| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiu-Lan Ma, Piu Chan, Mitsunobu Yoshii, Kenji Uéd. Alpha-synuclein aggregation and neurodegenerative diseases. Journal of Alzheimer's disease : JAD. vol 5. issue 2. 2003-09-16. PMID:12719631. |
later, the discovery of two missense mutations (g88c and g209a), which resulted in ala30pro (a30p) and ala53thr (a53t) substitutions, of the alpha-synuclein gene in certain autosomal-dominant early onset familial parkinson's disease (pd) has greatly promoted the understanding of the role of alpha-synuclein in the pathogenesis of neurodegenerative diseases, such as pd, dementia with lewy bodies (dlb) and multiple system atrophy (msa) [5,6,51,75]. |
2003-09-16 |
2023-08-12 |
human |
| S S Lee, Y M Kim, E Junn, G Lee, K-H Park, M Tanaka, R D Ronchetti, M M Quezado, M M Mouradia. Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies. Neurobiology of aging. vol 24. issue 5. 2003-09-12. PMID:12885576. |
alpha-synuclein is a presynaptic protein that accumulates abnormally in lewy bodies of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2003-09-12 |
2023-08-12 |
Not clear |
| Marta Weinstock, Elena Gorodetsky, Tatyana Poltyrev, Aviva Gross, Yotam Sagi, Moussa Youdi. A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 4. 2003-08-29. PMID:12787840. |
degeneration of cholinergic cortical neurons is one of the main reasons for the cognitive deficit in dementia of the alzheimer type (ad) and in dementia with lewy bodies (dlb). |
2003-08-29 |
2023-08-12 |
mouse |
| U P Mosimann, I G McKeit. Dementia with lewy bodies--diagnosis and treatment. Swiss medical weekly. vol 133. issue 9-10. 2003-08-20. PMID:12707840. |
dementia with lewy bodies (dlb) accounts for 15-20% of all autopsy confirmed dementias in old age. |
2003-08-20 |
2023-08-12 |
Not clear |
| U P Mosimann, I G McKeit. Dementia with lewy bodies--diagnosis and treatment. Swiss medical weekly. vol 133. issue 9-10. 2003-08-20. PMID:12707840. |
dlb is clinically under-diagnosed and frequently misclassified as systemic delirium or dementia due to alzheimer's disease or cerebrovascular disease. |
2003-08-20 |
2023-08-12 |
Not clear |
| Kumlesh K Dev, Katja Hofele, Samuel Barbieri, Vladimir L Buchman, Herman van der Putte. Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology. vol 45. issue 1. 2003-08-11. PMID:12814657. |
these include prevalent conditions such as parkinson's disease (pd), dementia with lewy bodies (dlb), and the lewy body variant of alzheimer's disease (lbvad), as well as rarer conditions including multiple systems atrophy (msa), and neurodegeneration with brain iron accumulation type-1 (nbia-1). |
2003-08-11 |
2023-08-12 |
mouse |
| Yoshihiko Horimoto, Mitsuhiro Matsumoto, Hiroyasu Akatsu, Hiroyuki Ikari, Kiyohide Kojima, Takayuki Yamamoto, Yasushi Otsuka, Kosei Ojika, Ryuzo Ueda, Kenji Kosak. Autonomic dysfunctions in dementia with Lewy bodies. Journal of neurology. vol 250. issue 5. 2003-07-25. PMID:12736730. |
twenty-nine cases of both clinically and neuropathologically diagnosed dementia with lewy bodies (dlb) were retrospectively examined for autonomic symptoms. |
2003-07-25 |
2023-08-12 |
Not clear |
| C Colosimo, A J Hughes, L Kilford, A J Lee. Lewy body cortical involvement may not always predict dementia in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 7. 2003-07-22. PMID:12810766. |
the authors present here a series of patients with diagnosis of pd in life and no significant cognitive impairment who, at necropsy, satisfied the current neuropathological criteria for dementia with lewy bodies (dlb). |
2003-07-22 |
2023-08-12 |
Not clear |
| Omi Katsuse, Eizo Iseki, Wami Marui, Kenji Kosak. Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies. Journal of the neurological sciences. vol 211. issue 1-2. 2003-07-21. PMID:12767494. |
we investigated 10 dementia with lewy bodies (dlb) brains showing various degrees of lewy pathology using alpha-synuclein-immunohistochemistry, and morphologically divided cortical lewy bodies (lb) into six developmental stages. |
2003-07-21 |
2023-08-12 |
Not clear |
| Lauren T Bonner, Debby W Tsuang, Monique M Cherrier, Charisma J Eugenio, Q Du Jennifer, Ellen J Steinbart, Pornprot Limprasert, Albert R La Spada, Benjamin Seltzer, Thomas D Bird, James B Leveren. Familial dementia with Lewy bodies with an atypical clinical presentation. Journal of geriatric psychiatry and neurology. vol 16. issue 1. 2003-07-16. PMID:12641375. |
the authors report a case of a 64-year-old male with alzheimer's disease (ad) and dementia with lewy bodies (dlb) pathology at autopsy who did not manifest the core symptoms of dlb until very late in his clinical course. |
2003-07-16 |
2023-08-12 |
Not clear |
| Lauren T Bonner, Debby W Tsuang, Monique M Cherrier, Charisma J Eugenio, Q Du Jennifer, Ellen J Steinbart, Pornprot Limprasert, Albert R La Spada, Benjamin Seltzer, Thomas D Bird, James B Leveren. Familial dementia with Lewy bodies with an atypical clinical presentation. Journal of geriatric psychiatry and neurology. vol 16. issue 1. 2003-07-16. PMID:12641375. |
