| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongjuan Sun, Fangfen Yuan, Xuemei Shen, Guanglian Xiong, Jing W. Role of COMT in ADHD: a systematic meta-analysis. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23907791. |
considerable evidence has implicated involvement of dopaminergic system and the prefrontal cortex (pfc) in the pathomechanism of adhd. |
2014-10-27 |
2023-08-12 |
Not clear |
| Hongjuan Sun, Fangfen Yuan, Xuemei Shen, Guanglian Xiong, Jing W. Role of COMT in ADHD: a systematic meta-analysis. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23907791. |
the catechol-o-methyltransferase (comt) gene is of particular interest for adhd as its crucial role in the degradation of dopamine in the pfc. |
2014-10-27 |
2023-08-12 |
Not clear |
| Amanda E Hernan, Abigail Alexander, Kyle R Jenks, Jeremy Barry, Pierre-Pascal Lenck-Santini, Elena Isaeva, Gregory L Holmes, Rod C Scot. Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. Neurobiology of disease. vol 63. 2014-09-19. PMID:24269731. |
we conclude that gabaergic blockade during early-life and resultant focal iis in the pfc disrupt neural networks and are associated with long-term consequences for behavior at a time when iis are no longer present, and thus may have important implications for adhd and autism spectrum disorder associated with childhood epilepsy. |
2014-09-19 |
2023-08-12 |
rat |
| Taryn Castro, Heidi Eliana Mateus, Dora Janeth Fonseca, Diego Forero, Carlos Martín Restrepo, Claudia Talero, Alberto Vélez, Paul Laissu. Sequence analysis of the ADRA2A coding region in children affected by attention deficit hyperactivity disorder. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 12. 2014-07-23. PMID:24178896. |
although adhd etiology remains elusive, the adra2a candidate gene underlies a particular interest, since it participates in the prefrontal cortex regulation of executive function. |
2014-07-23 |
2023-08-12 |
Not clear |
| Jean-G Gehricke, Chiara Polzonetti, Cyrus Caburian, Enrico Gratto. Prefrontal hemodynamic changes during cigarette smoking in young adult smokers with and without ADHD. Pharmacology, biochemistry, and behavior. vol 112. 2014-07-16. PMID:24125785. |
smoking in individuals with adhd may increase vasoconstriction of cerebral arteries in the prefrontal cortex, which may contribute to a reduction in hbo2. |
2014-07-16 |
2023-08-12 |
Not clear |
| Chih-Hung Ko, Ju-Yu Yen, Cheng-Fang Yen, Cheng-Sheng Chen, Wei-Chen Lin, Peng-Wei Wang, Gin-Chung Li. Brain activation deficit in increased-load working memory tasks among adults with ADHD using fMRI. European archives of psychiatry and clinical neuroscience. vol 263. issue 7. 2014-05-08. PMID:23645101. |
further analysis demonstrated that the adhd group exhibited a greater decrease in brain activation over the left fronto-parietal network, including the precuneus, sma, insula/inferior frontal lobe, and dorsolateral prefrontal cortex, than the control group. |
2014-05-08 |
2023-08-12 |
Not clear |
| Trevor Humby, Jessica B Eddy, Mark A Good, Amy C Reichelt, Lawrence S Wilkinso. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23657439. |
a novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in adhd, and serotonin 2c receptor antagonism. |
2014-05-05 |
2023-08-12 |
mouse |
| Satoshi Tsujimoto, Akira Yasumura, Yushiro Yamashita, Miyuki Torii, Makiko Kaga, Masumi Inagak. Increased prefrontal oxygenation related to distractor-resistant working memory in children with attention-deficit/hyperactivity disorder (ADHD). Child psychiatry and human development. vol 44. issue 5. 2014-05-02. PMID:23385518. |
to this end, we studied hemodynamic activity in the prefrontal cortex using near-infrared spectroscopy while 16 children with adhd and 10 typically developing (td) children performed a working memory task. |
2014-05-02 |
2023-08-12 |
Not clear |
| Michael H Ston. A new look at borderline personality disorder and related disorders: hyper-reactivity in the limbic system and lower centers. Psychodynamic psychiatry. vol 41. issue 3. 2014-04-23. PMID:24001165. |
if one shifts the spotlight to neurophysiology, as captured by mri studies, however, it emerges that an important subtype of bpd, and also bd, adhd, and ied-share common features of abnormalities and peculiarities in the limbic system and in the cortex, especially the prefrontal cortex. |
2014-04-23 |
2023-08-12 |
Not clear |
| Masato Umehara, Yukio Ago, Kazumi Fujita, Naoki Hiramatsu, Kazuhiro Takuma, Toshio Matsud. Effects of serotonin-norepinephrine reuptake inhibitors on locomotion and prefrontal monoamine release in spontaneously hypertensive rats. European journal of pharmacology. vol 702. issue 1-3. 2014-02-04. PMID:23376565. |
catecholamine neurotransmission in the prefrontal cortex plays a key role in the therapeutic actions of drugs for attention-deficit/hyperactivity disorder (adhd). |
2014-02-04 |
2023-08-12 |
rat |
| Masato Umehara, Yukio Ago, Kazumi Fujita, Naoki Hiramatsu, Kazuhiro Takuma, Toshio Matsud. Effects of serotonin-norepinephrine reuptake inhibitors on locomotion and prefrontal monoamine release in spontaneously hypertensive rats. European journal of pharmacology. vol 702. issue 1-3. 2014-02-04. PMID:23376565. |
