| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byron Creese, Clive Ballard, Dag Aarsland, Elisabet Londos, Sally Sharp, Emma Jone. No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. Neuroscience letters. vol 531. issue 1. 2013-04-30. PMID:23069674. |
we sought to determine whether the comt val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd). |
2013-04-30 |
2023-08-12 |
human |
| Éva M Szegő, Tiago F Outeiro, Pawel Kermer, Jörg B Schul. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22579457. |
dementia in parkinson's disease (pdd) and dementia with lewy bodies (dlb) are characterized by loss of acetylcholine (ach) from cortical areas. |
2013-04-29 |
2023-08-12 |
mouse |
| Shinichiro Hibi, Yasuhiro Yamaguchi, Yumi Umeda-Kameyama, Hiroshi Yamamoto, Katsuya Iijima, Toshimitsu Momose, Masahiro Akishita, Yasuyoshi Ouch. The high frequency of periodic limb movements in patients with Lewy body dementia. Journal of psychiatric research. vol 46. issue 12. 2013-04-26. PMID:22835911. |
although dementia with lewy bodies (dlb) is the second most common form of neurodegenerative dementia after alzheimer's disease (ad), the clinical diagnosis is frequently difficult. |
2013-04-26 |
2023-08-12 |
Not clear |
| O S Levin, E E Vasenina, M A Anikina, T A Makotrov. [Dementia with Lewy bodies]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 112. issue 10 Pt 2. 2013-04-22. PMID:23250604. |
current concepts on the clinical presentations, diagnosis and treatment of dementia with lewy bodies (dlb), that makes up 10% percent of dementia cases, are considered. |
2013-04-22 |
2023-08-12 |
Not clear |
| Moussa B H Youdi. Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline. Experimental neurobiology. vol 22. issue 1. 2013-04-16. PMID:23585716. |
employing the pharmacophore of our anti-parkinson drug rasagiline (azilect, n-propagrgyl-1-r-aminoindan), we have developed a series of novel multi-functional neuroprotective drugs (a) [tv-3326 (n-propargyl-3r-aminoindan-5yl)-ethyl methylcarbamate)], with both cholinesterase-butyrylesterase and brain selective monoamine-oxidase (mao) a/b inhibitory activities and (b) the iron chelator-radical scavenging-brain selective monoamine oxidase (mao) a/b inhibitor and m30 possessing the neuroprotective and neurorescuing propargyl moiety of rasagiline, as potential treatment of ad, dlb and pd with dementia. |
2013-04-16 |
2023-08-12 |
mouse |
| Hitoshi Sohma, Shin-Ichi Imai, Norio Takei, Hirohito Honda, Kyoichi Matsumoto, Kumiko Utsumi, Kayo Matsuki, Eri Hashimoto, Toshikazu Saito, Yasuo Koka. Evaluation of annexin A5 as a biomarker for Alzheimer's disease and dementia with lewy bodies. Frontiers in aging neuroscience. vol 5. 2013-04-12. PMID:23576984. |
on the other hand, ad has been identified to share a number of clinical and pathological features with dementia with lewy bodies (dlb). |
2013-04-12 |
2023-08-12 |
Not clear |
| Françoise J Siepel, Arvid Rongve, Tirza C Buter, Mona K Beyer, Clive G Ballard, Jan Booij, Dag Aarslan. (123I)FP-CIT SPECT in suspected dementia with Lewy bodies: a longitudinal case study. BMJ open. vol 3. issue 4. 2013-04-11. PMID:23572198. |
little is known regarding the 'false-negative' or 'false-positive' striatal dopamine transporter binding on spect for the diagnosis of dementia with lewy bodies (dlb). |
2013-04-11 |
2023-08-12 |
Not clear |
| Camillo Marra, Davide Quaranta, Paolo Profice, Fabio Pilato, Fioravante Capone, Francesco Iodice, Vincenzo Di Lazzaro, Guido Gainott. Central cholinergic dysfunction measured "in vivo" correlates with different behavioral disorders in Alzheimer's disease and dementia with Lewy body. Brain stimulation. vol 5. issue 4. 2013-04-10. PMID:22019082. |
however, cholinergic deficits are not homogeneous and they are distributed differently in the basal forebrain and brainstem among alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2013-04-10 |
2023-08-12 |
Not clear |
| Hiroshige Fujishiro, Eizo Iseki, Koji Kasanuki, Norio Murayama, Kazumi Ota, Masaru Suzuki, Kiyoshi Sat. Glucose hypometabolism in primary visual cortex is commonly associated with clinical features of dementia with Lewy bodies regardless of cognitive conditions. International journal of geriatric psychiatry. vol 27. issue 11. 2013-04-10. PMID:22250011. |
although metabolic reduction in the primary visual cortex on [(18) f]-fluoro-d-glucose (fdg) positron emission tomographic (pet) scans is the hallmark of dementia with lewy bodies (dlb) for differential diagnosis from alzheimer's disease, the clinical significance of the metabolic pattern in patients without dementia remains unknown. |
2013-04-10 |
2023-08-12 |
Not clear |
| Hiroshige Fujishiro, Eizo Iseki, Koji Kasanuki, Norio Murayama, Kazumi Ota, Masaru Suzuki, Kiyoshi Sat. Glucose hypometabolism in primary visual cortex is commonly associated with clinical features of dementia with Lewy bodies regardless of cognitive conditions. International journal of geriatric psychiatry. vol 27. issue 11. 2013-04-10. PMID:22250011. |
