| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Randy P Auerbach, Roee Admon, Diego A Pizzagall. Adolescent depression: stress and reward dysfunction. Harvard review of psychiatry. vol 22. issue 3. 2014-12-23. PMID:24704785. |
third, consistent with a diathesis-stress model, the interaction between stress and premorbid reward dysfunction may contribute to the onset of depression. |
2014-12-23 |
2023-08-13 |
human |
| Randy P Auerbach, Roee Admon, Diego A Pizzagall. Adolescent depression: stress and reward dysfunction. Harvard review of psychiatry. vol 22. issue 3. 2014-12-23. PMID:24704785. |
to highlight the translational potential of these insights, a hypothetical case study is provided as a means of demonstrating the importance of targeting reward dysfunction in both assessment and treatment of adolescent depression. |
2014-12-23 |
2023-08-13 |
human |
| Thomas E Schlaepfer, Bettina H Bewernick, Sarah Kayser, Rene Hurlemann, Volker A Coene. Deep brain stimulation of the human reward system for major depression--rationale, outcomes and outlook. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24513970. |
deep brain stimulation of the human reward system for major depression--rationale, outcomes and outlook. |
2014-12-15 |
2023-08-12 |
human |
| Thomas E Schlaepfer, Bettina H Bewernick, Sarah Kayser, Rene Hurlemann, Volker A Coene. Deep brain stimulation of the human reward system for major depression--rationale, outcomes and outlook. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24513970. |
this overview summarizes research on the mechanisms of brain networks with respect to psychiatric diseases and--as a novelty--extrapolates to the role of the reward system in dbs for patients with treatment-resistant depression. |
2014-12-15 |
2023-08-12 |
human |
| Thomas E Schlaepfer, Bettina H Bewernick, Sarah Kayser, Rene Hurlemann, Volker A Coene. Deep brain stimulation of the human reward system for major depression--rationale, outcomes and outlook. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24513970. |
on the scientific side, the reward system has an important yet clearly under-recognized role in both neurobiology and treatment of depression. |
2014-12-15 |
2023-08-12 |
human |
| Małgorzata Frankowska, Joanna Jastrzębska, Ewa Nowak, Magdalena Białko, Edmund Przegaliński, Małgorzata Fili. The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression. Behavioural brain research. vol 266. 2014-12-12. PMID:24613240. |
the effects of n-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression. |
2014-12-12 |
2023-08-12 |
rat |
| Małgorzata Frankowska, Joanna Jastrzębska, Ewa Nowak, Magdalena Białko, Edmund Przegaliński, Małgorzata Fili. The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression. Behavioural brain research. vol 266. 2014-12-12. PMID:24613240. |
nac (25-100mg/kg) given acutely or repeatedly did not alter the co-occurrence of cocaine reward and depression but effectively reduced the cocaine-seeking behavior observed in both phenotypes. |
2014-12-12 |
2023-08-12 |
rat |
| A J Robison, Vincent Vialou, Hao-Sheng Sun, Benoit Labonte, Sam A Golden, Caroline Dias, Gustavo Turecki, Carol Tamminga, Scott Russo, Michelle Mazei-Robison, Eric J Nestle. Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24240473. |
recent work in addiction models demonstrates that the transcription factor Δfosb and protein kinase calmodulin-dependent protein kinase ii (camkii) are co-regulated in nucleus accumbens (nac), a brain reward region implicated in both addiction and depression models including social defeat. |
2014-12-01 |
2023-08-12 |
mouse |
| Tal Gonen, Haggai Sharon, Godfrey Pearlson, Talma Hendle. Moods as ups and downs of the motivation pendulum: revisiting reinforcement sensitivity theory (RST) in bipolar disorder. Frontiers in behavioral neuroscience. vol 8. 2014-11-18. PMID:25404902. |
corresponding to current neurobehavioral theories in psychiatry, this theory links abnormal motivational drives to abnormal behavior; viewing depression and mania as two abnormal extremes of reward driven processes leading to either under or over approach tendencies, respectively. |
2014-11-18 |
2023-08-13 |
Not clear |
| Geoffrey B C Hall, Andrea M B Milne, Glenda M Macquee. An fMRI study of reward circuitry in patients with minimal or extensive history of major depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 3. 2014-11-04. PMID:23990079. |
an fmri study of reward circuitry in patients with minimal or extensive history of major depression. |
2014-11-04 |
2023-08-12 |
human |
| Geoffrey B C Hall, Andrea M B Milne, Glenda M Macquee. An fMRI study of reward circuitry in patients with minimal or extensive history of major depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 3. 2014-11-04. PMID:23990079. |
in addition, areas such as the nucleus accumbens, anterior cingulate and ventral prefrontal cortices were activated greatest by controls during reward processing, less by patients early in the course of illness and least by patients with highly recurrent illness-suggesting that these areas are sensitive to the impact of disease burden and repeated episodes of depression. |
