| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliezer Masliah, Edward Rockenstein, Michael Mante, Leslie Crews, Brian Spencer, Anthony Adame, Christina Patrick, Margarita Trejo, Kiren Ubhi, Troy T Rohn, Sarah Mueller-Steiner, Peter Seubert, Robin Barbour, Lisa McConlogue, Manuel Buttini, Dora Games, Dale Schen. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559417. |
dementia with lewy bodies (dlb) and parkinson's disease (pd) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (α-syn). |
2011-11-28 |
2023-08-12 |
Not clear |
| M E Kalaitzakis, A J Walls, R K B Pearce, S M Gentlema. Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20951207. |
striatal aβ peptide deposition mirrors dementia and differentiates dlb and pdd from other parkinsonian syndromes. |
2011-11-22 |
2023-08-12 |
Not clear |
| M E Kalaitzakis, A J Walls, R K B Pearce, S M Gentlema. Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20951207. |
recent neuropathological studies have described widespread amyloid-β peptide (aβ) deposition in the striatum of patients with lewy body disorders, particularly in parkinson's disease with dementia (pdd) and dementia with lewy bodies (dlb). |
2011-11-22 |
2023-08-12 |
Not clear |
| M E Kalaitzakis, A J Walls, R K B Pearce, S M Gentlema. Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20951207. |
employing immunohistochemistry, we examined striatal aβ deposition in the caudate nucleus and putamen of 52 pd, 41 pdd, 14 dlb, 7 multiple system atrophy (msa) and 14 progressive supranuclear palsy (psp) cases in relation to the presence of dementia. |
2011-11-22 |
2023-08-12 |
Not clear |
| M E Kalaitzakis, A J Walls, R K B Pearce, S M Gentlema. Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20951207. |
we conclude that striatal aβ pathology is common in both pdd and dlb and may reflect the development of dementia in these conditions. |
2011-11-22 |
2023-08-12 |
Not clear |
| Yasushi Yamamoto, Masahisa Onoguchi, Akihiko Wada, Katsuhiro Sarada, Masuo Haramoto, Akio Komatsu, Hajime Kitagaki, Syuhei Yamaguch. [Evaluation of shortened protocol of graph plot method with ¹²³I-IMP]. Nihon Hoshasen Gijutsu Gakkai zasshi. vol 67. issue 5. 2011-11-22. PMID:21666376. |
we compared count ratios of the decreased area to an area of the healthy side, quantitative values, and results of statistical analysis of the shortened protocol and the conventional method for cases of cerebral infarction and of dementia with lewy bodies (dlb). |
2011-11-22 |
2023-08-12 |
Not clear |
| Kunikazu Tanji, Fumiaki Mori, Katsumi Kito, Akiyoshi Kakita, Junsei Mimura, Ken Itoh, Hitoshi Takahashi, Tetsu Kamitani, Koichi Wakabayash. Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease. Journal of neuropathology and experimental neurology. vol 70. issue 10. 2011-11-15. PMID:21937912. |
α-synuclein is a major component of lewy bodies in parkinson disease (pd) and dementia with lewy bodies (dlb). |
2011-11-15 |
2023-08-12 |
mouse |
| Ezra Mulugeta, Elisabet Londos, Oskar Hansson, Clive Ballard, Ragnhild Skogseth, Lennart Minthon, Kaj Blennow, Henrik Zetterberg, Dag Aarslan. Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates. International journal of Alzheimer's disease. vol 2011. 2011-11-10. PMID:21966597. |
we measured cerebrospinal fluid (csf) levels of the soluble isoforms of amyloid precursor protein (app; sappα sappβ) and other csf biomarkers in 107 patients with alzheimer's disease (ad), dementia with lewy body dementia (dlb), parkinson's disease dementia (pdd), and normal controls (nc) using commercial kits. |
2011-11-10 |
2023-08-12 |
Not clear |
| Ezra Mulugeta, Elisabet Londos, Oskar Hansson, Clive Ballard, Ragnhild Skogseth, Lennart Minthon, Kaj Blennow, Henrik Zetterberg, Dag Aarslan. Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates. International journal of Alzheimer's disease. vol 2011. 2011-11-10. PMID:21966597. |
dlb and pdd were combined in a lewy body dementia group (lbd). |
2011-11-10 |
2023-08-12 |
Not clear |
| Shinsuke Fujioka, Melissa E Murray, Parastou Foroutan, Katherine J Schweitzer, Dennis W Dickson, Samuel C Grant, Zbigniew K Wszole. [Magnetic resonance imaging with 21.1 T and pathological correlations--diffuse Lewy body disease]. Rinsho shinkeigaku = Clinical neurology. vol 51. issue 8. 2011-11-03. PMID:21878728. |
we investigated fixed basal ganglia specimens, including globus pallidus and putamen, with 21.1-tesla mri allowing us to achieve a microscopic level resolution from a patient with pathologically confirmed dementia with lewy bodies (dlb) and a neurologically normal control case. |
2011-11-03 |
2023-08-12 |
Not clear |
| Glenda M Halliday, Janice L Holton, Tamas Revesz, Dennis W Dickso. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta neuropathologica. vol 122. issue 2. 2011-11-02. PMID:21720849. |
