| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aaron S Weisbrod, Erin S Barry, Alice M Graham, Michael Eklund, Neil E Grunber. Decreased BDNF in female but not male rats after exposure to stress: a sex-sensitive rat model of stress? Stress (Amsterdam, Netherlands). vol 22. issue 5. 2020-03-23. PMID:31134851. |
the literature has consistently emphasized a relationship between chronic stress and depression as well as the involvement of brain-derived neurotrophic factor (bdnf). |
2020-03-23 |
2023-08-13 |
human |
| Aaron S Weisbrod, Erin S Barry, Alice M Graham, Michael Eklund, Neil E Grunber. Decreased BDNF in female but not male rats after exposure to stress: a sex-sensitive rat model of stress? Stress (Amsterdam, Netherlands). vol 22. issue 5. 2020-03-23. PMID:31134851. |
it was hypothesized that stress (chronic unpredictable mild stress [cums], shock stress [ss]) would result in greater deleterious alterations in behavior (open field activity [ofa]) and biological (serum bdnf, body weight [bw]) indices of depression for female rats as compared to male rats. |
2020-03-23 |
2023-08-13 |
human |
| Lauretta El Hayek, Mohamad Khalifeh, Victor Zibara, Rawad Abi Assaad, Nancy Emmanuel, Nabil Karnib, Rim El-Ghandour, Patrick Nasrallah, Maria Bilen, Pascale Ibrahim, Joe Younes, Edwina Abou Haidar, Nour Barmo, Vanessa Jabre, Joseph S Stephan, Sama F Sleima. Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 13. 2020-03-18. PMID:30692222. |
these effects depend on increases in hippocampal bdnf, a growth factor associated with cognitive improvement and the alleviation of depression symptoms. |
2020-03-18 |
2023-08-13 |
Not clear |
| Caroline Park, Joshua D Rosenblat, Elisa Brietzke, Zihang Pan, Yena Lee, Bing Cao, Hannah Zuckerman, Anastasia Kalantarova, Roger S McIntyr. Stress, epigenetics and depression: A systematic review. Neuroscience and biobehavioral reviews. vol 102. 2020-03-17. PMID:31005627. |
stress-associated epigenetic changes in the following genes were correlated with depression: nrc31, slca4, bdnf, fkbp5, ska2, oxtr, lingo3, pou3f1 and itgb1. |
2020-03-17 |
2023-08-13 |
human |
| Xiangyu Fang, Xueru Xu, Xingwu Lin, Rongguo Li. Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model. Brain research bulletin. vol 146. 2020-03-10. PMID:30639279. |
downregulated spinal irf8 and bdnf in nac are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat sni model. |
2020-03-10 |
2023-08-13 |
rat |
| Francesca Caracci, Joyce Harary, Sherry Simkovic, Giulio Maria Pasinett. Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity. Journal of agricultural and food chemistry. vol 68. issue 7. 2020-02-26. PMID:31532659. |
major depressive disorder (mdd) is associated with stress-induced immune dysregulation and reduced brain-derived neurotrophic factor (bdnf) levels in sensitive brain regions associated with depression. |
2020-02-26 |
2023-08-13 |
Not clear |
| Yun Wang, Jing Ni, Ce Gao, Liming Xie, Lingyan Zhai, Guiyun Cui, Xiaoxing Yi. Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:31022424. |
1 l-1β, tnf-α and cox-2), increased bdnf expression and neurogenesis, restored the dysfunction of atp production and oxidative stress in inflammation- induced depression. |
2020-02-14 |
2023-08-13 |
mouse |
| Guanyun Yan, Meng Zhang, Yafang Liu, Mei Yi. Efficacy of vortioxetine combined cognitive behaviour intervention therapy on brain-derived neurotrophic factor level on depressive patients. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 19. issue 5. 2020-02-13. PMID:30780196. |
to evaluate the effect of vortioxetine combined with cognitive behaviour intervention on the level of brain-derived neurotrophic factor (bdnf) in the serum of patients with depression and its therapeutic effect. |
2020-02-13 |
2023-08-13 |
Not clear |
| Tatiana A Gudasheva, Polina Povarnina, Alexey V Tarasiuk, Sergey B Seredeni. The Low Molecular Weight Brain-derived Neurotrophic Factor Mimetics with Antidepressant-like Activity. Current pharmaceutical design. vol 25. issue 6. 2020-02-10. PMID:30931847. |
brain derived neurotrophic factor (bdnf) and signaling through its tropomyosin-related tyrosine kinase b (trkb) receptor, represents one of the most promising therapeutic targets for treating depression. |
2020-02-10 |
2023-08-13 |
Not clear |
| Tatiana A Gudasheva, Polina Povarnina, Alexey V Tarasiuk, Sergey B Seredeni. The Low Molecular Weight Brain-derived Neurotrophic Factor Mimetics with Antidepressant-like Activity. Current pharmaceutical design. vol 25. issue 6. 2020-02-10. PMID:30931847. |
the article reflects on the current literature on the role of bdnf as a promising therapeutic target in the treatment of depression and on the current advances in the development of small molecules on the base of this neurotrophin as potential antidepressants. |
2020-02-10 |
2023-08-13 |
Not clear |
| Elisabeth Maria van Zutphen, Didi Rhebergen, Eric van Exel, Mardien Leoniek Oudega, Filip Bouckaert, Pascal Sienaert, Matthieu Vandenbulcke, Max Stek, Annemieke Dol. Brain-derived neurotrophic factor as a possible predictor of electroconvulsive therapy outcome. Translational psychiatry. vol 9. issue 1. 2020-02-06. PMID:31127089. |
