Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
A D Rose. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993484. |
an analysis of the current applications for three distinctly different applications of apoe genotyping was presented with the following conclusions: (1) predictive testing for cognitively intact persons was not recommended; (2) apoe genotyping is a promising adjunct for use in the differential diagnosis of patients with dementia; and (3) apoe genotyping may have a use in selecting therapies; however, further prospective studies are necessary. |
1997-02-04 |
2023-08-12 |
Not clear |
R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
previous case-control studies on this group of subjects have documented the role of the apolipoprotein e (apoe) epsilon 4 as a risk factor for dementia. |
1997-02-04 |
2023-08-12 |
human |
R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
subsequent analyses between apoe and the age of the patients with dementia have shown that most of the epsilon 4 effect is manifest in subjects under 75 years of age. |
1997-02-04 |
2023-08-12 |
human |
R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
the presence of an apoe epsilon 4 carrier status is the best predictor of subsequent development of dementia in these individuals. |
1997-02-04 |
2023-08-12 |
human |
R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
these studies indicate that apoe is an important risk factor for ad, and in patients with a mild cognitive impairment, apoe may be useful in predicting who is likely to progress to dementia. |
1997-02-04 |
2023-08-12 |
human |
N R Relkin, Y J Kwon, J Tsai, S Gand. The National Institute on Aging/Alzheimer's Association recommendations on the application of apolipoprotein E genotyping to Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993494. |
the group acknowledged that a robust association exists between possession of the apoe epsilon 4 allele and the risk of late-onset ad and cited evidence that this allele is more strongly associated with ad than any other form of dementia. |
1997-02-04 |
2023-08-12 |
Not clear |
N Schupf, D Kapell, J H Lee, W Zigman, B Canto, B Tycko, R Mayeu. Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome. Annals of neurology. vol 40. issue 5. 1997-01-23. PMID:8957023. |
we examined the influence of apolipoprotein e (apoe) genotype on risk of dementia in 82 adults with down's syndrome (ds). |
1997-01-23 |
2023-08-12 |
Not clear |
A Chauhan, T Pirttilä, P Mehta, V P Chauhan, H M Wisniewsk. Effect of cerebrospinal fluid from normal and Alzheimer's patients with different apolipoprotein E phenotypes on in vitro aggregation of amyloid beta-protein. Journal of the neurological sciences. vol 141. issue 1-2. 1997-01-17. PMID:8880693. |
there was a positive correlation between csf apoe concentrations and a beta aggregation; whereas age, csf soluble a beta levels or severity of dementia did not correlate with a beta aggregation. |
1997-01-17 |
2023-08-12 |
Not clear |
J C Troncoso, C H Kawas, C K Chang, M F Folstein, J C Hedree. Lack of association of the apoE4 allele with hippocampal sclerosis dementia. Neuroscience letters. vol 204. issue 1-2. 1997-01-17. PMID:8929997. |
we determined the apolipoprotein e4 (apoe) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (hsd), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. |
1997-01-17 |
2023-08-12 |
Not clear |
M Landén, C Hesse, P Fredman, B Regland, A Wallin, K Blenno. Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform. Dementia (Basel, Switzerland). vol 7. issue 5. 1997-01-10. PMID:8872419. |
we examined cerebrospinal fluid (csf) apoe in a material consisting of 23 patients with early-onset ad (ead), 31 with late-onset ad (lad), 16 with frontal-lobe dementia (fld), 25 with vascular dementia (vad) and 25 controls. |
1997-01-10 |
2023-08-12 |
Not clear |
M Landén, C Hesse, P Fredman, B Regland, A Wallin, K Blenno. Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform. Dementia (Basel, Switzerland). vol 7. issue 5. 1997-01-10. PMID:8872419. |
