| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Arnold, E Joo, M G Martinoli, N Roy, J Q Trojanowski, R E Gur, T Cannon, R A Pric. Apolipoprotein E genotype in schizophrenia: frequency, age of onset, and neuropathologic features. Neuroreport. vol 8. issue 6. 1997-08-07. PMID:9172167. |
however, the apoe epsilon 4 genotype was associated with a younger age of onset of schizophrenia, and in an elderly subsample, individuals with the epsilon 4 allele more frequently exhibited co-existent dementia and had more neurofibrillary pathology (although none of the cases met criteria for alzheimer's disease). |
1997-08-07 |
2023-08-12 |
Not clear |
| H Arai, S Higuchi, H Sasak. Apolipoprotein E genotyping and cerebrospinal fluid tau protein: implications for the clinical diagnosis of Alzheimer's disease. Gerontology. vol 43 Suppl 1. 1997-08-04. PMID:9187933. |
apolipoprotein e (apoe) genotyping was conducted in sporadic alzheimer's disease (ad, n = 91) as well as in other dementing disorders including parkinson's disease (pd, n = 73), autopsy-confirmed diffuse lewy body disease (dlbd, n = 16), progressive supranuclear palsy (n = 13), vascular dementia (n = 55), alcoholic dementia (n =25) and normal control subjects (n = 77). |
1997-08-04 |
2023-08-12 |
human |
| L Minthon, C Hesse, M Sjögren, E Englund, L Gustafson, K Blenno. The apolipoprotein E epsilon4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease. Neuroscience letters. vol 226. issue 1. 1997-07-21. PMID:9153643. |
the apolipoprotein (apoe) epsilon4 allele was studied in fronto-temporal dementia (ftd), a diagnostic category including the specific disorders pick's disease and frontal lobe degeneration of non-alzheimer type (fld). |
1997-07-21 |
2023-08-12 |
Not clear |
| B D Jordan, N R Relkin, L D Ravdin, A R Jacobs, A Bennett, S Gand. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA. vol 278. issue 2. 1997-07-17. PMID:9214529. |
given the similarities between alzheimer disease and dementia pugilistica, we evaluated the relationship between apolipoprotein e (apoe) genotype and chronic traumatic brain injury (ctbi) in boxers to determine whether there is a genetic susceptibility to the effects of head trauma. |
1997-07-17 |
2023-08-12 |
Not clear |
| M Stevens, C M van Duijn, P de Knijff, C van Broeckhoven, P Heutink, B A Oostra, M F Niermeijer, J C van Swiete. Apolipoprotein E gene and sporadic frontal lobe dementia. Neurology. vol 48. issue 6. 1997-07-10. PMID:9191760. |
we studied the connection between the apoe gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (fld) derived from a population-based study in the netherlands. |
1997-07-10 |
2023-08-12 |
Not clear |
| D C Steffens, B L Plassman, M J Helms, K A Welsh-Bohmer, A M Saunders, J C Breitne. A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biological psychiatry. vol 41. issue 8. 1997-06-17. PMID:9099411. |
results were similar when the sample was stratified by twin pair, so that a single genetic marker is unlikely to explain the relation among depression, apoe, and dementia. |
1997-06-17 |
2023-08-12 |
Not clear |
| M R Farlo. Alzheimer's disease: clinical implications of the apolipoprotein E genotype. Neurology. vol 48. issue 5 Suppl 6. 1997-06-09. PMID:9153158. |
insufficient evidence also exists at this time to recommend apoe genotyping as an adjuvant for the differential diagnosis of dementia or as a possible predictor for response to drug therapy. |
1997-06-09 |
2023-08-12 |
Not clear |
| F Pasquier, D Ley. Why are stroke patients prone to develop dementia? Journal of neurology. vol 244. issue 3. 1997-05-29. PMID:9050953. |
secondly, post-stroke dementia may be due to an associated asymptomatic alzheimer pathology; the reasons for such an association are that (1) some cases of dementia occurring after a stroke are progressive and alzheimer's disease (ad) is the most frequent cause of progressive dementia; (2) age and apoe epsilon 4 genotype are risk factors for both ad and ischaemic stroke; (3) a vasculopathy is often associated with ad. |
1997-05-29 |
2023-08-12 |
Not clear |
| G S Zubenko, R Henderson, J S Stiffler, S Stabler, J Rosen, B B Kapla. Association of the APOE epsilon 4 allele with clinical subtypes of late life depression. Biological psychiatry. vol 40. issue 10. 1997-05-13. PMID:8915560. |