α-synuclein deposits in neuronal lewy bodies and lewy neurites in idiopathic parkinson's disease (pd) and dementia with lewy bodies (dlb), as well as incidentally in a number of other conditions. |
2011-11-02 |
2023-08-12 |
Not clear |
| T J Ferman, B F Boeve, G E Smith, S-C Lin, M H Silber, O Pedraza, Z Wszolek, N R Graff-Radford, R Uitti, J Van Gerpen, W Pao, D Knopman, V S Pankratz, K Kantarci, B Boot, J E Parisi, B N Dugger, H Fujishiro, R C Petersen, D W Dickso. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology. vol 77. issue 9. 2011-10-27. PMID:21849645. |
to determine whether adding rem sleep behavior disorder (rbd) to the dementia with lewy bodies (dlb) diagnostic criteria improves classification accuracy of autopsy-confirmed dlb. |
2011-10-27 |
2023-08-12 |
Not clear |
| Gregor K Wenning, Florian Krismer, Werner Poew. New insights into atypical parkinsonism. Current opinion in neurology. vol 24. issue 4. 2011-10-17. PMID:21577106. |
atypical parkinsonian disorders (apds) comprise a heterogenous group of disorders including multiple system atrophy (msa), dementia with lewy bodies (dlb), progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). |
2011-10-17 |
2023-08-12 |
Not clear |
| Hedvig Welander, Sai Vineela Bontha, Thomas Näsström, Mikael Karlsson, Fredrik Nikolajeff, Karin Danzer, Marcus Kostka, Hannu Kalimo, Lars Lannfelt, Martin Ingelsson, Joakim Bergströ. Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro. Biochemical and biophysical research communications. vol 412. issue 1. 2011-10-14. PMID:21798243. |
deposition of fibrillar α-synuclein as lewy bodies is the neuropathological hallmark of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2011-10-14 |
2023-08-12 |
human |
| Victor L Villemagne, Kevin Ong, Rachel S Mulligan, Gerhard Holl, Svetlana Pejoska, Gareth Jones, Graeme O'Keefe, Uwe Ackerman, Henri Tochon-Danguy, J Gordon Chan, Cornelia B Reininger, Lueder Fels, Barbara Putz, Beate Rohde, Colin L Masters, Christopher C Row. Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 52. issue 8. 2011-10-07. PMID:21764791. |
the purpose of the study program was to compare cortical amyloid deposition using (18)f-florbetaben and pet in controls and subjects with mild cognitive impairment (mci), frontotemporal lobar degeneration (ftld), dementia with lewy bodies (dlb), vascular dementia (vad), parkinson disease (pd), and alzheimer disease (ad). |
2011-10-07 |
2023-08-12 |
human |
| Lisa Fellner, Kurt A Jellinger, Gregor K Wenning, Nadia Stefanov. Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts. Acta neuropathologica. vol 121. issue 6. 2011-09-13. PMID:21562886. |
parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa) are adult onset neurodegenerative disorders characterised by prominent intracellular α-synuclein aggregates (α-synucleinopathies). |
2011-09-13 |
2023-08-12 |
human |
| Donald L Bliwise, Nathaniel D Mercaldo, Alon Y Avidan, Bradley F Boeve, Sophia A Greer, Walter A Kukul. Sleep disturbance in dementia with Lewy bodies and Alzheimer's disease: a multicenter analysis. Dementia and geriatric cognitive disorders. vol 31. issue 3. 2011-09-12. PMID:21474933. |
evidence suggests that patients with dementia with lewy bodies (dlb) may have more nocturnal sleep disturbance than patients with alzheimer's disease (ad). |
2011-09-12 |
2023-08-12 |
Not clear |
| Youngshin Lim, Victoria M Kehm, Edward B Lee, James H Soper, Chi Li, John Q Trojanowski, Virginia M-Y Le. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734300. |
abnormally accumulated α-synuclein (α-syn) is a pathological hallmark of lewy body-related disorders such as parkinson's disease (pd) and dementia with lewy body disease (dlb). |
2011-09-09 |
2023-08-12 |
mouse |
| Youngshin Lim, Victoria M Kehm, Edward B Lee, James H Soper, Chi Li, John Q Trojanowski, Virginia M-Y Le. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734300. |
however, it is not well understood whether and how abnormal accumulation of α-syn leads to cognitive impairment or dementia in pd and dlb. |
2011-09-09 |
2023-08-12 |
mouse |
| Victor L Villemagne, Nobuyuki Okamura, Svetlana Pejoska, John Drago, Rachel S Mulligan, Gaël Chételat, Uwe Ackermann, Graeme O'Keefe, Gareth Jones, Sylvia Gong, Henry Tochon-Danguy, Hank F Kung, Colin L Masters, Daniel M Skovronsky, Christopher C Row. In vivo assessment of vesicular monoamine transporter type 2 in dementia with lewy bodies and Alzheimer disease. Archives of neurology. vol 68. issue 7. 2011-09-09. PMID:21747030. |
to assess the diagnostic potential of imaging striatal monoaminergic terminal integrity with the vesicular monoamine transporter type 2 (vmat2) radioligand (18)f 9-fluropropyl-(+)-dihydrotetrabenazine ([(18)f]av-133) and positron emission tomography to distinguish dementia with lewy bodies (dlb) from alzheimer disease (ad). |
2011-09-09 |
2023-08-12 |
Not clear |