| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Tang, Qiong Huang, Yan Wang, Zheng-Yu Wang, Yu-You Ya. Assessment of CSF Aβ42 as an aid to discriminating Alzheimer's disease from other dementias and mild cognitive impairment: a meta-analysis of 50 studies. Journal of the neurological sciences. vol 345. issue 1-2. 2015-05-28. PMID:25086857. |
the aim of our study is to evaluate the clinical importance of cerebrospinal fluid (csf) β-amyloid 42 (aβ42) in mci, ad and other dementias, more specifically: frontotemporal dementia (ftd), dementia with lewy bodies (dlb), parkinson's disease (pd) with dementia (pdd) and vascular dementia (vad). |
2015-05-28 |
2023-08-13 |
Not clear |
| Maja A A Binnewijzend, Joost P A Kuijer, Wiesje M van der Flier, Marije R Benedictus, Christiane M Möller, Yolande A L Pijnenburg, Afina W Lemstra, Niels D Prins, Mike P Wattjes, Bart N M van Berckel, Philip Scheltens, Frederik Barkho. Distinct perfusion patterns in Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies. European radiology. vol 24. issue 9. 2015-05-26. PMID:24996793. |
to compare pseudo-continuous arterial spin-labelled (pcasl) magnetic resonance imaging (mri) measured quantitative cerebral blood flow (cbf) of patients with frontotemporal dementia (ftd), dementia with lewy bodies (dlb), alzheimer's disease (ad) and controls, in a region of interest (roi) and voxel-wise fashion. |
2015-05-26 |
2023-08-13 |
Not clear |
| JianGuo Zhong, PingLei Pan, ZhenYu Dai, HaiCun Sh. Voxelwise meta-analysis of gray matter abnormalities in dementia with Lewy bodies. European journal of radiology. vol 83. issue 10. 2015-05-15. PMID:25043498. |
increasing neuroimaging studies have revealed brain gray matter (gm) atrophy by voxel-based morphometry (vbm) studies in patients with dementia with lewy bodies (dlb) relative to healthy controls. |
2015-05-15 |
2023-08-13 |
Not clear |
| Daniel F Tardiff, Vikram Khurana, Chee Yeun Chung, Susan Lindquis. From yeast to patient neurons and back again: powerful new discovery platform. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 10. 2015-05-14. PMID:25131316. |
no disease-modifying therapies are available for synucleinopathies, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple systems atrophy (msa). |
2015-05-14 |
2023-08-13 |
Not clear |
| Kanta Tanaka, Ikko Wada, Taro Okunomiya, Atsushi Shima, Daisuke Kambe, Akiyo Shinde, Takashi Kageyama, Toshihiko Suenag. Dropped head syndrome preceding the onset of dementia with Lewy bodies. Internal medicine (Tokyo, Japan). vol 53. issue 8. 2015-05-11. PMID:24739611. |
we diagnosed the patient with dementia with lewy bodies (dlb). |
2015-05-11 |
2023-08-13 |
Not clear |
| Jun Mitsui, Takashi Matsukawa, Hidenao Sasaki, Ichiro Yabe, Masaaki Matsushima, Alexandra Dürr, Alexis Brice, Hiroshi Takashima, Akio Kikuchi, Masashi Aoki, Hiroyuki Ishiura, Tsutomu Yasuda, Hidetoshi Date, Budrul Ahsan, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yasuo Nakahara, Yoshio Momose, Yuji Takahashi, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Takamichi Hattori, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Tomoyoshi Kondo, Shigeo Murayama, Nobutaka Hattori, Mitsutoshi Yamamoto, Miho Murata, Wataru Satake, Tatsushi Toda, Alessandro Filla, Thomas Klockgether, Ullrich Wüllner, Garth Nicholson, Sid Gilman, Caroline M Tanner, Walter A Kukull, Mathew B Stern, Virginia M-Y Lee, John Q Trojanowski, Eliezer Masliah, Phillip A Low, Paola Sandroni, Laurie J Ozelius, Tatiana Foroud, Shoji Tsuj. Variants associated with Gaucher disease in multiple system atrophy. Annals of clinical and translational neurology. vol 2. issue 4. 2015-04-24. PMID:25909086. |