family history revealed 7 relatives with a history of dementia including 4 with possible or probable dlb. |
2003-07-16 |
2023-08-12 |
Not clear |
| Yuko Saito, Akiko Kawashima, Nyoka N Ruberu, Hideo Fujiwara, Shunichi Koyama, Motoji Sawabe, Tomio Arai, Hiroshi Nagura, Hiroshi Yamanouchi, Masato Hasegawa, Takeshi Iwatsubo, Shigeo Murayam. Accumulation of phosphorylated alpha-synuclein in aging human brain. Journal of neuropathology and experimental neurology. vol 62. issue 6. 2003-07-16. PMID:12834109. |
this novel pathology was abundantly present around lbs and also involved the limbic subcortical white matter, the cerebral cortical molecular layer, and the spongiform changes of the medial temporal lobe associated with cases of dementia with lbs (dlb). |
2003-07-16 |
2023-08-12 |
human |
| Margaret A Piggott, Jonathan Owens, John O'Brien, Sean Colloby, John Fenwick, David Wyper, Evelyn Jaros, Mary Johnson, Robert H Perry, Elaine K Perr. Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease. Journal of chemical neuroanatomy. vol 25. issue 3. 2003-07-10. PMID:12706204. |
derivatives of the muscarinic antagonist 3-quinuclidinyl-4-iodobenzilate (qnb), particularly [123i]-(r,r)-i-qnb, are currently being assessed as in vivo ligands to monitor muscarinic receptors in alzheimer's disease (ad) and dementia with lewy bodies (dlb), relating changes to disease symptoms and to treatment response with cholinergic medication. |
2003-07-10 |
2023-08-12 |
human |
| T Rahkonen, U Eloniemi-Sulkava, S Rissanen, A Vatanen, P Viramo, R Sulkav. Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 6. 2003-07-08. PMID:12754338. |
to estimate the prevalence of dementia with lewy bodies (dlb) according to the consensus criteria in a general population aged 75 years or older. |
2003-07-08 |
2023-08-12 |
Not clear |
| Hitoshi Takahashi, Keizo Yoshida, Takio Sugita, Hisashi Higuchi, Tetsuo Shimiz. Quetiapine treatment of psychotic symptoms and aggressive behavior in patients with dementia with Lewy bodies: a case series. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 3. 2003-06-23. PMID:12691793. |
the authors describe here the clinical outcomes of quetiapine treatment in nine patients with dementia with lewy bodies (dlb) who manifested psychotic symptoms and aggressive behavior. |
2003-06-23 |
2023-08-12 |
Not clear |
| Joshua P Fessel, Christine Hulette, Suzanne Powell, L Jackson Roberts, Jing Zhan. Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. Journal of neurochemistry. vol 85. issue 3. 2003-06-17. PMID:12694390. |
in this study, we attempted to compare the levels of f2-isops and isofs esterified in phospholipids in the substantia nigra (sn) from patients with pd to those of age-matched controls as well as patients with other neurodegenerative diseases, including dementia with lewy body disease (dlb), multiple system atrophy (msa), and alzheimer's disease (ad). |
2003-06-17 |
2023-08-12 |
Not clear |
| Larissa A Munishkina, Cassandra Phelan, Vladimir N Uversky, Anthony L Fin. Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes. Biochemistry. vol 42. issue 9. 2003-06-16. PMID:12614167. |
intracellular proteinaceous inclusions (lewy bodies and lewy neurites) of alpha-synuclein are pathological hallmarks of neurodegenerative diseases such as parkinson's disease, dementia with lewy bodies (dlb), and multiple systemic atrophy. |
2003-06-16 |
2023-08-12 |
Not clear |
| Martine Simard, Robert van Reekum, David Myra. Visuospatial impairment in dementia with Lewy bodies and Alzheimer's disease: a process analysis approach. International journal of geriatric psychiatry. vol 18. issue 5. 2003-06-13. PMID:12766913. |
reports of differential impairments on visual-construction tasks in dementia with lewy bodies (dlb) and alzheimer's disease (ad) are sometimes controversial, whereas visual-perceptual data are lacking. |
2003-06-13 |
2023-08-12 |
human |
| Yuri Trembath, Carolyn Rosenberg, John F Ervin, Donald E Schmechel, Perry Gaskell, Margaret Pericak-Vance, Jeffery Vance, Christine M Hulett. Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677449. |
here we describe the analysis of 22 ad families, each with at least one family member with a postmortem diagnosis of dementia with lewy bodies (dlb). |
2003-06-06 |
2023-08-12 |
Not clear |
| Wami Marui, Eizo Iseki, Masanori Kato, Kenji Kosak. Degeneration of tyrosine hydroxylase-immunoreactive neurons in the cerebral cortex and hippocampus of patients with dementia with Lewy bodies. Neuroscience letters. vol 340. issue 3. 2003-05-30. PMID:12672537. |
we immunohistochemically investigated the degeneration of tyrosine hydroxylase (th)-positive neurons in the cerebral cortex and hippocampus of dementia with lewy bodies (dlb) brains. |
2003-05-30 |
2023-08-12 |
Not clear |