| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuhei Chiba, Hiroshige Fujishiro, Kazumi Ota, Koji Kasanuki, Heii Arai, Yoshio Hirayasu, Kiyoshi Sato, Eizo Isek. Clinical profiles of dementia with Lewy bodies with and without Alzheimer's disease-like hypometabolism. International journal of geriatric psychiatry. vol 30. issue 3. 2015-09-24. PMID:24839913. |
it is well known that alzheimer's disease (ad)-type pathology is commonly present in dementia with lewy bodies (dlb) brains and that the degree of ad-type pathology has an influence on the clinical characteristics of dlb. |
2015-09-24 |
2023-08-13 |
Not clear |
| Chiara Cerami, Pasquale Anthony Della Rosa, Giuseppe Magnani, Roberto Santangelo, Alessandra Marcone, Stefano F Cappa, Daniela Peran. Brain metabolic maps in Mild Cognitive Impairment predict heterogeneity of progression to dementia. NeuroImage. Clinical. vol 7. 2015-09-24. PMID:25610780. |
the spm analysis showed: 1) normal brain metabolism in 14 mci cases, none of them progressing to dementia; 2) the typical temporo-parietal pattern suggestive for prodromal ad in 15 cases, 11 of them progressing to ad; 3) brain hypometabolism suggestive of frontotemporal lobar degeneration (ftld) subtypes in 7 and dementia with lewy bodies (dlb) in 2 subjects (all fulfilled ftld or dlb clinical criteria at follow-up); and 4) 7 mci cases showed a selective unilateral or bilateral temporo-medial hypometabolism without the typical ad pattern, and they all remained stable. |
2015-09-24 |
2023-08-13 |
human |
| Elijah Mak, Li Su, Guy B Williams, Rosie Watson, Michael Firbank, Andrew M Blamire, John T O'Brie. Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies. NeuroImage. Clinical. vol 7. 2015-09-24. PMID:25685712. |
we compared pbvc in ad and dementia with lewy bodies (dlb), and investigated associations with clinical measures. |
2015-09-24 |
2023-08-13 |
Not clear |
| Zuzana Nedelska, Tanis J Ferman, Bradley F Boeve, Scott A Przybelski, Timothy G Lesnick, Melissa E Murray, Jeffrey L Gunter, Matthew L Senjem, Prashanti Vemuri, Glenn E Smith, Yonas E Geda, Jonathan Graff-Radford, David S Knopman, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Kejal Kantarc. Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25128280. |
dementia with lewy bodies (dlb) is characterized by preserved whole brain and medial temporal lobe volumes compared with alzheimer's disease dementia (ad) on magnetic resonance imaging. |
2015-09-21 |
2023-08-13 |
human |
| Laura Bonanni, Bernardo Perfetti, Stefania Bifolchetti, John-Paul Taylor, Raffaella Franciotti, Lucilla Parnetti, Astrid Thomas, Marco Onofr. Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25129239. |
mild cognitive impairment (mci) as a precursor of dementia with lewy bodies (dlb) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of dlb. |
2015-09-21 |
2023-08-13 |
human |
| Laura Bonanni, Bernardo Perfetti, Stefania Bifolchetti, John-Paul Taylor, Raffaella Franciotti, Lucilla Parnetti, Astrid Thomas, Marco Onofr. Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25129239. |
at the end of follow-up, 20 subjects had developed probable dlb (mci-dlb), 14 had probable ad (mci-ad), 8 did not convert to dementia, 5 developed a non-ad/dlb dementia. |
2015-09-21 |
2023-08-13 |
human |
| Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Makoto Hosono, Yuzuru Yamazoe, Takamichi Murakam. Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition. Annals of nuclear medicine. vol 29. issue 1. 2015-09-21. PMID:25270712. |
there is evidence that some cases of patients with dementia with lewy bodies (dlb) can demonstrate alzheimer disease (ad) like reduced glucose metabolism without amyloid deposition. |
2015-09-21 |
2023-08-13 |
Not clear |
| J Scott Miners, Ruth Renfrew, Marta Swirski, Seth Lov. Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1. Acta neuropathologica communications. vol 2. 2015-09-17. PMID:25476568. |
we measured calpain-1 activity by fluorogenic activity assay, kallikrein-6 level by sandwich elisa, and levels of α-synuclein and α-synuclein phosphorylated at serine 129 (α-synuclein-p129), in post-mortem brain tissue in pure dementia with lewy bodies (dlb, n=12), alzheimer's disease (ad, n=20) and age-matched controls (n=19). |
2015-09-17 |
2023-08-13 |
Not clear |
| David R Whitfield, Julie Vallortigara, Amani Alghamdi, Tibor Hortobágyi, Clive Ballard, Alan J Thomas, John T O'Brien, Dag Aarsland, Paul T Franci. Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 23. issue 2. 2015-09-10. PMID:24953873. |
