| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael X Henderson, Dustin J Covell, Charlotte Hiu-Yan Chung, Rose M Pitkin, Raizel M Sandler, Samantha C Decker, Dawn M Riddle, Bin Zhang, Ronald J Gathagan, Michael J James, John Q Trojanowski, Kurt R Brunden, Virginia M Y Lee, Kelvin C Lu. Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease. Neurobiology of disease. vol 136. 2021-01-04. PMID:31837422. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. |
2021-01-04 |
2023-08-13 |
mouse |
| Nicolas Nicastro, Elijah Mak, Guy B Williams, Ajenthan Surendranathan, W Richard Bevan-Jones, Luca Passamonti, Patricia Vàzquez Rodrìguez, Li Su, Robert Arnold, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, James B Rowe, John T O'Brie. Correlation of microglial activation with white matter changes in dementia with Lewy bodies. NeuroImage. Clinical. vol 25. 2021-01-04. PMID:32032816. |
dementia with lewy bodies (dlb) is characterized by alpha-synuclein protein deposition with variable degree of concurrent alzheimer's pathology. |
2021-01-04 |
2023-08-13 |
Not clear |
| Meenakshi Dauwan, Jessica J van der Zande, Edwin van Dellen, Iris E C Sommer, Philip Scheltens, Afina W Lemstra, Cornelis J Sta. Random forest to differentiate dementia with Lewy bodies from Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 4. 2021-01-02. PMID:27722196. |
the aim of this study was to build a random forest classifier to improve the diagnostic accuracy in differentiating dementia with lewy bodies (dlb) from alzheimer's disease (ad) and to quantify the relevance of multimodal diagnostic measures, with a focus on electroencephalography (eeg). |
2021-01-02 |
2023-08-13 |
Not clear |
| Melissa Scholefield, Richard D Unwin, Garth J S Coope. Shared perturbations in the metallome and metabolome of Alzheimer's, Parkinson's, Huntington's, and dementia with Lewy bodies: A systematic review. Ageing research reviews. vol 63. 2020-12-30. PMID:32846222. |
despite differences in presentation, age-related dementing diseases such as alzheimer's (ad), parkinson's (pd), and huntington's diseases (hd), and dementia with lewy bodies (dlb) may share pathogenic processes. |
2020-12-30 |
2023-08-13 |
Not clear |
| Rachel Underwood, Bing Wang, Christine Carico, Robert H Whitaker, William J Placzek, Talene A Yacoubia. The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein. The Journal of biological chemistry. vol 295. issue 23. 2020-12-28. PMID:32350025. |
α-synuclein (αsyn) is the primary component of proteinaceous aggregates termed lewy bodies that pathologically define synucleinopathies including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2020-12-28 |
2023-08-13 |
Not clear |
| Giovanni Bellomo, Federico Paolini Paoletti, Elena Chipi, Maya Petricciuolo, Simone Simoni, Nicola Tambasco, Lucilla Parnett. A/T/(N) Profile in Cerebrospinal Fluid of Parkinson's Disease with/without Cognitive Impairment and Dementia with Lewy Bodies. Diagnostics (Basel, Switzerland). vol 10. issue 12. 2020-12-26. PMID:33256252. |
neuropathological investigations report that in synucleinopathies with dementia, namely parkinson's disease (pd) with dementia (pdd) and dementia with lewy bodies (dlb), the histopathological hallmarks of alzheimer's disease (ad), in particular amyloid plaques, are frequently observed. |
2020-12-26 |
2023-08-13 |
Not clear |
| Thomas Näsström, Jörgen Ådén, Fumina Shibata, Per Ola Andersson, Björn C G Karlsso. A Capped Peptide of the Aggregation Prone NAC 71-82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations. International journal of molecular sciences. vol 21. issue 5. 2020-12-24. PMID:32120928. |
although lewy bodies and lewy neurites are hallmarks of parkinson's disease (pd) and dementia with lewy bodies (dlb), misfolded α-synuclein oligomers are nowadays believed to be key for the development of these diseases. |
2020-12-24 |
2023-08-13 |
Not clear |
| M G Førland, O-B Tysnes, D Aarsland, J Maple-Grødem, K F Pedersen, G Alves, J Lang. The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology. European journal of neurology. vol 27. issue 1. 2020-12-23. PMID:31293044. |
parkinson's disease (pd), dementia with lewy bodies (dlb) and alzheimer's disease (ad) are three of the most common neurodegenerative disorders. |
2020-12-23 |
2023-08-13 |
Not clear |
| Tatiana Orme, Dena Hernandez, Owen A Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q Trojanowski, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J Stone, Dennis W Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bra. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:31996268. |
dementia with lewy bodies (dlb) is a clinically heterogeneous disorder with a substantial burden on healthcare. |
2020-12-23 |
2023-08-13 |
Not clear |
| Tatiana Orme, Dena Hernandez, Owen A Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q Trojanowski, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J Stone, Dennis W Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bra. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:31996268. |
we analyzed variants in 60 genes implicated in dlb, alzheimer's disease, parkinson's disease, frontotemporal dementia, and atypical parkinsonian or dementia disorders, in order to determine their frequency in dlb. |