glucocerebrosidase gene (gba) variants that cause gaucher disease are associated with parkinson disease (pd) and dementia with lewy bodies (dlb). |
2015-04-24 |
2023-08-13 |
Not clear |
| David R Lee, Ian McKeith, Urs Mosimann, Arunima Ghosh-Nodial, Louise Grayson, Barbara Wilson, Alan J Thoma. The dementia cognitive fluctuation scale, a new psychometric test for clinicians to identify cognitive fluctuations in people with dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 22. issue 9. 2015-04-22. PMID:24332982. |
cognitive fluctuation (cf) is a common feature of dementia and a core diagnostic symptom for dementia with lewy bodies (dlb). |
2015-04-22 |
2023-08-12 |
Not clear |
| David R Lee, Ian McKeith, Urs Mosimann, Arunima Ghosh-Nodial, Louise Grayson, Barbara Wilson, Alan J Thoma. The dementia cognitive fluctuation scale, a new psychometric test for clinicians to identify cognitive fluctuations in people with dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 22. issue 9. 2015-04-22. PMID:24332982. |
this study aimed to develop a psychometric test that could be used by clinicians to facilitate the identification of cf and improve the recognition and diagnosis of dlb and parkinson disease, and to improve differential diagnosis of other dementias. |
2015-04-22 |
2023-08-12 |
Not clear |
| Hien T Tran, Charlotte Hiu-Yan Chung, Michiyo Iba, Bin Zhang, John Q Trojanowski, Kelvin C Luk, Virginia M Y Le. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell reports. vol 7. issue 6. 2015-04-16. PMID:24931606. |
accumulation of misfolded alpha-synuclein (α-syn) into lewy bodies (lbs) and lewy neurites (lns) is a major hallmark of parkinson's disease (pd) and dementia with lbs (dlb). |
2015-04-16 |
2023-08-13 |
mouse |
| Karen E Murphy, Louise Cottle, Amanda M Gysbers, Antony A Cooper, Glenda M Hallida. ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252509. |
this apparent conflict in protein levels might have arisen from examining lewy body disease cases with coexisting alzheimer-type pathologies.to assess whether atp13a2 levels in lewy body disease are modified by alzheimer-type β-amyloid deposition, we evaluated cases of pure pd and pure dementia with lewy bodies (dlb) for changes in atp13a2, α-synuclein and β-amyloid protein levels in cortical regions with and without lewy bodies. |
2015-03-31 |
2023-08-12 |
human |
| Radoslaw Magierski, Tomasz Sobo. Magnetic resonance spectroscopy in the diagnosis of dementia with Lewy bodies. BioMed research international. vol 2014. 2015-03-31. PMID:25110697. |
dementia with lewy bodies (dlb) is considered to be the second most frequent primary degenerative dementing illness after alzheimer's disease (ad). |
2015-03-31 |
2023-08-13 |
Not clear |
| Radoslaw Magierski, Tomasz Sobo. Magnetic resonance spectroscopy in the diagnosis of dementia with Lewy bodies. BioMed research international. vol 2014. 2015-03-31. PMID:25110697. |
dlb, together with parkinson's disease (pd), parkinson's disease with dementia (pdd) belong to α-synucleinopathies--a group of neurodegenerative diseases associated with pathological accumulation of the α-synuclein protein. |
2015-03-31 |
2023-08-13 |
Not clear |
| Radoslaw Magierski, Tomasz Sobo. Magnetic resonance spectroscopy in the diagnosis of dementia with Lewy bodies. BioMed research international. vol 2014. 2015-03-31. PMID:25110697. |
dementia due to pd and dlb shares clinical symptoms and neuropsychological profiles. |
2015-03-31 |
2023-08-13 |
Not clear |
