| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sam A Golden, Daniel J Christoffel, Mitra Heshmati, Georgia E Hodes, Jane Magida, Keithara Davis, Michael E Cahill, Caroline Dias, Efrain Ribeiro, Jessica L Ables, Pamela J Kennedy, Alfred J Robison, Javier Gonzalez-Maeso, Rachael L Neve, Gustavo Turecki, Subroto Ghose, Carol A Tamminga, Scott J Russ. Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nature medicine. vol 19. issue 3. 2013-05-09. PMID:23416703. |
depression induces structural and functional synaptic plasticity in brain reward circuits, although the mechanisms promoting these changes and their relevance to behavioral outcomes are unknown. |
2013-05-09 |
2023-08-12 |
mouse |
| F Woodward Hopf, Taban Seif, Shinjae Chung, Olivier Civell. MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ. vol 1. 2013-05-07. PMID:23646281. |
the mch and dopamine receptor systems have been shown to modulate a number of behaviors related to reward processing, addiction, and neuropsychiatric conditions such as schizophrenia and depression. |
2013-05-07 |
2023-08-12 |
Not clear |
| Joshua H Jennings, Dennis R Sparta, Alice M Stamatakis, Randall L Ung, Kristen E Pleil, Thomas L Kash, Garret D Stube. Distinct extended amygdala circuits for divergent motivational states. Nature. vol 496. issue 7444. 2013-04-29. PMID:23515155. |
the co-morbidity of anxiety and dysfunctional reward processing in illnesses such as addiction and depression suggests that common neural circuitry contributes to these disparate neuropsychiatric symptoms. |
2013-04-29 |
2023-08-12 |
mouse |
| Benjamin L Hankin, Emily K Wetter, Kate Flor. Appetitive motivation and negative emotion reactivity among remitted depressed youth. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. vol 41. issue 5. 2013-03-14. PMID:22901275. |
findings suggest that depression among youth is related to dysregulated appetitive motivation and associated negative emotional reactivity after failing to achieve an important, self-relevant goal and not attaining reward. |
2013-03-14 |
2023-08-12 |
Not clear |
| Benjamin L Hankin, Emily K Wetter, Kate Flor. Appetitive motivation and negative emotion reactivity among remitted depressed youth. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. vol 41. issue 5. 2013-03-14. PMID:22901275. |
these deficits in reward processing appear to be specific to depression as externalizing disordered youth did not display negative emotional reactivity to failure after their appetitive motivation system was activated. |
2013-03-14 |
2023-08-12 |
Not clear |
| Dipesh Chaudhury, Jessica J Walsh, Allyson K Friedman, Barbara Juarez, Stacy M Ku, Ja Wook Koo, Deveroux Ferguson, Hsing-Chen Tsai, Lisa Pomeranz, Daniel J Christoffel, Alexander R Nectow, Mats Ekstrand, Ana Domingos, Michelle S Mazei-Robison, Ezekiell Mouzon, Mary Kay Lobo, Rachael L Neve, Jeffrey M Friedman, Scott J Russo, Karl Deisseroth, Eric J Nestler, Ming-Hu Ha. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature. vol 493. issue 7433. 2013-03-04. PMID:23235832. |
phasic firing of the neurons, which is well known to encode reward signals, is upregulated by repeated social-defeat stress, a highly validated mouse model of depression. |
2013-03-04 |
2023-08-12 |
mouse |
| Chaoqiong Ma, Jurong Ding, Jun Li, Wenbin Guo, Zhiliang Long, Feng Liu, Qing Gao, Ling Zeng, Jingping Zhao, Huafu Che. Resting-state functional connectivity bias of middle temporal gyrus and caudate with altered gray matter volume in major depression. PloS one. vol 7. issue 9. 2013-02-28. PMID:23028892. |
these results suggest that the abnormal dmn and reward circuit activity might be biomarkers of depression trait. |
2013-02-28 |
2023-08-12 |
Not clear |
| Ciara McCabe, Caroline Woffindale, Catherine J Harmer, Philip J Cowe. Neural processing of reward and punishment in young people at increased familial risk of depression. Biological psychiatry. vol 72. issue 7. 2013-02-06. PMID:22704059. |
neural processing of reward and punishment in young people at increased familial risk of depression. |
2013-02-06 |
2023-08-12 |
Not clear |
| Claudia Menne-Lothmann, Nele Jacobs, Catherine Derom, Evert Thiery, Jim van Os, Marieke Wicher. Genetic and environmental causes of individual differences in daily life positive affect and reward experience and its overlap with stress-sensitivity. Behavior genetics. vol 42. issue 5. 2013-02-05. PMID:22976548. |
stress-sensitivity, indexing depression vulnerability, and reward experience were non-overlapping, suggesting that resilience traits are independent from stress-sensitivity levels in a general population sample. |
2013-02-05 |
2023-08-12 |
Not clear |
| Lampros Perogamvros, Sophie Schwart. The roles of the reward system in sleep and dreaming. Neuroscience and biobehavioral reviews. vol 36. issue 8. 2012-12-27. PMID:22669078. |
the ml-da system is implicated in reward and emotional functions, and it is perturbed in schizophrenia, addiction, and depression. |
2012-12-27 |
2023-08-12 |
Not clear |
