| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominik Brück, Gregor K Wenning, Nadia Stefanova, Lisa Fellne. Glia and alpha-synuclein in neurodegeneration: A complex interaction. Neurobiology of disease. vol 85. 2016-09-21. PMID:25766679. |
α-synucleinopathies (asp) comprise adult-onset, progressive neurodegenerative disorders such as parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa) that are characterized by α-synuclein (as) aggregates in neurons or glia. |
2016-09-21 |
2023-08-13 |
Not clear |
| Stephen N Gomperts, Marta Marquie, Joseph J Locascio, Stephen Bayer, Keith A Johnson, John H Growdo. PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies. Neuro-degenerative diseases. vol 16. issue 1-2. 2016-09-20. PMID:26655867. |
effective therapies for dementia with lewy bodies (dlb) and parkinson's disease (pd) dementia will require accurate diagnosis and an understanding of the contribution of distinct molecular pathologies to these diseases. |
2016-09-20 |
2023-08-13 |
Not clear |
| Hiroshige Fujishiro, Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Youta Torii, Shinji Matsunaga, Norio Ozaki, Mari Yoshida, Kiyoshi Fujit. Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 16. issue 2. 2016-09-16. PMID:25919332. |
discrepancies between clinical and pathological diagnoses of dementia with lewy bodies (dlb) may occur because the full disease progression remains unclear, especially during the early stage. |
2016-09-16 |
2023-08-13 |
Not clear |
| Mariangela Spano, Maria Signorelli, Roberta Vitaliani, Eugenio Aguglia, Bruno Giomett. The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review. Functional neurology. vol 30. issue 3. 2016-09-13. PMID:26346695. |
the hallmark of dementia with lewy bodies (dlb) is the “lewy body”, an abnormal aggregation of alpha-synuclein found in some areas of the brain. |
2016-09-13 |
2023-08-13 |
Not clear |
| Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata, Hiroshi Matsud. The cingulate island sign within early Alzheimer's disease-specific hypoperfusion volumes of interest is useful for differentiating Alzheimer's disease from dementia with Lewy bodies. EJNMMI research. vol 6. issue 1. 2016-09-13. PMID:27620458. |
in addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (pcg) relative to the precunei is known as the cingulate island sign (cis) in the patients with dementia with lewy bodies (dlb). |
2016-09-13 |
2023-08-13 |
human |
| Dag Aarslan. Cognitive impairment in Parkinson's disease and dementia with Lewy bodies. Parkinsonism & related disorders. vol 22 Suppl 1. 2016-09-12. PMID:26411499. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) share clinical and pathological similarities. |
2016-09-12 |
2023-08-13 |
Not clear |
| Alexandra I Soto-Ortolaza, Owen A Ros. Genetic susceptibility variants in parkinsonism. Parkinsonism & related disorders. vol 22 Suppl 1. 2016-09-12. PMID:26414118. |
the main forms of parkinsonism are, parkinson's disease (pd), dementia with lewy bodies (dlb), multiple system atrophy (msa), progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). |
2016-09-12 |
2023-08-13 |
Not clear |
| Farzana Pervin, Carolyn Edwards, Carol F Lipp. Dementia With Lew Body: Impacts of Surgery. American journal of Alzheimer's disease and other dementias. vol 31. issue 1. 2016-09-08. PMID:26006790. |
patients who have dementia with lewy bodies (dlb) and undergo surgery may develop aggravated postoperative cognitive dysfunction or postoperative delirium. |
2016-09-08 |
2023-08-13 |
Not clear |
| Farzana Pervin, Carolyn Edwards, Carol F Lipp. Dementia With Lew Body: Impacts of Surgery. American journal of Alzheimer's disease and other dementias. vol 31. issue 1. 2016-09-08. PMID:26006790. |
many patients with dlb respond poorly to surgery and anesthesia, and their conditions may worsen if they have other medical complications along with dementia. |
2016-09-08 |
2023-08-13 |
Not clear |
| Farzana Pervin, Carolyn Edwards, Carol F Lipp. Dementia With Lew Body: Impacts of Surgery. American journal of Alzheimer's disease and other dementias. vol 31. issue 1. 2016-09-08. PMID:26006790. |
this article reviews postoperative complications and various surgery-related risk factors for dlb in light of other dementias such as alzheimer's disease, as their neuropathologic features overlap with those of dlb. |
2016-09-08 |
2023-08-13 |
Not clear |
| Brian Spencer, Stephanie Williams, Edward Rockenstein, Elvira Valera, Wei Xin, Michael Mante, Jazmin Florio, Anthony Adame, Eliezer Masliah, Michael R Sierk. α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease. Annals of clinical and translational neurology. vol 3. issue 8. 2016-09-08. PMID:27606342. |
progressive accumulation of α-synuclein (α-syn) has been associated with parkinson's disease (pd) and dementia with lewy body (dlb). |
2016-09-08 |
2023-08-13 |
Not clear |
| Mari Suzuki, Nobuhiro Fujikake, Toshihide Takeuchi, Ayako Kohyama-Koganeya, Kazuki Nakajima, Yoshio Hirabayashi, Keiji Wada, Yoshitaka Naga. Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease. Human molecular genetics. vol 24. issue 23. 2016-08-26. PMID:26362253. |