depression is a common symptom in dementia with lewy bodies (dlb), parkinson disease dementia (pdd), and alzheimer disease (ad), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. |
2015-09-10 |
2023-08-13 |
Not clear |
| Asa Hatami, Marie-Francoise Chessele. Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits. Current topics in behavioral neurosciences. vol 22. 2015-09-10. PMID:25218491. |
two of the most common synucleinopathies are parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2015-09-10 |
2023-08-13 |
mouse |
| Asa Hatami, Marie-Francoise Chessele. Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits. Current topics in behavioral neurosciences. vol 22. 2015-09-10. PMID:25218491. |
in contrast, dementia is the dominating feature of dlb from the disease onset. |
2015-09-10 |
2023-08-13 |
mouse |
| Qiang Zhang, Young-Cho Kim, Nandakumar S Narayana. Disease-modifying therapeutic directions for Lewy-Body dementias. Frontiers in neuroscience. vol 9. 2015-09-08. PMID:26347604. |
dementia with lewy bodies (dlb) is the second leading cause of dementia following alzheimer's disease (ad) and accounts for up to 25% of all dementia. |
2015-09-08 |
2023-08-13 |
Not clear |
| Bo Zhou, Min Wen, Wen-Feng Yu, Chun-Lin Zhang, Ling Jia. The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α -Synuclein Levels in Parkinson's Disease: A Meta-Analysis. Parkinson's disease. vol 2015. 2015-09-04. PMID:26336612. |
no significant difference in mean concentration of csf α-syn was found between pd and dementia with lewy bodies (dlb). |
2015-09-04 |
2023-08-13 |
human |
| E-J Bae, H-J Lee, Y-H Jang, S Michael, E Masliah, D S Min, S-J Le. Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates. Cell death and differentiation. vol 21. issue 7. 2015-09-01. PMID:24632948. |
finally, we demonstrated that both pld activity and expression levels were reduced in brain tissues of dementia with lewy bodies (dlb) patients, whereas the amounts of α-synuclein and p62 were increased in the same tissue samples. |
2015-09-01 |
2023-08-12 |
Not clear |
| Keith A Wesnes, Dag Aarsland, Clive Ballard, Elisabet Londo. Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies. International journal of geriatric psychiatry. vol 30. issue 1. 2015-08-31. PMID:24737460. |
in both dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd), attentional dysfunction is a core clinical feature together with disrupted episodic memory. |
2015-08-31 |
2023-08-13 |
Not clear |
| Timo S Spehl, Lars Frings, Sabine Hellwig, Cornelius Weiller, Michael Hüll, Philipp T Meyer, Florian Amtag. Role of semiquantitative assessment of regional binding potential in 123I-FP-CIT SPECT for the differentiation of frontotemporal dementia, dementia with Lewy bodies, and Alzheimer's dementia. Clinical nuclear medicine. vol 40. issue 1. 2015-08-31. PMID:25140560. |
i-fp-cit spect is increasingly used to differentiate between alzheimer's dementia (ad) and dementia with lewy bodies (dlb). |
2015-08-31 |
2023-08-13 |
Not clear |
| Angelo Del Sole, Giulia Perini, Michela Lecchi, Claudio Mariani, Giovanni Lucignani, Francesca Cleric. Correlation between 123I-FP-CIT brain SPECT and parkinsonism in dementia with Lewy bodies: caveat for clinical use. Clinical nuclear medicine. vol 40. issue 1. 2015-08-31. PMID:25290294. |
although parkinsonism is considered a core feature of dementia with lewy bodies (dlb), it is occasionally mild or even absent. |
2015-08-31 |
2023-08-13 |
Not clear |
| Peizhong Ma. Oxidative Stress and Its Clinical Applications in Dementia. Journal of neurodegenerative diseases. vol 2013. 2015-08-28. PMID:26316986. |
alzheimer's disease (ad)- associated dementia and dementia with lewy bodies (dlb) are the most common forms of dementia, in which oxidative stress is significantly involved. |
2015-08-28 |
2023-08-13 |
Not clear |
| Satoshi Orim. [Differential diagnosis of dementia with lewy bodies]. Brain and nerve = Shinkei kenkyu no shinpo. vol 67. issue 4. 2015-08-24. PMID:25846590. |
kosaka and colleagues first reported dementia with lewy bodies (dlb) in 1976. |
2015-08-24 |
2023-08-13 |
Not clear |
| R Scott Mackin, Philip Insel, Jing Zhang, Brian Mohlenhoff, Douglas Galasko, Michael Weiner, Niklas Mattsso. Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25125463. |
reduced cerebrospinal fluid (csf) α-synuclein has been described in synucleinopathies, including dementia with lewy bodies (dlb). |
2015-08-21 |
2023-08-13 |
Not clear |