2014-11-04 |
2023-08-12 |
human |
| Geoffrey B C Hall, Andrea M B Milne, Glenda M Macquee. An fMRI study of reward circuitry in patients with minimal or extensive history of major depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 3. 2014-11-04. PMID:23990079. |
reward processing in people with depression may be associated with diminished signaling of incentive salience, a reduction in the formation of reward-related associations and heightened sensitivities for negatively valenced stimuli, all of which could contribute to symptoms of depression. |
2014-11-04 |
2023-08-12 |
human |
| Elizabeth W Gonzalez, Marcia Polansky, Carol F Lippa, Laura N Gitlin, Jaclene A Zauszniewsk. Enhancing resourcefulness to improve outcomes in family caregivers and persons with Alzheimer's disease: a pilot randomized trial. International journal of Alzheimer's disease. vol 2014. 2014-10-20. PMID:25328754. |
this pilot randomized trial tested an intervention aimed at enhancing resourcefulness in family caregivers of persons with dementia, postulating that caregivers' emotional outcomes (anxiety and depression) and role outcomes (reward, strain, mutuality, and preparedness) would be improved, and problem behaviors in the care recipients (persons with dementia) would be reduced as a result of the intervention. |
2014-10-20 |
2023-08-13 |
human |
| Thomas M Olino, Dana L McMakin, Judith K Morgan, Jennifer S Silk, Boris Birmaher, David A Axelson, Douglas E Williamson, Ronald E Dahl, Neal D Ryan, Erika E Forbe. Reduced reward anticipation in youth at high-risk for unipolar depression: a preliminary study. Developmental cognitive neuroscience. vol 8. 2014-09-29. PMID:24369885. |
we investigated whether self-reports of pa and fmri-measured striatal response to reward, a neural correlate of pa, are reduced in adolescent youth at high familial risk for depression (hr) relative to youth at low familial risk for depression (lr). |
2014-09-29 |
2023-08-12 |
Not clear |
| Thomas M Olino, Dana L McMakin, Judith K Morgan, Jennifer S Silk, Boris Birmaher, David A Axelson, Douglas E Williamson, Ronald E Dahl, Neal D Ryan, Erika E Forbe. Reduced reward anticipation in youth at high-risk for unipolar depression: a preliminary study. Developmental cognitive neuroscience. vol 8. 2014-09-29. PMID:24369885. |
further examinations of prospective associations between reward response and depression onset are needed. |
2014-09-29 |
2023-08-12 |
Not clear |
| Melynda D Casement, Amanda E Guyer, Alison E Hipwell, Rose L McAloon, Amy M Hoffmann, Kathryn E Keenan, Erika E Forbe. Girls' challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms. Developmental cognitive neuroscience. vol 8. 2014-09-29. PMID:24397999. |
developmental models of psychopathology posit that exposure to social stressors may confer risk for depression in adolescent girls by disrupting neural reward circuitry. |
2014-09-29 |
2023-08-12 |
human |
| Melynda D Casement, Amanda E Guyer, Alison E Hipwell, Rose L McAloon, Amy M Hoffmann, Kathryn E Keenan, Erika E Forbe. Girls' challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms. Developmental cognitive neuroscience. vol 8. 2014-09-29. PMID:24397999. |
these findings are consistent with developmental models that emphasize the adverse impact of early psychosocial stressors on neural reward processing and risk for depression in adolescence. |
2014-09-29 |
2023-08-12 |
human |
| Anahi Collado, Soraida D Castillo, Fabian Maero, C W Lejuez, Laura Macpherso. Pilot of the brief behavioral activation treatment for depression in latinos with limited english proficiency: preliminary evaluation of efficacy and acceptability. Behavior therapy. vol 45. issue 1. 2014-09-12. PMID:24411118. |
increases in activation corresponded concurrently with decreases in depression (p=.01), while environmental reward preceded decreases in depressive symptomatology (all p's ≤ .04). |
2014-09-12 |
2023-08-12 |
human |
| Anahi Collado, Soraida D Castillo, Fabian Maero, C W Lejuez, Laura Macpherso. Pilot of the brief behavioral activation treatment for depression in latinos with limited english proficiency: preliminary evaluation of efficacy and acceptability. Behavior therapy. vol 45. issue 1. 2014-09-12. PMID:24411118. |
follow-up analyses revealed sustained clinical gains in depression and activation, and an increase in environmental reward at follow-up. |
2014-09-12 |
2023-08-12 |
human |
| Dandan Liu, Linghan Hu, Junqi Zhang, Ping Zhang, Shengtian L. Attenuated inhibition of medium spiny neurons participates in the pathogenesis of childhood depression. Neural regeneration research. vol 9. issue 10. 2014-09-10. PMID:25206763. |
accumulating evidence suggests that the nucleus accumbens, which is involved in mechanisms of reward and addiction, plays a role in the pathogenesis of depression and in the action of antidepressants. |
2014-09-10 |
2023-08-13 |
rat |