| C Nocjar, J Zhang, P Feng, J Panksep. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. vol 218. 2012-11-16. PMID:22626650. |
two brain neuropeptides that have been implicated in anhedonia symptomology in preclinical depression models are dynorphin and orexin; which are concentrated along lateral hypothalamic dopamine reward pathways. |
2012-11-16 |
2023-08-12 |
rat |
| Jang Ho Park, Hoyoung An, Eun Sook Jang, Seockhoon Chun. The influence of personality and dysfunctional sleep-related cognitions on the severity of insomnia. Psychiatry research. vol 197. issue 3. 2012-11-13. PMID:22365274. |
stepwise multiple regression analysis showed that sleep-related cognitions, depression and reward dependence scores were significant determinants of insomnia severity, and that sleep-related cognitions and self-transcendence were significant positive determinants of sleep quality. |
2012-11-13 |
2023-08-12 |
Not clear |
| Jang Ho Park, Hoyoung An, Eun Sook Jang, Seockhoon Chun. The influence of personality and dysfunctional sleep-related cognitions on the severity of insomnia. Psychiatry research. vol 197. issue 3. 2012-11-13. PMID:22365274. |
reward dependence, depression and sleep-related cognitions were associated with insomnia severity, and comparison with previous findings implied that 'internalizing behavior' and depression may be more plausible candidates for the link between personality and insomnia than anxiety. |
2012-11-13 |
2023-08-12 |
Not clear |
| Tomoyuki Furuyashiki, Yuichi Deguch. [Roles of altered striatal function in major depression]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 8. 2012-10-18. PMID:22868883. |
given the role of the striatum in behavioral learning with positive reinforcers, abnormalities as such suggest that impairment in reward processing and/or reinforcement learning in major depression is the basis of anhedonia and reduced psychomotor activity. |
2012-10-18 |
2023-08-12 |
human |
| Gabriel S Dichter, Rachel V Kozink, F Joseph McClernon, Moria J Smosk. Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes. Journal of affective disorders. vol 136. issue 3. 2012-10-09. PMID:22036801. |
remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes. |
2012-10-09 |
2023-08-12 |
Not clear |
| Delphine Raucher-Chéné, Fabien Gierski, Bérengère Hübsch, Christine-Vanessa Cuervo-Lombard, Céline Bera-Potelle, Renaud Cohen, Jean-Pierre Kahn, Arthur Kaladjian, Frédéric Limosi. Depression, anxiety and personality dimensions in female first-degree relatives of alcohol-dependent probands. Archives of women's mental health. vol 15. issue 3. 2012-09-13. PMID:22411191. |
family history positive women showed significant higher prevalence rates of depression and agoraphobia, and exhibited lower scores on reward dependence, self-directedness and cooperativeness dimensions. |
2012-09-13 |
2023-08-12 |
Not clear |
| Xi Lu, Zi Chen, Xiaoyi Cui, Masayo Uji, Wataru Miyazaki, Masako Oda, Toshiaki Nagata, Toshinori Kitamura, Takahiko Kato. Effects of temperament and character profiles on state and trait depression and anxiety: a prospective study of a Japanese youth population. Depression research and treatment. vol 2012. 2012-09-10. PMID:22957225. |
structural regression modeling showed that (1) only high novelty seeking predicted t2 anxiety score, (2) trait depression and anxiety were linked to high harm avoidance and low self-directedness, and (3) trait depression was linked to high self-transcendence whereas trait anxiety was linked to low reward dependence, persistence, and cooperativeness. |
2012-09-10 |
2023-08-12 |
Not clear |
| Marlena M Ryba, Derek R Hopk. Gender Differences in Depression: Assessing Mediational Effects of Overt Behaviors and Environmental Reward through Daily Diary Monitoring. Depression research and treatment. vol 2012. 2012-08-23. PMID:22454769. |
gender differences in depression: assessing mediational effects of overt behaviors and environmental reward through daily diary monitoring. |
2012-08-23 |
2023-08-12 |
Not clear |
| Marlena M Ryba, Derek R Hopk. Gender Differences in Depression: Assessing Mediational Effects of Overt Behaviors and Environmental Reward through Daily Diary Monitoring. Depression research and treatment. vol 2012. 2012-08-23. PMID:22454769. |
to further explore the relation between gender and depression, this study used daily diaries to examine gender differences within thirteen behavioral domains and whether differential frequency of overt behaviors and environmental reward mediated the relationship between gender and depression severity. |
2012-08-23 |
2023-08-12 |
Not clear |
| Marlena M Ryba, Derek R Hopk. Gender Differences in Depression: Assessing Mediational Effects of Overt Behaviors and Environmental Reward through Daily Diary Monitoring. Depression research and treatment. vol 2012. 2012-08-23. PMID:22454769. |
this effect was attenuated by the mediator (total environmental reward) such that to the extent females exhibited increased environmental reward, the gender effect on depression was attenuated. |
2012-08-23 |
2023-08-12 |
Not clear |