2020-12-23 |
2023-08-13 |
Not clear |
| Hidekazu Kanetaka, Soichiro Shimizu, Yuta Inagawa, Daisuke Hirose, Naoto Takenoshita, Hirofumi Sakurai, Haruo Hany. Differentiating Mild Cognitive Impairment, Alzheimer's Disease, and Dementia With Lewy Bodies Using Cingulate Island Sign on Perfusion IMP-SPECT. Frontiers in neurology. vol 11. 2020-12-18. PMID:33329310. |
the cingulate island sign (cis) on fludeoxyglucose (fdg)-positron emission tomography (pet) is a supporting biomarker of dementia with lewy bodies (dlb). |
2020-12-18 |
2023-08-13 |
Not clear |
| Joseph R Phillips, Elie Matar, Kaylena A Ehgoetz Martens, Glenda M Halliday, Ahmed A Moustafa, Simon J G Lewi. Evaluating the Sustained Attention Response Task to Quantify Cognitive Fluctuations in Dementia With Lewy Bodies. Journal of geriatric psychiatry and neurology. vol 33. issue 6. 2020-12-10. PMID:31672077. |
cognitive fluctuations (cfs) are a core diagnostic feature of dementia with lewy bodies (dlb). |
2020-12-10 |
2023-08-13 |
Not clear |
| Takayuki Katayama, Jun Sawada, Shiori Kikuchi-Takeguchi, Kohei Kano, Kae Takahashi, Tsukasa Saito, Atsutaka Okizaki, Naoyuki Haseb. Cerebrospinal fluid levels of alpha-synuclein, amyloid β, tau, phosphorylated tau, and neuron-specific enolase in patients with Parkinson's disease, dementia with Lewy bodies or other neurological disorders: Their relationships with cognition and nuclear medicine imaging findings. Neuroscience letters. vol 715. 2020-12-10. PMID:31733322. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are common neurodegenerative disorders, but no established biochemical markers for these diseases have been identified. |
2020-12-10 |
2023-08-13 |
human |
| Teodora Petrova, Camila Orellana, Vesna Jelic, Anne-Rita Oeksengaard, Jon Snaedal, Peter Høgh, Birgitte Bo Andersen, Mala Naik, Knut Engedal, Lars-Olof Wahlund, Daniel Ferreir. Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases. Psychiatry research. Neuroimaging. vol 302. 2020-12-07. PMID:32505903. |
cholinergic dysfunction is central in alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2020-12-07 |
2023-08-13 |
Not clear |
| Yu-Mi Jeon, Younghwi Kwon, Myungjin Jo, Shinrye Lee, Seyeon Kim, Hyung-Jun Ki. The Role of Glial Mitochondria in α-Synuclein Toxicity. Frontiers in cell and developmental biology. vol 8. 2020-12-07. PMID:33262983. |
the abnormal accumulation of alpha-synuclein (α-syn) aggregates in neurons and glial cells is widely known to be associated with many neurodegenerative diseases, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2020-12-07 |
2023-08-13 |
Not clear |
| Robert H Unger, Patrick M Flanigan, Mitra Khosravi, James B Leverenz, Babak Tous. Clinical and Imaging Characteristics Associated with Color Vision Impairment in Lewy Body Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31683482. |
color vision impairment (cvi) has been reported in dementia with lewy bodies (dlb) and prodromal lewy body disease (pro-lbd). |
2020-12-04 |
2023-08-13 |
Not clear |
| James Gratwicke, Ludvic Zrinzo, Joshua Kahan, Amy Peters, Una Brechany, Ann McNichol, Mazda Beigi, Harith Akram, Jonathan Hyam, Ashwini Oswal, Brian Day, Laura Mancini, John Thornton, Tarek Yousry, Sebastian J Crutch, John-Paul Taylor, Ian McKeith, Lynn Rochester, Jonathan M Schott, Patricia Limousin, David Burn, Martin N Rossor, Marwan Hariz, Marjan Jahanshahi, Thomas Foltyni. Bilateral nucleus basalis of Meynert deep brain stimulation for dementia with Lewy bodies: A randomised clinical trial. Brain stimulation. vol 13. issue 4. 2020-12-04. PMID:32334074. |
dementia with lewy bodies (dlb) is the second most common form of dementia. |
2020-12-04 |
2023-08-13 |
Not clear |
| Vijay Gupta, Safa Salim, Issam Hmila, Nishant N Vaikath, Indulekha P Sudhakaran, Simona S Ghanem, Nour K Majbour, Sara A Abdulla, Mohamed M Emara, Houari B Abdesselem, Tamas Lukacsovich, Daniel Erskine, Omar M A El-Agna. Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32424162. |
synucleinopathies including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa) are characterized by pathological accumulation of α-synuclein (α-syn). |
2020-12-04 |
2023-08-13 |
human |
| Karin Gmitterová, Joanna Gawinecka, Franc Llorens, Daniela Varges, Peter Valkovič, Inga Zer. Cerebrospinal fluid markers analysis in the differential diagnosis of dementia with Lewy bodies and Parkinson's disease dementia. European archives of psychiatry and clinical neuroscience. vol 270. issue 4. 2020-11-30. PMID:30083957. |
dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) share a couple of clinical similarities that is often a source of diagnostic pitfalls. |
2020-11-30 |
2023-08-13 |
Not clear |
| Hisayoshi Oka, Tadashi Umehara, Atsuo Nakahara, Hiromasa Matsun. Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson's disease and de novo dementia with Lewy bodies. BMC neurology. vol 20. issue 1. 2020-11-23. PMID:32948137. |
cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (bp) dysregulation, in parkinson's disease (pd), but the association between these factors in dementia with lewy bodies (dlb) is uncertain. |
2020-11-23 |
2023-08-13 |
Not clear |