designer drugs; dreadds) had no effect on the initial synaptic inhibition, but reversed synaptic and cognitive depression in the long term. |
2020-06-22 |
2023-08-13 |
mouse |
| Shuo Jiang, Quan-Ai Zhang, Qin Guo, Zhong D. The glutamatergic system and astrocytic impairment in rat hippocampus: a comparative study of underlying etiology and pathophysiology of depression. Journal of integrative neuroscience. vol 18. issue 4. 2020-06-22. PMID:31912696. |
the glutamatergic system and astrocytic impairment in rat hippocampus: a comparative study of underlying etiology and pathophysiology of depression. |
2020-06-22 |
2023-08-13 |
rat |
| Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P Guiar. Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 30. 2020-06-17. PMID:31160539. |
our results indicated that hfd-fed mice displayed impairment in the electrical activity of dorsal raphe 5-ht neurons, attenuated hippocampal extracellular 5-ht concentrations and anxiety, one of the most visible and early symptoms of depression. |
2020-06-17 |
2023-08-13 |
mouse |
| Wei-Yang Chen, Huaibo Zhang, Eleonora Gatta, Elizabeth J Glover, Subhash C Pandey, Amy W Lase. The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal. Alcohol (Fayetteville, N.Y.). vol 78. 2020-06-12. PMID:30851364. |
the goal of this study was to examine depression-like behavior during alcohol withdrawal and associated changes in histone acetylation and expression of histone deacetylase 2 (hdac2) in the hippocampus, a brain region critical for mood regulation and depression. |
2020-06-12 |
2023-08-13 |
rat |
| Samuel J Millard, Jeremy S Lum, Francesca Fernandez, Katrina Weston-Green, Kelly A Newel. Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression. Journal of psychopharmacology (Oxford, England). vol 33. issue 2. 2020-05-22. PMID:30698051. |
perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: a comparison between sprague-dawley rats and the wistar-kyoto rat model of depression. |
2020-05-22 |
2023-08-13 |
rat |
| Wenya Huang, Xianjun Meng, Yang Huang, Siyu Liu, Anning Zhu, Peng Li, Yu Wang, Bangyi Tang, Jiahua Shi, Yiqing Ca. Nitric Oxide and Cyclic Guanosine Monophosphate Signaling Mediates the Antidepressant Effects of Acupuncture in the Rat Model of Chronic Unpredictable Mild Stress. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-21. PMID:31785199. |
results acupuncture reversed the behaviors associated with depression in the cums rat model and reduced the expression of components of the no and cgmp pathway in the rat hippocampus and plasma. |
2020-05-21 |
2023-08-13 |
rat |
| Rachel Ellis, Anna Fernandes, Julian G Simmons, Lisa Mundy, George Patton, Nicholas B Allen, Sarah Whittl. Relationships between adrenarcheal hormones, hippocampal volumes and depressive symptoms in children. Psychoneuroendocrinology. vol 104. 2020-05-18. PMID:30802711. |
increasing evidence suggests that androgens that rise during adrenarche, most notably dehyrdoepiandrosterone (dhea) and testosterone, may be involved both in the development of the hippocampus, and risk for depression. |
2020-05-18 |
2023-08-13 |
human |
| Xueyang Deng, Jiao Fu, Yang Song, Bingru Xu, Zhouye Ji, Qinglong Guo, Shiping M. Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30738183. |
intriguingly, glucocorticoid resistance occurred in cs-exposed mice, with elevated serum corticosterone and suppressed hippocampal gr levels, which suggested a novel potential regulatory mechanism underlying copd-induced depression comorbidity. |
2020-05-13 |
2023-08-13 |
mouse |
| Paulo Wagner Linhares Lima Filho, Adriano José Maia Chaves Filho, Charliene Freire Xavier Vieira, Tatiana de Queiroz Oliveira, Michelle Verde Ramo Soares, Paloma Marinho Jucá, Joao Quevedo, Tatiana Barichello, Danielle Macedo, Francisco das Chagas Medeiro. Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30798429. |
therefore, this study demonstrates that em is related to several features of clinical depression and proposes the contribution of hippocampal oxidative state and neurotrophic support for the emergence of these changes. |
2020-05-11 |
2023-08-13 |
rat |
| Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purve. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology. vol 318. issue 2. 2020-05-11. PMID:31869244. |
cyclophosphamide-induced cystitis results in nlrp3-mediated inflammation in the hippocampus and symptoms of depression in rats. |
2020-05-11 |
2023-08-13 |
rat |
| Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purve. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology. vol 318. issue 2. 2020-05-11. PMID:31869244. |