alpha-synuclein (αsyn) plays a central role in the pathogenesis of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2016-08-26 |
2023-08-13 |
drosophila_melanogaster |
| Itsuku Suzuki, Miwa Noguchi, Mitsumi Arito, Toshiyuki Sato, Kazuki Omoteyama, Mioto Maedomari, Hiroshi Hasegawa, Naoya Suematsu, Kazuki Okamoto, Tomohiro Kato, Noboru Yamaguchi, Manae S Kurokaw. Serum peptides as candidate biomarkers for dementia with Lewy bodies. International journal of geriatric psychiatry. vol 30. issue 12. 2016-08-25. PMID:25754375. |
for diagnosis of dementia with lewy bodies (dlb), we tried to find blood biomarkers for the disease. |
2016-08-25 |
2023-08-13 |
Not clear |
| Kirk A Frey, Martin A Lodge, Carolyn Cidis Meltzer, Patrick J Peller, Terence Z Wong, Christopher P Hess, Jeffrey R Petrella, Haris I Sair, Rathan M Subramania. ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia. Clinical nuclear medicine. vol 41. issue 2. 2016-08-19. PMID:26646994. |
four primary neurodegenerative etiologies of dementia have been defined: alzheimer disease (ad), vascular dementia, frontotemporal dementia (ftd), and dementia with lewy bodies (dlb). |
2016-08-19 |
2023-08-13 |
Not clear |
| Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mor. On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases. PloS one. vol 11. issue 4. 2016-08-18. PMID:27055151. |
abnormal cardiac uptake of 123i-metaiodobenzylguanidine (123i-mibg) is a diagnostic marker of lewy body diseases (lbds), e.g., parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2016-08-18 |
2023-08-13 |
Not clear |
| Marie Y Davis, Kien Trinh, Ruth E Thomas, Selina Yu, Alexandre A Germanos, Brittany N Whitley, Sergio Pablo Sardi, Thomas J Montine, Leo J Pallanc. Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration. PLoS genetics. vol 12. issue 3. 2016-08-08. PMID:27019408. |
mutations in the glucosidase, beta, acid (gba1) gene cause gaucher's disease, and are the most common genetic risk factor for parkinson's disease (pd) and dementia with lewy bodies (dlb) excluding variants of low penetrance. |
2016-08-08 |
2023-08-13 |
human |
| Aiko Ishiki, Maki Kamada, Yuki Kawamura, Chiaki Terao, Fumiko Shimoda, Naoki Tomita, Hiroyuki Arai, Katsutoshi Furukaw. Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration. Journal of neurochemistry. vol 136. issue 2. 2016-08-01. PMID:26485083. |
although high levels of astrocyte-secreted glial fibrillar acidic protein (gfap) in the csf of patients with alzheimer's disease (ad) have been reported, the levels of gfap in the csf have not been fully investigated in other neurological disorders that cause dementia, such as dementia with lewy bodies (dlb) and frontotemporal lobar degeneration (ftld). |
2016-08-01 |
2023-08-13 |
human |
| Aiko Ishiki, Maki Kamada, Yuki Kawamura, Chiaki Terao, Fumiko Shimoda, Naoki Tomita, Hiroyuki Arai, Katsutoshi Furukaw. Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration. Journal of neurochemistry. vol 136. issue 2. 2016-08-01. PMID:26485083. |
we propose the following mechanism concerning the amount of glial fibrillar acidic protein (gfap) in the cerebrospinal fluid (csf) in alzheimer's disease (ad), dementia with lewy bodies (dlb), and frontotemporal lobar degeneration (ftld). |
2016-08-01 |
2023-08-13 |
human |
| b' Ronald L Walton, Alexandra I Soto-Ortolaza, Melissa E Murray, Oswaldo Lorenzo-Betancor, Kotaro Ogaki, Michael G Heckman, Sruti Rayaprolu, Rosa Rademakers, Nil\\xc3\\xbcfer Ertekin-Taner, Ryan J Uitti, Jay A van Gerpen, Zbigniew K Wszolek, Glenn E Smith, Kejal Kantarci, Val J Lowe, Joseph E Parisi, David T Jones, Rodolfo Savica, Jonathan Graff-Radford, David S Knopman, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Dennis W Dickson, Bradley F Boeve, Owen A Ross, Catherine Labb\\xc3\\xa. TREM2 p.R47H substitution is not associated with dementia with Lewy bodies. Neurology. Genetics. vol 2. issue 4. 2016-07-26. PMID:27458607.' |
dementia with lewy bodies (dlb) is the second leading cause of neurodegenerative dementia in the elderly and is clinically characterized by the presence of cognitive decline, parkinsonism, rem sleep behavior disorder, and visual hallucinations. |
2016-07-26 |
2023-08-13 |
Not clear |
| b' Ronald L Walton, Alexandra I Soto-Ortolaza, Melissa E Murray, Oswaldo Lorenzo-Betancor, Kotaro Ogaki, Michael G Heckman, Sruti Rayaprolu, Rosa Rademakers, Nil\\xc3\\xbcfer Ertekin-Taner, Ryan J Uitti, Jay A van Gerpen, Zbigniew K Wszolek, Glenn E Smith, Kejal Kantarci, Val J Lowe, Joseph E Parisi, David T Jones, Rodolfo Savica, Jonathan Graff-Radford, David S Knopman, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Dennis W Dickson, Bradley F Boeve, Owen A Ross, Catherine Labb\\xc3\\xa. TREM2 p.R47H substitution is not associated with dementia with Lewy bodies. Neurology. Genetics. vol 2. issue 4. 2016-07-26. PMID:27458607.' |
(2) the clinical characteristics of dlb share overlapping features with alzheimer disease dementia (ad) and parkinson disease (pd). |
2016-07-26 |
2023-08-13 |
Not clear |