| Ellen Gelpi, Judith Navarro-Otano, Eduardo Tolosa, Carles Gaig, Yaroslau Compta, María Jesús Rey, Maria José Martí, Isabel Hernández, Francesc Valldeoriola, Ramon Reñé, Teresa Ribalt. Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 8. 2015-03-30. PMID:24395122. |
detailed postmortem histopathological study of brain and peripheral tissues from 28 brain bank donors (10 with parkinson's disease [pd], 5 with dementia with lb [dlb], and 13 with non-lb diseases including atypical parkinsonism and non-lb dementia). |
2015-03-30 |
2023-08-12 |
Not clear |
| Christos Proukakis, Maryiam Shoaee, James Morris, Timothy Brier, Eleanna Kara, Una-Marie Sheerin, Gavin Charlesworth, Eduardo Tolosa, Henry Houlden, Nicholas W Wood, Anthony H Schapir. Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 8. 2015-03-30. PMID:24752924. |
although alpha-synuclein (snca) is crucial to the pathogenesis of parkinson's disease (pd) and dementia with lewy bodies (dlb), mutations in the gene appear to be rare. |
2015-03-30 |
2023-08-13 |
Not clear |
| Masaaki Waragai, Saori Hata, Toshiharu Suzuki, Ryotaro Ishii, Chihiro Fujii, Takahiko Tokuda, Hiroyuki Arai, Takashi Ohrui, Susumu Higuchi, Madoka Yoshida, Kazuei Igarashi, Masaru Moriya, Naomichi Iwai, Kenichi Uemur. Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787913. |
at the 3-year follow-up, the 228 subject were classified as follows: 93 healthy subjects, 42 mci-non-converters (mci-nc), 25 mci-converters to ad (mci-c), 44 ad, 8 dementia with lewy bodies (dlb), 5 normal pressure hydrocephalus, and 11 patients with other neurological diseases. |
2015-03-30 |
2023-08-13 |
human |
| Masaaki Waragai, Saori Hata, Toshiharu Suzuki, Ryotaro Ishii, Chihiro Fujii, Takahiko Tokuda, Hiroyuki Arai, Takashi Ohrui, Susumu Higuchi, Madoka Yoshida, Kazuei Igarashi, Masaru Moriya, Naomichi Iwai, Kenichi Uemur. Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787913. |
furthermore, the 118 subjects without dementia and mta showing only a decreased naa/mi ratio at baseline developed to mci-c, ad, and dlb 3 years later. |
2015-03-30 |
2023-08-13 |
human |
| Katie Hall, Sujeong Yang, Olga Sauchanka, Maria Grazia Spillantini, Oleg Anichtchi. Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein. Experimental neurology. vol 264. 2015-03-30. PMID:25450466. |
accumulation and aggregation of alpha-synuclein in cortical and hippocampal areas is a pathological sign for dementia with lewy bodies (dlb) and parkinson's disease with dementia. |
2015-03-30 |
2023-08-13 |
mouse |
| Hui-Fu Wang, Jin-Tai Yu, Shao-Wen Tang, Teng Jiang, Chen-Chen Tan, Xiang-Fei Meng, Chong Wang, Meng-Shan Tan, Lan Ta. Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 2. 2015-03-27. PMID:24828899. |
recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to parkinson's disease (cind-pd or pdd) and dementia with lewy bodies (dlb) were completed. |
2015-03-27 |
2023-08-13 |
Not clear |
| b' Gabor G Kovacs, Leonid Breydo, Ryan Green, Viktor Kis, Gina Puska, P\\xc3\\xa9ter L\\xc5\\x91rincz, Laura Perju-Dumbrava, Regina Giera, Walter Pirker, Mirjam Lutz, Ingolf Lachmann, Herbert Budka, Vladimir N Uversky, Kinga Moln\\xc3\\xa1r, Lajos L\\xc3\\xa1szl\\xc3\\xb. Intracellular processing of disease-associated \\xce\\xb1-synuclein in the human brain suggests prion-like cell-to-cell spread. Neurobiology of disease. vol 69. 2015-03-12. PMID:24878508.' |
dementia with lewy bodies (dlb), parkinson's disease (pd) and multiple system atrophy are characterized by the deposition of disease-associated α-synuclein. |
2015-03-12 |
2023-08-13 |
human |