thus, we conclude that cp-induced cystitis causes nlrp3-dependent hippocampal inflammation leading to depression symptoms in rats. |
2020-05-11 |
2023-08-13 |
rat |
| Xun Yang, Guowei Wang, Xue Gong, Cheng Huang, Qiang Mao, Li Zeng, Peng Zheng, Yinhua Qin, Fei Ye, Bin Lian, Chanjuan Zhou, Haiyang Wang, Wei Zhou, Peng Xi. Effects of chronic stress on intestinal amino acid pathways. Physiology & behavior. vol 204. 2020-05-04. PMID:30831184. |
moreover, we performed an integrated analysis of related differential amino acids in the hippocampus, peripheral blood mononuclear cells (pbmcs), urine and cerebellum identified in our previous studies using the cums rat model to further our understanding of amino acid metabolism in depression. |
2020-05-04 |
2023-08-13 |
rat |
| Huirong Guo, Bailing Huang, Yali Wang, Yanyan Zhang, Quangang Ma, Yuming Re. Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microRNA-26a expression. International immunopharmacology. vol 82. 2020-04-27. PMID:32088640. |
bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microrna-26a expression. |
2020-04-27 |
2023-08-13 |
rat |
| Lianqing Zhang, Xinyu Hu, Lu Lu, Bin Li, Xiaoxiao Hu, Xuan Bu, Hailong Li, Shi Tang, Yanchun Yang, Neil Roberts, John A Sweeney, Qiyong Gong, Xiaoqi Huan. Abnormalities of hippocampal shape and subfield volumes in medication-free patients with obsessive-compulsive disorder. Human brain mapping. vol 40. issue 14. 2020-04-13. PMID:31188536. |
in this study, we sought to identify alterations of hippocampal shape and subfield volumes in a relatively large sample of medication-free obsessive-compulsive disorder (ocd) patients without comorbid depression. |
2020-04-13 |
2023-08-13 |
Not clear |
| Ajung Kim, Hyun-Gug Jung, Yeong-Eun Kim, Seung-Chan Kim, Jae-Yong Park, Seok-Geun Lee, Eun Mi Hwan. The Knockdown of TREK-1 in Hippocampal Neurons Attenuate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. International journal of molecular sciences. vol 20. issue 23. 2020-04-13. PMID:31771312. |
to study the role of hippocampal neuronal trek-1 in a lipopolysaccharide (lps)-induced depression model, we injected aav-hsyn-bfp (nctl group) or aav-hsyn-bfp-cre (ncre group) virus into the hippocampus of cd-trek-1 kd mice. |
2020-04-13 |
2023-08-13 |
mouse |
| Randall L Davi. Understanding depression: the hippocampus might hold the answer in a CREB-regulated transcription coactivator: An Editorial for 'AAV-mediated over-expression of CRTC1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide-induced depression-like behavior in mice' on page 111. Journal of neurochemistry. vol 149. issue 1. 2020-04-10. PMID:30874310. |
understanding depression: the hippocampus might hold the answer in a creb-regulated transcription coactivator: an editorial for 'aav-mediated over-expression of crtc1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide-induced depression-like behavior in mice' on page 111. |
2020-04-10 |
2023-08-13 |
mouse |
| William A Schraegle, Nancy L Nussbaum, Jeffrey B Titu. Executive Dysfunction and Depression in Pediatric Temporal Lobe Epilepsy: The Contribution of Hippocampal Sclerosis and Psychosocial Factors. Journal of the International Neuropsychological Society : JINS. vol 24. issue 6. 2020-04-09. PMID:29573759. |
executive dysfunction and depression in pediatric temporal lobe epilepsy: the contribution of hippocampal sclerosis and psychosocial factors. |
2020-04-09 |
2023-08-13 |
Not clear |
| Tomoyuki Furuyashiki, Satoshi Akiyama, Shiho Kitaok. Roles of multiple lipid mediators in stress and depression. International immunology. vol 31. issue 9. 2020-04-08. PMID:30810163. |
chronic stress up-regulates hippocampal expression of 5-lipoxygenase, hence synthesis of cysteinyl leukotrienes, thereby inducing depression through their receptors. |
2020-04-08 |
2023-08-13 |
Not clear |
| Jing Meng, Dong-Ming Wang, Li-Ling Lu. CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-07. PMID:31629950. |
in the present study, we found that ctrp3 expression levels were markedly reduced in hippocampus of mice with depression induced by chronic unpredictable mild stress (cums). |
2020-04-07 |
2023-08-13 |
mouse |
| Qin-Qin Wang, Chun-Mei Wang, Bao-Hua Cheng, Chun-Qing Yang, Bo Bai, Jing Che. Signaling transduction regulated by 5-hydroxytryptamine 1A receptor and orexin receptor 2 heterodimers. Cellular signalling. vol 54. 2020-04-06. PMID:30481562. |
moreover, 5-ht1ar and ox2r are involved in the pathogenesis of neurological diseases such as depression with deficiency of hippocampus plasticity. |
2020-04-06 |
2023-08-13 |
Not clear |