this study assesses the association between pre-treatment bdnf levels and ect outcome in severe late-life unipolar depression (lld). |
2020-02-06 |
2023-08-13 |
Not clear |
| Laura Kranaster, Rainer Hellweg, Alexander Sartoriu. Association between the novel seizure quality index for the outcome prediction in electroconvulsive therapy and brain-derived neurotrophic factor serum levels. Neuroscience letters. vol 704. 2020-02-05. PMID:30978454. |
it was proposed that seizure quality reflected by the sqi will be positively correlated with the levels of serum bdnf after ect in patients with depression. |
2020-02-05 |
2023-08-13 |
Not clear |
| Camila Medeiros Costa, Gabriella Luciana de Oliveira, Angélica Cristina Sousa Fonseca, Raquel de Carvalho Lana, Janaíne Cunha Polese, Andrei Pereira Pernambuc. Levels of cortisol and neurotrophic factor brain-derived in Parkinson's disease. Neuroscience letters. vol 708. 2020-02-03. PMID:31265872. |
the aim of this study was to evaluate salivary cortisol and plasma brain-derived neurotrophic factor (bdnf) in people with pd, to compare them with healthy controls and to associate them with levels of anxiety and depression. |
2020-02-03 |
2023-08-13 |
Not clear |
| Deokho Kim, Quan Feng Liu, Ha Jin Jeong, Seung-Hee Han, Dong-Il Kim, Songhee Jeo. A Modified Formulation of Sutaehwan Ameliorates Menopausal Anxiety, Depression and Heart Hypertrophy in the VCD-Induced Menopausal Mouse Model. Biological & pharmaceutical bulletin. vol 42. issue 9. 2020-01-27. PMID:31474708. |
treatment with sth_kp17001 reversed vcd-induced anxiety and depression through amp-activated protein kinase (ampk) activation and brain-derived neurotrophic factor (bdnf) expression in the cerebral cortex, while improving heart hypertrophy through inactivation of inhibitor of kappab α (iκbα) in the heart. |
2020-01-27 |
2023-08-13 |
mouse |
| Atsushi Sawamoto, Satoshi Okuyama, Mitsunari Nakajima, Yoshiko Furukaw. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacological reports : PR. vol 71. issue 4. 2020-01-16. PMID:31195342. |
in our previous in vivo studies using ischemic and depression mouse models, we revealed that citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (hmf) exerts neuroprotective effects by enhancing the expression of bdnf in astrocytes within the hippocampus. |
2020-01-16 |
2023-08-13 |
mouse |
| John Q Wang, Limin Ma. The ERK Pathway: Molecular Mechanisms and Treatment of Depression. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30737641. |
in addition to erk, the brain-derived neurotrophic factor (bdnf), an immediate upstream regulator of erk, the camp response element-binding protein (creb), a transcription factor downstream to erk, and the mapk phosphatase (mkp) are equally vulnerable to depression. |
2020-01-09 |
2023-08-13 |
Not clear |
| Peng Huang, Tingting Gao, Zhaoyang Dong, Chuying Zhou, Yuling Lai, Ting Pan, Yuan Liu, Xiaoshan Zhao, Xuegang Sun, Heyu Hua, Ge Wen, Lei Gao, Zhiping L. Corrigendum to "Neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: Associations correlations between BDNF levels and BOLD - fMRI signals" [Brain Res. Bull. 142(2018) 107-115]. Brain research bulletin. vol 153. 2020-01-08. PMID:31699272. |
corrigendum to "neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: associations correlations between bdnf levels and bold - fmri signals" [brain res. |
2020-01-08 |
2023-08-13 |
mouse |
| Ryan E Ross, Michael E Saladin, Mark S George, Chris M Gregor. High-Intensity Aerobic Exercise Acutely Increases Brain-derived Neurotrophic Factor. Medicine and science in sports and exercise. vol 51. issue 8. 2020-01-06. PMID:30829963. |
reduced brain-derived neurotrophic factor (bdnf) and elevated cortisol have been implicated in the pathophysiology of depression and appear to normalize with antidepressant treatment. |
2020-01-06 |
2023-08-13 |
Not clear |
| Luciana Cadore Stefani, Fabricio M Leite, Maria da Graça L Tarragó, Simone A Zanette, Andressa de Souza, Stela M Castro, Wolnei Caum. BDNF and serum S100B levels according the spectrum of structural pathology in chronic pain patients. Neuroscience letters. vol 706. 2019-12-27. PMID:31100426. |
ancova analysis followed by heteroscedasticity-consistent covariance matrix was performed to evaluate bdnf and s100b levels, adjusted for depression severity, pain levels and use of analgesics according different pathologies. |
2019-12-27 |
2023-08-13 |
Not clear |
| Maryam S Khan, Gwyneth W Y Wu, Victor I Reus, Christina M Hough, Daniel Lindqvist, Åsa Westrin, Brenton M Nier, Owen M Wolkowitz, Synthia H Mello. Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder. Psychiatry research. vol 273. 2019-12-24. PMID:30640051. |
the "neurotrophic hypothesis of depression" posits that low levels of brain-derived neurotrophic factor (bdnf) are associated with major depressive disorder (mdd). |
2019-12-24 |
2023-08-13 |
human |