| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olugbenro Akintade, Floyd Pierre. Acute presentation of dementia with Lewy bodies. Clinical medicine (London, England). vol 19. issue 4. 2020-08-31. PMID:31308115. |
acute presentations for dementia, particularly dementia with lewy bodies (dlb), are rare and can pose diagnostic challenges.we present a case of a 75-year-old woman who was previously fit, well and independent in all activities of daily living. |
2020-08-31 |
2023-08-13 |
Not clear |
| Saki Yoshinaga, Tomoyuki Yamanaka, Haruko Miyazaki, Ayami Okuzumi, Akiko Hiyama, Shigeo Murayama, Nobuyuki Nukin. Preserved proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to disease-related structural study. Biochemical and biophysical research communications. vol 522. issue 3. 2020-08-31. PMID:31785806. |
one of the pathological proteins, alpha-synuclein (α-syn), accumulates in the brains of parkinson disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa), which are designated as synucleinopathies. |
2020-08-31 |
2023-08-13 |
mouse |
| Senthil T Kumar, Sonia Donzelli, Anass Chiki, Muhammed Muazzam Kamil Syed, Hilal A Lashue. A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research. Journal of neurochemistry. vol 153. issue 1. 2020-08-31. PMID:31925956. |
increasing evidence suggests that the process of alpha-synuclein (α-syn) aggregation from monomers into amyloid fibrils and lewy bodies, via oligomeric intermediates plays an essential role in the pathogenesis of different synucleinopathies, including parkinson's disease (pd), multiple system atrophy and dementia with lewy bodies (dlb). |
2020-08-31 |
2023-08-13 |
Not clear |
| Ketil Oppedal, Miguel G Borda, Daniel Ferreira, Eric Westman, Dag Aarslan. European DLB consortium: diagnostic and prognostic biomarkers in dementia with Lewy bodies, a multicenter international initiative. Neurodegenerative disease management. vol 9. issue 5. 2020-08-24. PMID:31580225. |
european dlb consortium: diagnostic and prognostic biomarkers in dementia with lewy bodies, a multicenter international initiative. |
2020-08-24 |
2023-08-13 |
Not clear |
| A P Kiely, J S Miners, R Courtney, C Strand, S Love, J L Holto. Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy. Neuropathology and applied neurobiology. vol 45. issue 4. 2020-08-21. PMID:29993134. |
there is evidence that accumulation of α-synuclein (α-syn) in parkinson's disease (pd) and dementia with lewy bodies (dlb) results from impaired removal of α-syn rather than its overproduction. |
2020-08-21 |
2023-08-13 |
Not clear |
| Ian G McKeith, Tanis J Ferman, Alan J Thomas, Frédéric Blanc, Bradley F Boeve, Hiroshige Fujishiro, Kejal Kantarci, Cristina Muscio, John T O'Brien, Ronald B Postuma, Dag Aarsland, Clive Ballard, Laura Bonanni, Paul Donaghy, Murat Emre, James E Galvin, Douglas Galasko, Jennifer G Goldman, Stephen N Gomperts, Lawrence S Honig, Manabu Ikeda, James B Leverenz, Simon J G Lewis, Karen S Marder, Mario Masellis, David P Salmon, John Paul Taylor, Debby W Tsuang, Zuzana Walker, Pietro Tirabosch. Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology. vol 94. issue 17. 2020-08-21. PMID:32241955. |
the prodromal phase of dementia with lewy bodies (dlb) includes (1) mild cognitive impairment (mci), (2) delirium-onset, and (3) psychiatric-onset presentations. |
2020-08-21 |
2023-08-13 |
Not clear |
| Y Y Fathy, A J Jonker, E Oudejans, F J J de Jong, A-M W van Dam, A J M Rozemuller, W D J van de Ber. Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies. Neuropathology and applied neurobiology. vol 45. issue 3. 2020-08-19. PMID:29797340. |
in parkinson's disease (pd) and dementia with lewy bodies (dlb), it reveals α-synuclein pathology in advanced stages. |
2020-08-19 |
2023-08-13 |
human |
| Charlotte Louise Eversfield, Llwyd David Orto. Auditory and visual hallucination prevalence in Parkinson's disease and dementia with Lewy bodies: a systematic review and meta-analysis. Psychological medicine. vol 49. issue 14. 2020-08-17. PMID:30474581. |
non-motor features of parkinson's disease (pd) and dementia with lewy bodies (dlb), such as auditory hallucinations (ah), contribute to disease burden but are not well understood. |
2020-08-17 |
2023-08-13 |
Not clear |