in this study, we examined the effects of acute treatment with serotonin-norepinephrine reuptake inhibitors on locomotion and the extracellular levels of monoamines in the prefrontal cortex in spontaneously hypertensive rats (shr), an animal model of adhd. |
2014-02-04 |
2023-08-12 |
rat |
| Rebecca M Hakvoort Schwerdtfeger, Nadia Alahyane, Donald C Brien, Brian C Coe, Patrick W Stroman, Douglas P Muno. Preparatory neural networks are impaired in adults with attention-deficit/hyperactivity disorder during the antisaccade task. NeuroImage. Clinical. vol 2. 2013-11-01. PMID:24179760. |
interestingly, unlike controls, adults with adhd produced greater activation than controls in dorsolateral prefrontal cortex during antisaccade execution, perhaps as part of compensatory mechanisms to optimize antisaccade production. |
2013-11-01 |
2023-08-12 |
human |
| Ziarih Hawi, Natasha Matthews, Joseph Wagner, Robyn H Wallace, Tim J Butler, Alasdair Vance, Lindsey Kent, Michael Gill, Mark A Bellgrov. DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex. PloS one. vol 8. issue 4. 2013-10-22. PMID:23593184. |
dna variation in the snap25 gene confers risk to adhd and is associated with reduced expression in prefrontal cortex. |
2013-10-22 |
2023-08-12 |
mouse |
| Sucharita S Somkuwar, Mahesh Darna, Kathleen M Kantak, Linda P Dwoski. Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood. Biochemical pharmacology. vol 86. issue 2. 2013-09-03. PMID:23623751. |
attention deficit/hyperactivity disorder (adhd) is attributed to dysfunction of the prefrontal cortex. |
2013-09-03 |
2023-08-12 |
rat |
| Sucharita S Somkuwar, Mahesh Darna, Kathleen M Kantak, Linda P Dwoski. Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood. Biochemical pharmacology. vol 86. issue 2. 2013-09-03. PMID:23623751. |
importantly, prefrontal cortex subregions, orbitofrontal cortex (ofc) and medial prefrontal cortex (mpfc), have been shown to have distinct roles in adhd and cocaine self-administration. |
2013-09-03 |
2023-08-12 |
rat |
| Sharwin Tafazoli, Joseph O'Neill, Anthony Bejjani, Ronald Ly, Noriko Salamon, James T McCracken, Jeffry R Alger, Jennifer G Levit. 1H MRSI of middle frontal gyrus in pediatric ADHD. Journal of psychiatric research. vol 47. issue 4. 2013-08-21. PMID:23273650. |
neuroimaging studies in multiple modalities have implicated the left or right dorsolateral prefrontal cortex (here, middle frontal gyrus) in attentional functions, in adhd, and in dopamine agonist treatment of adhd. |
2013-08-21 |
2023-08-12 |
Not clear |
| Taciana G Costa Dias, Vanessa B Wilson, Deepti R Bathula, Swathi P Iyer, Kathryn L Mills, Bria L Thurlow, Corinne A Stevens, Erica D Musser, Samuel D Carpenter, David S Grayson, Suzanne H Mitchell, Joel T Nigg, Damien A Fai. Reward circuit connectivity relates to delay discounting in children with attention-deficit/hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 1. 2013-08-19. PMID:23206930. |
we found that functional connectivity of nacc was atypical in children with adhd and the adhd-related increased connectivity between nacc and the prefrontal cortex was associated with greater impulsivity (steeper delayed-reward discounting). |
2013-08-19 |
2023-08-12 |
human |
| Taciana G Costa Dias, Vanessa B Wilson, Deepti R Bathula, Swathi P Iyer, Kathryn L Mills, Bria L Thurlow, Corinne A Stevens, Erica D Musser, Samuel D Carpenter, David S Grayson, Suzanne H Mitchell, Joel T Nigg, Damien A Fai. Reward circuit connectivity relates to delay discounting in children with attention-deficit/hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 1. 2013-08-19. PMID:23206930. |
these findings are consistent with the hypothesis that atypical signaling of the nacc to the prefrontal cortex in adhd may lead to excessive approach and failure in estimating future consequences; thus, leading to impulsive behavior. |
2013-08-19 |
2023-08-12 |
human |
| A Christakou, C M Murphy, K Chantiluke, A I Cubillo, A B Smith, V Giampietro, E Daly, C Ecker, D Robertson, D G Murphy, K Rubi. Disorder-specific functional abnormalities during sustained attention in youth with Attention Deficit Hyperactivity Disorder (ADHD) and with autism. Molecular psychiatry. vol 18. issue 2. 2013-08-12. PMID:22290121. |
adhd and asd boys had significantly reduced activation relative to controls in bilateral striato-thalamic regions, left dorsolateral prefrontal cortex (dlpfc) and superior parietal cortex. |
2013-08-12 |
2023-08-12 |
Not clear |
| Jen-Tang Cheng, Jay-Shake L. Intra-orbitofrontal cortex injection of haloperidol removes the beneficial effect of methylphenidate on reversal learning of spontaneously hypertensive rats in an attentional set-shifting task. Behavioural brain research. vol 239. 2013-06-04. PMID:23159707. |
furthermore, dysfunctions of prefrontal cortex can impair inhibitory controls of adhd patients, resulting in their impulsive behaviors. |
2013-06-04 |
2023-08-12 |
human |