the purpose of this study was to investigate the clinical profiles of patients without dementia with the metabolic pattern and its relevance to dlb. |
2013-04-10 |
2023-08-12 |
Not clear |
| David R Lee, John-Paul Taylor, Alan J Thoma. Assessment of cognitive fluctuation in dementia: a systematic review of the literature. International journal of geriatric psychiatry. vol 27. issue 10. 2013-04-10. PMID:22278997. |
they are a recognised feature of the dementias, especially dementia with lewy bodies (dlb) and parkinson's disease dementia. |
2013-04-10 |
2023-08-12 |
Not clear |
| David R Lee, John-Paul Taylor, Alan J Thoma. Assessment of cognitive fluctuation in dementia: a systematic review of the literature. International journal of geriatric psychiatry. vol 27. issue 10. 2013-04-10. PMID:22278997. |
no published reviews of cf in dementia exist despite this being an important clinical phenomenon and a core diagnostic feature of dlb. |
2013-04-10 |
2023-08-12 |
Not clear |
| Eduardo Prado, Pongsatorn Paholpak, Myha Ngo, Verna Porter, Liana G Apostolova, Rogério Marrocos, John M Ringma. Agitation and psychosis associated with dementia with lewy bodies exacerbated by modafinil use. American journal of Alzheimer's disease and other dementias. vol 27. issue 7. 2013-04-09. PMID:22892657. |
dementia with lewy bodies (dlb) is commonly associated with excessive daytime somnolence (eds). |
2013-04-09 |
2023-08-12 |
Not clear |
| Keiko Mori, Yasushi Iwasaki, Masumi Ito, Maya Mimuro, Mari Yoshid. [Decreased myocardial uptake of meta-iodobenzylguanidine in an autopsy-confirmed case of corticobasal degeneration with Lewy bodies restricted to the sympathetic ganglia]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 6. 2013-04-08. PMID:22790801. |
a diagnosis of dementia with lewy bodies (dlb) was made, but l-dopa treatment was not effective. |
2013-04-08 |
2023-08-12 |
Not clear |
| Satoshi Tanikawa, Fumiaki Mori, Kunikazu Tanji, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayash. Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy. Neuroscience letters. vol 527. issue 1. 2013-04-08. PMID:22947304. |
recent studies have shown that autophagosomal proteins are present in α-synuclein aggregates in neurons and glial cells in parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2013-04-08 |
2023-08-12 |
Not clear |
| D Aarsland, C Ballard, A Rongve, M Broadstock, P Svenningsso. Clinical trials of dementia with Lewy bodies and Parkinson's disease dementia. Current neurology and neuroscience reports. vol 12. issue 5. 2013-04-03. PMID:22806065. |
despite the frequency and importance of dementia associated with parkinson's disease (pdd) and dementia with lewy bodies (dlb), there is relatively little evidence on which to base treatment. |
2013-04-03 |
2023-08-12 |
Not clear |
| Gulistan Bahat, Fatih Tufan, Sibel Akin, Nigun Erten, Mehmet Akif Kara. Probable dementia associated with Lewy body pathology as a cause of prolonged acute confusional state in a 79-year-old patient. Aging clinical and experimental research. vol 24. issue 2. 2013-03-29. PMID:22842839. |
differentiation of "dementia with lewy body pathology" (dlb) and delirium may be problematic in some cases, due to some of their common clinical characteristics such as fluctuations and hallucinations. |
2013-03-29 |
2023-08-12 |
Not clear |
| Ronald B Postuma, Jean-Francois Gagnon, Jacques Y Montplaisi. REM Sleep Behavior Disorder and Prodromal Neurodegeneration - Where Are We Headed? Tremor and other hyperkinetic movements (New York, N.Y.). vol 3. 2013-03-28. PMID:23532774. |
the most important implication of research into this area is that patients with idiopathic rbd are at very high risk of developing synuclein-mediated neurodegenerative disease (parkinson's disease [pd], dementia with lewy bodies [dlb], and multiple system atrophy), with risk estimates that approximate 40-65% at 10 years. |
2013-03-28 |
2023-08-12 |
human |
| Douglas G Walker, Lih-Fen Lue, Charles H Adler, Holly A Shill, John N Caviness, Marwan N Sabbagh, Haruhiko Akiyama, Geidy E Serrano, Lucia I Sue, Thomas G Beac. Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains. Experimental neurology. vol 240. 2013-03-25. PMID:23201181. |
modifications of α-synuclein resulting in changes in its conformation are considered to be key pathological events for lewy body diseases (lbd), which include parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2013-03-25 |
2023-08-12 |
human |
| He-Jin Lee, Ji-Eun Suk, Kyung-Won Lee, Seung-Hwa Park, Peter C Blumbergs, Wei-Ping Gai, Seung-Jae Le. Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice. Experimental neurobiology. vol 20. issue 4. 2013-03-14. PMID:22355263. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are characterized by abnormal deposition of α-synuclein aggregates in many regions of the central and peripheral nervous systems. |
2013-03-14 |
2023-08-12 |
mouse |