| Anne Botzung, Nathalie Philippi, Vincent Noblet, Paulo Loureiro de Sousa, Frédéric Blan. Pay attention to the basal ganglia: a volumetric study in early dementia with Lewy bodies. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31864422. |
cortical and subcortical cognitive impairments are usually found in dementia with lewy bodies (dlb). |
2020-08-06 |
2023-08-13 |
Not clear |
| Balvindar Singh, Ana Covelo, Héctor Martell-Martínez, Carmen Nanclares, Mathew A Sherman, Emmanuel Okematti, Joyce Meints, Peter J Teravskis, Christopher Gallardo, Alena V Savonenko, Michael A Benneyworth, Sylvain E Lesné, Dezhi Liao, Alfonso Araque, Michael K Le. Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31168644. |
parkinson's disease dementia (pdd) and dementia with lewy bodies (dlb) are clinically and neuropathologically highly related α-synucleinopathies that collectively constitute the second leading cause of neurodegenerative dementias. |
2020-08-04 |
2023-08-13 |
mouse |
| Alberto Benussi, Mario Grassi, Fernando Palluzzi, Giacomo Koch, Vincenzo Di Lazzaro, Raffaele Nardone, Valentina Cantoni, Valentina Dell'Era, Enrico Premi, Alessandro Martorana, Francesco di Lorenzo, Sonia Bonnì, Federico Ranieri, Fioravante Capone, Gabriella Musumeci, Maria Sofia Cotelli, Alessandro Padovani, Barbara Borron. Classification Accuracy of Transcranial Magnetic Stimulation for the Diagnosis of Neurodegenerative Dementias. Annals of neurology. vol 87. issue 3. 2020-08-03. PMID:31925823. |
in this study, we assessed the classification performance of tms parameters in the differential diagnosis of common neurodegenerative disorders, including alzheimer disease (ad), dementia with lewy bodies (dlb), and frontotemporal dementia (ftd). |
2020-08-03 |
2023-08-13 |
Not clear |
| Isabelle Lavenir, Daniela Passarella, Masami Masuda-Suzukake, Annabelle Curry, Janice L Holton, Bernardino Ghetti, Michel Goeder. Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31522685. |
synucleinopathies [parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa)] share filamentous α-synuclein assemblies in nerve cells and glial cells. |
2020-07-30 |
2023-08-13 |
mouse |
| Han Soo Yoo, Sangwon Lee, Seok Jong Chung, Yang Hyun Lee, Byoung Seok Ye, Young H Sohn, Mijin Yun, Phil Hyu Le. Clinical and striatal dopamine transporter predictors of β-amyloid in dementia with Lewy bodies. Neurology. vol 94. issue 13. 2020-07-30. PMID:32086384. |
to investigate the relationship between β-amyloid (aβ) deposition and striatal dopamine depletion, cognitive functions, and neuropsychiatric symptoms in dementia with lewy bodies (dlb). |
2020-07-30 |
2023-08-13 |
Not clear |
| Luca Beretta, Silvia Paola Caminiti, Roberto Santangelo, Giuseppe Magnani, Francesca Ferrari-Pellegrini, Paolo Caffarra, Daniela Peran. Two distinct pathological substrates associated with MMSE-pentagons item deficit in DLB and AD. Neuropsychologia. vol 133. 2020-07-29. PMID:31446008. |
dementia with lewy bodies (dlb) is characterized by a prominent deficit in visuospatial abilities. |
2020-07-29 |
2023-08-13 |
Not clear |
| Laura J de Schipper, Anne Hafkemeijer, Jeroen van der Grond, Johan Marinus, Johanna M L Henselmans, Jacobus J van Hilte. Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 4. 2020-07-29. PMID:31524178. |
dementia with lewy bodies (dlb) and parkinson's disease (pd) are considered subtypes of the α-synucleinopathy continuum that show similar and dissimilar clinical and morphological features. |
2020-07-29 |
2023-08-13 |
Not clear |
| Sven J van der Lee, Olivia J Conway, Iris Jansen, Minerva M Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R van Eijk, Najada Stringa, Jason A Chen, Anna Zettergren, Till F M Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E Savage, Jonas Mengel-From, Sonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J Keogh, Kaj Blennow, Ingmar Skoog, Manuel A Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illán-Gala, Wei Wei, Bernard Jeune, Adelina Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesi, Christopher M Morris, Begoña Indakoetxea, Lyduine E Collij, Martin Scherer, Estrella Morenas-Rodríguez, James W Ironside, Bart N M van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L Strickland, Pau Pastor, Eloy Rodríguez Rodríguez, Bradley F Boeve, Ronald C Petersen, Tanis J Ferman, Jay A van