the apoe genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. |
1997-05-13 |
2023-08-12 |
Not clear |
| S Higuchi, H Arai, T Nakagawa, T Muramatsu, H Sasaki, J Q Trojanowsk. The apolipoprotein E gene in Binswanger's disease and vascular dementia. Clinical genetics. vol 50. issue 6. 1997-05-09. PMID:9147873. |
the frequency of the epsilon 4 allele of the apoe (apoe4) in bd patients and non-bd vascular dementia patients did not differ from that observed in the nondemented elderly controls, but it was significantly lower than the frequency in ad patients. |
1997-05-09 |
2023-08-12 |
Not clear |
| S Higuchi, H Arai, T Nakagawa, T Muramatsu, H Sasaki, J Q Trojanowsk. The apolipoprotein E gene in Binswanger's disease and vascular dementia. Clinical genetics. vol 50. issue 6. 1997-05-09. PMID:9147873. |
these results and other recent observations suggest that one or more factors other than the apoe gene contribute to the pathogenesis of dementia in bd and non-bd vascular dementia. |
1997-05-09 |
2023-08-12 |
Not clear |
| D Tsuang, M A Raskind, J Leverenz, E R Peskind, G Schellenberg, T D Bir. The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018389. |
we examined apoe genotypes and their effects on age of onset in a family with an autosomal dominant "neurofibrillary tangle only" dementia. |
1997-04-02 |
2023-08-12 |
Not clear |
| A J Slooter, M X Tang, C M van Duijn, Y Stern, A Ott, K Bell, M M Breteler, C Van Broeckhoven, T K Tatemichi, B Tycko, A Hofman, R Mayeu. Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. JAMA. vol 277. issue 10. 1997-03-19. PMID:9052712. |
to investigate the association between the apolipoprotein e (apoe) genotypes and dementia in patients with stroke, defined as either vascular dementia (vad) or alzheimer disease with cerebrovascular disease (ad with cvd). |
1997-03-19 |
2023-08-12 |
Not clear |
| T A Treves, N M Bornstein, J Chapman, S Klimovitzki, R Verchovsky, A Asherov, I O Veshchev, A D Korczy. APOE-epsilon 4 in patients with Alzheimer disease and vascular dementia. Alzheimer disease and associated disorders. vol 10. issue 4. 1997-02-25. PMID:8939277. |
the apolipoprotein e (apoe) epsilon 4 allele has been consistently found to be frequent in patients with progressive degenerative dementia of the alzheimer type (dat). |
1997-02-25 |
2023-08-12 |
Not clear |
| B T Hyman, T Gomez-Isla, G W Rebeck, M Briggs, H Chung, H L West, S Greenberg, S Mui, S Nichols, R Wallace, J H Growdo. Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993478. |
thus, inheritance of apoe epsilon 4 is a major biological risk factor for ad, but it has limited utility as a prognostic indicator for development of dementia in an individual. |
1997-02-04 |
2023-08-12 |
Not clear |
| A D Rose. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993484. |
an analysis of the current applications for three distinctly different applications of apoe genotyping was presented with the following conclusions: (1) predictive testing for cognitively intact persons was not recommended; (2) apoe genotyping is a promising adjunct for use in the differential diagnosis of patients with dementia; and (3) apoe genotyping may have a use in selecting therapies; however, further prospective studies are necessary. |
1997-02-04 |
2023-08-12 |
Not clear |
| R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
previous case-control studies on this group of subjects have documented the role of the apolipoprotein e (apoe) epsilon 4 as a risk factor for dementia. |
1997-02-04 |
2023-08-12 |
human |
| R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
subsequent analyses between apoe and the age of the patients with dementia have shown that most of the epsilon 4 effect is manifest in subjects under 75 years of age. |
1997-02-04 |
2023-08-12 |
human |
| R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
the presence of an apoe epsilon 4 carrier status is the best predictor of subsequent development of dementia in these individuals. |
1997-02-04 |
2023-08-12 |
human |
| R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
these studies indicate that apoe is an important risk factor for ad, and in patients with a mild cognitive impairment, apoe may be useful in predicting who is likely to progress to dementia. |
1997-02-04 |
2023-08-12 |
human |