our findings support that apoe is involved in the pathogenesis of dementia disorders, both degenerative and vascular, but the csf-apoe level is not influenced by the apoe isoforms. |
1997-01-10 |
2023-08-12 |
Not clear |
S M Albert, B Gurland, G Maestre, D M Jacobs, Y Stern, R Mayeu. APOE genotype influences functional status among elderly without dementia. American journal of medical genetics. vol 60. issue 6. 1996-12-05. PMID:8825902. |
apoe genotype influences functional status among elderly without dementia. |
1996-12-05 |
2023-08-12 |
human |
R Sulkava, K Kainulainen, A Verkkoniemi, L Niinistö, E Sobel, Z Davanipour, T Polvikoski, M Haltia, K Kontul. APOE alleles in Alzheimer's disease and vascular dementia in a population aged 85+. Neurobiology of aging. vol 17. issue 3. 1996-12-03. PMID:8725898. |
apoe alleles in alzheimer's disease and vascular dementia in a population aged 85+. |
1996-12-03 |
2023-08-12 |
Not clear |
H S Soininen, P J Riekkine. Apolipoprotein E, memory and Alzheimer's disease. Trends in neurosciences. vol 19. issue 6. 1996-12-03. PMID:8761956. |
furthermore, ad patients with two apoe epsilon 4 alleles have more-severe loss in hippocampal volume in magnetic resonance imaging (mri) scans, and more impairment in tests assessing delayed memory, than ad patients without the epsilon 4 allele, in spite of similar global severity of dementia. |
1996-12-03 |
2023-08-12 |
human |
J H Growdon, J J Locascio, S Corkin, T Gomez-Isla, B T Hyma. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology. vol 47. issue 2. 1996-11-26. PMID:8757018. |
inheritance of the apolipoprotein e (apoe) epsilon 4 allele is a risk factor for developing alzheimer's disease (ad) and is associated with a lower age of dementia onset. |
1996-11-26 |
2023-08-12 |
Not clear |
J H Growdon, J J Locascio, S Corkin, T Gomez-Isla, B T Hyma. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology. vol 47. issue 2. 1996-11-26. PMID:8757018. |
the purpose of this study was to determine whether apoe genotypes differentially influence the course of cognitive decline in ad dementia. |
1996-11-26 |
2023-08-12 |
Not clear |
T Pirttilä, T Lehtimäki, J Rinne, K Mattila, H Frey, T Nikkar. The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia. Acta neurologica Scandinavica. vol 93. issue 5. 1996-11-22. PMID:8800346. |
we used the ninds-airen criteria to diagnose vascular dementia (vd), and compared apolipoprotein e (apoe) allele frequencies and apoe concentrations in serum and cerebrospinal fluid (csf) between patients with possible (n = 19) and probable (n = 33) vd and controls (n = 105). |
1996-11-22 |
2023-08-12 |
Not clear |
S Itabashi, H Arai, S Higuchi, H Sasaki, J Q Trojanowsk. APOE epsilon 4 allele in Alzheimer's and non-Alzheimer's dementias. Lancet (London, England). vol 348. issue 9032. 1996-11-08. PMID:8843828. |
apoe epsilon 4 allele in alzheimer's and non-alzheimer's dementias. |
1996-11-08 |
2023-08-12 |
Not clear |
C Brayne, C R Harrington, C M Wischik, F A Huppert, L Y Chi, J H Xuereb, D W O'Connor, E S Payke. Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population. Dementia (Basel, Switzerland). vol 7. issue 3. 1996-11-07. PMID:8740632. |
in order to assess the influence of this allele on both dementia and cognitive decline in the elderly we have determined the apoe genotype of 150 individuals over the age of 75 years who have taken part in a longitudinal study. |
1996-11-07 |
2023-08-12 |
Not clear |
C Brayne, C R Harrington, C M Wischik, F A Huppert, L Y Chi, J H Xuereb, D W O'Connor, E S Payke. Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population. Dementia (Basel, Switzerland). vol 7. issue 3. 1996-11-07. PMID:8740632. |
these findings confirm a genetic heterogeneity in late-onset sporadic ad and prompt caution in the use of apoe genotype to predict an elderly individual's susceptibility to either dementia or cognitive decline. |
1996-11-07 |
2023-08-12 |
Not clear |