Gerpen, Marcel J T Reinders, Ryan J Uitti, Lluís Tárraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Mercè Boada, Uwe K Zettl, Natasja M van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo López de Munain, Alexander Pantelyat, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, David Knopman, Rosa Rademakers, Afina W Lemstra, Yolande A L Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F Chinnery, Bernhard Hemmer, Martijn A Huisman, Juan Troncoso, Fermin Moreno, Ellen A Nohr, Thorkild I A Sørensen, Peter Heutink, Pascual Sánchez-Juan, Danielle Posthuma, Jordi Clarimón, Kaare Christensen, Nilüfer Ertekin-Taner, Sonja W Scholz, Alfredo Ramirez, Agustín Ruiz, Eline Slagboom, Wiesje M van der Flier, Henne Holsteg. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta neuropathologica. vol 138. issue 2. 2020-07-20. PMID:31131421. |
we replicated the association of rs72824905-g with reduced ad risk and we found an association with reduced risk of dementia with lewy bodies (dlb) and frontotemporal dementia (ftd). |
2020-07-20 |
2023-08-13 |
Not clear |
| Thomas G Beach, Charles H Adler, Nan Zhang, Geidy E Serrano, Lucia I Sue, Erika Driver-Dunckley, Shayamal H Mehta, Edouard E Zamrini, Marwan N Sabbagh, Holly A Shill, Christine M Belden, David R Shprecher, Richard J Caselli, Eric M Reiman, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony J Intorcia, Michael J Glass, Jessica E Walker, Michael M Callan, Javon C Oliver, Richard Arce, Richard C Gerki. Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer's disease dementia. PloS one. vol 15. issue 4. 2020-07-15. PMID:32320406. |
many subjects with neuropathologically-confirmed dementia with lewy bodies (dlb) are never diagnosed during life, instead being categorized as alzheimer's disease dementia (add) or unspecified dementia. |
2020-07-15 |
2023-08-13 |
human |
| Thomas G Beach, Charles H Adler, Nan Zhang, Geidy E Serrano, Lucia I Sue, Erika Driver-Dunckley, Shayamal H Mehta, Edouard E Zamrini, Marwan N Sabbagh, Holly A Shill, Christine M Belden, David R Shprecher, Richard J Caselli, Eric M Reiman, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony J Intorcia, Michael J Glass, Jessica E Walker, Michael M Callan, Javon C Oliver, Richard Arce, Richard C Gerki. Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer's disease dementia. PloS one. vol 15. issue 4. 2020-07-15. PMID:32320406. |
consensus clinicopathological diagnostic criteria were used to define add and dlb, as well as parkinson's disease with dementia (pdd), with (pdd+ad) or without (pdd-ad) concurrent ad; a group with add and lewy body disease (lbd) not meeting criteria for dlb (adlb) and a clinically normal control group were also included. |
2020-07-15 |
2023-08-13 |
human |
| Thomas G Beach, Charles H Adler, Nan Zhang, Geidy E Serrano, Lucia I Sue, Erika Driver-Dunckley, Shayamal H Mehta, Edouard E Zamrini, Marwan N Sabbagh, Holly A Shill, Christine M Belden, David R Shprecher, Richard J Caselli, Eric M Reiman, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony J Intorcia, Michael J Glass, Jessica E Walker, Michael M Callan, Javon C Oliver, Richard Arce, Richard C Gerki. Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer's disease dementia. PloS one. vol 15. issue 4. 2020-07-15. PMID:32320406. |
olfactory function testing may be a convenient and inexpensive strategy for enriching dementia studies or clinical trials with dlb subjects, or conversely, reducing the inclusion of dlb subjects in add studies or trials. |
2020-07-15 |
2023-08-13 |
human |
| Noa Bregman, Gitit Kavé, Anat Mirelman, Avner Thaler, Mali Gana Weisz, Anat Bar-Shira, Avi Orr-Urtreger, Nir Giladi, Tamara Shine. Distinguishing Dementia With Lewy Bodies From Alzheimer Disease: What is the Influence of the GBA Genotype in Ashkenazi Jews? Alzheimer disease and associated disorders. vol 33. issue 3. 2020-07-10. PMID:30640255. |
we tested the hypothesis that ashkenazi jewish (aj) patients who have dementia with lewy bodies (dlb) and carry glucocerebrosidase (gba) mutations will have verbal fluency deficits different from those found in alzheimer disease (ad), whereas aj patients with dlb who have no gba mutations will have similar deficits in verbal fluency to those found in ad. |
2020-07-10 |
2023-08-13 |
Not clear |